DUF4238 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 28

Species:

Leishmania braziliensis

UniProt:

A4HB32_LEIBR

TriTrypDb:

LbrM.20.2710 , LBRM2903_200039400

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.496
CLV_NRD_NRD_1	48	50	PF00675	0.409
CLV_PCSK_KEX2_1	146	148	PF00082	0.480
CLV_PCSK_KEX2_1	400	402	PF00082	0.607
CLV_PCSK_KEX2_1	47	49	PF00082	0.404
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.514
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.508
CLV_PCSK_SKI1_1	191	195	PF00082	0.365
CLV_PCSK_SKI1_1	303	307	PF00082	0.327
CLV_PCSK_SKI1_1	331	335	PF00082	0.439
CLV_PCSK_SKI1_1	91	95	PF00082	0.459
DOC_MAPK_DCC_7	269	279	PF00069	0.342
DOC_MAPK_gen_1	331	341	PF00069	0.475
DOC_MAPK_gen_1	47	58	PF00069	0.487
DOC_MAPK_MEF2A_6	250	257	PF00069	0.346
DOC_MAPK_MEF2A_6	52	60	PF00069	0.511
DOC_PP2B_LxvP_1	112	115	PF13499	0.357
DOC_PP4_FxxP_1	80	83	PF00568	0.322
DOC_SPAK_OSR1_1	384	388	PF12202	0.433
DOC_USP7_MATH_1	293	297	PF00917	0.507
DOC_USP7_MATH_1	399	403	PF00917	0.407
DOC_USP7_UBL2_3	299	303	PF12436	0.419
DOC_WW_Pin1_4	106	111	PF00397	0.343
DOC_WW_Pin1_4	182	187	PF00397	0.374
DOC_WW_Pin1_4	258	263	PF00397	0.377
DOC_WW_Pin1_4	8	13	PF00397	0.553
LIG_14-3-3_CanoR_1	250	256	PF00244	0.365
LIG_14-3-3_CanoR_1	359	366	PF00244	0.400
LIG_14-3-3_CanoR_1	89	98	PF00244	0.529
LIG_Actin_WH2_2	237	252	PF00022	0.370
LIG_Actin_WH2_2	321	336	PF00022	0.404
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_CtBP_PxDLS_1	115	119	PF00389	0.360
LIG_FHA_1	107	113	PF00498	0.361
LIG_FHA_1	381	387	PF00498	0.382
LIG_FHA_1	82	88	PF00498	0.374
LIG_FHA_2	293	299	PF00498	0.532
LIG_FHA_2	362	368	PF00498	0.457
LIG_Integrin_isoDGR_2	321	323	PF01839	0.325
LIG_LIR_Gen_1	148	158	PF02991	0.493
LIG_LIR_Gen_1	66	72	PF02991	0.489
LIG_LIR_Nem_3	106	111	PF02991	0.477
LIG_LIR_Nem_3	148	154	PF02991	0.459
LIG_LIR_Nem_3	64	70	PF02991	0.426
LIG_Pex14_2	308	312	PF04695	0.434
LIG_PTB_Apo_2	203	210	PF02174	0.416
LIG_PTB_Phospho_1	203	209	PF10480	0.416
LIG_REV1ctd_RIR_1	305	315	PF16727	0.384
LIG_SH2_PTP2	326	329	PF00017	0.405
LIG_SH2_SRC	234	237	PF00017	0.331
LIG_SH2_STAP1	54	58	PF00017	0.409
LIG_SH2_STAT3	314	317	PF00017	0.463
LIG_SH2_STAT5	209	212	PF00017	0.454
LIG_SH2_STAT5	234	237	PF00017	0.351
LIG_SH2_STAT5	290	293	PF00017	0.517
LIG_SH2_STAT5	326	329	PF00017	0.346
LIG_SH3_1	326	332	PF00018	0.426
LIG_SH3_2	329	334	PF14604	0.436
LIG_SH3_3	326	332	PF00018	0.360
