Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB37_LEIBR

TriTrypDb:

LbrM.20.2760 , LBRM2903_200040000

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.546
CLV_NRD_NRD_1	147	149	PF00675	0.510
CLV_NRD_NRD_1	254	256	PF00675	0.573
CLV_NRD_NRD_1	273	275	PF00675	0.660
CLV_NRD_NRD_1	313	315	PF00675	0.569
CLV_NRD_NRD_1	329	331	PF00675	0.663
CLV_NRD_NRD_1	378	380	PF00675	0.676
CLV_PCSK_KEX2_1	253	255	PF00082	0.696
CLV_PCSK_KEX2_1	273	275	PF00082	0.666
CLV_PCSK_KEX2_1	311	313	PF00082	0.639
CLV_PCSK_KEX2_1	329	331	PF00082	0.669
CLV_PCSK_KEX2_1	378	380	PF00082	0.612
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.548
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.658
CLV_PCSK_PC7_1	374	380	PF00082	0.598
CLV_PCSK_SKI1_1	21	25	PF00082	0.550
CLV_PCSK_SKI1_1	257	261	PF00082	0.597
CLV_PCSK_SKI1_1	302	306	PF00082	0.583
DEG_CRL4_CDT2_1	139	150	PF00400	0.501
DOC_ANK_TNKS_1	295	302	PF00023	0.546
DOC_MAPK_gen_1	253	264	PF00069	0.651
DOC_MAPK_gen_1	348	358	PF00069	0.529
DOC_MAPK_HePTP_8	252	264	PF00069	0.461
DOC_MAPK_MEF2A_6	255	264	PF00069	0.466
DOC_MAPK_NFAT4_5	257	265	PF00069	0.473
DOC_USP7_MATH_1	317	321	PF00917	0.607
DOC_USP7_MATH_1	323	327	PF00917	0.549
DOC_USP7_MATH_1	96	100	PF00917	0.657
DOC_USP7_UBL2_3	253	257	PF12436	0.417
DOC_WW_Pin1_4	119	124	PF00397	0.643
DOC_WW_Pin1_4	179	184	PF00397	0.582
DOC_WW_Pin1_4	343	348	PF00397	0.523
LIG_14-3-3_CanoR_1	12	20	PF00244	0.390
LIG_14-3-3_CanoR_1	136	142	PF00244	0.583
LIG_14-3-3_CanoR_1	219	223	PF00244	0.524
LIG_14-3-3_CanoR_1	273	280	PF00244	0.625
LIG_14-3-3_CanoR_1	378	386	PF00244	0.549
LIG_14-3-3_CanoR_1	78	83	PF00244	0.566
LIG_14-3-3_CanoR_1	87	95	PF00244	0.639
LIG_BRCT_BRCA1_1	141	145	PF00533	0.504
LIG_Clathr_ClatBox_1	237	241	PF01394	0.480
LIG_FHA_1	149	155	PF00498	0.553
LIG_FHA_1	74	80	PF00498	0.499
LIG_FHA_2	222	228	PF00498	0.543
LIG_FHA_2	285	291	PF00498	0.658
LIG_FHA_2	371	377	PF00498	0.586
LIG_LIR_Gen_1	218	225	PF02991	0.483
LIG_LIR_Nem_3	218	223	PF02991	0.530
LIG_MLH1_MIPbox_1	141	145	PF16413	0.504
LIG_Pex14_1	9	13	PF04695	0.422
LIG_REV1ctd_RIR_1	142	153	PF16727	0.500
LIG_RPA_C_Fungi	250	262	PF08784	0.416
LIG_SH2_CRK	220	224	PF00017	0.482
LIG_SH2_NCK_1	220	224	PF00017	0.478
LIG_SH2_STAP1	225	229	PF00017	0.439
LIG_SH2_STAT3	340	343	PF00017	0.536
LIG_SH2_STAT5	22	25	PF00017	0.454
LIG_SH2_STAT5	340	343	PF00017	0.536
LIG_SH2_STAT5	394	397	PF00017	0.511
LIG_SH3_3	159	165	PF00018	0.617
LIG_SH3_3	364	370	PF00018	0.626
LIG_Sin3_3	258	265	PF02671	0.436
LIG_TRAF2_1	112	115	PF00917	0.682
LIG_TRAF2_1	166	169	PF00917	0.502
LIG_TRAF2_1	385	388	PF00917	0.609
LIG_TYR_ITSM	216	223	PF00017	0.486
