RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB42_LEIBR

TriTrypDb:

LbrM.20.2820 , LBRM2903_200041400

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HB42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.397
CLV_NRD_NRD_1	526	528	PF00675	0.293
CLV_PCSK_KEX2_1	279	281	PF00082	0.384
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.384
CLV_PCSK_SKI1_1	476	480	PF00082	0.505
DEG_APCC_DBOX_1	22	30	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.690
DEG_SPOP_SBC_1	5	9	PF00917	0.565
DOC_ANK_TNKS_1	469	476	PF00023	0.356
DOC_CKS1_1	152	157	PF01111	0.372
DOC_CKS1_1	337	342	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	417	420	PF00134	0.290
DOC_MAPK_gen_1	279	285	PF00069	0.643
DOC_MAPK_gen_1	527	536	PF00069	0.502
DOC_MAPK_MEF2A_6	125	132	PF00069	0.540
DOC_MAPK_MEF2A_6	279	287	PF00069	0.525
DOC_PP1_RVXF_1	446	452	PF00149	0.388
DOC_PP1_RVXF_1	507	513	PF00149	0.617
DOC_PP1_RVXF_1	84	90	PF00149	0.275
DOC_PP2B_LxvP_1	417	420	PF13499	0.528
DOC_PP2B_LxvP_1	559	562	PF13499	0.312
DOC_SPAK_OSR1_1	550	554	PF12202	0.256
DOC_USP7_MATH_1	162	166	PF00917	0.240
DOC_USP7_MATH_1	462	466	PF00917	0.428
DOC_USP7_MATH_1	5	9	PF00917	0.715
DOC_WW_Pin1_4	12	17	PF00397	0.651
DOC_WW_Pin1_4	151	156	PF00397	0.373
DOC_WW_Pin1_4	336	341	PF00397	0.413
DOC_WW_Pin1_4	518	523	PF00397	0.527
LIG_14-3-3_CanoR_1	249	258	PF00244	0.396
LIG_14-3-3_CanoR_1	298	308	PF00244	0.538
LIG_14-3-3_CanoR_1	503	510	PF00244	0.649
LIG_14-3-3_CanoR_1	79	84	PF00244	0.347
LIG_14-3-3_CanoR_1	86	92	PF00244	0.241
LIG_Actin_WH2_2	129	147	PF00022	0.218
LIG_Actin_WH2_2	437	455	PF00022	0.411
LIG_Actin_WH2_2	581	596	PF00022	0.453
LIG_APCC_ABBA_1	319	324	PF00400	0.408
LIG_BRCT_BRCA1_1	263	267	PF00533	0.381
LIG_BRCT_BRCA1_1	373	377	PF00533	0.337
LIG_BRCT_BRCA1_1	378	382	PF00533	0.413
LIG_Clathr_ClatBox_1	312	316	PF01394	0.199
LIG_CSL_BTD_1	337	340	PF09270	0.281
LIG_deltaCOP1_diTrp_1	110	116	PF00928	0.527
LIG_deltaCOP1_diTrp_1	254	258	PF00928	0.267
LIG_DLG_GKlike_1	376	383	PF00625	0.250
LIG_eIF4E_1	439	445	PF01652	0.272
LIG_FHA_1	109	115	PF00498	0.645
LIG_FHA_1	181	187	PF00498	0.364
LIG_FHA_1	288	294	PF00498	0.584
LIG_FHA_1	337	343	PF00498	0.311
LIG_FHA_1	444	450	PF00498	0.397
LIG_FHA_1	519	525	PF00498	0.516
LIG_FHA_1	52	58	PF00498	0.549
LIG_FHA_1	530	536	PF00498	0.463
LIG_FHA_1	556	562	PF00498	0.412
LIG_FHA_1	64	70	PF00498	0.274
LIG_FHA_1	82	88	PF00498	0.423
LIG_FHA_1	9	15	PF00498	0.635
LIG_FHA_2	469	475	PF00498	0.436
LIG_FHA_2	506	512	PF00498	0.475
