Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB35_LEIBR

TriTrypDb:

LbrM.20.2740 , LBRM2903_200039800

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.613
CLV_C14_Caspase3-7	30	34	PF00656	0.459
CLV_C14_Caspase3-7	375	379	PF00656	0.457
CLV_NRD_NRD_1	167	169	PF00675	0.381
CLV_NRD_NRD_1	35	37	PF00675	0.620
CLV_NRD_NRD_1	388	390	PF00675	0.459
CLV_NRD_NRD_1	573	575	PF00675	0.713
CLV_NRD_NRD_1	92	94	PF00675	0.626
CLV_PCSK_KEX2_1	388	390	PF00082	0.461
CLV_PCSK_KEX2_1	84	86	PF00082	0.626
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.626
CLV_PCSK_SKI1_1	405	409	PF00082	0.495
CLV_PCSK_SKI1_1	523	527	PF00082	0.508
CLV_PCSK_SKI1_1	84	88	PF00082	0.686
CLV_Separin_Metazoa	231	235	PF03568	0.391
DEG_APCC_DBOX_1	388	396	PF00400	0.553
DEG_MDM2_SWIB_1	423	431	PF02201	0.568
DEG_SCF_FBW7_1	246	253	PF00400	0.538
DEG_SPOP_SBC_1	544	548	PF00917	0.470
DEG_SPOP_SBC_1	578	582	PF00917	0.542
DOC_CKS1_1	247	252	PF01111	0.715
DOC_CYCLIN_RxL_1	165	174	PF00134	0.386
DOC_CYCLIN_RxL_1	401	412	PF00134	0.429
DOC_MAPK_gen_1	223	232	PF00069	0.365
DOC_MAPK_gen_1	388	395	PF00069	0.474
DOC_MAPK_gen_1	44	53	PF00069	0.665
DOC_MAPK_gen_1	84	92	PF00069	0.659
DOC_PP1_RVXF_1	166	173	PF00149	0.377
DOC_PP1_RVXF_1	87	93	PF00149	0.443
DOC_PP2B_LxvP_1	109	112	PF13499	0.488
DOC_PP2B_LxvP_1	230	233	PF13499	0.467
DOC_PP2B_LxvP_1	381	384	PF13499	0.563
DOC_PP2B_LxvP_1	6	9	PF13499	0.512
DOC_USP7_MATH_1	176	180	PF00917	0.613
DOC_USP7_MATH_1	250	254	PF00917	0.756
DOC_USP7_MATH_1	384	388	PF00917	0.583
DOC_USP7_MATH_1	570	574	PF00917	0.706
DOC_USP7_MATH_1	61	65	PF00917	0.545
DOC_USP7_UBL2_3	80	84	PF12436	0.635
DOC_WW_Pin1_4	145	150	PF00397	0.587
DOC_WW_Pin1_4	246	251	PF00397	0.764
DOC_WW_Pin1_4	259	264	PF00397	0.551
DOC_WW_Pin1_4	415	420	PF00397	0.512
DOC_WW_Pin1_4	473	478	PF00397	0.691
LIG_14-3-3_CanoR_1	175	181	PF00244	0.582
LIG_14-3-3_CanoR_1	223	233	PF00244	0.486
LIG_14-3-3_CanoR_1	308	312	PF00244	0.603
LIG_14-3-3_CanoR_1	321	325	PF00244	0.514
LIG_14-3-3_CanoR_1	527	533	PF00244	0.482
LIG_Actin_WH2_2	50	68	PF00022	0.664
LIG_Actin_WH2_2	511	529	PF00022	0.321
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BRCT_BRCA1_1	1	5	PF00533	0.503
LIG_BRCT_BRCA1_1	19	23	PF00533	0.426
LIG_BRCT_BRCA1_1	450	454	PF00533	0.474
LIG_BRCT_BRCA1_1	579	583	PF00533	0.762
LIG_Clathr_ClatBox_1	342	346	PF01394	0.508
LIG_Clathr_ClatBox_1	392	396	PF01394	0.572
LIG_deltaCOP1_diTrp_1	414	423	PF00928	0.522
LIG_deltaCOP1_diTrp_1	534	539	PF00928	0.469
LIG_eIF4E_1	277	283	PF01652	0.505
LIG_FHA_1	175	181	PF00498	0.576
LIG_FHA_1	225	231	PF00498	0.599
LIG_FHA_1	262	268	PF00498	0.600
LIG_FHA_1	308	314	PF00498	0.608
LIG_FHA_1	388	394	PF00498	0.478
LIG_FHA_1	416	422	PF00498	0.548
LIG_FHA_2	131	137	PF00498	0.767
LIG_FHA_2	238	244	PF00498	0.781
LIG_FHA_2	247	253	PF00498	0.777
