Interleukin 17 receptor B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB34_LEIBR

TriTrypDb:

LbrM.20.2730

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HB34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.459
CLV_NRD_NRD_1	241	243	PF00675	0.753
CLV_PCSK_KEX2_1	145	147	PF00082	0.731
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.731
CLV_PCSK_SKI1_1	265	269	PF00082	0.638
CLV_PCSK_SKI1_1	308	312	PF00082	0.621
CLV_PCSK_SKI1_1	6	10	PF00082	0.649
DEG_SCF_FBW7_1	19	26	PF00400	0.368
DEG_SPOP_SBC_1	76	80	PF00917	0.390
DOC_CKS1_1	20	25	PF01111	0.378
DOC_CYCLIN_RxL_1	303	315	PF00134	0.330
DOC_MAPK_FxFP_2	187	190	PF00069	0.347
DOC_MAPK_gen_1	196	205	PF00069	0.469
DOC_MAPK_gen_1	304	312	PF00069	0.478
DOC_MAPK_MEF2A_6	196	205	PF00069	0.443
DOC_MAPK_MEF2A_6	282	291	PF00069	0.494
DOC_PP4_FxxP_1	187	190	PF00568	0.322
DOC_USP7_MATH_1	253	257	PF00917	0.591
DOC_USP7_MATH_1	76	80	PF00917	0.404
DOC_USP7_UBL2_3	255	259	PF12436	0.409
DOC_WW_Pin1_4	171	176	PF00397	0.506
DOC_WW_Pin1_4	19	24	PF00397	0.450
DOC_WW_Pin1_4	270	275	PF00397	0.350
DOC_WW_Pin1_4	293	298	PF00397	0.326
DOC_WW_Pin1_4	316	321	PF00397	0.404
DOC_WW_Pin1_4	340	345	PF00397	0.384
LIG_14-3-3_CanoR_1	136	142	PF00244	0.413
LIG_14-3-3_CanoR_1	263	268	PF00244	0.451
LIG_14-3-3_CanoR_1	339	344	PF00244	0.366
LIG_14-3-3_CanoR_1	6	15	PF00244	0.422
LIG_14-3-3_CanoR_1	94	99	PF00244	0.476
LIG_eIF4E_1	204	210	PF01652	0.466
LIG_FHA_1	20	26	PF00498	0.332
LIG_FHA_1	294	300	PF00498	0.367
LIG_FHA_1	381	387	PF00498	0.357
LIG_FHA_1	408	414	PF00498	0.376
LIG_FHA_1	419	425	PF00498	0.510
LIG_FHA_1	67	73	PF00498	0.477
LIG_FHA_1	88	94	PF00498	0.467
LIG_FHA_1	98	104	PF00498	0.403
LIG_FHA_2	39	45	PF00498	0.598
LIG_IRF3_LxIS_1	287	292	PF10401	0.411
LIG_LIR_Apic_2	315	320	PF02991	0.403
LIG_LIR_Gen_1	379	390	PF02991	0.423
LIG_LIR_Gen_1	410	420	PF02991	0.224
LIG_LIR_Nem_3	104	109	PF02991	0.409
LIG_LIR_Nem_3	266	272	PF02991	0.414
LIG_LIR_Nem_3	311	317	PF02991	0.379
LIG_LIR_Nem_3	379	385	PF02991	0.443
LIG_LIR_Nem_3	410	415	PF02991	0.224
LIG_NRBOX	414	420	PF00104	0.450
LIG_PDZ_Class_2	421	426	PF00595	0.617
LIG_Pex14_1	184	188	PF04695	0.346
LIG_Pex14_1	264	268	PF04695	0.493
LIG_Pex14_2	384	388	PF04695	0.330
LIG_SH2_CRK	20	24	PF00017	0.506
LIG_SH2_CRK	317	321	PF00017	0.385
LIG_SH2_CRK	382	386	PF00017	0.362
LIG_SH2_PTP2	33	36	PF00017	0.285
LIG_SH2_SRC	33	36	PF00017	0.285
LIG_SH2_STAP1	382	386	PF00017	0.313
LIG_SH2_STAT3	141	144	PF00017	0.462
LIG_SH2_STAT5	185	188	PF00017	0.405
LIG_SH2_STAT5	204	207	PF00017	0.429
LIG_SH2_STAT5	270	273	PF00017	0.393
LIG_SH2_STAT5	317	320	PF00017	0.416
LIG_SH2_STAT5	33	36	PF00017	0.285
LIG_SH2_STAT5	382	385	PF00017	0.372
LIG_SH3_1	317	323	PF00018	0.409
LIG_SH3_3	238	244	PF00018	0.559
LIG_SH3_3	268	274	PF00018	0.396
LIG_SH3_3	299	305	PF00018	0.482
LIG_SH3_3	317	323	PF00018	0.363
