Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania braziliensis

UniProt:

A4HB36_LEIBR

TriTrypDb:

LbrM.20.2750 , LBRM2903_200039900

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB36

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009306	protein secretion	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0030254	protein secretion by the type III secretion system	4	6
GO:0032940	secretion by cell	3	6
GO:0033036	macromolecule localization	2	6
GO:0035592	establishment of protein localization to extracellular region	4	6
GO:0045184	establishment of protein localization	3	6
GO:0046903	secretion	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0055085	transmembrane transport	2	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071692	protein localization to extracellular region	5	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0071806	protein transmembrane transport	3	6
GO:0140352	export from cell	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.637
CLV_C14_Caspase3-7	427	431	PF00656	0.387
CLV_C14_Caspase3-7	560	564	PF00656	0.356
CLV_C14_Caspase3-7	70	74	PF00656	0.560
CLV_NRD_NRD_1	134	136	PF00675	0.593
CLV_NRD_NRD_1	213	215	PF00675	0.616
CLV_NRD_NRD_1	331	333	PF00675	0.673
CLV_NRD_NRD_1	38	40	PF00675	0.642
CLV_NRD_NRD_1	569	571	PF00675	0.488
CLV_PCSK_KEX2_1	198	200	PF00082	0.717
CLV_PCSK_KEX2_1	213	215	PF00082	0.551
CLV_PCSK_KEX2_1	330	332	PF00082	0.674
CLV_PCSK_KEX2_1	42	44	PF00082	0.654
CLV_PCSK_KEX2_1	569	571	PF00082	0.488
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.606
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.654
CLV_PCSK_PC7_1	327	333	PF00082	0.666
CLV_PCSK_SKI1_1	288	292	PF00082	0.655
CLV_PCSK_SKI1_1	356	360	PF00082	0.665
CLV_PCSK_SKI1_1	39	43	PF00082	0.643
CLV_PCSK_SKI1_1	479	483	PF00082	0.251
DEG_APCC_DBOX_1	372	380	PF00400	0.553
DEG_APCC_DBOX_1	496	504	PF00400	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.857
DEG_SCF_FBW7_2	546	553	PF00400	0.455
DEG_SPOP_SBC_1	162	166	PF00917	0.587
DEG_SPOP_SBC_1	9	13	PF00917	0.430
DOC_CDC14_PxL_1	481	489	PF14671	0.455
DOC_CYCLIN_RxL_1	315	329	PF00134	0.648
DOC_MAPK_MEF2A_6	475	484	PF00069	0.622
DOC_PP2B_LxvP_1	170	173	PF13499	0.722
DOC_PP2B_LxvP_1	482	485	PF13499	0.455
DOC_USP7_MATH_1	10	14	PF00917	0.406
DOC_USP7_MATH_1	179	183	PF00917	0.589
DOC_USP7_MATH_1	225	229	PF00917	0.579
DOC_USP7_MATH_1	274	278	PF00917	0.449
DOC_WW_Pin1_4	101	106	PF00397	0.769
DOC_WW_Pin1_4	130	135	PF00397	0.840
DOC_WW_Pin1_4	163	168	PF00397	0.827
