Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB29_LEIBR

TriTrypDb:

LbrM.20.2680 , LBRM2903_200038900

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.550
CLV_NRD_NRD_1	212	214	PF00675	0.520
CLV_PCSK_KEX2_1	173	175	PF00082	0.419
CLV_PCSK_KEX2_1	212	214	PF00082	0.568
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.358
CLV_PCSK_SKI1_1	258	262	PF00082	0.314
CLV_PCSK_SKI1_1	361	365	PF00082	0.461
CLV_PCSK_SKI1_1	376	380	PF00082	0.392
CLV_PCSK_SKI1_1	69	73	PF00082	0.603
CLV_PCSK_SKI1_1	87	91	PF00082	0.492
CLV_PCSK_SKI1_1	95	99	PF00082	0.479
DEG_APCC_DBOX_1	211	219	PF00400	0.464
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DEG_SCF_FBW7_2	59	65	PF00400	0.497
DOC_CKS1_1	322	327	PF01111	0.544
DOC_CKS1_1	338	343	PF01111	0.486
DOC_CKS1_1	59	64	PF01111	0.495
DOC_CYCLIN_RxL_1	358	367	PF00134	0.505
DOC_CYCLIN_RxL_1	373	383	PF00134	0.439
DOC_MAPK_gen_1	118	128	PF00069	0.456
DOC_MAPK_gen_1	19	30	PF00069	0.477
DOC_MAPK_gen_1	85	92	PF00069	0.428
DOC_MAPK_MEF2A_6	23	32	PF00069	0.495
DOC_PP1_RVXF_1	211	218	PF00149	0.526
DOC_PP1_RVXF_1	67	73	PF00149	0.528
DOC_PP4_FxxP_1	114	117	PF00568	0.577
DOC_USP7_MATH_1	284	288	PF00917	0.539
DOC_USP7_MATH_1	31	35	PF00917	0.439
DOC_USP7_MATH_1	74	78	PF00917	0.632
DOC_USP7_UBL2_3	173	177	PF12436	0.358
DOC_WW_Pin1_4	318	323	PF00397	0.738
DOC_WW_Pin1_4	337	342	PF00397	0.522
DOC_WW_Pin1_4	58	63	PF00397	0.518
DOC_WW_Pin1_4	79	84	PF00397	0.585
DOC_WW_Pin1_4	90	95	PF00397	0.436
LIG_14-3-3_CanoR_1	131	137	PF00244	0.501
LIG_14-3-3_CanoR_1	152	156	PF00244	0.477
LIG_14-3-3_CanoR_1	19	23	PF00244	0.513
LIG_14-3-3_CanoR_1	212	218	PF00244	0.451
LIG_14-3-3_CanoR_1	264	271	PF00244	0.613
LIG_14-3-3_CanoR_1	35	44	PF00244	0.422
LIG_APCC_ABBA_1	96	101	PF00400	0.597
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.595
LIG_BRCT_BRCA1_1	25	29	PF00533	0.403
LIG_BRCT_BRCA1_1	286	290	PF00533	0.394
LIG_FHA_1	131	137	PF00498	0.481
LIG_FHA_1	146	152	PF00498	0.521
LIG_FHA_1	289	295	PF00498	0.565
LIG_FHA_1	305	311	PF00498	0.748
LIG_FHA_1	322	328	PF00498	0.484
LIG_FHA_1	380	386	PF00498	0.588
LIG_FHA_2	19	25	PF00498	0.453
LIG_Integrin_RGD_1	174	176	PF01839	0.586
LIG_LIR_Apic_2	113	117	PF02991	0.565
LIG_LIR_Apic_2	337	341	PF02991	0.501
LIG_LIR_Gen_1	176	183	PF02991	0.427
LIG_LIR_Gen_1	200	210	PF02991	0.414
LIG_LIR_Gen_1	26	37	PF02991	0.352
LIG_LIR_Gen_1	9	18	PF02991	0.383
LIG_LIR_Nem_3	176	181	PF02991	0.430
LIG_LIR_Nem_3	200	205	PF02991	0.428
LIG_LIR_Nem_3	26	32	PF02991	0.423
LIG_LIR_Nem_3	367	373	PF02991	0.565
LIG_LIR_Nem_3	9	13	PF02991	0.342
LIG_LRP6_Inhibitor_1	363	369	PF00058	0.522
LIG_Pex14_2	18	22	PF04695	0.425
LIG_REV1ctd_RIR_1	15	24	PF16727	0.438
LIG_RPA_C_Fungi	30	42	PF08784	0.614
LIG_SH2_CRK	178	182	PF00017	0.424
LIG_SH2_STAP1	112	116	PF00017	0.555
LIG_SH2_STAP1	178	182	PF00017	0.315
LIG_SH2_STAP1	37	41	PF00017	0.522
LIG_SH2_STAT5	10	13	PF00017	0.476
LIG_SH2_STAT5	115	118	PF00017	0.374
