Putative putative pyruvate/indole-pyruvate carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha-keto-acid decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB43_LEIBR

TriTrypDb:

LbrM.20.2830 , LBRM2903_200041700

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0016829	lyase activity	2	6
GO:0016830	carbon-carbon lyase activity	3	6
GO:0016831	carboxy-lyase activity	4	6
GO:0019842	vitamin binding	3	6
GO:0030976	thiamine pyrophosphate binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0047434	indolepyruvate decarboxylase activity	5	5
GO:0050997	quaternary ammonium group binding	2	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:1901681	sulfur compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.510
CLV_C14_Caspase3-7	518	522	PF00656	0.623
CLV_NRD_NRD_1	186	188	PF00675	0.521
CLV_NRD_NRD_1	429	431	PF00675	0.257
CLV_PCSK_KEX2_1	186	188	PF00082	0.521
CLV_PCSK_KEX2_1	429	431	PF00082	0.257
CLV_PCSK_SKI1_1	112	116	PF00082	0.471
CLV_PCSK_SKI1_1	152	156	PF00082	0.400
DOC_CKS1_1	140	145	PF01111	0.510
DOC_MAPK_DCC_7	297	305	PF00069	0.510
DOC_MAPK_gen_1	161	168	PF00069	0.510
DOC_MAPK_gen_1	297	305	PF00069	0.296
DOC_MAPK_gen_1	454	462	PF00069	0.468
DOC_MAPK_MEF2A_6	376	385	PF00069	0.445
DOC_MAPK_RevD_3	148	162	PF00069	0.257
DOC_PP2B_LxvP_1	395	398	PF13499	0.510
DOC_PP2B_PxIxI_1	95	101	PF00149	0.510
DOC_PP4_FxxP_1	25	28	PF00568	0.510
DOC_PP4_FxxP_1	353	356	PF00568	0.396
DOC_PP4_FxxP_1	533	536	PF00568	0.322
DOC_USP7_MATH_1	270	274	PF00917	0.511
DOC_USP7_UBL2_3	546	550	PF12436	0.765
DOC_WW_Pin1_4	139	144	PF00397	0.510
DOC_WW_Pin1_4	189	194	PF00397	0.375
DOC_WW_Pin1_4	352	357	PF00397	0.591
LIG_14-3-3_CanoR_1	152	159	PF00244	0.510
LIG_Actin_RPEL_3	362	381	PF02755	0.308
LIG_Actin_WH2_2	288	306	PF00022	0.510
LIG_Actin_WH2_2	440	458	PF00022	0.257
LIG_Clathr_ClatBox_1	147	151	PF01394	0.257
LIG_eIF4E_1	11	17	PF01652	0.257
LIG_FHA_1	153	159	PF00498	0.510
LIG_FHA_1	215	221	PF00498	0.456
LIG_FHA_1	359	365	PF00498	0.497
LIG_FHA_1	389	395	PF00498	0.473
LIG_FHA_1	456	462	PF00498	0.263
LIG_FHA_1	501	507	PF00498	0.570
LIG_FHA_1	73	79	PF00498	0.510
LIG_FHA_2	116	122	PF00498	0.259
LIG_FHA_2	333	339	PF00498	0.326
LIG_FHA_2	441	447	PF00498	0.510
LIG_FHA_2	48	54	PF00498	0.471
LIG_FHA_2	537	543	PF00498	0.419
LIG_LIR_Apic_2	22	28	PF02991	0.510
LIG_LIR_Apic_2	344	350	PF02991	0.663
LIG_LIR_Apic_2	351	356	PF02991	0.544
LIG_LIR_Apic_2	411	417	PF02991	0.510
LIG_LIR_Gen_1	458	467	PF02991	0.270
LIG_LIR_Gen_1	477	485	PF02991	0.510
LIG_LIR_Nem_3	317	323	PF02991	0.380
LIG_LIR_Nem_3	458	462	PF02991	0.270
LIG_LIR_Nem_3	477	483	PF02991	0.504
LIG_Pex14_1	343	347	PF04695	0.652
LIG_Pex14_1	476	480	PF04695	0.591
LIG_Pex14_2	229	233	PF04695	0.243
LIG_Pex14_2	31	35	PF04695	0.510
LIG_Pex14_2	472	476	PF04695	0.323
LIG_PTB_Apo_2	461	468	PF02174	0.510
LIG_PTB_Phospho_1	461	467	PF10480	0.510
LIG_REV1ctd_RIR_1	309	318	PF16727	0.510
LIG_SH2_CRK	414	418	PF00017	0.510
LIG_SH2_NCK_1	414	418	PF00017	0.510
LIG_SH2_NCK_1	480	484	PF00017	0.569
LIG_SH2_PTP2	165	168	PF00017	0.510
LIG_SH2_PTP2	459	462	PF00017	0.510
LIG_SH2_STAP1	241	245	PF00017	0.257
LIG_SH2_STAT3	63	66	PF00017	0.510
LIG_SH2_STAT5	11	14	PF00017	0.427
LIG_SH2_STAT5	165	168	PF00017	0.510
LIG_SH2_STAT5	258	261	PF00017	0.510
LIG_SH2_STAT5	262	265	PF00017	0.444
LIG_SH2_STAT5	414	417	PF00017	0.510
LIG_SH2_STAT5	459	462	PF00017	0.510
LIG_SH2_STAT5	467	470	PF00017	0.378
LIG_SH2_STAT5	6	9	PF00017	0.510
LIG_SH3_2	178	183	PF14604	0.505
LIG_SH3_3	174	180	PF00018	0.456
LIG_SH3_3	234	240	PF00018	0.490
LIG_SH3_3	318	324	PF00018	0.257
LIG_SH3_3	538	544	PF00018	0.692
LIG_SUMO_SIM_anti_2	379	384	PF11976	0.377
LIG_SUMO_SIM_par_1	379	384	PF11976	0.377