DOC_WW_Pin1_4	175	180	PF00397	0.614
DOC_WW_Pin1_4	408	413	PF00397	0.556
DOC_WW_Pin1_4	546	551	PF00397	0.456
DOC_WW_Pin1_4	85	90	PF00397	0.508
LIG_14-3-3_CanoR_1	106	113	PF00244	0.584
LIG_14-3-3_CanoR_1	213	221	PF00244	0.561
LIG_14-3-3_CanoR_1	373	377	PF00244	0.671
LIG_14-3-3_CanoR_1	381	387	PF00244	0.600
LIG_14-3-3_CanoR_1	489	495	PF00244	0.455
LIG_14-3-3_CanoR_1	537	544	PF00244	0.483
LIG_Actin_WH2_2	523	539	PF00022	0.636
LIG_BRCT_BRCA1_1	181	185	PF00533	0.581
LIG_Clathr_ClatBox_1	470	474	PF01394	0.636
LIG_FHA_1	142	148	PF00498	0.621
LIG_FHA_1	157	163	PF00498	0.615
LIG_FHA_1	369	375	PF00498	0.431
LIG_FHA_1	456	462	PF00498	0.594
LIG_FHA_1	475	481	PF00498	0.411
LIG_FHA_1	547	553	PF00498	0.545
LIG_FHA_1	557	563	PF00498	0.658
LIG_FHA_1	566	572	PF00498	0.370
LIG_FHA_1	9	15	PF00498	0.664
LIG_FHA_2	199	205	PF00498	0.638
LIG_FHA_2	336	342	PF00498	0.674
LIG_FHA_2	558	564	PF00498	0.347
LIG_LIR_Gen_1	478	487	PF02991	0.636
LIG_LIR_Gen_1	59	65	PF02991	0.671
LIG_LIR_Nem_3	383	389	PF02991	0.631
LIG_LIR_Nem_3	478	484	PF02991	0.636
LIG_LIR_Nem_3	59	63	PF02991	0.678
LIG_SH2_CRK	25	29	PF00017	0.620
LIG_SH2_PTP2	483	486	PF00017	0.636
LIG_SH2_STAP1	283	287	PF00017	0.404
LIG_SH2_STAP1	501	505	PF00017	0.636
LIG_SH2_STAT3	207	210	PF00017	0.543
LIG_SH2_STAT5	15	18	PF00017	0.610
LIG_SH2_STAT5	245	248	PF00017	0.456
LIG_SH2_STAT5	44	47	PF00017	0.661
LIG_SH2_STAT5	483	486	PF00017	0.618
LIG_SH3_3	402	408	PF00018	0.805
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.393
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.652
LIG_SUMO_SIM_par_1	469	474	PF11976	0.636
LIG_TRAF2_1	338	341	PF00917	0.674
LIG_WRC_WIRS_1	57	62	PF05994	0.653
MOD_CDC14_SPxK_1	133	136	PF00782	0.622
MOD_CDK_SPK_2	101	106	PF00069	0.578
MOD_CDK_SPK_2	130	135	PF00069	0.840
MOD_CDK_SPK_2	163	168	PF00069	0.735
MOD_CDK_SPxK_1	130	136	PF00069	0.626
MOD_CDK_SPxxK_3	408	415	PF00069	0.562
MOD_CK1_1	101	107	PF00069	0.583
MOD_CK1_1	115	121	PF00069	0.817
MOD_CK1_1	122	128	PF00069	0.756
MOD_CK1_1	130	136	PF00069	0.601
MOD_CK1_1	215	221	PF00069	0.560
MOD_CK1_1	228	234	PF00069	0.638
MOD_CK1_1	539	545	PF00069	0.482
MOD_CK1_1	59	65	PF00069	0.418
MOD_CK1_1	88	94	PF00069	0.690
MOD_CK2_1	206	212	PF00069	0.809
MOD_CK2_1	335	341	PF00069	0.673
MOD_CK2_1	372	378	PF00069	0.667
MOD_GlcNHglycan	107	110	PF01048	0.556
MOD_GlcNHglycan	114	117	PF01048	0.521
MOD_GlcNHglycan	144	147	PF01048	0.765
MOD_GlcNHglycan	148	151	PF01048	0.793
MOD_GlcNHglycan	214	217	PF01048	0.567
MOD_GlcNHglycan	232	235	PF01048	0.650
MOD_GlcNHglycan	397	400	PF01048	0.553