LIG_SH2_STAT5	231	234	PF00017	0.524
LIG_SH3_3	316	322	PF00018	0.667
LIG_SH3_3	330	336	PF00018	0.478
LIG_SH3_3	56	62	PF00018	0.567
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.326
LIG_SUMO_SIM_anti_2	9	16	PF11976	0.373
LIG_SUMO_SIM_par_1	306	315	PF11976	0.507
LIG_UBA3_1	28	33	PF00899	0.546
MOD_CDK_SPK_2	58	63	PF00069	0.493
MOD_CDK_SPK_2	90	95	PF00069	0.434
MOD_CDK_SPxK_1	79	85	PF00069	0.504
MOD_CK1_1	130	136	PF00069	0.461
MOD_CK1_1	154	160	PF00069	0.492
MOD_CK1_1	266	272	PF00069	0.536
MOD_CK1_1	321	327	PF00069	0.714
MOD_CK1_1	9	15	PF00069	0.372
MOD_CK2_1	18	24	PF00069	0.437
MOD_CK2_1	213	219	PF00069	0.438
MOD_CK2_1	74	80	PF00069	0.678
MOD_GlcNHglycan	222	226	PF01048	0.573
MOD_GlcNHglycan	314	317	PF01048	0.729
MOD_GlcNHglycan	356	359	PF01048	0.500
MOD_GlcNHglycan	54	57	PF01048	0.622
MOD_GlcNHglycan	65	68	PF01048	0.681
MOD_GSK3_1	126	133	PF00069	0.598
MOD_GSK3_1	159	166	PF00069	0.459
MOD_GSK3_1	2	9	PF00069	0.397
MOD_GSK3_1	284	291	PF00069	0.424
MOD_GSK3_1	297	304	PF00069	0.551
MOD_GSK3_1	31	38	PF00069	0.446
MOD_GSK3_1	317	324	PF00069	0.562
MOD_N-GLC_1	239	244	PF02516	0.408
MOD_N-GLC_1	354	359	PF02516	0.471
MOD_N-GLC_1	364	369	PF02516	0.494
MOD_NEK2_1	126	131	PF00069	0.369
MOD_NEK2_1	18	23	PF00069	0.421
MOD_NEK2_1	188	193	PF00069	0.524
MOD_NEK2_1	288	293	PF00069	0.415
MOD_NEK2_1	301	306	PF00069	0.606
MOD_NEK2_1	311	316	PF00069	0.758
MOD_NEK2_1	364	369	PF00069	0.599
MOD_NEK2_1	379	384	PF00069	0.467
MOD_NEK2_2	197	202	PF00069	0.541
MOD_NEK2_2	356	361	PF00069	0.418
MOD_PIKK_1	288	294	PF00454	0.389
MOD_PKA_2	130	136	PF00069	0.622
MOD_PKA_2	151	157	PF00069	0.466
MOD_PKA_2	18	24	PF00069	0.552
MOD_PKA_2	263	269	PF00069	0.470
MOD_Plk_1	163	169	PF00069	0.492
MOD_Plk_1	23	29	PF00069	0.394
MOD_Plk_1	239	245	PF00069	0.405
MOD_Plk_1	364	370	PF00069	0.450
MOD_Plk_1	379	385	PF00069	0.352
MOD_Plk_4	132	138	PF00069	0.614
MOD_Plk_4	154	160	PF00069	0.604
MOD_Plk_4	213	219	PF00069	0.453
MOD_Plk_4	297	303	PF00069	0.416
MOD_Plk_4	37	43	PF00069	0.632
MOD_Plk_4	380	386	PF00069	0.408
MOD_Plk_4	6	12	PF00069	0.587
MOD_ProDKin_1	318	324	PF00069	0.740
MOD_ProDKin_1	337	343	PF00069	0.520
MOD_ProDKin_1	58	64	PF00069	0.519
MOD_ProDKin_1	79	85	PF00069	0.581
MOD_ProDKin_1	90	96	PF00069	0.440
MOD_SUMO_for_1	348	351	PF00179	0.411
MOD_SUMO_for_1	62	65	PF00179	0.498
MOD_SUMO_rev_2	101	108	PF00179	0.513
TRG_ENDOCYTIC_2	10	13	PF00928	0.476
TRG_ENDOCYTIC_2	178	181	PF00928	0.427
TRG_NES_CRM1_1	278	292	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P515	Leptomonas seymouri	66%	100%
A0A0S4J2A2	Bodo saltans	32%	100%
A0A1X0PA56	Trypanosomatidae	47%	100%
A0A3Q8IHQ1	Leishmania donovani	78%	100%
A0A3R7KID6	Trypanosoma rangeli	48%	100%
A4IA86	Leishmania infantum	78%	100%
C9ZM18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B599	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2N4	Leishmania major	78%	100%
V5BKV3	Trypanosoma cruzi	48%	100%