LIG_SH3_3	338	344	PF00018	0.370
LIG_SH3_3	56	62	PF00018	0.417
LIG_TYR_ITIM	267	272	PF00017	0.399
LIG_UBA3_1	151	157	PF00899	0.341
LIG_UBA3_1	225	229	PF00899	0.357
LIG_UBA3_1	414	422	PF00899	0.380
MOD_CDK_SPK_2	316	321	PF00069	0.414
MOD_CDK_SPxxK_3	171	178	PF00069	0.493
MOD_CK1_1	107	113	PF00069	0.216
MOD_CK1_1	254	260	PF00069	0.549
MOD_CK1_1	292	298	PF00069	0.344
MOD_CK1_1	354	360	PF00069	0.439
MOD_CK1_1	97	103	PF00069	0.281
MOD_CK2_1	107	113	PF00069	0.462
MOD_GlcNHglycan	25	28	PF01048	0.595
MOD_GlcNHglycan	358	362	PF01048	0.539
MOD_GlcNHglycan	59	62	PF01048	0.751
MOD_GlcNHglycan	79	82	PF01048	0.675
MOD_GSK3_1	125	132	PF00069	0.399
MOD_GSK3_1	19	26	PF00069	0.515
MOD_GSK3_1	247	254	PF00069	0.579
MOD_GSK3_1	278	285	PF00069	0.469
MOD_GSK3_1	289	296	PF00069	0.244
MOD_GSK3_1	308	315	PF00069	0.448
MOD_GSK3_1	376	383	PF00069	0.471
MOD_GSK3_1	45	52	PF00069	0.586
MOD_GSK3_1	7	14	PF00069	0.420
MOD_GSK3_1	93	100	PF00069	0.355
MOD_LATS_1	378	384	PF00433	0.357
MOD_N-GLC_2	131	133	PF02516	0.667
MOD_NEK2_1	137	142	PF00069	0.393
MOD_NEK2_1	176	181	PF00069	0.347
MOD_NEK2_1	289	294	PF00069	0.421
MOD_NEK2_1	312	317	PF00069	0.359
MOD_NEK2_1	397	402	PF00069	0.490
MOD_NEK2_1	93	98	PF00069	0.396
MOD_PIKK_1	123	129	PF00454	0.399
MOD_PIKK_1	257	263	PF00454	0.463
MOD_PIKK_1	45	51	PF00454	0.460
MOD_PIKK_1	87	93	PF00454	0.285
MOD_PKA_1	145	151	PF00069	0.442
MOD_PKA_2	11	17	PF00069	0.442
MOD_PKA_2	137	143	PF00069	0.408
MOD_PKA_2	145	151	PF00069	0.507
MOD_PKA_2	281	287	PF00069	0.531
MOD_PKA_2	376	382	PF00069	0.509
MOD_PKA_2	93	99	PF00069	0.479
MOD_PKB_1	337	345	PF00069	0.279
MOD_Plk_1	380	386	PF00069	0.348
MOD_Plk_1	397	403	PF00069	0.508
MOD_Plk_2-3	38	44	PF00069	0.402
MOD_Plk_4	263	269	PF00069	0.462
MOD_Plk_4	308	314	PF00069	0.395
MOD_Plk_4	380	386	PF00069	0.314
MOD_Plk_4	398	404	PF00069	0.347
MOD_Plk_4	407	413	PF00069	0.275
MOD_Plk_4	94	100	PF00069	0.478
MOD_ProDKin_1	171	177	PF00069	0.495
MOD_ProDKin_1	19	25	PF00069	0.442
MOD_ProDKin_1	270	276	PF00069	0.354
MOD_ProDKin_1	293	299	PF00069	0.334
MOD_ProDKin_1	316	322	PF00069	0.401
MOD_ProDKin_1	340	346	PF00069	0.384
MOD_SUMO_rev_2	342	350	PF00179	0.476
MOD_SUMO_rev_2	366	373	PF00179	0.496
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.493
TRG_ENDOCYTIC_2	185	188	PF00928	0.358
TRG_ENDOCYTIC_2	269	272	PF00928	0.391
TRG_ENDOCYTIC_2	382	385	PF00928	0.440
TRG_ER_diArg_1	135	138	PF00400	0.369
TRG_ER_diArg_1	29	32	PF00400	0.372
TRG_ER_diArg_1	337	340	PF00400	0.446
TRG_NLS_MonoExtN_4	304	310	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK0	Leptomonas seymouri	47%	96%
A0A3R7MRN0	Trypanosoma rangeli	22%	100%
A0A3S7X898	Leishmania donovani	71%	100%
A4IAN5	Leishmania infantum	70%	100%
E9B5A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q2M9	Leishmania major	69%	100%
V5BQG2	Trypanosoma cruzi	22%	100%