Putative exosome subunit rrp6p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome subunit rrp6p homologue, putative

Species:

Leishmania braziliensis

UniProt:

A4HB27_LEIBR

TriTrypDb:

LbrM.20.2660 , LBRM2903_200038700

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	12
GO:0000178	exosome (RNase complex)	4	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB27

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	12
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	12
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031125	rRNA 3'-end processing	9	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043628	regulatory ncRNA 3'-end processing	8	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016076	snRNA catabolic process	7	1
GO:0016077	sno(s)RNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034661	ncRNA catabolic process	6	1
GO:0042868	antisense RNA metabolic process	7	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071036	nuclear polyadenylation-dependent snoRNA catabolic process	8	1
GO:0071037	nuclear polyadenylation-dependent snRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	8	1
GO:0071040	nuclear polyadenylation-dependent antisense transcript catabolic process	8	1
GO:0071041	antisense RNA transcript catabolic process	7	1
GO:0071043	CUT metabolic process	7	1
GO:0071044	histone mRNA catabolic process	8	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0106354	tRNA surveillance	7	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000175	3'-5'-RNA exonuclease activity	7	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0004532	RNA exonuclease activity	5	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0036094	small molecule binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.297
CLV_C14_Caspase3-7	108	112	PF00656	0.297
CLV_C14_Caspase3-7	537	541	PF00656	0.572
CLV_C14_Caspase3-7	547	551	PF00656	0.690
CLV_NRD_NRD_1	119	121	PF00675	0.556
CLV_NRD_NRD_1	165	167	PF00675	0.565
CLV_NRD_NRD_1	48	50	PF00675	0.390
CLV_NRD_NRD_1	720	722	PF00675	0.506
CLV_NRD_NRD_1	74	76	PF00675	0.284
CLV_PCSK_KEX2_1	165	167	PF00082	0.565
CLV_PCSK_KEX2_1	706	708	PF00082	0.577
CLV_PCSK_KEX2_1	72	74	PF00082	0.332
CLV_PCSK_KEX2_1	720	722	PF00082	0.467
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.586
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.315
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.488
CLV_PCSK_SKI1_1	248	252	PF00082	0.327
CLV_PCSK_SKI1_1	396	400	PF00082	0.245
CLV_PCSK_SKI1_1	439	443	PF00082	0.401
CLV_PCSK_SKI1_1	458	462	PF00082	0.166
CLV_PCSK_SKI1_1	496	500	PF00082	0.306
CLV_PCSK_SKI1_1	573	577	PF00082	0.622
CLV_PCSK_SKI1_1	599	603	PF00082	0.695
CLV_PCSK_SKI1_1	706	710	PF00082	0.678
CLV_PCSK_SKI1_1	721	725	PF00082	0.571
CLV_Separin_Metazoa	497	501	PF03568	0.392
DEG_APCC_DBOX_1	154	162	PF00400	0.457
DEG_ODPH_VHL_1	297	309	PF01847	0.469
DOC_CKS1_1	171	176	PF01111	0.510
DOC_CKS1_1	236	241	PF01111	0.462
DOC_CYCLIN_RxL_1	245	254	PF00134	0.550
DOC_CYCLIN_RxL_1	393	403	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.514
DOC_MAPK_gen_1	165	171	PF00069	0.524
DOC_MAPK_gen_1	417	426	PF00069	0.280
DOC_MAPK_MEF2A_6	417	426	PF00069	0.423
DOC_MAPK_MEF2A_6	510	519	PF00069	0.546
DOC_PP2B_LxvP_1	341	344	PF13499	0.445
DOC_PP4_FxxP_1	171	174	PF00568	0.433
DOC_PP4_FxxP_1	210	213	PF00568	0.455