LIG_TRAF2_1	443	446	PF00917	0.510
LIG_TRFH_1	453	457	PF08558	0.510
MOD_CK1_1	105	111	PF00069	0.364
MOD_CK1_1	192	198	PF00069	0.552
MOD_CK1_1	352	358	PF00069	0.580
MOD_CK1_1	388	394	PF00069	0.549
MOD_CK2_1	270	276	PF00069	0.510
MOD_CK2_1	332	338	PF00069	0.322
MOD_CK2_1	440	446	PF00069	0.374
MOD_CK2_1	47	53	PF00069	0.471
MOD_CK2_1	536	542	PF00069	0.406
MOD_CK2_1	87	93	PF00069	0.510
MOD_GlcNHglycan	130	133	PF01048	0.510
MOD_GlcNHglycan	196	199	PF01048	0.576
MOD_GlcNHglycan	357	360	PF01048	0.524
MOD_GlcNHglycan	391	394	PF01048	0.547
MOD_GlcNHglycan	80	84	PF01048	0.481
MOD_GSK3_1	202	209	PF00069	0.364
MOD_GSK3_1	338	345	PF00069	0.517
MOD_GSK3_1	384	391	PF00069	0.552
MOD_GSK3_1	408	415	PF00069	0.510
MOD_GSK3_1	87	94	PF00069	0.425
MOD_N-GLC_1	341	346	PF02516	0.660
MOD_N-GLC_1	486	491	PF02516	0.557
MOD_N-GLC_2	494	496	PF02516	0.584
MOD_NEK2_1	115	120	PF00069	0.471
MOD_NEK2_1	199	204	PF00069	0.458
MOD_NEK2_1	207	212	PF00069	0.310
MOD_NEK2_1	288	293	PF00069	0.380
MOD_NEK2_1	385	390	PF00069	0.440
MOD_NEK2_1	408	413	PF00069	0.510
MOD_NEK2_1	505	510	PF00069	0.333
MOD_NEK2_1	91	96	PF00069	0.369
MOD_NEK2_2	6	11	PF00069	0.257
MOD_PIKK_1	105	111	PF00454	0.510
MOD_PIKK_1	516	522	PF00454	0.358
MOD_PKA_2	516	522	PF00069	0.358
MOD_Plk_1	332	338	PF00069	0.322
MOD_Plk_1	476	482	PF00069	0.581
MOD_Plk_1	79	85	PF00069	0.510
MOD_Plk_2-3	465	471	PF00069	0.510
MOD_Plk_4	258	264	PF00069	0.387
MOD_Plk_4	270	276	PF00069	0.489
MOD_Plk_4	455	461	PF00069	0.388
MOD_ProDKin_1	139	145	PF00069	0.510
MOD_ProDKin_1	189	195	PF00069	0.367
MOD_ProDKin_1	352	358	PF00069	0.585
TRG_ENDOCYTIC_2	165	168	PF00928	0.481
TRG_ENDOCYTIC_2	459	462	PF00928	0.510
TRG_ENDOCYTIC_2	480	483	PF00928	0.498
TRG_ER_diArg_1	185	187	PF00400	0.520
TRG_ER_diArg_1	429	431	PF00400	0.257
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILD2	Leishmania donovani	86%	94%
A0PL16	Mycobacterium ulcerans (strain Agy99)	42%	97%
A0QBE6	Mycobacterium avium (strain 104)	42%	98%
A0R480	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	42%	99%
A1KGY5	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	42%	98%
A2XFI3	Oryza sativa subsp. indica	31%	91%
A2Y5L9	Oryza sativa subsp. indica	31%	91%
A2YQ76	Oryza sativa subsp. indica	31%	94%
A4IA92	Leishmania infantum	86%	94%
A5U0P1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	42%	98%
A5YBJ6	Lactobacillus casei	20%	86%
D5AKX8	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	21%	93%
E9B5B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O06335	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
O08353	Methanococcus aeolicus	24%	92%
O19929	Cyanidium caldarium	24%	94%
O33112	Mycobacterium leprae (strain TN)	25%	88%
O42873	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	96%
O78518	Guillardia theta	24%	96%
O82647	Arabidopsis thaliana	33%	91%
O85293	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	22%	96%
P00893	Escherichia coli (strain K12)	25%	96%
P06169	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P06672	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	31%	97%
P07003	Escherichia coli (strain K12)	24%	96%
P07342	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	80%
P08142	Escherichia coli (strain K12)	21%	98%
P09114	Nicotiana tabacum	22%	83%
P09342	Nicotiana tabacum	23%	82%
P0A623	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	25%	89%
P0AEP7	Escherichia coli (strain K12)	21%	93%
P0AEP8	Escherichia coli O157:H7	21%	93%
P0CH62	Azoarcus sp.	22%	93%
P0DP90	Escherichia coli (strain K12)	23%	100%
P0DUV9	Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / NBRC 104400 / YIM 0006)	22%	93%
P14874	Brassica napus	23%	86%
