Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB47_LEIBR

TriTrypDb:

LbrM.20.2870 , LBRM2903_200042200

Length:

203

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 183
NetGPI	no	yes: 0, no: 194

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

Expansion

Sequence features

A4HB47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB47

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.452
CLV_PCSK_FUR_1	75	79	PF00082	0.460
CLV_PCSK_KEX2_1	77	79	PF00082	0.554
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.457
CLV_PCSK_SKI1_1	38	42	PF00082	0.571
DEG_Nend_UBRbox_4	1	3	PF02207	0.431
DOC_CKS1_1	26	31	PF01111	0.423
DOC_MAPK_gen_1	108	117	PF00069	0.522
DOC_MAPK_MEF2A_6	108	117	PF00069	0.526
DOC_PP1_RVXF_1	36	42	PF00149	0.248
DOC_PP2B_LxvP_1	199	202	PF13499	0.633
DOC_PP4_FxxP_1	33	36	PF00568	0.373
DOC_WW_Pin1_4	25	30	PF00397	0.417
LIG_BRCT_BRCA1_1	189	193	PF00533	0.254
LIG_EH1_1	12	20	PF00400	0.460
LIG_eIF4E_1	13	19	PF01652	0.453
LIG_FHA_1	63	69	PF00498	0.344
LIG_FHA_2	57	63	PF00498	0.351
LIG_LIR_Apic_2	30	36	PF02991	0.480
LIG_LIR_Gen_1	190	201	PF02991	0.446
LIG_LIR_Nem_3	190	196	PF02991	0.454
LIG_PDZ_Class_2	198	203	PF00595	0.403
LIG_Pex14_1	189	193	PF04695	0.291
LIG_PTB_Apo_2	172	179	PF02174	0.252
LIG_PTB_Apo_2	192	199	PF02174	0.469
LIG_PTB_Phospho_1	172	178	PF10480	0.252
LIG_SH2_CRK	13	17	PF00017	0.441
LIG_SH2_SRC	176	179	PF00017	0.247
LIG_SH2_STAT5	13	16	PF00017	0.545
LIG_SH2_STAT5	185	188	PF00017	0.394
LIG_SH3_3	157	163	PF00018	0.252
LIG_SH3_3	23	29	PF00018	0.398
LIG_TYR_ITIM	11	16	PF00017	0.553
MOD_CK1_1	42	48	PF00069	0.267
MOD_CK1_1	86	92	PF00069	0.329
MOD_GlcNHglycan	41	44	PF01048	0.509
MOD_GlcNHglycan	92	95	PF01048	0.518
MOD_GSK3_1	86	93	PF00069	0.365
MOD_N-GLC_1	147	152	PF02516	0.531
MOD_N-GLC_1	156	161	PF02516	0.539
MOD_N-GLC_2	54	56	PF02516	0.496
MOD_NEK2_2	147	152	PF00069	0.263
MOD_PIKK_1	158	164	PF00454	0.253
MOD_PK_1	156	162	PF00069	0.248
MOD_PKA_2	63	69	PF00069	0.412
MOD_Plk_1	147	153	PF00069	0.366
MOD_Plk_4	45	51	PF00069	0.350
MOD_Plk_4	86	92	PF00069	0.347
MOD_ProDKin_1	25	31	PF00069	0.417
TRG_ENDOCYTIC_2	13	16	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	26%	100%
A0A0N0P547	Leptomonas seymouri	37%	100%
A0A0N0P993	Leptomonas seymouri	26%	91%
A0A0N1HWY5	Leptomonas seymouri	27%	100%
A0A0N1PDH0	Leptomonas seymouri	54%	100%
A0A1X0NUH1	Trypanosomatidae	23%	89%
A0A1X0P988	Trypanosomatidae	37%	100%
A0A381MTA7	Leishmania infantum	36%	100%
A0A381MTB8	Leishmania infantum	33%	100%
A0A381MTC7	Leishmania infantum	33%	99%
A0A381MTN2	Leishmania infantum	35%	100%
A0A381MVY0	Leishmania infantum	36%	100%
A0A3Q8ID16	Leishmania donovani	25%	100%