DOC_PP4_FxxP_1	301	304	PF00568	0.456
DOC_USP7_MATH_1	102	106	PF00917	0.313
DOC_USP7_MATH_1	149	153	PF00917	0.677
DOC_USP7_MATH_1	175	179	PF00917	0.488
DOC_USP7_MATH_1	486	490	PF00917	0.462
DOC_USP7_MATH_1	592	596	PF00917	0.629
DOC_USP7_MATH_1	597	601	PF00917	0.609
DOC_USP7_MATH_2	148	154	PF00917	0.480
DOC_USP7_UBL2_3	25	29	PF12436	0.285
DOC_USP7_UBL2_3	358	362	PF12436	0.456
DOC_USP7_UBL2_3	451	455	PF12436	0.445
DOC_USP7_UBL2_3	720	724	PF12436	0.704
DOC_WW_Pin1_4	170	175	PF00397	0.466
DOC_WW_Pin1_4	235	240	PF00397	0.431
DOC_WW_Pin1_4	471	476	PF00397	0.435
DOC_WW_Pin1_4	604	609	PF00397	0.644
LIG_14-3-3_CanoR_1	371	380	PF00244	0.550
LIG_14-3-3_CanoR_1	73	79	PF00244	0.342
LIG_APCC_ABBA_1	413	418	PF00400	0.430
LIG_BIR_III_4	188	192	PF00653	0.518
LIG_BRCT_BRCA1_1	128	132	PF00533	0.568
LIG_BRCT_BRCA1_1	17	21	PF00533	0.573
LIG_BRCT_BRCA1_1	345	349	PF00533	0.456
LIG_BRCT_BRCA1_1	608	612	PF00533	0.520
LIG_deltaCOP1_diTrp_1	315	324	PF00928	0.445
LIG_deltaCOP1_diTrp_1	559	562	PF00928	0.639
LIG_FHA_1	11	17	PF00498	0.479
LIG_FHA_1	228	234	PF00498	0.316
LIG_FHA_1	383	389	PF00498	0.435
LIG_FHA_1	435	441	PF00498	0.420
LIG_FHA_1	474	480	PF00498	0.527
LIG_FHA_1	504	510	PF00498	0.515
LIG_FHA_1	574	580	PF00498	0.581
LIG_FHA_1	65	71	PF00498	0.399
LIG_FHA_2	171	177	PF00498	0.501
LIG_FHA_2	276	282	PF00498	0.456
LIG_FHA_2	492	498	PF00498	0.486
LIG_FHA_2	643	649	PF00498	0.457
LIG_LIR_Gen_1	26	35	PF02991	0.328
LIG_LIR_Gen_1	352	359	PF02991	0.456
LIG_LIR_Gen_1	609	618	PF02991	0.532
LIG_LIR_Nem_3	18	24	PF02991	0.469
LIG_LIR_Nem_3	26	30	PF02991	0.259
LIG_LIR_Nem_3	263	267	PF02991	0.439
LIG_LIR_Nem_3	323	327	PF02991	0.445
LIG_LIR_Nem_3	352	357	PF02991	0.445
LIG_LIR_Nem_3	384	390	PF02991	0.436
LIG_LIR_Nem_3	559	563	PF02991	0.612
LIG_NRBOX	394	400	PF00104	0.445
LIG_PCNA_yPIPBox_3	303	314	PF02747	0.506
LIG_SH2_CRK	267	271	PF00017	0.366
LIG_SH2_CRK	27	31	PF00017	0.313
LIG_SH2_CRK	392	396	PF00017	0.425
LIG_SH2_CRK	563	567	PF00017	0.649
LIG_SH2_NCK_1	345	349	PF00017	0.514
LIG_SH2_SRC	39	42	PF00017	0.313
LIG_SH2_STAP1	345	349	PF00017	0.514
LIG_SH2_STAP1	39	43	PF00017	0.313
LIG_SH2_STAT3	265	268	PF00017	0.456
LIG_SH2_STAT3	380	383	PF00017	0.445
LIG_SH2_STAT5	186	189	PF00017	0.331
LIG_SH2_STAT5	327	330	PF00017	0.445
LIG_SH2_STAT5	390	393	PF00017	0.446
LIG_SH3_3	142	148	PF00018	0.623
LIG_SH3_3	178	184	PF00018	0.554
LIG_SH3_3	221	227	PF00018	0.468
LIG_SH3_3	233	239	PF00018	0.292
LIG_SH3_3	5	11	PF00018	0.669
LIG_SH3_3	568	574	PF00018	0.600
LIG_SH3_3	627	633	PF00018	0.593
LIG_SH3_3	697	703	PF00018	0.653
LIG_SH3_5	35	39	PF00018	0.332
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.543
LIG_SUMO_SIM_anti_2	54	64	PF11976	0.384
LIG_SUMO_SIM_par_1	482	489	PF11976	0.451
LIG_SUMO_SIM_par_1	54	64	PF11976	0.338
LIG_TRAF2_1	219	222	PF00917	0.325
LIG_TRAF2_1	278	281	PF00917	0.531
LIG_TRAF2_1	679	682	PF00917	0.608
MOD_CK1_1	28	34	PF00069	0.379
MOD_CK1_1	581	587	PF00069	0.669
MOD_CK1_1	604	610	PF00069	0.652
MOD_CK1_1	667	673	PF00069	0.637
MOD_CK1_1	77	83	PF00069	0.331
MOD_CK2_1	102	108	PF00069	0.281
MOD_CK2_1	20	26	PF00069	0.523
MOD_CK2_1	274	280	PF00069	0.459
MOD_CK2_1	491	497	PF00069	0.445
MOD_CK2_1	592	598	PF00069	0.642
MOD_CK2_1	668	674	PF00069	0.660
MOD_Cter_Amidation	118	121	PF01082	0.541
MOD_Cter_Amidation	718	721	PF01082	0.631
MOD_GlcNHglycan	152	155	PF01048	0.665
MOD_GlcNHglycan	17	20	PF01048	0.416