LIG_SUMO_SIM_par_1	109	117	PF11976	0.345
LIG_SUMO_SIM_par_1	260	267	PF11976	0.318
LIG_TRAF2_1	377	380	PF00917	0.521
LIG_UBA3_1	193	200	PF00899	0.456
LIG_WRC_WIRS_1	304	309	PF05994	0.333
LIG_WW_3	11	15	PF00397	0.480
MOD_CDC14_SPxK_1	11	14	PF00782	0.618
MOD_CDK_SPxK_1	8	14	PF00069	0.617
MOD_CK1_1	185	191	PF00069	0.388
MOD_CK1_1	199	205	PF00069	0.509
MOD_CK1_1	218	224	PF00069	0.480
MOD_CK1_1	258	264	PF00069	0.368
MOD_CK1_1	361	367	PF00069	0.429
MOD_CK1_1	59	65	PF00069	0.415
MOD_CK2_1	349	355	PF00069	0.490
MOD_CK2_1	361	367	PF00069	0.379
MOD_GlcNHglycan	298	302	PF01048	0.468
MOD_GlcNHglycan	371	374	PF01048	0.481
MOD_GlcNHglycan	375	378	PF01048	0.458
MOD_GlcNHglycan	91	94	PF01048	0.482
MOD_GSK3_1	153	160	PF00069	0.521
MOD_GSK3_1	174	181	PF00069	0.328
MOD_GSK3_1	196	203	PF00069	0.566
MOD_GSK3_1	215	222	PF00069	0.322
MOD_GSK3_1	251	258	PF00069	0.346
MOD_GSK3_1	29	36	PF00069	0.690
MOD_GSK3_1	293	300	PF00069	0.478
MOD_GSK3_1	361	368	PF00069	0.475
MOD_GSK3_1	369	376	PF00069	0.437
MOD_GSK3_1	59	66	PF00069	0.329
MOD_N-GLC_1	218	223	PF02516	0.482
MOD_NEK2_1	168	173	PF00069	0.353
MOD_NEK2_1	257	262	PF00069	0.339
MOD_NEK2_1	56	61	PF00069	0.533
MOD_NEK2_2	29	34	PF00069	0.442
MOD_PK_1	14	20	PF00069	0.482
MOD_PKA_2	293	299	PF00069	0.423
MOD_PKA_2	358	364	PF00069	0.383
MOD_Plk_1	14	20	PF00069	0.482
MOD_Plk_1	218	224	PF00069	0.539
MOD_Plk_1	29	35	PF00069	0.555
MOD_Plk_1	56	62	PF00069	0.462
MOD_Plk_2-3	349	355	PF00069	0.506
MOD_Plk_4	303	309	PF00069	0.333
MOD_Plk_4	365	371	PF00069	0.541
MOD_Plk_4	56	62	PF00069	0.510
MOD_Plk_4	63	69	PF00069	0.483
MOD_ProDKin_1	106	112	PF00069	0.340
MOD_ProDKin_1	182	188	PF00069	0.380
MOD_ProDKin_1	258	264	PF00069	0.388
MOD_ProDKin_1	8	14	PF00069	0.555
MOD_SUMO_for_1	145	148	PF00179	0.501
TRG_DiLeu_BaEn_1	96	101	PF01217	0.248
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.334
TRG_ENDOCYTIC_2	67	70	PF00928	0.349
TRG_ER_diArg_1	47	49	PF00400	0.425
TRG_ER_diLys_1	398	403	PF00400	0.399
TRG_NES_CRM1_1	163	178	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E1	Leptomonas seymouri	72%	85%
A0A0S4INK9	Bodo saltans	49%	92%
A0A1X0PAR0	Trypanosomatidae	61%	95%
A0A3S7X876	Leishmania donovani	83%	93%
A0A422NNH0	Trypanosoma rangeli	59%	80%
A4IAN7	Leishmania infantum	83%	93%
C9ZM15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	94%
E9B5A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	92%
Q4Q2N1	Leishmania major	86%	100%
V5DLX6	Trypanosoma cruzi	59%	100%