Phosphatidylinositol-4-phosphate-5-kinase-likep ro tein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol phosphate kinase alpha

Species:

Leishmania braziliensis

UniProt:

A4HB28_LEIBR

TriTrypDb:

LbrM.20.2670 , LBRM2903_200038800

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB28

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0044237	cellular metabolic process	2	10
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016307	phosphatidylinositol phosphate kinase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.623
CLV_NRD_NRD_1	357	359	PF00675	0.377
CLV_NRD_NRD_1	378	380	PF00675	0.319
CLV_NRD_NRD_1	508	510	PF00675	0.319
CLV_NRD_NRD_1	522	524	PF00675	0.319
CLV_NRD_NRD_1	82	84	PF00675	0.368
CLV_PCSK_KEX2_1	103	105	PF00082	0.527
CLV_PCSK_KEX2_1	356	358	PF00082	0.375
CLV_PCSK_KEX2_1	378	380	PF00082	0.319
CLV_PCSK_KEX2_1	394	396	PF00082	0.319
CLV_PCSK_KEX2_1	524	526	PF00082	0.423
CLV_PCSK_KEX2_1	81	83	PF00082	0.426
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.375
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.375
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.423
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.426
CLV_PCSK_SKI1_1	191	195	PF00082	0.751
CLV_PCSK_SKI1_1	234	238	PF00082	0.370
CLV_PCSK_SKI1_1	276	280	PF00082	0.319
CLV_PCSK_SKI1_1	378	382	PF00082	0.341
CLV_PCSK_SKI1_1	431	435	PF00082	0.461
CLV_PCSK_SKI1_1	439	443	PF00082	0.295
CLV_PCSK_SKI1_1	473	477	PF00082	0.319
CLV_PCSK_SKI1_1	5	9	PF00082	0.613
CLV_PCSK_SKI1_1	509	513	PF00082	0.461
CLV_PCSK_SKI1_1	66	70	PF00082	0.394
CLV_PCSK_SKI1_1	71	75	PF00082	0.422
DEG_APCC_DBOX_1	4	12	PF00400	0.630
DEG_SCF_FBW7_1	256	262	PF00400	0.322
DOC_CKS1_1	256	261	PF01111	0.418
DOC_CYCLIN_RxL_1	2	10	PF00134	0.682
DOC_CYCLIN_RxL_1	373	384	PF00134	0.250
DOC_MAPK_gen_1	315	324	PF00069	0.412
DOC_MAPK_gen_1	59	67	PF00069	0.289
DOC_MAPK_MEF2A_6	318	326	PF00069	0.203
DOC_MAPK_MEF2A_6	60	69	PF00069	0.273
DOC_MAPK_RevD_3	67	82	PF00069	0.418
DOC_PP1_RVXF_1	535	542	PF00149	0.319
DOC_USP7_MATH_1	259	263	PF00917	0.319
DOC_USP7_MATH_1	29	33	PF00917	0.677
DOC_USP7_MATH_1	37	41	PF00917	0.749
DOC_USP7_UBL2_3	339	343	PF12436	0.319
DOC_WW_Pin1_4	128	133	PF00397	0.536
DOC_WW_Pin1_4	223	228	PF00397	0.351
DOC_WW_Pin1_4	255	260	PF00397	0.325
DOC_WW_Pin1_4	367	372	PF00397	0.377
DOC_WW_Pin1_4	42	47	PF00397	0.762
DOC_WW_Pin1_4	452	457	PF00397	0.359
LIG_14-3-3_CanoR_1	188	194	PF00244	0.689
LIG_14-3-3_CanoR_1	195	200	PF00244	0.649
LIG_14-3-3_CanoR_1	318	326	PF00244	0.345
LIG_14-3-3_CanoR_1	357	362	PF00244	0.357
LIG_14-3-3_CanoR_1	431	438	PF00244	0.428
LIG_14-3-3_CanoR_1	439	445	PF00244	0.375
LIG_14-3-3_CanoR_1	473	482	PF00244	0.343
LIG_14-3-3_CanoR_1	523	531	PF00244	0.415
LIG_14-3-3_CanoR_1	71	79	PF00244	0.507
LIG_Actin_WH2_2	302	317	PF00022	0.461
LIG_Actin_WH2_2	426	441	PF00022	0.308
LIG_APCC_ABBAyCdc20_2	465	471	PF00400	0.203
