P-loop containing nucleoside triphosphate hydrolase protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HB30_LEIBR

TriTrypDb:

LbrM.20.2690 , LBRM2903_200039000

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HB30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.560
CLV_NRD_NRD_1	85	87	PF00675	0.760
CLV_PCSK_KEX2_1	111	113	PF00082	0.598
CLV_PCSK_KEX2_1	161	163	PF00082	0.560
CLV_PCSK_KEX2_1	51	53	PF00082	0.746
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.598
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.798
CLV_PCSK_SKI1_1	192	196	PF00082	0.575
DEG_APCC_DBOX_1	177	185	PF00400	0.398
DEG_Kelch_Keap1_1	73	78	PF01344	0.440
DOC_ANK_TNKS_1	73	80	PF00023	0.523
DOC_CYCLIN_RxL_1	153	163	PF00134	0.217
DOC_MAPK_DCC_7	87	97	PF00069	0.370
DOC_MAPK_gen_1	178	186	PF00069	0.217
DOC_MAPK_gen_1	19	27	PF00069	0.566
DOC_USP7_MATH_1	128	132	PF00917	0.360
DOC_USP7_MATH_1	23	27	PF00917	0.240
DOC_WW_Pin1_4	171	176	PF00397	0.370
DOC_WW_Pin1_4	57	62	PF00397	0.504
LIG_14-3-3_CanoR_1	207	216	PF00244	0.328
LIG_14-3-3_CanoR_1	86	93	PF00244	0.484
LIG_Actin_WH2_2	1	18	PF00022	0.576
LIG_Actin_WH2_2	147	163	PF00022	0.360
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	173	177	PF00533	0.360
LIG_EH1_1	27	35	PF00400	0.240
LIG_FHA_1	112	118	PF00498	0.356
LIG_FHA_1	132	138	PF00498	0.162
LIG_FHA_1	153	159	PF00498	0.305
LIG_FHA_1	48	54	PF00498	0.517
LIG_FHA_1	86	92	PF00498	0.490
LIG_FHA_2	139	145	PF00498	0.217
LIG_FHA_2	220	226	PF00498	0.361
LIG_FHA_2	237	243	PF00498	0.379
LIG_LIR_Gen_1	120	129	PF02991	0.316
LIG_LIR_Gen_1	202	208	PF02991	0.398
LIG_LIR_Gen_1	26	36	PF02991	0.392
LIG_LIR_Nem_3	120	124	PF02991	0.316
LIG_LIR_Nem_3	26	31	PF02991	0.397
LIG_Pex14_1	109	113	PF04695	0.301
LIG_SH2_CRK	40	44	PF00017	0.423
LIG_SH2_PTP2	121	124	PF00017	0.331
LIG_SH2_PTP2	42	45	PF00017	0.403
LIG_SH2_SRC	121	124	PF00017	0.344
LIG_SH2_SRC	42	45	PF00017	0.315
LIG_SH2_STAP1	113	117	PF00017	0.398
LIG_SH2_STAT5	113	116	PF00017	0.301
LIG_SH2_STAT5	121	124	PF00017	0.301
LIG_SH2_STAT5	219	222	PF00017	0.305
LIG_SH2_STAT5	42	45	PF00017	0.338
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.360
LIG_SUMO_SIM_par_1	222	227	PF11976	0.423
LIG_UBA3_1	97	106	PF00899	0.301
MOD_CDC14_SPxK_1	60	63	PF00782	0.436
MOD_CDK_SPK_2	57	62	PF00069	0.435
MOD_CDK_SPxK_1	57	63	PF00069	0.436
MOD_CDK_SPxxK_3	171	178	PF00069	0.370
MOD_CDK_SPxxK_3	57	64	PF00069	0.437
MOD_CK1_1	104	110	PF00069	0.259
MOD_CK1_1	131	137	PF00069	0.360
MOD_CK1_1	54	60	PF00069	0.546
MOD_CK1_1	72	78	PF00069	0.528
MOD_CK2_1	207	213	PF00069	0.321
MOD_CK2_1	219	225	PF00069	0.302
MOD_CK2_1	72	78	PF00069	0.438
MOD_GlcNHglycan	1	4	PF01048	0.573
MOD_GlcNHglycan	103	106	PF01048	0.501
MOD_GlcNHglycan	75	78	PF01048	0.751
MOD_GSK3_1	195	202	PF00069	0.345
MOD_GSK3_1	47	54	PF00069	0.502
MOD_GSK3_1	65	72	PF00069	0.527
MOD_GSK3_1	87	94	PF00069	0.407
MOD_N-GLC_1	138	143	PF02516	0.562
MOD_N-GLC_1	171	176	PF02516	0.560
MOD_NEK2_1	15	20	PF00069	0.702
MOD_NEK2_1	160	165	PF00069	0.315
MOD_NEK2_1	236	241	PF00069	0.435
MOD_NEK2_2	23	28	PF00069	0.240
MOD_PK_1	195	201	PF00069	0.357
MOD_PKA_1	111	117	PF00069	0.398
MOD_PKA_1	51	57	PF00069	0.542
MOD_PKA_2	111	117	PF00069	0.398
MOD_PKA_2	131	137	PF00069	0.162
MOD_PKA_2	15	21	PF00069	0.546
MOD_PKA_2	160	166	PF00069	0.325
MOD_PKA_2	51	57	PF00069	0.519
MOD_PKA_2	73	79	PF00069	0.617
MOD_PKA_2	80	86	PF00069	0.446
MOD_Plk_1	236	242	PF00069	0.325
MOD_Plk_4	104	110	PF00069	0.246
MOD_Plk_4	117	123	PF00069	0.294
MOD_Plk_4	219	225	PF00069	0.394
MOD_Plk_4	23	29	PF00069	0.448
MOD_Plk_4	87	93	PF00069	0.440
MOD_ProDKin_1	171	177	PF00069	0.370
MOD_ProDKin_1	57	63	PF00069	0.505
MOD_SUMO_rev_2	143	151	PF00179	0.376
TRG_ENDOCYTIC_2	113	116	PF00928	0.337
TRG_ENDOCYTIC_2	121	124	PF00928	0.308
TRG_ENDOCYTIC_2	203	206	PF00928	0.364
TRG_ENDOCYTIC_2	40	43	PF00928	0.419
TRG_ER_diArg_1	129	132	PF00400	0.360
TRG_ER_diArg_1	160	162	PF00400	0.360
TRG_NLS_Bipartite_1	51	67	PF00514	0.460
TRG_NLS_MonoCore_2	61	66	PF00514	0.439
TRG_NLS_MonoExtN_4	59	66	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F6	Leptomonas seymouri	60%	98%
A0A3R7RME9	Trypanosoma rangeli	29%	100%
A0A3S7X8C5	Leishmania donovani	71%	96%
A4IA87	Leishmania infantum	70%	96%
E9B5A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q2N3	Leishmania major	67%	100%
V5B5B3	Trypanosoma cruzi	25%	98%