LeishMANIAdb
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Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like domain-containing protein
Gene product:
Tir chaperone protein (CesT) family, putative
Species:
Leishmania braziliensis
UniProt:
A4HB36_LEIBR
TriTrypDb:
LbrM.20.2750 , LBRM2903_200039900 *
Length:
572

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB36
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB36

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 6
GO:0008104 protein localization 4 6
GO:0009306 protein secretion 4 6
GO:0009987 cellular process 1 6
GO:0015031 protein transport 4 6
GO:0030254 protein secretion by the type III secretion system 4 6
GO:0032940 secretion by cell 3 6
GO:0033036 macromolecule localization 2 6
GO:0035592 establishment of protein localization to extracellular region 4 6
GO:0045184 establishment of protein localization 3 6
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 18 22 PF00656 0.637
CLV_C14_Caspase3-7 427 431 PF00656 0.387
CLV_C14_Caspase3-7 560 564 PF00656 0.356
CLV_C14_Caspase3-7 70 74 PF00656 0.560
CLV_NRD_NRD_1 134 136 PF00675 0.593
CLV_NRD_NRD_1 213 215 PF00675 0.616
CLV_NRD_NRD_1 331 333 PF00675 0.673
CLV_NRD_NRD_1 38 40 PF00675 0.642
CLV_NRD_NRD_1 569 571 PF00675 0.488
CLV_PCSK_KEX2_1 198 200 PF00082 0.717
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IIE0 Leishmania donovani 72% 100%
A4IAN3 Leishmania infantum 72% 100%
E9B5A6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q4Q2M7 Leishmania major 69% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS