RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB33_LEIBR

TriTrypDb:

LbrM.20.2720 , LBRM2903_200039500

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HB33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB33

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.651
CLV_NRD_NRD_1	16	18	PF00675	0.631
CLV_NRD_NRD_1	9	11	PF00675	0.641
CLV_PCSK_KEX2_1	16	18	PF00082	0.609
CLV_PCSK_KEX2_1	9	11	PF00082	0.650
CLV_PCSK_PC7_1	5	11	PF00082	0.653
DOC_MAPK_gen_1	38	45	PF00069	0.509
DOC_PP2B_LxvP_1	48	51	PF13499	0.457
LIG_14-3-3_CanoR_1	21	25	PF00244	0.815
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	172	176	PF00533	0.582
LIG_deltaCOP1_diTrp_1	126	132	PF00928	0.529
LIG_FHA_1	134	140	PF00498	0.542
LIG_FHA_1	153	159	PF00498	0.548
LIG_FHA_2	195	201	PF00498	0.524
LIG_LIR_Gen_1	118	129	PF02991	0.529
LIG_LIR_Nem_3	118	124	PF02991	0.535
LIG_LIR_Nem_3	126	132	PF02991	0.529
LIG_LYPXL_yS_3	78	81	PF13949	0.550
LIG_PCNA_PIPBox_1	99	108	PF02747	0.528
LIG_PCNA_yPIPBox_3	99	108	PF02747	0.558
LIG_Pex14_1	128	132	PF04695	0.529
LIG_REV1ctd_RIR_1	129	139	PF16727	0.449
LIG_SH2_GRB2like	141	144	PF00017	0.563
LIG_SH2_SRC	141	144	PF00017	0.563
LIG_SH2_STAT5	105	108	PF00017	0.531
LIG_SH2_STAT5	164	167	PF00017	0.509
MOD_CK1_1	144	150	PF00069	0.579
MOD_CK1_1	20	26	PF00069	0.588
MOD_CK1_1	201	207	PF00069	0.671
MOD_CK1_1	209	215	PF00069	0.728
MOD_CK1_1	218	224	PF00069	0.654
MOD_CK1_1	226	232	PF00069	0.544
MOD_CK1_1	32	38	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.697
MOD_CK2_1	196	202	PF00069	0.521
MOD_CK2_1	9	15	PF00069	0.693
MOD_GlcNHglycan	206	209	PF01048	0.666
MOD_GlcNHglycan	213	217	PF01048	0.603
MOD_GlcNHglycan	243	246	PF01048	0.545
MOD_GlcNHglycan	32	35	PF01048	0.631
MOD_GSK3_1	194	201	PF00069	0.668
MOD_GSK3_1	202	209	PF00069	0.793
MOD_GSK3_1	211	218	PF00069	0.541
MOD_GSK3_1	219	226	PF00069	0.540
MOD_GSK3_1	227	234	PF00069	0.526
MOD_GSK3_1	28	35	PF00069	0.669
MOD_N-GLC_1	226	231	PF02516	0.528
MOD_N-GLC_1	241	246	PF02516	0.511
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	171	176	PF00069	0.445
MOD_NEK2_1	181	186	PF00069	0.566
MOD_PIKK_1	144	150	PF00454	0.569
MOD_PIKK_1	95	101	PF00454	0.530
MOD_PKA_1	17	23	PF00069	0.601
MOD_PKA_1	9	15	PF00069	0.642
MOD_PKA_2	20	26	PF00069	0.550
MOD_PKA_2	219	225	PF00069	0.591
MOD_PKA_2	231	237	PF00069	0.525
MOD_PKA_2	4	10	PF00069	0.675
MOD_Plk_1	144	150	PF00069	0.613
MOD_Plk_2-3	231	237	PF00069	0.620
MOD_Plk_4	157	163	PF00069	0.562
MOD_SUMO_rev_2	127	136	PF00179	0.565
TRG_ENDOCYTIC_2	129	132	PF00928	0.475
TRG_ENDOCYTIC_2	78	81	PF00928	0.550
TRG_NLS_Bipartite_1	9	29	PF00514	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M7	Leptomonas seymouri	63%	98%
A0A3S7X890	Leishmania donovani	87%	99%
A4IAN6	Leishmania infantum	87%	99%
E9B5A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q2N0	Leishmania major	87%	99%