DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania braziliensis

UniProt:

A4HB45_LEIBR

TriTrypDb:

LbrM.20.2850 , LBRM2903_200041900

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	44	46	PF00675	0.444
CLV_PCSK_FUR_1	170	174	PF00082	0.535
CLV_PCSK_KEX2_1	112	114	PF00082	0.294
CLV_PCSK_KEX2_1	172	174	PF00082	0.529
CLV_PCSK_KEX2_1	54	56	PF00082	0.449
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.314
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.529
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.463
DOC_MAPK_gen_1	170	179	PF00069	0.536
DOC_MAPK_gen_1	34	42	PF00069	0.457
DOC_MAPK_gen_1	45	52	PF00069	0.463
DOC_MAPK_RevD_3	158	173	PF00069	0.615
DOC_PP4_FxxP_1	118	121	PF00568	0.208
DOC_WW_Pin1_4	154	159	PF00397	0.703
LIG_14-3-3_CanoR_1	170	179	PF00244	0.648
LIG_14-3-3_CanoR_1	34	42	PF00244	0.439
LIG_APCC_ABBA_1	80	85	PF00400	0.339
LIG_BIR_III_2	155	159	PF00653	0.453
LIG_FHA_1	155	161	PF00498	0.554
LIG_FHA_1	172	178	PF00498	0.646
LIG_LYPXL_S_1	82	86	PF13949	0.294
LIG_LYPXL_yS_3	83	86	PF13949	0.294
LIG_MAD2	113	121	PF02301	0.294
LIG_MYND_1	158	162	PF01753	0.613
LIG_SH2_CRK	56	60	PF00017	0.494
LIG_SH3_3	156	162	PF00018	0.638
LIG_SH3_3	61	67	PF00018	0.484
LIG_TRAF2_1	162	165	PF00917	0.644
LIG_UBA3_1	176	182	PF00899	0.525
MOD_CK1_1	154	160	PF00069	0.451
MOD_CK1_1	24	30	PF00069	0.585
MOD_Cter_Amidation	52	55	PF01082	0.470
MOD_GlcNHglycan	142	145	PF01048	0.696
MOD_GlcNHglycan	17	20	PF01048	0.514
MOD_GlcNHglycan	26	29	PF01048	0.452
MOD_GSK3_1	102	109	PF00069	0.302
MOD_GSK3_1	146	153	PF00069	0.494
MOD_N-GLC_1	165	170	PF02516	0.581
MOD_N-GLC_1	22	27	PF02516	0.521
MOD_NEK2_1	128	133	PF00069	0.508
MOD_NEK2_1	2	7	PF00069	0.538
MOD_NEK2_1	21	26	PF00069	0.573
MOD_NEK2_1	29	34	PF00069	0.474
MOD_PIKK_1	22	28	PF00454	0.590
MOD_PK_1	36	42	PF00069	0.324
MOD_PKA_1	172	178	PF00069	0.646
MOD_PKA_2	172	178	PF00069	0.655
MOD_Plk_1	128	134	PF00069	0.441
MOD_Plk_1	165	171	PF00069	0.634
MOD_Plk_4	172	178	PF00069	0.646
MOD_ProDKin_1	154	160	PF00069	0.697
TRG_DiLeu_BaEn_4	164	170	PF01217	0.575
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.599
TRG_ENDOCYTIC_2	83	86	PF00928	0.317
TRG_ER_diArg_1	61	64	PF00400	0.513
TRG_ER_diArg_1	97	100	PF00400	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU88	Leptomonas seymouri	69%	91%
A0A0S4IIF2	Bodo saltans	34%	88%
A0A1X0PA15	Trypanosomatidae	55%	100%
A0A3R7NSK5	Trypanosoma rangeli	55%	100%
A0A3S7X894	Leishmania donovani	75%	99%
A4IA94	Leishmania infantum	76%	99%
C9ZM00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B5B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q2L7	Leishmania major	78%	100%