Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB48_LEIBR

TriTrypDb:

LbrM.20.2880 , LBRM2903_200042300

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.380
CLV_MEL_PAP_1	267	273	PF00089	0.538
CLV_NRD_NRD_1	165	167	PF00675	0.592
CLV_NRD_NRD_1	219	221	PF00675	0.585
CLV_PCSK_KEX2_1	468	470	PF00082	0.484
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.484
CLV_PCSK_SKI1_1	124	128	PF00082	0.516
CLV_PCSK_SKI1_1	180	184	PF00082	0.539
CLV_PCSK_SKI1_1	187	191	PF00082	0.458
CLV_PCSK_SKI1_1	257	261	PF00082	0.532
CLV_PCSK_SKI1_1	463	467	PF00082	0.301
DEG_APCC_DBOX_1	179	187	PF00400	0.426
DEG_SCF_FBW7_1	85	91	PF00400	0.384
DOC_ANK_TNKS_1	322	329	PF00023	0.370
DOC_CKS1_1	175	180	PF01111	0.340
DOC_CKS1_1	85	90	PF01111	0.457
DOC_MAPK_DCC_7	180	188	PF00069	0.403
DOC_MAPK_gen_1	468	474	PF00069	0.569
DOC_MAPK_MEF2A_6	180	188	PF00069	0.418
DOC_PP1_RVXF_1	234	241	PF00149	0.467
DOC_PP1_RVXF_1	263	270	PF00149	0.391
DOC_PP1_RVXF_1	359	365	PF00149	0.411
DOC_PP2B_LxvP_1	127	130	PF13499	0.394
DOC_PP4_FxxP_1	182	185	PF00568	0.287
DOC_SPAK_OSR1_1	323	327	PF12202	0.248
DOC_USP7_MATH_1	120	124	PF00917	0.385
DOC_USP7_MATH_1	156	160	PF00917	0.383
DOC_USP7_MATH_1	404	408	PF00917	0.602
DOC_USP7_MATH_1	457	461	PF00917	0.550
DOC_USP7_MATH_1	88	92	PF00917	0.520
DOC_USP7_MATH_1	93	97	PF00917	0.453
DOC_WW_Pin1_4	174	179	PF00397	0.410
DOC_WW_Pin1_4	433	438	PF00397	0.600
DOC_WW_Pin1_4	442	447	PF00397	0.497
DOC_WW_Pin1_4	84	89	PF00397	0.570
LIG_14-3-3_CanoR_1	187	193	PF00244	0.295
LIG_14-3-3_CanoR_1	196	205	PF00244	0.354
LIG_14-3-3_CanoR_1	21	29	PF00244	0.393
LIG_14-3-3_CanoR_1	291	296	PF00244	0.313
LIG_14-3-3_CanoR_1	304	311	PF00244	0.369
LIG_14-3-3_CanoR_1	323	327	PF00244	0.324
LIG_14-3-3_CanoR_1	361	367	PF00244	0.411
LIG_14-3-3_CanoR_1	37	45	PF00244	0.435
LIG_14-3-3_CanoR_1	386	395	PF00244	0.598
LIG_14-3-3_CanoR_1	418	428	PF00244	0.545
LIG_14-3-3_CanoR_1	458	466	PF00244	0.560
LIG_14-3-3_CanoR_1	77	81	PF00244	0.383
LIG_14-3-3_CanoR_1	90	100	PF00244	0.474
LIG_Actin_WH2_2	381	398	PF00022	0.592
LIG_AP2alpha_1	305	309	PF02296	0.373
LIG_APCC_ABBA_1	377	382	PF00400	0.334
LIG_BIR_III_2	33	37	PF00653	0.353
LIG_BRCT_BRCA1_1	305	309	PF00533	0.437
LIG_Clathr_ClatBox_1	111	115	PF01394	0.407
LIG_CtBP_PxDLS_1	437	441	PF00389	0.611
LIG_deltaCOP1_diTrp_1	105	110	PF00928	0.355
LIG_FHA_1	107	113	PF00498	0.364
LIG_FHA_1	242	248	PF00498	0.323
LIG_FHA_1	26	32	PF00498	0.499
LIG_FHA_1	348	354	PF00498	0.380
LIG_FHA_1	390	396	PF00498	0.489
LIG_FHA_2	100	106	PF00498	0.308
LIG_FHA_2	275	281	PF00498	0.297
LIG_FHA_2	28	34	PF00498	0.361
LIG_FHA_2	420	426	PF00498	0.664
LIG_LIR_Apic_2	173	178	PF02991	0.335
LIG_LIR_Apic_2	181	185	PF02991	0.279
LIG_LIR_Gen_1	190	198	PF02991	0.373
LIG_LIR_Gen_1	237	247	PF02991	0.334
LIG_LIR_Gen_1	425	435	PF02991	0.636
LIG_LIR_Nem_3	171	175	PF02991	0.315
LIG_LIR_Nem_3	190	195	PF02991	0.331
LIG_LIR_Nem_3	200	205	PF02991	0.335
LIG_LIR_Nem_3	237	243	PF02991	0.368
LIG_LIR_Nem_3	306	311	PF02991	0.335
LIG_LIR_Nem_3	365	369	PF02991	0.346
LIG_LIR_Nem_3	425	431	PF02991	0.646
LIG_MLH1_MIPbox_1	305	309	PF16413	0.440
