rRNA maturation RNase YbeY

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized protein family UPF0054, putative

Species:

Leishmania braziliensis

UniProt:

A4HB49_LEIBR

TriTrypDb:

LbrM.20.2890 , LBRM2903_200042400

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB49

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.362
CLV_NRD_NRD_1	16	18	PF00675	0.378
CLV_NRD_NRD_1	183	185	PF00675	0.324
CLV_PCSK_FUR_1	141	145	PF00082	0.362
CLV_PCSK_KEX2_1	143	145	PF00082	0.338
CLV_PCSK_KEX2_1	16	18	PF00082	0.378
CLV_PCSK_KEX2_1	183	185	PF00082	0.291
CLV_PCSK_PC7_1	139	145	PF00082	0.386
CLV_PCSK_SKI1_1	4	8	PF00082	0.457
DEG_APCC_DBOX_1	121	129	PF00400	0.482
DEG_APCC_DBOX_1	36	44	PF00400	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.328
DOC_CDC14_PxL_1	150	158	PF14671	0.562
DOC_MAPK_gen_1	16	27	PF00069	0.581
DOC_MAPK_gen_1	72	82	PF00069	0.567
DOC_MAPK_MEF2A_6	20	29	PF00069	0.556
DOC_MAPK_MEF2A_6	201	208	PF00069	0.588
DOC_MAPK_NFAT4_5	20	28	PF00069	0.586
DOC_MAPK_RevD_3	131	144	PF00069	0.586
DOC_PP4_FxxP_1	82	85	PF00568	0.405
DOC_WW_Pin1_4	9	14	PF00397	0.426
LIG_14-3-3_CanoR_1	144	154	PF00244	0.567
LIG_Clathr_ClatBox_1	26	30	PF01394	0.562
LIG_EH1_1	20	28	PF00400	0.562
LIG_eIF4E_1	155	161	PF01652	0.534
LIG_FHA_1	10	16	PF00498	0.458
LIG_FHA_1	147	153	PF00498	0.565
LIG_FHA_1	60	66	PF00498	0.482
LIG_FHA_2	99	105	PF00498	0.502
LIG_LIR_Gen_1	130	140	PF02991	0.526
LIG_LIR_Gen_1	41	48	PF02991	0.558
LIG_LIR_Gen_1	66	73	PF02991	0.527
LIG_LIR_Nem_3	130	135	PF02991	0.489
LIG_LIR_Nem_3	136	140	PF02991	0.486
LIG_LIR_Nem_3	41	45	PF02991	0.558
LIG_LIR_Nem_3	66	70	PF02991	0.555
LIG_NRBOX	21	27	PF00104	0.433
LIG_SH2_CRK	137	141	PF00017	0.586
LIG_SH2_SRC	155	158	PF00017	0.534
LIG_SH2_STAP1	34	38	PF00017	0.562
LIG_SH2_STAT3	47	50	PF00017	0.405
LIG_SH2_STAT5	155	158	PF00017	0.474
LIG_SH3_3	148	154	PF00018	0.534
LIG_SUMO_SIM_par_1	124	130	PF11976	0.483
LIG_SUMO_SIM_par_1	25	30	PF11976	0.562
LIG_TYR_ITIM	135	140	PF00017	0.480
LIG_WRC_WIRS_1	64	69	PF05994	0.444
MOD_CDK_SPxxK_3	9	16	PF00069	0.454
MOD_CK2_1	98	104	PF00069	0.301
MOD_GlcNHglycan	118	121	PF01048	0.301
MOD_GSK3_1	55	62	PF00069	0.348
MOD_NEK2_1	116	121	PF00069	0.471
MOD_NEK2_1	65	70	PF00069	0.337
MOD_PKA_2	59	65	PF00069	0.402
MOD_Plk_4	111	117	PF00069	0.425
MOD_ProDKin_1	9	15	PF00069	0.420
TRG_AP2beta_CARGO_1	130	139	PF09066	0.227
TRG_DiLeu_BaEn_1	18	23	PF01217	0.266
TRG_ENDOCYTIC_2	137	140	PF00928	0.400
TRG_ER_diArg_1	138	141	PF00400	0.417
TRG_ER_diArg_1	143	145	PF00400	0.397
TRG_ER_diArg_1	15	17	PF00400	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1C3	Leptomonas seymouri	50%	98%
A0A0S4ILL3	Bodo saltans	40%	89%
A0A1X0PA77	Trypanosomatidae	32%	98%
A0A3R7KIB7	Trypanosoma rangeli	39%	100%
A0A3S7X8C1	Leishmania donovani	78%	100%
A4IA97	Leishmania infantum	80%	100%
C9ZLZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B5B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2L4	Leishmania major	77%	100%