Protein Abitram

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein Abitram

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB40_LEIBR

TriTrypDb:

LbrM.20.2790 , LBRM2903_200040500

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.608
CLV_NRD_NRD_1	87	89	PF00675	0.526
CLV_PCSK_KEX2_1	46	48	PF00082	0.295
CLV_PCSK_KEX2_1	87	89	PF00082	0.526
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.295
CLV_PCSK_SKI1_1	123	127	PF00082	0.540
CLV_PCSK_SKI1_1	58	62	PF00082	0.515
CLV_Separin_Metazoa	84	88	PF03568	0.485
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.529
DOC_MAPK_gen_1	120	128	PF00069	0.325
DOC_PP1_RVXF_1	98	104	PF00149	0.485
DOC_PP2B_LxvP_1	35	38	PF13499	0.347
DOC_USP7_MATH_1	10	14	PF00917	0.690
DOC_USP7_MATH_1	17	21	PF00917	0.667
DOC_WW_Pin1_4	5	10	PF00397	0.621
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_4	203	207	PF00653	0.658
LIG_EVH1_2	37	41	PF00568	0.340
LIG_FHA_2	198	204	PF00498	0.475
LIG_FHA_2	37	43	PF00498	0.593
LIG_LIR_Apic_2	144	148	PF02991	0.373
LIG_LIR_Gen_1	176	184	PF02991	0.368
LIG_LIR_Gen_1	191	199	PF02991	0.381
LIG_LIR_Gen_1	29	38	PF02991	0.549
LIG_LIR_Gen_1	39	49	PF02991	0.312
LIG_LIR_Nem_3	176	181	PF02991	0.367
LIG_LIR_Nem_3	189	193	PF02991	0.432
LIG_LIR_Nem_3	29	35	PF02991	0.549
LIG_LIR_Nem_3	39	44	PF02991	0.321
LIG_REV1ctd_RIR_1	101	111	PF16727	0.517
LIG_SH2_CRK	145	149	PF00017	0.359
LIG_SH2_NCK_1	145	149	PF00017	0.412
LIG_SH2_PTP2	32	35	PF00017	0.613
LIG_SH2_STAP1	193	197	PF00017	0.534
LIG_SH2_STAT3	48	51	PF00017	0.356
LIG_SH2_STAT5	145	148	PF00017	0.493
LIG_SH2_STAT5	154	157	PF00017	0.475
LIG_SH2_STAT5	178	181	PF00017	0.373
LIG_SH2_STAT5	32	35	PF00017	0.504
LIG_SH2_STAT5	43	46	PF00017	0.342
LIG_SH2_STAT5	48	51	PF00017	0.249
LIG_SH3_3	178	184	PF00018	0.299
LIG_SH3_3	30	36	PF00018	0.548
MOD_CK1_1	8	14	PF00069	0.686
MOD_CK2_1	188	194	PF00069	0.550
MOD_Cter_Amidation	118	121	PF01082	0.480
MOD_GlcNHglycan	12	15	PF01048	0.695
MOD_GlcNHglycan	18	22	PF01048	0.652
MOD_GSK3_1	129	136	PF00069	0.459
MOD_GSK3_1	4	11	PF00069	0.537
MOD_N-GLC_1	129	134	PF02516	0.473
MOD_N-GLC_2	63	65	PF02516	0.368
MOD_NEK2_1	28	33	PF00069	0.606
MOD_NEK2_1	68	73	PF00069	0.355
MOD_PK_1	133	139	PF00069	0.348
MOD_Plk_1	143	149	PF00069	0.466
MOD_Plk_1	188	194	PF00069	0.313
MOD_Plk_1	28	34	PF00069	0.571
MOD_Plk_2-3	189	195	PF00069	0.495
MOD_Plk_4	133	139	PF00069	0.344
MOD_ProDKin_1	5	11	PF00069	0.621
MOD_SUMO_for_1	99	102	PF00179	0.279
MOD_SUMO_rev_2	53	60	PF00179	0.541
TRG_ENDOCYTIC_2	178	181	PF00928	0.365
TRG_ENDOCYTIC_2	193	196	PF00928	0.386
TRG_ENDOCYTIC_2	32	35	PF00928	0.613
TRG_ER_diArg_1	86	88	PF00400	0.538
TRG_NLS_Bipartite_1	46	62	PF00514	0.281
TRG_NLS_MonoCore_2	119	124	PF00514	0.472
TRG_NLS_MonoExtN_4	120	125	PF00514	0.462
TRG_NLS_MonoExtN_4	55	62	PF00514	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J2	Leptomonas seymouri	69%	100%
A0A0S4ILQ4	Bodo saltans	35%	97%
A0A1X0PA68	Trypanosomatidae	48%	100%
A0A3S7X8B1	Leishmania donovani	84%	100%
A0A422NNR6	Trypanosoma rangeli	48%	100%
A4IAM9	Leishmania infantum	84%	100%
C9ZM07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B5B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q1LU93	Danio rerio	30%	100%
Q28G67	Xenopus tropicalis	30%	100%
Q29S16	Bos taurus	32%	100%
Q4Q2M3	Leishmania major	82%	100%
Q54TD9	Dictyostelium discoideum	28%	100%
Q5RFS0	Pongo abelii	32%	100%
Q5ZHW7	Gallus gallus	32%	100%
Q6GR35	Xenopus laevis	31%	100%
Q80ZQ9	Mus musculus	33%	100%
Q9NX38	Homo sapiens	32%	100%
Q9VFR1	Drosophila melanogaster	26%	98%