LeishMANIAdb
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Lipophosphoglycan biosynthetic protein (Lpg2)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Lipophosphoglycan biosynthetic protein (Lpg2)
Gene product:
lipophosphoglycan biosynthetic protein (lpg2)
Species:
Leishmania braziliensis
UniProt:
A4HB31_LEIBR
TriTrypDb:
LbrM.20.2700 , LBRM2903_200039100 *
Length:
341

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 12
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 12
GO:0098588 bounding membrane of organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HB31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB31

Function

Biological processes
Term Name Level Count
GO:0001817 regulation of cytokine production 4 1
GO:0001818 negative regulation of cytokine production 5 1
GO:0002577 regulation of antigen processing and presentation 4 1
GO:0002578 negative regulation of antigen processing and presentation 5 1
GO:0002682 regulation of immune system process 3 1
GO:0002683 negative regulation of immune system process 4 1
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010629 negative regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0032655 regulation of interleukin-12 production 5 1
GO:0032695 negative regulation of interleukin-12 production 6 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0048519 negative regulation of biological process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050896 response to stimulus 1 1
GO:0051239 regulation of multicellular organismal process 3 1
GO:0051241 negative regulation of multicellular organismal process 4 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052553 modulation by symbiont of host immune response 6 1
GO:0052572 response to host immune response 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0075136 response to host 3 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 12
GO:0005458 GDP-mannose transmembrane transporter activity 6 12
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 12
GO:0022857 transmembrane transporter activity 2 12
GO:0036080 purine nucleotide-sugar transmembrane transporter activity 5 12
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 12
GO:0015291 secondary active transmembrane transporter activity 4 1
GO:0015297 antiporter activity 5 1
GO:0022804 active transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 306 310 PF00656 0.498
CLV_PCSK_SKI1_1 149 153 PF00082 0.465
CLV_PCSK_SKI1_1 174 178 PF00082 0.228
CLV_PCSK_SKI1_1 224 228 PF00082 0.397
CLV_PCSK_SKI1_1 305 309 PF00082 0.376
DEG_MDM2_SWIB_1 239 247 PF02201 0.397
DEG_Nend_UBRbox_3 1 3 PF02207 0.584
DOC_CKS1_1 150 155 PF01111 0.238
DOC_CYCLIN_yCln2_LP_2 196 202 PF00134 0.269
DOC_MAPK_MEF2A_6 107 116 PF00069 0.363
DOC_MAPK_MEF2A_6 124 132 PF00069 0.363
DOC_MAPK_MEF2A_6 75 84 PF00069 0.424
DOC_MAPK_NFAT4_5 75 83 PF00069 0.442
DOC_PP2B_LxvP_1 196 199 PF13499 0.269
DOC_WW_Pin1_4 124 129 PF00397 0.460
DOC_WW_Pin1_4 149 154 PF00397 0.238
DOC_WW_Pin1_4 246 251 PF00397 0.417
DOC_WW_Pin1_4 319 324 PF00397 0.579
LIG_BRCT_BRCA1_1 196 200 PF00533 0.269
LIG_BRCT_BRCA1_1 320 324 PF00533 0.517
LIG_deltaCOP1_diTrp_1 148 157 PF00928 0.217
LIG_eIF4E_1 131 137 PF01652 0.288
LIG_FHA_1 125 131 PF00498 0.471
LIG_FHA_1 217 223 PF00498 0.259
LIG_FHA_1 236 242 PF00498 0.221
LIG_FHA_1 250 256 PF00498 0.466
LIG_FHA_1 277 283 PF00498 0.306
LIG_FHA_1 59 65 PF00498 0.487
LIG_FHA_2 306 312 PF00498 0.614
LIG_LIR_Apic_2 148 153 PF02991 0.238
LIG_LIR_Gen_1 129 139 PF02991 0.318
LIG_LIR_Gen_1 159 168 PF02991 0.271
LIG_LIR_Gen_1 18 27 PF02991 0.392
LIG_LIR_Gen_1 238 247 PF02991 0.265
LIG_LIR_Gen_1 321 329 PF02991 0.520
LIG_LIR_Gen_1 65 74 PF02991 0.469
LIG_LIR_Gen_1 81 92 PF02991 0.252