LIG_FHA_2	345	351	PF00498	0.522
LIG_FHA_2	366	372	PF00498	0.546
LIG_FHA_2	546	552	PF00498	0.672
LIG_FHA_2	9	15	PF00498	0.636
LIG_LIR_Gen_1	206	215	PF02991	0.419
LIG_LIR_Gen_1	316	326	PF02991	0.508
LIG_LIR_Gen_1	336	345	PF02991	0.220
LIG_LIR_Gen_1	433	443	PF02991	0.457
LIG_LIR_Gen_1	458	468	PF02991	0.544
LIG_LIR_Gen_1	489	497	PF02991	0.495
LIG_LIR_Gen_1	530	541	PF02991	0.559
LIG_LIR_Nem_3	2	8	PF02991	0.676
LIG_LIR_Nem_3	206	210	PF02991	0.426
LIG_LIR_Nem_3	316	322	PF02991	0.519
LIG_LIR_Nem_3	336	341	PF02991	0.222
LIG_LIR_Nem_3	350	355	PF02991	0.365
LIG_LIR_Nem_3	433	439	PF02991	0.448
LIG_LIR_Nem_3	458	463	PF02991	0.495
LIG_LIR_Nem_3	489	493	PF02991	0.489
LIG_LIR_Nem_3	530	536	PF02991	0.576
LIG_MLH1_MIPbox_1	19	23	PF16413	0.478
LIG_MYND_1	77	81	PF01753	0.673
LIG_NRBOX	365	371	PF00104	0.519
LIG_Pex14_1	298	302	PF04695	0.421
LIG_Pex14_2	423	427	PF04695	0.488
LIG_Pex14_2	533	537	PF04695	0.601
LIG_PTB_Apo_2	454	461	PF02174	0.345
LIG_PTB_Phospho_1	454	460	PF10480	0.340
LIG_REV1ctd_RIR_1	84	93	PF16727	0.441
LIG_SH2_CRK	287	291	PF00017	0.490
LIG_SH2_CRK	302	306	PF00017	0.396
LIG_SH2_CRK	352	356	PF00017	0.320
LIG_SH2_NCK_1	302	306	PF00017	0.513
LIG_SH2_NCK_1	460	464	PF00017	0.628
LIG_SH2_NCK_1	490	494	PF00017	0.562
LIG_SH2_SRC	70	73	PF00017	0.687
LIG_SH2_STAP1	302	306	PF00017	0.430
LIG_SH2_STAP1	460	464	PF00017	0.586
LIG_SH2_STAT3	277	280	PF00017	0.308
LIG_SH2_STAT5	22	25	PF00017	0.591
LIG_SH2_STAT5	302	305	PF00017	0.421
LIG_SH2_STAT5	306	309	PF00017	0.432
LIG_SH2_STAT5	524	527	PF00017	0.563
LIG_SH2_STAT5	70	73	PF00017	0.721
LIG_SH3_3	134	140	PF00018	0.725
LIG_SH3_3	244	250	PF00018	0.705
LIG_SH3_3	474	480	PF00018	0.672
LIG_SH3_3	72	78	PF00018	0.686
LIG_SH3_4	80	87	PF00018	0.652
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.557
LIG_SUMO_SIM_par_1	339	347	PF11976	0.513
LIG_SUMO_SIM_par_1	354	361	PF11976	0.541
LIG_SUMO_SIM_par_1	406	412	PF11976	0.434
LIG_TRAF2_1	193	196	PF00917	0.603
LIG_TRAF2_1	548	551	PF00917	0.679
LIG_TYR_ITIM	300	305	PF00017	0.417
LIG_TYR_ITIM	488	493	PF00017	0.552
LIG_UBA3_1	217	225	PF00899	0.433
LIG_UBA3_1	342	348	PF00899	0.509
MOD_CDK_SPxxK_3	259	266	PF00069	0.447
MOD_CK1_1	144	150	PF00069	0.722
MOD_CK1_1	17	23	PF00069	0.721
MOD_CK1_1	174	180	PF00069	0.667
MOD_CK1_1	253	259	PF00069	0.728
MOD_CK1_1	261	267	PF00069	0.632
MOD_CK1_1	344	350	PF00069	0.531
MOD_CK1_1	387	393	PF00069	0.512
MOD_CK2_1	132	138	PF00069	0.771
MOD_CK2_1	203	209	PF00069	0.452
MOD_CK2_1	344	350	PF00069	0.505
MOD_CK2_1	455	461	PF00069	0.537
MOD_CK2_1	544	550	PF00069	0.732
MOD_CK2_1	61	67	PF00069	0.512
MOD_CK2_1	8	14	PF00069	0.682
MOD_GlcNHglycan	116	120	PF01048	0.693
MOD_GlcNHglycan	158	161	PF01048	0.495
MOD_GlcNHglycan	19	22	PF01048	0.720
MOD_GlcNHglycan	201	204	PF01048	0.485