LIG_BRCT_BRCA1_1	218	222	PF00533	0.450
LIG_BRCT_BRCA1_1	465	469	PF00533	0.203
LIG_Clathr_ClatBox_1	380	384	PF01394	0.203
LIG_EH_1	299	303	PF12763	0.461
LIG_EVH1_2	216	220	PF00568	0.551
LIG_FHA_1	129	135	PF00498	0.666
LIG_FHA_1	194	200	PF00498	0.749
LIG_FHA_1	331	337	PF00498	0.404
LIG_FHA_1	428	434	PF00498	0.437
LIG_FHA_1	56	62	PF00498	0.443
LIG_FHA_2	196	202	PF00498	0.723
LIG_FHA_2	219	225	PF00498	0.425
LIG_FHA_2	275	281	PF00498	0.325
LIG_FHA_2	333	339	PF00498	0.343
LIG_FHA_2	360	366	PF00498	0.363
LIG_FHA_2	446	452	PF00498	0.304
LIG_LIR_Gen_1	219	230	PF02991	0.459
LIG_LIR_Gen_1	241	248	PF02991	0.398
LIG_LIR_Gen_1	251	259	PF02991	0.404
LIG_LIR_Gen_1	299	309	PF02991	0.343
LIG_LIR_Gen_1	320	331	PF02991	0.420
LIG_LIR_Gen_1	400	409	PF02991	0.319
LIG_LIR_Nem_3	166	172	PF02991	0.622
LIG_LIR_Nem_3	219	225	PF02991	0.397
LIG_LIR_Nem_3	235	239	PF02991	0.381
LIG_LIR_Nem_3	241	247	PF02991	0.403
LIG_LIR_Nem_3	251	256	PF02991	0.404
LIG_LIR_Nem_3	299	305	PF02991	0.330
LIG_LIR_Nem_3	400	404	PF02991	0.319
LIG_LIR_Nem_3	493	499	PF02991	0.319
LIG_PDZ_Class_2	542	547	PF00595	0.319
LIG_REV1ctd_RIR_1	265	275	PF16727	0.319
LIG_SH2_CRK	169	173	PF00017	0.619
LIG_SH2_CRK	401	405	PF00017	0.319
LIG_SH2_NCK_1	26	30	PF00017	0.503
LIG_SH2_NCK_1	446	450	PF00017	0.203
LIG_SH2_PTP2	496	499	PF00017	0.319
LIG_SH2_STAP1	401	405	PF00017	0.319
LIG_SH2_STAP1	534	538	PF00017	0.202
LIG_SH2_STAT5	244	247	PF00017	0.391
LIG_SH2_STAT5	446	449	PF00017	0.420
LIG_SH2_STAT5	496	499	PF00017	0.319
LIG_SH2_STAT5	506	509	PF00017	0.333
LIG_SH3_1	81	87	PF00018	0.468
LIG_SH3_2	84	89	PF14604	0.472
LIG_SH3_3	81	87	PF00018	0.468
LIG_SUMO_SIM_par_1	379	384	PF11976	0.359
LIG_TRAF2_1	279	282	PF00917	0.343
LIG_TRFH_1	302	306	PF08558	0.333
LIG_TYR_ITIM	494	499	PF00017	0.319
LIG_TYR_ITSM	240	247	PF00017	0.266
LIG_UBA3_1	380	388	PF00899	0.321
MOD_CDK_SPxK_1	255	261	PF00069	0.319
MOD_CK1_1	170	176	PF00069	0.625
MOD_CK1_1	181	187	PF00069	0.505
MOD_CK1_1	255	261	PF00069	0.319
MOD_CK1_1	45	51	PF00069	0.669
MOD_CK1_1	92	98	PF00069	0.559
MOD_CK2_1	201	207	PF00069	0.670
MOD_CK2_1	274	280	PF00069	0.328
MOD_CK2_1	332	338	PF00069	0.343
MOD_CK2_1	349	355	PF00069	0.319
MOD_CK2_1	74	80	PF00069	0.543
MOD_GlcNHglycan	169	172	PF01048	0.729
MOD_GlcNHglycan	174	177	PF01048	0.747
MOD_GlcNHglycan	261	264	PF01048	0.319
MOD_GlcNHglycan	33	36	PF01048	0.736
MOD_GlcNHglycan	465	468	PF01048	0.385
MOD_GlcNHglycan	99	102	PF01048	0.555
MOD_GSK3_1	167	174	PF00069	0.618
MOD_GSK3_1	189	196	PF00069	0.691
MOD_GSK3_1	216	223	PF00069	0.523
MOD_GSK3_1	248	255	PF00069	0.319
MOD_GSK3_1	276	283	PF00069	0.319
MOD_GSK3_1	427	434	PF00069	0.272
MOD_GSK3_1	440	447	PF00069	0.273
MOD_GSK3_1	89	96	PF00069	0.477
MOD_N-GLC_1	167	172	PF02516	0.494
MOD_N-GLC_1	29	34	PF02516	0.579
MOD_N-GLC_1	97	102	PF02516	0.450
MOD_NEK2_1	126	131	PF00069	0.533
MOD_NEK2_1	172	177	PF00069	0.724