LIG_LIR_Nem_3 129 134 PF02991 0.173
LIG_LIR_Nem_3 152 157 PF02991 0.259
LIG_LIR_Nem_3 159 163 PF02991 0.247
LIG_LIR_Nem_3 166 172 PF02991 0.240
LIG_LIR_Nem_3 18 22 PF02991 0.392
LIG_LIR_Nem_3 197 203 PF02991 0.346
LIG_LIR_Nem_3 238 242 PF02991 0.213
LIG_LIR_Nem_3 279 284 PF02991 0.326
LIG_LIR_Nem_3 321 327 PF02991 0.597
LIG_LIR_Nem_3 61 66 PF02991 0.477
LIG_Pex14_2 134 138 PF04695 0.283
LIG_Pex14_2 239 243 PF04695 0.284
LIG_SH2_CRK 187 191 PF00017 0.428
LIG_SH2_CRK 192 196 PF00017 0.264
LIG_SH2_PTP2 281 284 PF00017 0.188
LIG_SH2_STAP1 169 173 PF00017 0.269
LIG_SH2_STAP1 35 39 PF00017 0.284
LIG_SH2_STAT5 131 134 PF00017 0.269
LIG_SH2_STAT5 142 145 PF00017 0.269
LIG_SH2_STAT5 169 172 PF00017 0.254
LIG_SH2_STAT5 281 284 PF00017 0.265
LIG_SH2_STAT5 294 297 PF00017 0.244
LIG_SH3_3 323 329 PF00018 0.649
LIG_SUMO_SIM_par_1 224 230 PF11976 0.209
LIG_SUMO_SIM_par_1 42 48 PF11976 0.344
LIG_TRAF2_1 328 331 PF00917 0.709
LIG_TYR_ITIM 190 195 PF00017 0.269
LIG_TYR_ITSM 277 284 PF00017 0.288
LIG_UBA3_1 53 59 PF00899 0.283
LIG_Vh1_VBS_1 286 304 PF01044 0.283
LIG_WRC_WIRS_1 131 136 PF05994 0.313
LIG_WRC_WIRS_1 157 162 PF05994 0.286
LIG_WRC_WIRS_1 236 241 PF05994 0.224
MOD_CK1_1 18 24 PF00069 0.286
MOD_CK1_1 217 223 PF00069 0.215
MOD_CK1_1 235 241 PF00069 0.287
MOD_CK1_1 246 252 PF00069 0.428
MOD_CK1_1 67 73 PF00069 0.359
MOD_CK1_1 86 92 PF00069 0.243
MOD_CK1_1 94 100 PF00069 0.251
MOD_CK2_1 305 311 PF00069 0.561
MOD_GlcNHglycan 305 308 PF01048 0.413
MOD_GlcNHglycan 65 69 PF01048 0.293
MOD_GSK3_1 126 133 PF00069 0.173
MOD_GSK3_1 163 170 PF00069 0.274
MOD_GSK3_1 172 179 PF00069 0.434
MOD_GSK3_1 214 221 PF00069 0.261
MOD_GSK3_1 227 234 PF00069 0.382
MOD_GSK3_1 245 252 PF00069 0.345
MOD_GSK3_1 314 321 PF00069 0.628
MOD_GSK3_1 83 90 PF00069 0.292
MOD_N-GLC_1 1 6 PF02516 0.367
MOD_N-GLC_1 297 302 PF02516 0.244
MOD_N-GLC_1 319 324 PF02516 0.443
MOD_NEK2_1 1 6 PF00069 0.645
MOD_NEK2_1 138 143 PF00069 0.243
MOD_NEK2_1 15 20 PF00069 0.258
MOD_NEK2_1 156 161 PF00069 0.248
MOD_NEK2_1 176 181 PF00069 0.325
MOD_NEK2_1 227 232 PF00069 0.305
MOD_NEK2_1 237 242 PF00069 0.228
MOD_NEK2_1 245 250 PF00069 0.339
MOD_NEK2_1 292 297 PF00069 0.361
MOD_NEK2_1 45 50 PF00069 0.220
MOD_NEK2_1 53 58 PF00069 0.181
MOD_NEK2_1 83 88 PF00069 0.262
MOD_Plk_1 1 7 PF00069 0.451
MOD_Plk_1 217 223 PF00069 0.254
MOD_Plk_1 64 70 PF00069 0.386
MOD_Plk_4 10 16 PF00069 0.275
MOD_Plk_4 101 107 PF00069 0.263
MOD_Plk_4 126 132 PF00069 0.295
MOD_Plk_4 138 144 PF00069 0.256
MOD_Plk_4 163 169 PF00069 0.257
MOD_Plk_4 172 178 PF00069 0.415
MOD_Plk_4 20 26 PF00069 0.332
MOD_Plk_4 232 238 PF00069 0.266
MOD_Plk_4 251 257 PF00069 0.381
MOD_Plk_4 262 268 PF00069 0.414
MOD_Plk_4 78 84 PF00069 0.254
MOD_ProDKin_1 124 130 PF00069 0.460
MOD_ProDKin_1 149 155 PF00069 0.238
MOD_ProDKin_1 246 252 PF00069 0.417
MOD_ProDKin_1 319 325 PF00069 0.580
MOD_SUMO_rev_2 330 335 PF00179 0.537
TRG_ENDOCYTIC_2 131 134 PF00928 0.269
TRG_ENDOCYTIC_2 187 190 PF00928 0.428
TRG_ENDOCYTIC_2 192 195 PF00928 0.264
TRG_ENDOCYTIC_2 281 284 PF00928 0.275
TRG_ENDOCYTIC_2 294 297 PF00928 0.310
TRG_ENDOCYTIC_2 66 69 PF00928 0.417
TRG_NES_CRM1_1 103 118 PF08389 0.269
TRG_NES_CRM1_1 36 47 PF08389 0.271

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVS9 Leptomonas seymouri 64% 100%
A0A0S4IKV6 Bodo saltans 20% 97%
A0A0S4J6I5 Bodo saltans 26% 100%
A0A0S4JCA2 Bodo saltans 24% 100%
A0A0S4JRM6 Bodo saltans 46% 100%
A0A0S4JRZ1 Bodo saltans 25% 100%
A0A1X0NIJ8 Trypanosomatidae 29% 100%
A0A1X0NJJ3 Trypanosomatidae 27% 100%
A0A1X0P9U5 Trypanosomatidae 60% 100%
A0A3Q8IUT2 Leishmania donovani 79% 100%
A0A422N243 Trypanosoma rangeli 54% 100%
A0A422ND47 Trypanosoma rangeli 20% 84%
A1C9R4 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 30% 90%