A0A3Q8IE85	Leishmania donovani	47%	100%
A0A3Q8IEC2	Leishmania donovani	33%	100%
A0A3Q8IEI1	Leishmania donovani	36%	100%
A0A3Q8IF65	Leishmania donovani	30%	100%
A0A3Q8IFB9	Leishmania donovani	70%	100%
A0A3Q8IFH7	Leishmania donovani	33%	99%
A0A3Q8IFI8	Leishmania donovani	24%	96%
A0A3Q8IH65	Leishmania donovani	32%	100%
A0A3Q8IHN2	Leishmania donovani	36%	100%
A0A3Q8IHW7	Leishmania donovani	37%	100%
A0A3Q8IHZ6	Leishmania donovani	36%	96%
A0A3Q8IIH1	Leishmania donovani	34%	100%
A0A3Q8IL03	Leishmania donovani	33%	100%
A0A3Q8IUK8	Leishmania donovani	37%	100%
A0A3Q8IUR5	Leishmania donovani	35%	100%
A0A3S5H662	Leishmania donovani	32%	100%
A0A3S5H663	Leishmania donovani	32%	100%
A0A3S5H665	Leishmania donovani	32%	100%
A0A3S5H666	Leishmania donovani	41%	100%
A0A3S5H667	Leishmania donovani	32%	100%
A0A3S5H7D2	Leishmania donovani	26%	100%
A0A3S5H7L2	Leishmania donovani	36%	99%
A0A3S5H7V9	Leishmania donovani	35%	100%
A0A3S5H7W2	Leishmania donovani	28%	100%
A0A3S5H7W6	Leishmania donovani	33%	100%
A0A3S7WQA0	Leishmania donovani	32%	100%
A0A3S7WQA8	Leishmania donovani	38%	100%
A0A3S7WQC1	Leishmania donovani	38%	100%
A0A3S7X2E6	Leishmania donovani	36%	100%
A0A3S7X381	Leishmania donovani	24%	97%
A0A3S7X453	Leishmania donovani	29%	100%
A0A3S7X472	Leishmania donovani	32%	100%
A0A3S7X7E5	Leishmania donovani	38%	81%
A0A3S7X7M4	Leishmania donovani	36%	96%
A0A3S7X7U1	Leishmania donovani	29%	97%
A0A3S7X7U4	Leishmania donovani	35%	78%
A0A3S7X7W2	Leishmania donovani	32%	97%
A0A3S7X7Y0	Leishmania donovani	34%	100%
A4H595	Leishmania braziliensis	30%	100%
A4H596	Leishmania braziliensis	30%	100%
A4H597	Leishmania braziliensis	30%	100%
A4H5D1	Leishmania braziliensis	36%	99%
A4H5D2	Leishmania braziliensis	34%	94%
A4H5G0	Leishmania braziliensis	37%	96%
A4H5G4	Leishmania braziliensis	34%	100%
A4H5G6	Leishmania braziliensis	31%	100%
A4H5G7	Leishmania braziliensis	30%	100%
A4H5G9	Leishmania braziliensis	33%	93%
A4H5H0	Leishmania braziliensis	33%	94%
A4H5H1	Leishmania braziliensis	34%	95%
A4H5H2	Leishmania braziliensis	36%	96%
A4H5H3	Leishmania braziliensis	34%	100%
A4H6C8	Leishmania braziliensis	35%	100%
A4H7D7	Leishmania braziliensis	34%	99%
A4H9E8	Leishmania braziliensis	35%	100%
A4H9E9	Leishmania braziliensis	35%	98%
A4HAJ4	Leishmania braziliensis	31%	100%
A4HAJ5	Leishmania braziliensis	33%	100%
A4HAJ6	Leishmania braziliensis	30%	100%
A4HAL1	Leishmania braziliensis	31%	94%
A4HAL2	Leishmania braziliensis	27%	99%
A4HAM2	Leishmania braziliensis	38%	99%
A4HAM4	Leishmania braziliensis	38%	99%
A4HAR1	Leishmania braziliensis	39%	99%
A4HAZ8	Leishmania braziliensis	36%	98%
A4HB00	Leishmania braziliensis	37%	99%
A4HB02	Leishmania braziliensis	36%	99%