MOD_GlcNHglycan	252	255	PF01048	0.792
MOD_GlcNHglycan	374	377	PF01048	0.470
MOD_GSK3_1	128	135	PF00069	0.770
MOD_GSK3_1	140	147	PF00069	0.701
MOD_GSK3_1	170	177	PF00069	0.611
MOD_GSK3_1	199	206	PF00069	0.511
MOD_GSK3_1	246	253	PF00069	0.792
MOD_GSK3_1	258	265	PF00069	0.671
MOD_GSK3_1	337	344	PF00069	0.523
MOD_GSK3_1	491	498	PF00069	0.522
MOD_GSK3_1	566	573	PF00069	0.687
MOD_GSK3_1	578	585	PF00069	0.679
MOD_GSK3_1	8	15	PF00069	0.611
MOD_N-GLC_1	140	145	PF02516	0.588
MOD_N-GLC_1	336	341	PF02516	0.552
MOD_N-GLC_1	544	549	PF02516	0.466
MOD_NEK2_1	170	175	PF00069	0.604
MOD_NEK2_1	199	204	PF00069	0.597
MOD_NEK2_1	210	215	PF00069	0.467
MOD_NEK2_1	300	305	PF00069	0.428
MOD_NEK2_1	307	312	PF00069	0.489
MOD_NEK2_1	431	436	PF00069	0.505
MOD_NEK2_1	448	453	PF00069	0.352
MOD_NEK2_1	526	531	PF00069	0.583
MOD_NEK2_1	553	558	PF00069	0.656
MOD_NEK2_2	61	66	PF00069	0.595
MOD_PIKK_1	441	447	PF00454	0.341
MOD_PKA_2	17	23	PF00069	0.482
MOD_PKA_2	170	176	PF00069	0.581
MOD_PKA_2	307	313	PF00069	0.595
MOD_PKA_2	320	326	PF00069	0.539
MOD_PKA_2	387	393	PF00069	0.523
MOD_PKA_2	466	472	PF00069	0.640
MOD_PKA_2	526	532	PF00069	0.415
MOD_PKA_2	570	576	PF00069	0.722
MOD_Plk_1	140	146	PF00069	0.674
MOD_Plk_1	336	342	PF00069	0.547
MOD_Plk_1	413	419	PF00069	0.497
MOD_Plk_1	455	461	PF00069	0.485
MOD_Plk_2-3	237	243	PF00069	0.771
MOD_Plk_4	148	154	PF00069	0.631
MOD_Plk_4	213	219	PF00069	0.330
MOD_Plk_4	253	259	PF00069	0.524
MOD_Plk_4	300	306	PF00069	0.355
MOD_Plk_4	320	326	PF00069	0.506
MOD_Plk_4	337	343	PF00069	0.458
MOD_Plk_4	365	371	PF00069	0.476
MOD_Plk_4	455	461	PF00069	0.591
MOD_Plk_4	508	514	PF00069	0.546
MOD_Plk_4	532	538	PF00069	0.524
MOD_Plk_4	579	585	PF00069	0.722
MOD_Plk_4	66	72	PF00069	0.626
MOD_ProDKin_1	145	151	PF00069	0.583
MOD_ProDKin_1	246	252	PF00069	0.765
MOD_ProDKin_1	259	265	PF00069	0.537
MOD_ProDKin_1	415	421	PF00069	0.502
MOD_ProDKin_1	473	479	PF00069	0.684
MOD_SUMO_for_1	79	82	PF00179	0.659
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.378
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.462
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.566
TRG_ENDOCYTIC_2	287	290	PF00928	0.494
TRG_ENDOCYTIC_2	302	305	PF00928	0.398
TRG_ENDOCYTIC_2	352	355	PF00928	0.425
TRG_ENDOCYTIC_2	460	463	PF00928	0.542
TRG_ENDOCYTIC_2	490	493	PF00928	0.555
TRG_ER_diArg_1	388	391	PF00400	0.510
TRG_NLS_MonoExtC_3	573	578	PF00514	0.489
TRG_NLS_MonoExtN_4	571	578	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P314	Leptomonas seymouri	52%	93%
A0A1X0P9X4	Trypanosomatidae	31%	100%
A0A3Q8IIR9	Leishmania donovani	71%	100%
A4IAN4	Leishmania infantum	71%	100%
C9ZM12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B5A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q2M8	Leishmania major	71%	100%
V5BV34	Trypanosoma cruzi	30%	100%