LIG_MYND_3	378	382	PF01753	0.598
LIG_Pex14_1	136	140	PF04695	0.313
LIG_Pex14_1	452	456	PF04695	0.563
LIG_Pex14_2	305	309	PF04695	0.373
LIG_REV1ctd_RIR_1	158	167	PF16727	0.343
LIG_SH2_CRK	175	179	PF00017	0.334
LIG_SH2_STAP1	311	315	PF00017	0.244
LIG_SH2_STAP1	45	49	PF00017	0.483
LIG_SH2_STAT5	149	152	PF00017	0.288
LIG_SH2_STAT5	45	48	PF00017	0.484
LIG_SH3_3	82	88	PF00018	0.431
LIG_SUMO_SIM_anti_2	470	476	PF11976	0.582
LIG_SUMO_SIM_par_1	115	123	PF11976	0.426
LIG_SUMO_SIM_par_1	27	33	PF11976	0.498
LIG_SUMO_SIM_par_1	355	360	PF11976	0.311
LIG_TRAF2_1	422	425	PF00917	0.671
LIG_UBA3_1	38	47	PF00899	0.470
LIG_WRC_WIRS_1	157	162	PF05994	0.385
LIG_WRC_WIRS_1	179	184	PF05994	0.314
MOD_CDK_SPxK_1	174	180	PF00069	0.415
MOD_CDK_SPxK_1	84	90	PF00069	0.374
MOD_CK1_1	159	165	PF00069	0.260
MOD_CK1_1	253	259	PF00069	0.347
MOD_CK1_1	416	422	PF00069	0.581
MOD_CK1_1	91	97	PF00069	0.565
MOD_CK1_1	99	105	PF00069	0.295
MOD_CK2_1	274	280	PF00069	0.310
MOD_CK2_1	417	423	PF00069	0.694
MOD_CK2_1	436	442	PF00069	0.457
MOD_CK2_1	99	105	PF00069	0.313
MOD_CMANNOS	107	110	PF00535	0.546
MOD_CMANNOS	363	366	PF00535	0.411
MOD_GlcNHglycan	146	149	PF01048	0.599
MOD_GlcNHglycan	312	316	PF01048	0.564
MOD_GlcNHglycan	39	42	PF01048	0.662
MOD_GlcNHglycan	415	418	PF01048	0.541
MOD_GlcNHglycan	91	94	PF01048	0.697
MOD_GSK3_1	170	177	PF00069	0.437
MOD_GSK3_1	21	28	PF00069	0.398
MOD_GSK3_1	246	253	PF00069	0.279
MOD_GSK3_1	412	419	PF00069	0.740
MOD_GSK3_1	438	445	PF00069	0.613
MOD_GSK3_1	49	56	PF00069	0.419
MOD_GSK3_1	84	91	PF00069	0.553
MOD_GSK3_1	95	102	PF00069	0.439
MOD_N-GLC_1	298	303	PF02516	0.575
MOD_N-GLC_1	43	48	PF02516	0.558
MOD_NEK2_1	188	193	PF00069	0.330
MOD_NEK2_1	362	367	PF00069	0.411
MOD_NEK2_1	381	386	PF00069	0.436
MOD_NEK2_1	388	393	PF00069	0.528
MOD_NEK2_2	156	161	PF00069	0.409
MOD_NEK2_2	197	202	PF00069	0.267
MOD_NEK2_2	49	54	PF00069	0.384
MOD_PIKK_1	113	119	PF00454	0.368
MOD_PIKK_1	21	27	PF00454	0.385
MOD_PKA_2	303	309	PF00069	0.431
MOD_PKA_2	322	328	PF00069	0.333
MOD_PKA_2	417	423	PF00069	0.569
MOD_PKA_2	457	463	PF00069	0.564
MOD_PKA_2	76	82	PF00069	0.386
MOD_PKA_2	89	95	PF00069	0.496
MOD_Plk_1	16	22	PF00069	0.484
MOD_Plk_1	170	176	PF00069	0.319
MOD_Plk_1	298	304	PF00069	0.366
MOD_Plk_1	381	387	PF00069	0.594
MOD_Plk_2-3	60	66	PF00069	0.377
MOD_Plk_4	106	112	PF00069	0.286
MOD_Plk_4	156	162	PF00069	0.365
MOD_Plk_4	404	410	PF00069	0.618
MOD_Plk_4	67	73	PF00069	0.402
MOD_Plk_4	76	82	PF00069	0.395
MOD_ProDKin_1	174	180	PF00069	0.415
MOD_ProDKin_1	433	439	PF00069	0.600
MOD_ProDKin_1	442	448	PF00069	0.493
MOD_ProDKin_1	84	90	PF00069	0.576
TRG_DiLeu_BaEn_4	64	70	PF01217	0.355
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.267
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.468
TRG_ENDOCYTIC_2	192	195	PF00928	0.370
TRG_ER_diArg_1	290	293	PF00400	0.315
TRG_NES_CRM1_1	320	334	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P448	Leptomonas seymouri	31%	96%
A0A3S7X8E6	Leishmania donovani	69%	100%
A4IA96	Leishmania infantum	69%	100%
E9B5B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q2L5	Leishmania major	68%	100%