P16467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P17597	Arabidopsis thaliana	24%	82%
P20906	Pseudomonas putida	23%	100%
P23234	Enterobacter cloacae	41%	100%
P26263	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P27696	Klebsiella pneumoniae	22%	98%
P27818	Brassica napus	25%	84%
P27819	Brassica napus	25%	84%
P27868	Arthrospira platensis	25%	95%
P28516	Zea mays	31%	90%
P33149	Kluyveromyces marxianus	36%	98%
P33287	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	96%
P34734	Hanseniaspora uvarum	34%	98%
P36620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
P37063	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	22%	91%
P37251	Bacillus subtilis (strain 168)	25%	96%
P40811	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	24%	96%
P42463	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	24%	88%
P45261	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	22%	96%
P51844	Aspergillus parasiticus	33%	95%
P51845	Nicotiana tabacum	30%	100%
P51846	Nicotiana tabacum	31%	90%
P51850	Pisum sativum	31%	93%
P51852	Azospirillum brasilense	26%	100%
P57321	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	23%	96%
P69683	Porphyra purpurea	25%	93%
P69684	Porphyra umbilicalis	25%	93%
P83779	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	97%
P87208	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	97%
P96591	Bacillus subtilis (strain 168)	23%	96%
P9WG36	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	42%	98%
P9WG37	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	42%	98%
P9WG40	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	89%
P9WG41	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	89%
Q02137	Lactococcus lactis subsp. lactis (strain IL1403)	23%	96%
Q04789	Bacillus subtilis (strain 168)	22%	96%
Q06408	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	87%
Q07471	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	90%
Q09737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
Q0CNV1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	97%
Q0D3D2	Oryza sativa subsp. japonica	31%	94%
Q0DHF6	Oryza sativa subsp. japonica	31%	91%
Q10MW3	Oryza sativa subsp. japonica	32%	91%
Q12629	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	98%
Q1XDF6	Neopyropia yezoensis	26%	93%
Q2UKV4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	96%
Q41768	Zea mays	24%	86%
Q41769	Zea mays	23%	86%
Q4Q2L9	Leishmania major	86%	100%
Q4WXX9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	97%
Q57725	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	93%
Q59498	Mycobacterium avium	23%	89%
Q6FJA3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	98%
Q6K2E8	Oryza sativa subsp. japonica	23%	85%
Q6SSJ3	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	23%	77%
Q742Q2	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	43%	98%
Q7U140	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	42%	98%
Q7U5G1	Parasynechococcus marenigrum (strain WH8102)	25%	89%
Q7XKQ8	Oryza sativa subsp. japonica	22%	83%
Q84H41	Alcaligenes xylosoxydans xylosoxydans	22%	91%
Q89AP7	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	23%	95%
Q8CHM7	Rattus norvegicus	22%	95%
Q92345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	97%
Q9CBD6	Mycobacterium leprae (strain TN)	40%	97%
Q9FFT4	Arabidopsis thaliana	33%	91%
Q9HUI8	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	24%	98%
Q9M039	Arabidopsis thaliana	32%	93%
Q9M040	Arabidopsis thaliana	31%	91%
Q9P7P6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	96%
Q9RQ65	Buchnera aphidicola subsp. Schlechtendalia chinensis	23%	96%
Q9UJ83	Homo sapiens	21%	95%