UBP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HB46_LEIBR

TriTrypDb:

LbrM.20.2860 , LBRM2903_200042000

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB46

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.564
CLV_C14_Caspase3-7	303	307	PF00656	0.668
CLV_C14_Caspase3-7	67	71	PF00656	0.611
CLV_NRD_NRD_1	127	129	PF00675	0.552
CLV_NRD_NRD_1	357	359	PF00675	0.591
CLV_NRD_NRD_1	382	384	PF00675	0.485
CLV_NRD_NRD_1	431	433	PF00675	0.562
CLV_PCSK_KEX2_1	127	129	PF00082	0.552
CLV_PCSK_KEX2_1	292	294	PF00082	0.502
CLV_PCSK_KEX2_1	356	358	PF00082	0.575
CLV_PCSK_KEX2_1	382	384	PF00082	0.520
CLV_PCSK_KEX2_1	431	433	PF00082	0.595
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.546
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.612
CLV_PCSK_SKI1_1	272	276	PF00082	0.616
CLV_PCSK_SKI1_1	292	296	PF00082	0.276
CLV_PCSK_SKI1_1	358	362	PF00082	0.511
CLV_PCSK_SKI1_1	392	396	PF00082	0.531
CLV_PCSK_SKI1_1	414	418	PF00082	0.568
CLV_PCSK_SKI1_1	444	448	PF00082	0.707
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DEG_SPOP_SBC_1	107	111	PF00917	0.396
DOC_MAPK_MEF2A_6	158	166	PF00069	0.513
DOC_USP7_MATH_1	107	111	PF00917	0.494
DOC_USP7_MATH_1	12	16	PF00917	0.606
DOC_USP7_MATH_1	324	328	PF00917	0.605
DOC_USP7_MATH_1	345	349	PF00917	0.612
DOC_USP7_MATH_1	394	398	PF00917	0.563
DOC_USP7_MATH_1	424	428	PF00917	0.338
DOC_USP7_MATH_1	457	461	PF00917	0.632
DOC_USP7_UBL2_3	260	264	PF12436	0.560
DOC_USP7_UBL2_3	269	273	PF12436	0.480
DOC_WW_Pin1_4	252	257	PF00397	0.718
LIG_14-3-3_CanoR_1	357	367	PF00244	0.521
LIG_14-3-3_CanoR_1	408	416	PF00244	0.469
LIG_14-3-3_CanoR_1	50	55	PF00244	0.568
LIG_Actin_WH2_2	35	52	PF00022	0.341
LIG_Actin_WH2_2	381	398	PF00022	0.498
LIG_Actin_WH2_2	402	419	PF00022	0.510
LIG_AP2alpha_2	161	163	PF02296	0.463
LIG_EH1_1	210	218	PF00400	0.631
LIG_FHA_1	114	120	PF00498	0.559
LIG_FHA_1	196	202	PF00498	0.450
LIG_FHA_1	359	365	PF00498	0.613
LIG_FHA_1	379	385	PF00498	0.545
LIG_FHA_1	80	86	PF00498	0.329
LIG_FHA_2	374	380	PF00498	0.590
LIG_FHA_2	417	423	PF00498	0.446
LIG_FHA_2	65	71	PF00498	0.635
LIG_LIR_Apic_2	75	81	PF02991	0.516
LIG_LIR_Gen_1	161	171	PF02991	0.452
LIG_LIR_Gen_1	174	181	PF02991	0.453
LIG_LIR_Gen_1	223	230	PF02991	0.682
LIG_LIR_Gen_1	335	343	PF02991	0.629
LIG_LIR_Nem_3	161	166	PF02991	0.452
LIG_LIR_Nem_3	223	229	PF02991	0.679
LIG_LIR_Nem_3	335	339	PF02991	0.619
LIG_LIR_Nem_3	340	346	PF02991	0.578
LIG_LIR_Nem_3	75	80	PF02991	0.504
LIG_SH2_CRK	281	285	PF00017	0.595
LIG_SH2_STAP1	270	274	PF00017	0.549
LIG_SH2_STAP1	281	285	PF00017	0.439
LIG_SH2_STAP1	296	300	PF00017	0.473
LIG_SH2_STAT3	296	299	PF00017	0.590
LIG_SH2_STAT3	97	100	PF00017	0.644
LIG_SH2_STAT5	170	173	PF00017	0.491
LIG_SH2_STAT5	55	58	PF00017	0.579
LIG_SH2_STAT5	79	82	PF00017	0.488
LIG_SH3_1	78	84	PF00018	0.577
LIG_SH3_3	78	84	PF00018	0.577