LIG_FHA_2	602	608	PF00498	0.622
LIG_FHA_2	8	14	PF00498	0.553
LIG_GBD_Chelix_1	52	60	PF00786	0.444
LIG_LIR_Gen_1	165	174	PF02991	0.281
LIG_LIR_Gen_1	256	265	PF02991	0.300
LIG_LIR_Gen_1	349	358	PF02991	0.541
LIG_LIR_Gen_1	369	380	PF02991	0.310
LIG_LIR_Gen_1	401	411	PF02991	0.438
LIG_LIR_Gen_1	54	60	PF02991	0.439
LIG_LIR_Gen_1	72	81	PF02991	0.279
LIG_LIR_LC3C_4	532	535	PF02991	0.295
LIG_LIR_LC3C_4	54	58	PF02991	0.401
LIG_LIR_Nem_3	165	169	PF02991	0.288
LIG_LIR_Nem_3	190	195	PF02991	0.293
LIG_LIR_Nem_3	256	261	PF02991	0.367
LIG_LIR_Nem_3	264	270	PF02991	0.310
LIG_LIR_Nem_3	349	353	PF02991	0.518
LIG_LIR_Nem_3	369	375	PF02991	0.320
LIG_LIR_Nem_3	436	442	PF02991	0.366
LIG_LIR_Nem_3	457	461	PF02991	0.397
LIG_LIR_Nem_3	54	58	PF02991	0.401
LIG_LIR_Nem_3	72	77	PF02991	0.280
LIG_PCNA_PIPBox_1	545	554	PF02747	0.288
LIG_PCNA_yPIPBox_3	48	56	PF02747	0.413
LIG_Pex14_1	263	267	PF04695	0.413
LIG_Pex14_1	70	74	PF04695	0.317
LIG_PTB_Apo_2	218	225	PF02174	0.475
LIG_PTB_Apo_2	269	276	PF02174	0.281
LIG_PTB_Phospho_1	218	224	PF10480	0.476
LIG_PTB_Phospho_1	269	275	PF10480	0.413
LIG_RPA_C_Fungi	498	510	PF08784	0.477
LIG_SH2_CRK	33	37	PF00017	0.325
LIG_SH2_CRK	439	443	PF00017	0.332
LIG_SH2_CRK	74	78	PF00017	0.306
LIG_SH2_PTP2	224	227	PF00017	0.313
LIG_SH2_PTP2	552	555	PF00017	0.521
LIG_SH2_STAT3	195	198	PF00017	0.362
LIG_SH2_STAT5	18	21	PF00017	0.459
LIG_SH2_STAT5	195	198	PF00017	0.362
LIG_SH2_STAT5	224	227	PF00017	0.335
LIG_SH2_STAT5	247	250	PF00017	0.522
LIG_SH2_STAT5	403	406	PF00017	0.426
LIG_SH2_STAT5	552	555	PF00017	0.521
LIG_SH2_STAT5	589	592	PF00017	0.403
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.263
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.314
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.246
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.269
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.360
LIG_SUMO_SIM_par_1	311	316	PF11976	0.426
LIG_SUMO_SIM_par_1	317	324	PF11976	0.522
LIG_SUMO_SIM_par_1	557	563	PF11976	0.381
LIG_SUMO_SIM_par_1	56	63	PF11976	0.342
LIG_SUMO_SIM_par_1	7	15	PF11976	0.433
LIG_TRAF2_1	604	607	PF00917	0.438
LIG_UBA3_1	560	567	PF00899	0.413
LIG_Vh1_VBS_1	525	543	PF01044	0.199
LIG_WRC_WIRS_1	163	168	PF05994	0.305
LIG_WRC_WIRS_1	350	355	PF05994	0.262
LIG_WW_1	30	33	PF00397	0.544
LIG_WW_3	418	422	PF00397	0.420
MOD_CK1_1	63	69	PF00069	0.417
MOD_CK1_1	7	13	PF00069	0.626
MOD_CK2_1	162	168	PF00069	0.296
MOD_CK2_1	317	323	PF00069	0.510
MOD_CK2_1	426	432	PF00069	0.494