A1CZJ3 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 31% 89%
A1DA52 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 30% 96%
A2AKQ0 Mus musculus 21% 96%
A2R9P4 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 30% 90%
A2VE55 Bos taurus 20% 96%
A3LWX1 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 30% 100%
A4IA88 Leishmania infantum 79% 100%
A4RM13 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 28% 87%
A5DIN8 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 29% 97%
A6RJQ8 Botryotinia fuckeliana (strain B05.10) 28% 87%
A6ZTW6 Saccharomyces cerevisiae (strain YJM789) 26% 100%
A7E558 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 28% 87%
A7S1L6 Nematostella vectensis 22% 100%
A7TES5 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 27% 100%
A7TR80 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 27% 100%
A8MRY9 Arabidopsis thaliana 21% 99%
A8N9T6 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 29% 95%
B0DI84 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 26% 100%
B0Y384 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 31% 89%
B3LHR7 Saccharomyces cerevisiae (strain RM11-1a) 26% 100%
B3LS51 Saccharomyces cerevisiae (strain RM11-1a) 29% 100%
B5VHH5 Saccharomyces cerevisiae (strain AWRI1631) 29% 100%
C7GSI5 Saccharomyces cerevisiae (strain JAY291) 29% 100%
C7GUZ7 Saccharomyces cerevisiae (strain JAY291) 26% 100%
C8Z742 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 27% 100%
C8Z830 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 26% 100%
C9ZM22 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9B5A1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
P0CE11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P0CS02 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 28% 86%
P0CS03 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 28% 86%
P0CS04 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 27% 81%
P0CS05 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 27% 81%
P40107 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q0CA27 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 30% 89%
Q0UG89 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 29% 90%
Q15B89 Sus scrofa 21% 99%
Q18779 Caenorhabditis elegans 24% 100%
Q1DTI4 Coccidioides immitis (strain RS) 28% 88%
Q2AAF6 Komagataella pastoris 29% 100%
Q2HA88 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 30% 87%
Q2UTL1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 30% 90%
Q4WTQ6 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 31% 89%
Q54YK1 Dictyostelium discoideum 25% 89%
Q5A477 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 92%
Q5AQY2 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 31% 96%
Q5AS82 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 90%
Q5RDC9 Pongo abelii 21% 96%
Q6C0U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 30% 100%
Q6CYD0 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 100%
Q6FRE5 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 100%
Q753T9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q762D5 Mus musculus 23% 100%
Q76EJ3 Homo sapiens 23% 100%
Q7SBC5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 30% 87%
Q84L08 Arabidopsis thaliana 25% 100%
Q84L09 Arabidopsis thaliana 27% 91%
Q941R4 Arabidopsis thaliana 30% 100%
Q94B65 Arabidopsis thaliana 25% 100%
Q95YI5 Drosophila melanogaster 22% 91%
Q968A5 Caenorhabditis elegans 21% 94%
Q9BIR6 Leishmania major 79% 100%
Q9NTN3 Homo sapiens 21% 96%
Q9S845 Arabidopsis thaliana 23% 92%
Q9UTK8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 99%
V5BMJ0 Trypanosoma cruzi 25% 100%
V5D4Q6 Trypanosoma cruzi 23% 100%
V5DLW9 Trypanosoma cruzi 50% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS