DRMBL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair metallo-beta-lactamase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB44_LEIBR

TriTrypDb:

LbrM.20.2840 , LBRM2903_200041800

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HB44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB44

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	499	505	PF00089	0.493
CLV_NRD_NRD_1	154	156	PF00675	0.546
CLV_NRD_NRD_1	211	213	PF00675	0.336
CLV_NRD_NRD_1	343	345	PF00675	0.639
CLV_PCSK_KEX2_1	154	156	PF00082	0.546
CLV_PCSK_KEX2_1	211	213	PF00082	0.465
CLV_PCSK_KEX2_1	437	439	PF00082	0.293
CLV_PCSK_KEX2_1	578	580	PF00082	0.754
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.308
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.754
CLV_PCSK_SKI1_1	155	159	PF00082	0.485
CLV_PCSK_SKI1_1	229	233	PF00082	0.327
CLV_PCSK_SKI1_1	235	239	PF00082	0.368
CLV_PCSK_SKI1_1	291	295	PF00082	0.514
DEG_APCC_DBOX_1	153	161	PF00400	0.376
DEG_Nend_UBRbox_2	1	3	PF02207	0.354
DEG_SCF_FBW7_1	20	27	PF00400	0.254
DEG_SCF_FBW7_2	362	368	PF00400	0.503
DEG_SPOP_SBC_1	36	40	PF00917	0.458
DEG_SPOP_SBC_1	586	590	PF00917	0.496
DEG_SPOP_SBC_1	601	605	PF00917	0.527
DOC_CKS1_1	362	367	PF01111	0.500
DOC_CYCLIN_RxL_1	152	159	PF00134	0.371
DOC_MAPK_gen_1	154	162	PF00069	0.411
DOC_MAPK_gen_1	211	220	PF00069	0.381
DOC_MAPK_gen_1	227	234	PF00069	0.236
DOC_MAPK_gen_1	276	285	PF00069	0.260
DOC_MAPK_MEF2A_6	154	162	PF00069	0.439
DOC_MAPK_MEF2A_6	227	234	PF00069	0.368
DOC_MAPK_RevD_3	330	345	PF00069	0.418
DOC_PP2B_LxvP_1	33	36	PF13499	0.499
DOC_PP2B_LxvP_1	451	454	PF13499	0.442
DOC_PP4_FxxP_1	167	170	PF00568	0.333
DOC_PP4_FxxP_1	387	390	PF00568	0.338
DOC_PP4_FxxP_1	470	473	PF00568	0.442
DOC_USP7_MATH_1	24	28	PF00917	0.536
DOC_USP7_MATH_1	244	248	PF00917	0.537
DOC_USP7_MATH_1	295	299	PF00917	0.615
DOC_USP7_MATH_1	36	40	PF00917	0.659
DOC_USP7_MATH_1	478	482	PF00917	0.442
DOC_USP7_MATH_1	570	574	PF00917	0.586
DOC_USP7_MATH_1	601	605	PF00917	0.698
DOC_USP7_MATH_1	98	102	PF00917	0.469
DOC_WW_Pin1_4	166	171	PF00397	0.286
DOC_WW_Pin1_4	20	25	PF00397	0.460
DOC_WW_Pin1_4	270	275	PF00397	0.355
DOC_WW_Pin1_4	301	306	PF00397	0.754
DOC_WW_Pin1_4	31	36	PF00397	0.573
DOC_WW_Pin1_4	358	363	PF00397	0.516
DOC_WW_Pin1_4	513	518	PF00397	0.468
DOC_WW_Pin1_4	602	607	PF00397	0.527
LIG_14-3-3_CanoR_1	278	284	PF00244	0.281
LIG_14-3-3_CanoR_1	344	348	PF00244	0.549
LIG_14-3-3_CanoR_1	4	8	PF00244	0.314
LIG_14-3-3_CanoR_1	452	461	PF00244	0.489
LIG_14-3-3_CanoR_1	511	516	PF00244	0.544
LIG_14-3-3_CanoR_1	557	563	PF00244	0.675
LIG_14-3-3_CanoR_1	567	577	PF00244	0.483
LIG_14-3-3_CanoR_1	597	606	PF00244	0.600
LIG_14-3-3_CanoR_1	645	651	PF00244	0.463
LIG_BIR_III_2	236	240	PF00653	0.485
LIG_BRCT_BRCA1_1	281	285	PF00533	0.498
LIG_BRCT_BRCA1_1	49	53	PF00533	0.433
LIG_BRCT_BRCA1_1	72	76	PF00533	0.350
LIG_Dynein_DLC8_1	177	183	PF01221	0.229
LIG_FHA_1	123	129	PF00498	0.432
LIG_FHA_1	179	185	PF00498	0.412
LIG_FHA_1	318	324	PF00498	0.568
LIG_FHA_1	375	381	PF00498	0.447
LIG_FHA_1	586	592	PF00498	0.661
LIG_FHA_1	593	599	PF00498	0.731
LIG_FHA_1	625	631	PF00498	0.501
LIG_FHA_2	181	187	PF00498	0.284
LIG_FHA_2	347	353	PF00498	0.642
LIG_FHA_2	477	483	PF00498	0.543
LIG_FHA_2	559	565	PF00498	0.602
LIG_FHA_2	615	621	PF00498	0.688
LIG_FHA_2	647	653	PF00498	0.694
LIG_GBD_Chelix_1	347	355	PF00786	0.493
LIG_LIR_Apic_2	106	110	PF02991	0.396
LIG_LIR_Apic_2	164	170	PF02991	0.318
LIG_LIR_Apic_2	385	390	PF02991	0.368
LIG_LIR_Apic_2	92	97	PF02991	0.543
LIG_LIR_Gen_1	422	432	PF02991	0.545
LIG_LIR_Gen_1	445	455	PF02991	0.489
LIG_LIR_Gen_1	610	620	PF02991	0.705
LIG_LIR_Nem_3	236	241	PF02991	0.409
LIG_LIR_Nem_3	267	271	PF02991	0.418
LIG_LIR_Nem_3	275	280	PF02991	0.371
LIG_LIR_Nem_3	287	293	PF02991	0.364
LIG_LIR_Nem_3	422	427	PF02991	0.565
LIG_LIR_Nem_3	445	451	PF02991	0.478
LIG_LIR_Nem_3	510	515	PF02991	0.574
LIG_LIR_Nem_3	610	616	PF02991	0.705
LIG_LIR_Nem_3	73	79	PF02991	0.336
LIG_LIR_Nem_3	84	90	PF02991	0.350
LIG_MLH1_MIPbox_1	72	76	PF16413	0.251
LIG_MYND_1	327	331	PF01753	0.429
LIG_Pex14_1	103	107	PF04695	0.333
LIG_Pex14_2	174	178	PF04695	0.475
LIG_Pex14_2	286	290	PF04695	0.444
LIG_Pex14_2	71	75	PF04695	0.246
LIG_PTAP_UEV_1	133	138	PF05743	0.304
LIG_PTB_Apo_2	390	397	PF02174	0.484
LIG_PTB_Phospho_1	390	396	PF10480	0.474
LIG_SH2_CRK	172	176	PF00017	0.458
LIG_SH2_CRK	277	281	PF00017	0.445
LIG_SH2_CRK	396	400	PF00017	0.460
LIG_SH2_CRK	424	428	PF00017	0.535
LIG_SH2_CRK	448	452	PF00017	0.431
LIG_SH2_PTP2	107	110	PF00017	0.527
LIG_SH2_PTP2	271	274	PF00017	0.231
LIG_SH2_SRC	107	110	PF00017	0.430
LIG_SH2_STAP1	139	143	PF00017	0.468
LIG_SH2_STAP1	424	428	PF00017	0.535
LIG_SH2_STAT5	107	110	PF00017	0.527
LIG_SH2_STAT5	223	226	PF00017	0.381
LIG_SH2_STAT5	271	274	PF00017	0.231
LIG_SH2_STAT5	448	451	PF00017	0.516
LIG_SH2_STAT5	7	10	PF00017	0.316
LIG_SH3_2	362	367	PF14604	0.500
LIG_SH3_3	106	112	PF00018	0.537
LIG_SH3_3	128	134	PF00018	0.617
LIG_SH3_3	325	331	PF00018	0.398
LIG_SH3_3	359	365	PF00018	0.543
LIG_SH3_3	603	609	PF00018	0.468
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.226
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.518
LIG_SUMO_SIM_par_1	425	431	PF11976	0.488
LIG_SUMO_SIM_par_1	587	596	PF11976	0.534
LIG_SUMO_SIM_par_1	649	657	PF11976	0.600
LIG_TRAF2_1	354	357	PF00917	0.499
LIG_TRAF2_1	617	620	PF00917	0.482
LIG_TYR_ITIM	394	399	PF00017	0.399
LIG_WRC_WIRS_1	72	77	PF05994	0.248
LIG_WW_2	109	112	PF00397	0.405
LIG_WW_3	208	212	PF00397	0.467
LIG_WW_3	96	100	PF00397	0.392
MOD_CDC14_SPxK_1	273	276	PF00782	0.346
MOD_CDK_SPK_2	301	306	PF00069	0.553
MOD_CDK_SPxK_1	270	276	PF00069	0.323
MOD_CDK_SPxK_1	361	367	PF00069	0.500
MOD_CDK_SPxxK_3	166	173	PF00069	0.254
MOD_CDK_SPxxK_3	513	520	PF00069	0.518
MOD_CK1_1	10	16	PF00069	0.492
MOD_CK1_1	251	257	PF00069	0.685
MOD_CK1_1	296	302	PF00069	0.697
MOD_CK1_1	310	316	PF00069	0.724
MOD_CK1_1	346	352	PF00069	0.593
MOD_CK1_1	358	364	PF00069	0.619
MOD_CK1_1	481	487	PF00069	0.388
MOD_CK1_1	501	507	PF00069	0.637
MOD_CK1_1	516	522	PF00069	0.522
MOD_CK1_1	590	596	PF00069	0.571
MOD_CK1_1	600	606	PF00069	0.536
MOD_CK2_1	180	186	PF00069	0.335
MOD_CK2_1	351	357	PF00069	0.662
MOD_CK2_1	476	482	PF00069	0.422
MOD_CK2_1	516	522	PF00069	0.632
MOD_CK2_1	614	620	PF00069	0.578
MOD_CK2_1	646	652	PF00069	0.572
MOD_GlcNHglycan	12	15	PF01048	0.579
MOD_GlcNHglycan	134	137	PF01048	0.454
MOD_GlcNHglycan	242	245	PF01048	0.507
MOD_GlcNHglycan	313	316	PF01048	0.601
MOD_GlcNHglycan	356	360	PF01048	0.782
MOD_GlcNHglycan	368	372	PF01048	0.799
MOD_GlcNHglycan	503	506	PF01048	0.382
MOD_GlcNHglycan	538	541	PF01048	0.703
MOD_GlcNHglycan	548	551	PF01048	0.489
MOD_GlcNHglycan	572	575	PF01048	0.665
MOD_GlcNHglycan	599	602	PF01048	0.537
MOD_GlcNHglycan	87	90	PF01048	0.497
MOD_GSK3_1	20	27	PF00069	0.425
MOD_GSK3_1	240	247	PF00069	0.565
MOD_GSK3_1	3	10	PF00069	0.365
MOD_GSK3_1	307	314	PF00069	0.702
MOD_GSK3_1	31	38	PF00069	0.452
MOD_GSK3_1	335	342	PF00069	0.477
MOD_GSK3_1	351	358	PF00069	0.731
MOD_GSK3_1	438	445	PF00069	0.345
MOD_GSK3_1	507	514	PF00069	0.530
MOD_GSK3_1	532	539	PF00069	0.616
MOD_GSK3_1	586	593	PF00069	0.654
MOD_GSK3_1	597	604	PF00069	0.652
MOD_GSK3_1	620	627	PF00069	0.556
MOD_GSK3_1	71	78	PF00069	0.320
MOD_N-GLC_1	310	315	PF02516	0.602
MOD_N-GLC_1	558	563	PF02516	0.581
MOD_N-GLC_2	61	63	PF02516	0.330
MOD_NEK2_1	163	168	PF00069	0.319
MOD_NEK2_1	279	284	PF00069	0.547
MOD_NEK2_1	285	290	PF00069	0.516
MOD_NEK2_1	3	8	PF00069	0.359
MOD_NEK2_1	317	322	PF00069	0.573
