Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania braziliensis

UniProt:

A4HB36_LEIBR

TriTrypDb:

LbrM.20.2750 , LBRM2903_200039900

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB36

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009306	protein secretion	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0030254	protein secretion by the type III secretion system	4	6
GO:0032940	secretion by cell	3	6
GO:0033036	macromolecule localization	2	6
GO:0035592	establishment of protein localization to extracellular region	4	6
GO:0045184	establishment of protein localization	3	6

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.637
CLV_C14_Caspase3-7	427	431	PF00656	0.387
CLV_C14_Caspase3-7	560	564	PF00656	0.356
CLV_C14_Caspase3-7	70	74	PF00656	0.560
CLV_NRD_NRD_1	134	136	PF00675	0.593
CLV_NRD_NRD_1	213	215	PF00675	0.616
CLV_NRD_NRD_1	331	333	PF00675	0.673
CLV_NRD_NRD_1	38	40	PF00675	0.642
CLV_NRD_NRD_1	569	571	PF00675	0.488
CLV_PCSK_KEX2_1	198	200	PF00082	0.717

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIE0	Leishmania donovani	72%	100%
A4IAN3	Leishmania infantum	72%	100%
E9B5A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2M7	Leishmania major	69%	100%

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