A4HBJ0	Leishmania braziliensis	31%	100%
A4HBJ1	Leishmania braziliensis	38%	100%
A4HBJ2	Leishmania braziliensis	36%	98%
A4HDI2	Leishmania braziliensis	22%	100%
A4HTM3	Leishmania infantum	40%	100%
A4HTM4	Leishmania infantum	37%	100%
A4HTM5	Leishmania infantum	38%	100%
A4I0W5	Leishmania infantum	25%	100%
A4I4J2	Leishmania infantum	35%	99%
A4I4J3	Leishmania infantum	38%	79%
A4I5B8	Leishmania infantum	24%	100%
A4I6E5	Leishmania infantum	32%	100%
A4I9Q4	Leishmania infantum	37%	100%
A4I9R4	Leishmania infantum	28%	100%
A4I9R5	Leishmania infantum	69%	100%
A4I9R7	Leishmania infantum	38%	100%
A4I9W8	Leishmania infantum	35%	78%
A4I9X0	Leishmania infantum	32%	97%
A4IA59	Leishmania infantum	34%	78%
A4IAL7	Leishmania infantum	37%	100%
A4IAM1	Leishmania infantum	36%	100%
A4IAM2	Leishmania infantum	36%	100%
C6K3X5	Leptomonas seymouri	27%	100%
C6K3X9	Leptomonas seymouri	24%	100%
E8NHC3	Leishmania infantum	32%	100%
E8NHD3	Leishmania infantum	37%	99%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	97%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	96%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	96%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	97%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AG81	Leishmania infantum	34%	100%
E9AG82	Leishmania infantum	34%	100%
E9AG83	Leishmania infantum	40%	100%
E9AG85	Leishmania infantum	34%	100%
E9AHI9	Leishmania infantum	37%	100%
E9AHT2	Leishmania infantum	37%	96%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	79%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
Q4Q1U9	Leishmania major	36%	96%
Q4Q305	Leishmania major	33%	96%
Q4Q309	Leishmania major	34%	100%
Q4Q313	Leishmania major	32%	97%
Q4Q325	Leishmania major	34%	100%
Q4Q327	Leishmania major	33%	98%
Q4Q329	Leishmania major	34%	97%
Q4Q333	Leishmania major	33%	97%
Q4Q335	Leishmania major	33%	96%
Q4Q337	Leishmania major	34%	97%
Q4Q339	Leishmania major	33%	96%
Q4Q341	Leishmania major	36%	90%
Q4Q397	Leishmania major	37%	100%
Q4Q3A7	Leishmania major	26%	96%
Q4Q3A8	Leishmania major	73%	100%
Q4Q3A9	Leishmania major	37%	100%
Q4Q3F7	Leishmania major	39%	100%
Q4Q6L8	Leishmania major	30%	100%
Q4Q7L6	Leishmania major	29%	92%
Q4Q7L7	Leishmania major	26%	100%
Q4Q7L8	Leishmania major	26%	100%
Q4QAK6	Leishmania major	28%	100%
Q4QAK7	Leishmania major	24%	97%
Q4QI84	Leishmania major	40%	88%
Q4QI85	Leishmania major	42%	97%
Q4QI86	Leishmania major	40%	88%
Q4QI87	Leishmania major	42%	97%
Q4QI88	Leishmania major	44%	94%
Q4QI92	Leishmania major	36%	100%
Q4QI93	Leishmania major	36%	100%
Q4QI95	Leishmania major	36%	100%
Q4QI97	Leishmania major	36%	100%
Q4QIA0	Leishmania major	35%	100%
Q4QIA1	Leishmania major	35%	100%