MOD_CDK_SPK_2	343	348	PF00069	0.523
MOD_CDK_SPxxK_3	119	126	PF00069	0.656
MOD_CK1_1	139	145	PF00069	0.674
MOD_CK1_1	14	20	PF00069	0.379
MOD_CK1_1	190	196	PF00069	0.665
MOD_CK1_1	221	227	PF00069	0.560
MOD_CK1_1	284	290	PF00069	0.616
MOD_CK1_1	342	348	PF00069	0.554
MOD_CK1_1	69	75	PF00069	0.558
MOD_CK2_1	221	227	PF00069	0.554
MOD_CK2_1	294	300	PF00069	0.612
MOD_CK2_1	86	92	PF00069	0.763
MOD_Cter_Amidation	300	303	PF01082	0.557
MOD_Cter_Amidation	327	330	PF01082	0.591
MOD_GlcNHglycan	109	112	PF01048	0.710
MOD_GlcNHglycan	15	19	PF01048	0.574
MOD_GlcNHglycan	154	157	PF01048	0.664
MOD_GlcNHglycan	207	210	PF01048	0.717
MOD_GlcNHglycan	266	272	PF01048	0.566
MOD_GlcNHglycan	319	322	PF01048	0.573
MOD_GlcNHglycan	325	328	PF01048	0.709
MOD_GSK3_1	148	155	PF00069	0.601
MOD_GSK3_1	190	197	PF00069	0.670
MOD_GSK3_1	211	218	PF00069	0.643
MOD_GSK3_1	221	228	PF00069	0.513
MOD_GSK3_1	269	276	PF00069	0.598
MOD_GSK3_1	280	287	PF00069	0.548
MOD_GSK3_1	303	310	PF00069	0.787
MOD_GSK3_1	339	346	PF00069	0.545
MOD_GSK3_1	66	73	PF00069	0.522
MOD_N-GLC_1	102	107	PF02516	0.518
MOD_NEK2_1	205	210	PF00069	0.668
MOD_NEK2_1	269	274	PF00069	0.591
MOD_NEK2_1	280	285	PF00069	0.655
MOD_NEK2_1	56	61	PF00069	0.756
MOD_NEK2_2	102	107	PF00069	0.518
MOD_PIKK_1	124	130	PF00454	0.626
MOD_PIKK_1	181	187	PF00454	0.688
MOD_PIKK_1	194	200	PF00454	0.570
MOD_PIKK_1	281	287	PF00454	0.703
MOD_PIKK_1	304	310	PF00454	0.543
MOD_PIKK_1	339	345	PF00454	0.604
MOD_PIKK_1	387	393	PF00454	0.629
MOD_PKA_1	148	154	PF00069	0.500
MOD_PKA_1	273	279	PF00069	0.537
MOD_PKA_1	302	308	PF00069	0.695
MOD_PKA_2	107	113	PF00069	0.647
MOD_PKA_2	11	17	PF00069	0.516
MOD_PKA_2	190	196	PF00069	0.683
MOD_PKA_2	205	211	PF00069	0.712
MOD_PKA_2	218	224	PF00069	0.514
MOD_PKA_2	272	278	PF00069	0.690
MOD_PKA_2	86	92	PF00069	0.598
MOD_Plk_1	215	221	PF00069	0.488
MOD_Plk_1	387	393	PF00069	0.646
MOD_Plk_4	218	224	PF00069	0.603
MOD_Plk_4	32	38	PF00069	0.578
MOD_Plk_4	78	84	PF00069	0.503
MOD_ProDKin_1	119	125	PF00069	0.642
MOD_ProDKin_1	179	185	PF00069	0.584
MOD_ProDKin_1	343	349	PF00069	0.521
MOD_SUMO_rev_2	142	151	PF00179	0.499
MOD_SUMO_rev_2	226	233	PF00179	0.518
MOD_SUMO_rev_2	294	304	PF00179	0.546
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.529
TRG_ENDOCYTIC_2	220	223	PF00928	0.558
TRG_ER_diArg_1	312	314	PF00400	0.576
TRG_ER_diArg_1	329	331	PF00400	0.639
TRG_ER_diArg_1	377	379	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB80	Leptomonas seymouri	32%	73%
A0A3Q8IFR9	Leishmania donovani	55%	99%
A4IAN2	Leishmania infantum	55%	99%
E9B5A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
Q4Q2M6	Leishmania major	57%	100%