MOD_NEK2_1	179	184	PF00069	0.754
MOD_NEK2_1	189	194	PF00069	0.610
MOD_NEK2_1	248	253	PF00069	0.319
MOD_NEK2_1	330	335	PF00069	0.368
MOD_NEK2_1	342	347	PF00069	0.243
MOD_NEK2_1	393	398	PF00069	0.325
MOD_NEK2_1	399	404	PF00069	0.310
MOD_NEK2_1	429	434	PF00069	0.363
MOD_NEK2_1	444	449	PF00069	0.189
MOD_NEK2_1	463	468	PF00069	0.286
MOD_NEK2_1	541	546	PF00069	0.319
MOD_NEK2_1	7	12	PF00069	0.666
MOD_NEK2_1	99	104	PF00069	0.549
MOD_PIKK_1	193	199	PF00454	0.747
MOD_PIKK_1	359	365	PF00454	0.319
MOD_PK_1	252	258	PF00069	0.418
MOD_PK_1	89	95	PF00069	0.521
MOD_PKA_1	356	362	PF00069	0.348
MOD_PKA_1	524	530	PF00069	0.375
MOD_PKA_2	126	132	PF00069	0.669
MOD_PKA_2	317	323	PF00069	0.345
MOD_PKA_2	356	362	PF00069	0.391
MOD_PKA_2	524	530	PF00069	0.418
MOD_Plk_1	146	152	PF00069	0.722
MOD_Plk_1	179	185	PF00069	0.755
MOD_Plk_1	239	245	PF00069	0.260
MOD_Plk_1	399	405	PF00069	0.319
MOD_Plk_1	434	440	PF00069	0.308
MOD_Plk_1	89	95	PF00069	0.422
MOD_Plk_2-3	14	20	PF00069	0.672
MOD_Plk_2-3	201	207	PF00069	0.719
MOD_Plk_4	195	201	PF00069	0.633
MOD_Plk_4	399	405	PF00069	0.324
MOD_Plk_4	516	522	PF00069	0.393
MOD_Plk_4	541	547	PF00069	0.328
MOD_ProDKin_1	128	134	PF00069	0.536
MOD_ProDKin_1	223	229	PF00069	0.349
MOD_ProDKin_1	255	261	PF00069	0.325
MOD_ProDKin_1	367	373	PF00069	0.377
MOD_ProDKin_1	42	48	PF00069	0.755
MOD_ProDKin_1	452	458	PF00069	0.359
MOD_SUMO_for_1	11	14	PF00179	0.645
MOD_SUMO_rev_2	338	345	PF00179	0.319
MOD_SUMO_rev_2	519	526	PF00179	0.461
TRG_DiLeu_BaEn_1	377	382	PF01217	0.418
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.203
TRG_ENDOCYTIC_2	169	172	PF00928	0.678
TRG_ENDOCYTIC_2	230	233	PF00928	0.363
TRG_ENDOCYTIC_2	244	247	PF00928	0.366
TRG_ENDOCYTIC_2	294	297	PF00928	0.306
TRG_ENDOCYTIC_2	401	404	PF00928	0.319
TRG_ENDOCYTIC_2	496	499	PF00928	0.319
TRG_ER_diArg_1	312	315	PF00400	0.407
TRG_ER_diArg_1	378	380	PF00400	0.449
TRG_ER_diArg_1	523	526	PF00400	0.475
TRG_ER_diArg_1	82	84	PF00400	0.368
TRG_NLS_Bipartite_1	103	123	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	379	384	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	62%	100%
A0A1X0P9B0	Trypanosomatidae	24%	100%
A0A1X0PB79	Trypanosomatidae	46%	100%
A0A381MTN1	Leishmania infantum	79%	100%
A0A3Q8ILB5	Leishmania donovani	79%	100%
A4HNP5	Leishmania braziliensis	22%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B598	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O13853	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	74%
O48709	Arabidopsis thaliana	32%	78%
Q4Q2N5	Leishmania major	77%	100%
Q56YP2	Arabidopsis thaliana	30%	73%
Q6EX42	Oryza sativa subsp. japonica	31%	68%
Q8L796	Arabidopsis thaliana	31%	73%
Q8L850	Arabidopsis thaliana	30%	67%
Q8RY89	Arabidopsis thaliana	28%	71%
Q9M149	Arabidopsis thaliana	26%	100%
Q9SUI2	Arabidopsis thaliana	30%	73%
V5BA13	Trypanosoma cruzi	27%	100%
V5BV28	Trypanosoma cruzi	47%	100%