MOD_GlcNHglycan	188	192	PF01048	0.521
MOD_GlcNHglycan	30	33	PF01048	0.460
MOD_GlcNHglycan	373	376	PF01048	0.350
MOD_GlcNHglycan	446	449	PF01048	0.502
MOD_GlcNHglycan	465	468	PF01048	0.144
MOD_GlcNHglycan	543	546	PF01048	0.644
MOD_GlcNHglycan	598	602	PF01048	0.591
MOD_GlcNHglycan	660	663	PF01048	0.711
MOD_GlcNHglycan	692	695	PF01048	0.658
MOD_GlcNHglycan	696	700	PF01048	0.653
MOD_GlcNHglycan	85	88	PF01048	0.346
MOD_GSK3_1	227	234	PF00069	0.438
MOD_GSK3_1	289	296	PF00069	0.462
MOD_GSK3_1	416	423	PF00069	0.360
MOD_GSK3_1	562	569	PF00069	0.499
MOD_GSK3_1	581	588	PF00069	0.642
MOD_GSK3_1	597	604	PF00069	0.597
MOD_GSK3_1	606	613	PF00069	0.530
MOD_GSK3_1	658	665	PF00069	0.676
MOD_GSK3_1	666	673	PF00069	0.706
MOD_GSK3_1	682	689	PF00069	0.766
MOD_GSK3_1	723	730	PF00069	0.490
MOD_GSK3_1	73	80	PF00069	0.229
MOD_LATS_1	51	57	PF00433	0.316
MOD_N-GLC_2	666	668	PF02516	0.489
MOD_NEK2_1	128	133	PF00069	0.569
MOD_NEK2_1	274	279	PF00069	0.442
MOD_NEK2_1	293	298	PF00069	0.475
MOD_NEK2_1	331	336	PF00069	0.443
MOD_NEK2_1	442	447	PF00069	0.407
MOD_NEK2_1	479	484	PF00069	0.445
MOD_NEK2_1	562	567	PF00069	0.570
MOD_NEK2_1	575	580	PF00069	0.471
MOD_NEK2_1	603	608	PF00069	0.640
MOD_NEK2_1	686	691	PF00069	0.605
MOD_NEK2_2	337	342	PF00069	0.469
MOD_PIKK_1	212	218	PF00454	0.543
MOD_PIKK_1	592	598	PF00454	0.657
MOD_PIKK_1	606	612	PF00454	0.587
MOD_PIKK_1	64	70	PF00454	0.408
MOD_PK_1	707	713	PF00069	0.627
MOD_PKA_1	73	79	PF00069	0.334
MOD_PKA_2	463	469	PF00069	0.501
MOD_PKA_2	640	646	PF00069	0.527
MOD_PKA_2	73	79	PF00069	0.366
MOD_PKB_1	369	377	PF00069	0.550
MOD_Plk_1	175	181	PF00069	0.298
MOD_Plk_1	322	328	PF00069	0.520
MOD_Plk_1	434	440	PF00069	0.405
MOD_Plk_1	597	603	PF00069	0.618
MOD_Plk_1	682	688	PF00069	0.740
MOD_Plk_4	102	108	PF00069	0.269
MOD_Plk_4	109	115	PF00069	0.250
MOD_Plk_4	231	237	PF00069	0.425
MOD_Plk_4	480	486	PF00069	0.506
MOD_Plk_4	55	61	PF00069	0.308
MOD_Plk_4	581	587	PF00069	0.561
MOD_ProDKin_1	170	176	PF00069	0.464
MOD_ProDKin_1	235	241	PF00069	0.431
MOD_ProDKin_1	471	477	PF00069	0.435
MOD_ProDKin_1	604	610	PF00069	0.644
MOD_SUMO_for_1	556	559	PF00179	0.626
MOD_SUMO_rev_2	653	659	PF00179	0.560
TRG_DiLeu_BaEn_1	598	603	PF01217	0.649
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.366
TRG_ENDOCYTIC_2	267	270	PF00928	0.456
TRG_ENDOCYTIC_2	27	30	PF00928	0.297
TRG_ENDOCYTIC_2	392	395	PF00928	0.425
TRG_ENDOCYTIC_2	563	566	PF00928	0.625
TRG_ER_diArg_1	164	166	PF00400	0.584
TRG_ER_diArg_1	368	371	PF00400	0.445
TRG_ER_diArg_1	73	75	PF00400	0.334
TRG_NLS_Bipartite_1	706	725	PF00514	0.705
TRG_NLS_MonoCore_2	71	76	PF00514	0.382
TRG_NLS_MonoExtC_3	719	724	PF00514	0.505
TRG_NLS_MonoExtN_4	71	76	PF00514	0.354
TRG_NLS_MonoExtN_4	720	725	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	371	376	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R9	Leptomonas seymouri	69%	100%
A0A0S4JND8	Bodo saltans	44%	99%
A0A1X0P9Z3	Trypanosomatidae	54%	100%
A0A381MTM9	Leishmania infantum	79%	99%
A0A3R7LLL0	Trypanosoma rangeli	53%	100%
A0A3S7X869	Leishmania donovani	79%	99%
C9ZM21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B597	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
P56960	Mus musculus	33%	83%
Q01780	Homo sapiens	33%	83%
Q12149	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4Q2N6	Leishmania major	79%	100%
V5BQF7	Trypanosoma cruzi	52%	100%