Ig-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB50_LEIBR

TriTrypDb:

LbrM.20.2900 , LBRM2903_200042500

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4HB50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.540
CLV_NRD_NRD_1	250	252	PF00675	0.495
CLV_NRD_NRD_1	333	335	PF00675	0.430
CLV_NRD_NRD_1	483	485	PF00675	0.443
CLV_NRD_NRD_1	51	53	PF00675	0.578
CLV_PCSK_KEX2_1	250	252	PF00082	0.495
CLV_PCSK_KEX2_1	333	335	PF00082	0.430
CLV_PCSK_KEX2_1	482	484	PF00082	0.425
CLV_PCSK_KEX2_1	51	53	PF00082	0.629
CLV_PCSK_KEX2_1	73	75	PF00082	0.361
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.351
CLV_PCSK_SKI1_1	100	104	PF00082	0.426
CLV_PCSK_SKI1_1	155	159	PF00082	0.725
CLV_PCSK_SKI1_1	351	355	PF00082	0.365
CLV_PCSK_SKI1_1	391	395	PF00082	0.411
CLV_PCSK_SKI1_1	484	488	PF00082	0.563
CLV_PCSK_SKI1_1	70	74	PF00082	0.417
DEG_Nend_UBRbox_2	1	3	PF02207	0.719
DEG_SPOP_SBC_1	341	345	PF00917	0.315
DOC_CKS1_1	119	124	PF01111	0.374
DOC_CYCLIN_RxL_1	348	359	PF00134	0.288
DOC_MAPK_MEF2A_6	210	219	PF00069	0.523
DOC_PP1_RVXF_1	349	356	PF00149	0.286
DOC_PP4_FxxP_1	134	137	PF00568	0.669
DOC_PP4_FxxP_1	235	238	PF00568	0.518
DOC_PP4_FxxP_1	31	34	PF00568	0.663
DOC_PP4_FxxP_1	423	426	PF00568	0.432
DOC_USP7_MATH_1	206	210	PF00917	0.443
DOC_USP7_MATH_1	375	379	PF00917	0.510
DOC_WW_Pin1_4	118	123	PF00397	0.371
DOC_WW_Pin1_4	425	430	PF00397	0.495
DOC_WW_Pin1_4	57	62	PF00397	0.629
LIG_14-3-3_CanoR_1	109	115	PF00244	0.466
LIG_14-3-3_CanoR_1	155	160	PF00244	0.658
LIG_14-3-3_CanoR_1	250	260	PF00244	0.405
LIG_14-3-3_CanoR_1	29	34	PF00244	0.673
LIG_14-3-3_CanoR_1	333	338	PF00244	0.385
LIG_14-3-3_CanoR_1	74	80	PF00244	0.570
LIG_14-3-3_CanoR_1	8	15	PF00244	0.784
LIG_APCC_ABBA_1	420	425	PF00400	0.304
LIG_APCC_ABBAyCdc20_2	419	425	PF00400	0.300
LIG_BRCT_BRCA1_1	153	157	PF00533	0.478
LIG_BRCT_BRCA1_1	208	212	PF00533	0.270
LIG_BRCT_BRCA1_1	231	235	PF00533	0.550
LIG_BRCT_BRCA1_1	470	474	PF00533	0.410
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.504
LIG_deltaCOP1_diTrp_1	416	423	PF00928	0.286
LIG_eIF4E_1	135	141	PF01652	0.651
LIG_eIF4E_1	178	184	PF01652	0.468
LIG_FHA_1	156	162	PF00498	0.713
LIG_FHA_1	221	227	PF00498	0.550
LIG_FHA_1	316	322	PF00498	0.361
LIG_FHA_1	412	418	PF00498	0.536
LIG_FHA_1	433	439	PF00498	0.502
LIG_FHA_2	119	125	PF00498	0.344
LIG_FHA_2	184	190	PF00498	0.571
LIG_FHA_2	297	303	PF00498	0.371
LIG_FHA_2	341	347	PF00498	0.547
LIG_FHA_2	434	440	PF00498	0.552
LIG_FHA_2	502	508	PF00498	0.600
LIG_FHA_2	79	85	PF00498	0.461
LIG_LIR_Apic_2	116	122	PF02991	0.462
LIG_LIR_Apic_2	131	137	PF02991	0.526