MOD_GlcNHglycan	445	448	PF01048	0.338
MOD_GlcNHglycan	532	535	PF01048	0.427
MOD_GlcNHglycan	538	541	PF01048	0.373
MOD_GlcNHglycan	69	72	PF01048	0.650
MOD_GlcNHglycan	90	93	PF01048	0.790
MOD_GlcNHglycan	98	101	PF01048	0.699
MOD_GSK3_1	101	108	PF00069	0.739
MOD_GSK3_1	115	122	PF00069	0.630
MOD_GSK3_1	142	149	PF00069	0.714
MOD_GSK3_1	175	182	PF00069	0.584
MOD_GSK3_1	220	227	PF00069	0.598
MOD_GSK3_1	368	375	PF00069	0.562
MOD_GSK3_1	391	398	PF00069	0.637
MOD_GSK3_1	4	11	PF00069	0.511
MOD_N-GLC_1	127	132	PF02516	0.642
MOD_N-GLC_1	179	184	PF02516	0.579
MOD_N-GLC_1	455	460	PF02516	0.435
MOD_N-GLC_1	65	70	PF02516	0.404
MOD_NEK2_1	290	295	PF00069	0.407
MOD_NEK2_1	530	535	PF00069	0.575
MOD_NEK2_1	536	541	PF00069	0.521
MOD_NEK2_1	544	549	PF00069	0.439
MOD_NEK2_1	565	570	PF00069	0.492
MOD_NEK2_1	65	70	PF00069	0.657
MOD_NEK2_2	10	15	PF00069	0.400
MOD_PIKK_1	122	128	PF00454	0.594
MOD_PIKK_1	156	162	PF00454	0.674
MOD_PIKK_1	206	212	PF00454	0.556
MOD_PIKK_1	336	342	PF00454	0.421
MOD_PKA_1	198	204	PF00069	0.559
MOD_PKA_2	105	111	PF00069	0.538
MOD_PKA_2	153	159	PF00069	0.738
MOD_PKA_2	198	204	PF00069	0.559
MOD_PKA_2	212	218	PF00069	0.506
MOD_PKA_2	372	378	PF00069	0.667
MOD_PKA_2	380	386	PF00069	0.586
MOD_PKA_2	474	480	PF00069	0.636
MOD_PKA_2	536	542	PF00069	0.636
MOD_PKA_2	93	99	PF00069	0.573
MOD_Plk_1	455	461	PF00069	0.636
MOD_Plk_1	65	71	PF00069	0.613
MOD_Plk_4	10	16	PF00069	0.391
MOD_Plk_4	490	496	PF00069	0.543
MOD_ProDKin_1	101	107	PF00069	0.770
MOD_ProDKin_1	130	136	PF00069	0.840
MOD_ProDKin_1	163	169	PF00069	0.826
MOD_ProDKin_1	175	181	PF00069	0.615
MOD_ProDKin_1	408	414	PF00069	0.559
MOD_ProDKin_1	546	552	PF00069	0.456
MOD_ProDKin_1	85	91	PF00069	0.518
MOD_SUMO_for_1	314	317	PF00179	0.645
MOD_SUMO_for_1	358	361	PF00179	0.585
MOD_SUMO_rev_2	248	254	PF00179	0.473
MOD_SUMO_rev_2	280	290	PF00179	0.609
MOD_SUMO_rev_2	335	344	PF00179	0.677
TRG_DiLeu_BaEn_4	285	291	PF01217	0.651
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.455
TRG_ENDOCYTIC_2	25	28	PF00928	0.620
TRG_ENDOCYTIC_2	483	486	PF00928	0.618
TRG_ENDOCYTIC_2	501	504	PF00928	0.521
TRG_ER_diArg_1	261	264	PF00400	0.653
TRG_ER_diArg_1	330	332	PF00400	0.674
TRG_ER_diArg_1	569	571	PF00400	0.488
TRG_NES_CRM1_1	247	259	PF08389	0.638
TRG_NES_CRM1_1	55	67	PF08389	0.655
TRG_NLS_MonoExtC_3	38	43	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIE0	Leishmania donovani	72%	100%
A4IAN3	Leishmania infantum	72%	100%
E9B5A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2M7	Leishmania major	69%	100%