MOD_NEK2_1	355	360	PF00069	0.623
MOD_NEK2_1	532	537	PF00069	0.641
MOD_NEK2_1	545	550	PF00069	0.645
MOD_NEK2_1	592	597	PF00069	0.666
MOD_NEK2_1	70	75	PF00069	0.313
MOD_NEK2_1	85	90	PF00069	0.332
MOD_NEK2_1	9	14	PF00069	0.393
MOD_PIKK_1	173	179	PF00454	0.485
MOD_PIKK_1	253	259	PF00454	0.631
MOD_PIKK_1	336	342	PF00454	0.461
MOD_PIKK_1	37	43	PF00454	0.579
MOD_PIKK_1	624	630	PF00454	0.601
MOD_PK_1	511	517	PF00069	0.652
MOD_PKA_2	3	9	PF00069	0.325
MOD_PKA_2	343	349	PF00069	0.546
MOD_PKA_2	366	372	PF00069	0.734
MOD_PKA_2	501	507	PF00069	0.544
MOD_PKA_2	85	91	PF00069	0.401
MOD_PKA_2	98	104	PF00069	0.519
MOD_PKB_1	276	284	PF00069	0.262
MOD_Plk_1	163	169	PF00069	0.294
MOD_Plk_1	351	357	PF00069	0.702
MOD_Plk_1	367	373	PF00069	0.510
MOD_Plk_1	481	487	PF00069	0.453
MOD_Plk_1	532	538	PF00069	0.523
MOD_Plk_1	558	564	PF00069	0.482
MOD_Plk_2-3	374	380	PF00069	0.480
MOD_Plk_4	103	109	PF00069	0.552
MOD_Plk_4	180	186	PF00069	0.252
MOD_Plk_4	187	193	PF00069	0.223
MOD_Plk_4	3	9	PF00069	0.347
MOD_Plk_4	382	388	PF00069	0.357
MOD_Plk_4	446	452	PF00069	0.284
MOD_Plk_4	558	564	PF00069	0.688
MOD_Plk_4	587	593	PF00069	0.730
MOD_Plk_4	646	652	PF00069	0.552
MOD_Plk_4	71	77	PF00069	0.377
MOD_ProDKin_1	166	172	PF00069	0.289
MOD_ProDKin_1	20	26	PF00069	0.467
MOD_ProDKin_1	270	276	PF00069	0.353
MOD_ProDKin_1	301	307	PF00069	0.755
MOD_ProDKin_1	31	37	PF00069	0.585
MOD_ProDKin_1	358	364	PF00069	0.517
MOD_ProDKin_1	513	519	PF00069	0.469
MOD_ProDKin_1	602	608	PF00069	0.528
TRG_DiLeu_BaEn_1	379	384	PF01217	0.499
TRG_DiLeu_BaEn_1	446	451	PF01217	0.403
TRG_DiLeu_BaEn_2	462	468	PF01217	0.266
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.353
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.405
TRG_ENDOCYTIC_2	139	142	PF00928	0.473
TRG_ENDOCYTIC_2	277	280	PF00928	0.376
TRG_ENDOCYTIC_2	396	399	PF00928	0.442
TRG_ENDOCYTIC_2	424	427	PF00928	0.399
TRG_ENDOCYTIC_2	448	451	PF00928	0.384
TRG_ER_diArg_1	210	212	PF00400	0.339
TRG_ER_diArg_1	497	500	PF00400	0.379
TRG_NLS_MonoExtC_3	577	583	PF00514	0.750
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB91	Leptomonas seymouri	47%	75%
A0A0S4INP1	Bodo saltans	27%	86%
A0A1X0P9Y1	Trypanosomatidae	31%	89%
A0A3Q8IHR3	Leishmania donovani	66%	99%
A0A3R7MJM0	Trypanosoma rangeli	32%	93%
A4IA93	Leishmania infantum	66%	81%
C9ZM02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
E9B5B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4Q2L8	Leishmania major	66%	99%
V5BQH0	Trypanosoma cruzi	33%	92%