LIG_LIR_Apic_2	232	238	PF02991	0.502
LIG_LIR_Gen_1	209	219	PF02991	0.263
LIG_LIR_Gen_1	309	320	PF02991	0.428
LIG_LIR_Gen_1	326	337	PF02991	0.426
LIG_LIR_Gen_1	366	377	PF02991	0.428
LIG_LIR_Gen_1	432	441	PF02991	0.310
LIG_LIR_Gen_1	471	478	PF02991	0.442
LIG_LIR_Nem_3	193	199	PF02991	0.598
LIG_LIR_Nem_3	209	215	PF02991	0.427
LIG_LIR_Nem_3	247	252	PF02991	0.479
LIG_LIR_Nem_3	309	315	PF02991	0.419
LIG_LIR_Nem_3	326	332	PF02991	0.389
LIG_LIR_Nem_3	366	372	PF02991	0.422
LIG_LIR_Nem_3	402	408	PF02991	0.489
LIG_LIR_Nem_3	432	437	PF02991	0.493
LIG_LIR_Nem_3	463	468	PF02991	0.531
LIG_LIR_Nem_3	471	477	PF02991	0.389
LIG_LIR_Nem_3	498	503	PF02991	0.640
LIG_LIR_Nem_3	65	69	PF02991	0.455
LIG_LIR_Nem_3	97	102	PF02991	0.504
LIG_MLH1_MIPbox_1	470	474	PF16413	0.457
LIG_NRBOX	286	292	PF00104	0.361
LIG_NRBOX	349	355	PF00104	0.534
LIG_NRBOX	389	395	PF00104	0.403
LIG_PDZ_Class_2	507	512	PF00595	0.497
LIG_Pex14_2	134	138	PF04695	0.589
LIG_Pex14_2	473	477	PF04695	0.419
LIG_PTB_Apo_2	467	474	PF02174	0.604
LIG_REV1ctd_RIR_1	463	473	PF16727	0.365
LIG_RPA_C_Fungi	205	217	PF08784	0.276
LIG_SH2_CRK	196	200	PF00017	0.622
LIG_SH2_CRK	369	373	PF00017	0.406
LIG_SH2_CRK	434	438	PF00017	0.472
LIG_SH2_GRB2like	503	506	PF00017	0.478
LIG_SH2_STAP1	434	438	PF00017	0.555
LIG_SH2_STAT5	173	176	PF00017	0.680
LIG_SH2_STAT5	296	299	PF00017	0.446
LIG_SH2_STAT5	369	372	PF00017	0.388
LIG_SH2_STAT5	434	437	PF00017	0.312
LIG_SH2_STAT5	503	506	PF00017	0.614
LIG_SH3_3	395	401	PF00018	0.391
LIG_SH3_3	423	429	PF00018	0.335
LIG_Sin3_3	285	292	PF02671	0.388
LIG_SUMO_SIM_par_1	156	163	PF11976	0.487
LIG_SUMO_SIM_par_1	197	202	PF11976	0.646
LIG_SUMO_SIM_par_1	391	397	PF11976	0.385
LIG_TRAF2_1	121	124	PF00917	0.575
LIG_TRAF2_1	20	23	PF00917	0.731
LIG_TRAF2_1	361	364	PF00917	0.387
LIG_TYR_ITIM	310	315	PF00017	0.387
LIG_TYR_ITIM	367	372	PF00017	0.376
LIG_TYR_ITSM	430	437	PF00017	0.316
LIG_UBA3_1	106	112	PF00899	0.488
MOD_CDK_SPxxK_3	118	125	PF00069	0.377
MOD_CK1_1	118	124	PF00069	0.416
MOD_CK1_1	273	279	PF00069	0.484
MOD_CK1_1	32	38	PF00069	0.684
MOD_CK1_1	345	351	PF00069	0.414
MOD_CK1_1	455	461	PF00069	0.507
MOD_CK1_1	501	507	PF00069	0.478
MOD_CK2_1	118	124	PF00069	0.348
MOD_CK2_1	183	189	PF00069	0.673
MOD_CK2_1	346	352	PF00069	0.478
MOD_CK2_1	433	439	PF00069	0.551
MOD_CK2_1	450	456	PF00069	0.519
MOD_CK2_1	80	86	PF00069	0.439
MOD_GlcNHglycan	143	146	PF01048	0.458
MOD_GlcNHglycan	231	234	PF01048	0.489
MOD_GlcNHglycan	283	286	PF01048	0.453
MOD_GlcNHglycan	31	34	PF01048	0.676
MOD_GlcNHglycan	372	375	PF01048	0.503
MOD_GlcNHglycan	377	380	PF01048	0.468