MOD_CK2_1	505	511	PF00069	0.406
MOD_CK2_1	601	607	PF00069	0.428
MOD_CK2_1	7	13	PF00069	0.441
MOD_CK2_1	79	85	PF00069	0.402
MOD_CMANNOS	252	255	PF00535	0.523
MOD_CMANNOS	412	415	PF00535	0.413
MOD_GlcNHglycan	303	306	PF01048	0.199
MOD_GlcNHglycan	398	401	PF01048	0.395
MOD_GlcNHglycan	428	431	PF01048	0.585
MOD_GlcNHglycan	518	521	PF01048	0.543
MOD_GlcNHglycan	617	620	PF01048	0.591
MOD_GSK3_1	283	290	PF00069	0.520
MOD_GSK3_1	367	374	PF00069	0.378
MOD_GSK3_1	4	11	PF00069	0.670
MOD_GSK3_1	59	66	PF00069	0.456
MOD_GSK3_1	598	605	PF00069	0.511
MOD_NEK2_1	283	288	PF00069	0.479
MOD_NEK2_1	308	313	PF00069	0.346
MOD_NEK2_1	317	322	PF00069	0.344
MOD_NEK2_1	330	335	PF00069	0.281
MOD_NEK2_1	386	391	PF00069	0.470
MOD_NEK2_1	396	401	PF00069	0.461
MOD_NEK2_1	413	418	PF00069	0.277
MOD_NEK2_1	483	488	PF00069	0.262
MOD_NEK2_1	584	589	PF00069	0.392
MOD_NEK2_1	598	603	PF00069	0.382
MOD_NEK2_1	6	11	PF00069	0.548
MOD_NEK2_1	60	65	PF00069	0.439
MOD_NEK2_1	615	620	PF00069	0.561
MOD_NEK2_1	87	92	PF00069	0.311
MOD_PIKK_1	468	474	PF00454	0.478
MOD_PK_1	126	132	PF00069	0.199
MOD_PKA_2	22	28	PF00069	0.315
MOD_PKA_2	502	508	PF00069	0.488
MOD_Plk_1	253	259	PF00069	0.413
MOD_Plk_1	606	612	PF00069	0.470
MOD_Plk_4	263	269	PF00069	0.262
MOD_Plk_4	308	314	PF00069	0.323
MOD_Plk_4	330	336	PF00069	0.374
MOD_Plk_4	349	355	PF00069	0.213
MOD_Plk_4	367	373	PF00069	0.495
MOD_Plk_4	386	392	PF00069	0.331
MOD_Plk_4	462	468	PF00069	0.468
MOD_Plk_4	495	501	PF00069	0.326
MOD_Plk_4	51	57	PF00069	0.529
MOD_Plk_4	573	579	PF00069	0.321
MOD_Plk_4	584	590	PF00069	0.454
MOD_Plk_4	73	79	PF00069	0.442
MOD_ProDKin_1	12	18	PF00069	0.565
MOD_ProDKin_1	151	157	PF00069	0.456
MOD_ProDKin_1	336	342	PF00069	0.413
MOD_ProDKin_1	518	524	PF00069	0.393
TRG_DiLeu_BaEn_1	323	328	PF01217	0.413
TRG_ENDOCYTIC_2	213	216	PF00928	0.388
TRG_ENDOCYTIC_2	224	227	PF00928	0.414
TRG_ENDOCYTIC_2	33	36	PF00928	0.417
TRG_ENDOCYTIC_2	350	353	PF00928	0.413
TRG_ENDOCYTIC_2	403	406	PF00928	0.302
TRG_ENDOCYTIC_2	439	442	PF00928	0.339
TRG_ENDOCYTIC_2	74	77	PF00928	0.312
TRG_ER_diArg_1	142	145	PF00400	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ84	Leptomonas seymouri	61%	100%
A0A1X0PA84	Trypanosomatidae	37%	95%
A0A3R7KG27	Trypanosoma rangeli	35%	100%
A0A3S7X8A1	Leishmania donovani	78%	97%
A4IA91	Leishmania infantum	78%	97%
C9ZM03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B5B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4Q2M0	Leishmania major	78%	100%
V5DLY6	Trypanosoma cruzi	34%	100%