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.505
LIG_SUMO_SIM_par_1	212	221	PF11976	0.532
LIG_TYR_ITSM	73	80	PF00017	0.531
MOD_CK1_1	110	116	PF00069	0.631
MOD_CK1_1	451	457	PF00069	0.671
MOD_CK1_1	99	105	PF00069	0.578
MOD_CK2_1	373	379	PF00069	0.563
MOD_CK2_1	409	415	PF00069	0.491
MOD_GlcNHglycan	110	113	PF01048	0.560
MOD_GlcNHglycan	147	150	PF01048	0.626
MOD_GlcNHglycan	16	19	PF01048	0.491
MOD_GlcNHglycan	244	247	PF01048	0.686
MOD_GlcNHglycan	266	269	PF01048	0.660
MOD_GlcNHglycan	324	327	PF01048	0.618
MOD_GlcNHglycan	450	453	PF01048	0.651
MOD_GlcNHglycan	459	462	PF01048	0.665
MOD_GlcNHglycan	94	97	PF01048	0.564
MOD_GSK3_1	106	113	PF00069	0.476
MOD_GSK3_1	216	223	PF00069	0.612
MOD_GSK3_1	466	473	PF00069	0.690
MOD_GSK3_1	92	99	PF00069	0.564
MOD_N-GLC_1	474	479	PF02516	0.623
MOD_NEK2_1	118	123	PF00069	0.523
MOD_NEK2_1	145	150	PF00069	0.397
MOD_NEK2_1	237	242	PF00069	0.483
MOD_NEK2_1	274	279	PF00069	0.595
MOD_NEK2_1	295	300	PF00069	0.560
MOD_NEK2_1	337	342	PF00069	0.627
MOD_NEK2_1	407	412	PF00069	0.471
MOD_NEK2_1	416	421	PF00069	0.396
MOD_NEK2_1	49	54	PF00069	0.379
MOD_NEK2_1	90	95	PF00069	0.574
MOD_OFUCOSY	117	123	PF10250	0.447
MOD_PIKK_1	110	116	PF00454	0.407
MOD_PIKK_1	195	201	PF00454	0.454
MOD_PIKK_1	295	301	PF00454	0.596
MOD_PIKK_1	426	432	PF00454	0.576
MOD_PIKK_1	96	102	PF00454	0.663
MOD_PKA_1	272	278	PF00069	0.641
MOD_PKA_1	358	364	PF00069	0.576
MOD_PKA_2	107	113	PF00069	0.398
MOD_PKA_2	407	413	PF00069	0.490
MOD_PKA_2	49	55	PF00069	0.600
MOD_Plk_1	90	96	PF00069	0.588
MOD_Plk_4	205	211	PF00069	0.510
MOD_Plk_4	222	228	PF00069	0.675
MOD_Plk_4	31	37	PF00069	0.475
MOD_Plk_4	345	351	PF00069	0.560
MOD_Plk_4	50	56	PF00069	0.597
MOD_Plk_4	73	79	PF00069	0.634
MOD_ProDKin_1	252	258	PF00069	0.716
MOD_SUMO_for_1	151	154	PF00179	0.512
MOD_SUMO_for_1	285	288	PF00179	0.562
MOD_SUMO_rev_2	257	266	PF00179	0.646
MOD_SUMO_rev_2	267	275	PF00179	0.579
MOD_SUMO_rev_2	287	294	PF00179	0.568
MOD_SUMO_rev_2	410	419	PF00179	0.520
TRG_DiLeu_BaEn_4	379	385	PF01217	0.591
TRG_ENDOCYTIC_2	176	179	PF00928	0.513
TRG_ENDOCYTIC_2	281	284	PF00928	0.588
TRG_ENDOCYTIC_2	336	339	PF00928	0.609
TRG_ENDOCYTIC_2	77	80	PF00928	0.493
TRG_ER_diArg_1	127	129	PF00400	0.552
TRG_ER_diArg_1	382	384	PF00400	0.520
TRG_ER_diArg_1	431	433	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV0	Leptomonas seymouri	65%	80%
A0A0S4ILW6	Bodo saltans	31%	84%
A0A1X0PAX0	Trypanosomatidae	33%	94%
A0A3Q8IEL0	Leishmania donovani	83%	100%
A0A422NNH1	Trypanosoma rangeli	37%	97%
A4IA95	Leishmania infantum	83%	82%
C9ZLZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9B5B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O13747	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	88%
Q4Q2L6	Leishmania major	79%	100%
Q7Z569	Homo sapiens	24%	81%
Q95QN6	Caenorhabditis elegans	25%	81%
Q99MP8	Mus musculus	24%	81%
V5DLZ1	Trypanosoma cruzi	33%	95%