MOD_GlcNHglycan	401	404	PF01048	0.552
MOD_GlcNHglycan	470	473	PF01048	0.511
MOD_GlcNHglycan	500	503	PF01048	0.595
MOD_GlcNHglycan	61	64	PF01048	0.522
MOD_GSK3_1	151	158	PF00069	0.687
MOD_GSK3_1	174	181	PF00069	0.624
MOD_GSK3_1	271	278	PF00069	0.482
MOD_GSK3_1	304	311	PF00069	0.480
MOD_GSK3_1	323	330	PF00069	0.267
MOD_GSK3_1	341	348	PF00069	0.320
MOD_GSK3_1	425	432	PF00069	0.418
MOD_GSK3_1	468	475	PF00069	0.456
MOD_GSK3_1	7	14	PF00069	0.757
MOD_GSK3_1	74	81	PF00069	0.515
MOD_GSK3_1	91	98	PF00069	0.434
MOD_N-GLC_1	460	465	PF02516	0.643
MOD_NEK2_1	102	107	PF00069	0.505
MOD_NEK2_1	110	115	PF00069	0.520
MOD_NEK2_1	183	188	PF00069	0.651
MOD_NEK2_1	219	224	PF00069	0.509
MOD_NEK2_1	229	234	PF00069	0.490
MOD_NEK2_1	271	276	PF00069	0.461
MOD_NEK2_1	308	313	PF00069	0.380
MOD_NEK2_1	315	320	PF00069	0.363
MOD_NEK2_1	321	326	PF00069	0.312
MOD_NEK2_1	327	332	PF00069	0.228
MOD_NEK2_1	365	370	PF00069	0.360
MOD_NEK2_1	380	385	PF00069	0.358
MOD_NEK2_1	450	455	PF00069	0.500
MOD_NEK2_1	478	483	PF00069	0.531
MOD_NEK2_1	7	12	PF00069	0.647
MOD_PIKK_1	321	327	PF00454	0.450
MOD_PIKK_1	455	461	PF00454	0.408
MOD_PKA_1	333	339	PF00069	0.426
MOD_PKA_1	73	79	PF00069	0.330
MOD_PKA_2	333	339	PF00069	0.389
MOD_PKA_2	7	13	PF00069	0.784
MOD_PKA_2	73	79	PF00069	0.582
MOD_Plk_1	201	207	PF00069	0.594
MOD_Plk_1	308	314	PF00069	0.369
MOD_Plk_1	365	371	PF00069	0.469
MOD_Plk_1	455	461	PF00069	0.605
MOD_Plk_2-3	346	352	PF00069	0.489
MOD_Plk_4	102	108	PF00069	0.391
MOD_Plk_4	316	322	PF00069	0.420
MOD_Plk_4	433	439	PF00069	0.451
MOD_Plk_4	461	467	PF00069	0.517
MOD_ProDKin_1	118	124	PF00069	0.377
MOD_ProDKin_1	425	431	PF00069	0.489
MOD_ProDKin_1	57	63	PF00069	0.624
MOD_SUMO_for_1	169	172	PF00179	0.483
MOD_SUMO_for_1	20	23	PF00179	0.479
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.533
TRG_ENDOCYTIC_2	196	199	PF00928	0.564
TRG_ENDOCYTIC_2	312	315	PF00928	0.395
TRG_ENDOCYTIC_2	369	372	PF00928	0.395
TRG_ENDOCYTIC_2	434	437	PF00928	0.481
TRG_ER_diArg_1	249	251	PF00400	0.503
TRG_ER_diArg_1	332	334	PF00400	0.430
TRG_ER_diArg_1	443	446	PF00400	0.564
TRG_ER_diArg_1	482	484	PF00400	0.535
TRG_ER_diArg_1	51	53	PF00400	0.578
TRG_NES_CRM1_1	382	396	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	351	356	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I9	Leptomonas seymouri	40%	94%
A0A1X0P9X1	Trypanosomatidae	28%	100%
A0A3R7RMD9	Trypanosoma rangeli	28%	100%
A0A3S7X887	Leishmania donovani	63%	98%
A4IA98	Leishmania infantum	63%	98%
C9ZLZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	99%
Q4Q2L3	Leishmania major	64%	100%
V5BV51	Trypanosoma cruzi	30%	100%