Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB26_LEIBR

TriTrypDb:

LbrM.20.2650 , LBRM2903_200038500 , LBRM2903_200038600

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4HB26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.456
CLV_NRD_NRD_1	345	347	PF00675	0.317
CLV_NRD_NRD_1	39	41	PF00675	0.480
CLV_NRD_NRD_1	399	401	PF00675	0.389
CLV_NRD_NRD_1	409	411	PF00675	0.385
CLV_NRD_NRD_1	637	639	PF00675	0.347
CLV_PCSK_KEX2_1	345	347	PF00082	0.331
CLV_PCSK_KEX2_1	39	41	PF00082	0.480
CLV_PCSK_KEX2_1	399	401	PF00082	0.392
CLV_PCSK_KEX2_1	409	411	PF00082	0.380
CLV_PCSK_KEX2_1	637	639	PF00082	0.347
CLV_PCSK_PC7_1	341	347	PF00082	0.307
CLV_PCSK_SKI1_1	131	135	PF00082	0.343
CLV_PCSK_SKI1_1	399	403	PF00082	0.398
CLV_PCSK_SKI1_1	410	414	PF00082	0.341
CLV_PCSK_SKI1_1	514	518	PF00082	0.324
DEG_APCC_DBOX_1	384	392	PF00400	0.545
DEG_APCC_DBOX_1	506	514	PF00400	0.441
DEG_SPOP_SBC_1	523	527	PF00917	0.183
DOC_CYCLIN_RxL_1	535	548	PF00134	0.265
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.516
DOC_MAPK_DCC_7	602	610	PF00069	0.294
DOC_MAPK_gen_1	505	512	PF00069	0.468
DOC_MAPK_MEF2A_6	159	167	PF00069	0.503
DOC_MAPK_MEF2A_6	505	512	PF00069	0.553
DOC_MAPK_MEF2A_6	602	610	PF00069	0.283
DOC_MAPK_NFAT4_5	505	513	PF00069	0.527
DOC_MAPK_RevD_3	389	405	PF00069	0.491
DOC_MAPK_RevD_3	624	638	PF00069	0.353
DOC_PP1_RVXF_1	129	136	PF00149	0.523
DOC_PP1_RVXF_1	512	518	PF00149	0.258
DOC_PP1_RVXF_1	538	545	PF00149	0.260
DOC_PP2B_LxvP_1	566	569	PF13499	0.323
DOC_PP4_FxxP_1	327	330	PF00568	0.590
DOC_USP7_MATH_1	200	204	PF00917	0.605
DOC_USP7_MATH_1	319	323	PF00917	0.565
DOC_USP7_MATH_1	4	8	PF00917	0.635
DOC_USP7_MATH_1	569	573	PF00917	0.433
DOC_USP7_MATH_1	58	62	PF00917	0.744
DOC_USP7_MATH_1	75	79	PF00917	0.763
DOC_USP7_MATH_2	80	86	PF00917	0.607
DOC_WW_Pin1_4	119	124	PF00397	0.589
DOC_WW_Pin1_4	88	93	PF00397	0.768
LIG_14-3-3_CanoR_1	131	136	PF00244	0.537
LIG_14-3-3_CanoR_1	169	177	PF00244	0.597
LIG_14-3-3_CanoR_1	183	187	PF00244	0.651
LIG_14-3-3_CanoR_1	363	373	PF00244	0.546
LIG_14-3-3_CanoR_1	43	48	PF00244	0.718
LIG_14-3-3_CanoR_1	499	503	PF00244	0.521
LIG_14-3-3_CanoR_1	507	513	PF00244	0.521
LIG_Actin_WH2_2	111	129	PF00022	0.635
LIG_BRCT_BRCA1_1	144	148	PF00533	0.487
LIG_BRCT_BRCA1_2	145	151	PF00533	0.461
LIG_Clathr_ClatBox_1	391	395	PF01394	0.526
LIG_CORNRBOX	480	488	PF00104	0.183
LIG_EH1_1	628	636	PF00400	0.571
LIG_eIF4E_1	599	605	PF01652	0.263
LIG_eIF4E_1	623	629	PF01652	0.523
LIG_FHA_1	159	165	PF00498	0.539
LIG_FHA_1	183	189	PF00498	0.625
LIG_FHA_1	3	9	PF00498	0.629
LIG_FHA_1	424	430	PF00498	0.536
LIG_FHA_1	436	442	PF00498	0.501
LIG_FHA_1	480	486	PF00498	0.369
LIG_FHA_1	499	505	PF00498	0.530
LIG_FHA_1	525	531	PF00498	0.297
LIG_FHA_1	592	598	PF00498	0.250
LIG_FHA_1	67	73	PF00498	0.693
LIG_FHA_2	169	175	PF00498	0.559
LIG_FHA_2	217	223	PF00498	0.670
LIG_FHA_2	276	282	PF00498	0.641
LIG_FHA_2	382	388	PF00498	0.506
LIG_FHA_2	43	49	PF00498	0.711
LIG_GBD_Chelix_1	480	488	PF00786	0.348
LIG_GBD_Chelix_1	631	639	PF00786	0.403
LIG_LIR_Apic_2	325	330	PF02991	0.579
LIG_LIR_Gen_1	321	331	PF02991	0.523
LIG_LIR_Gen_1	506	517	PF02991	0.466
LIG_LIR_Gen_1	539	545	PF02991	0.299
LIG_LIR_Gen_1	621	631	PF02991	0.381
LIG_LIR_Nem_3	147	153	PF02991	0.614
LIG_LIR_Nem_3	321	327	PF02991	0.521
LIG_LIR_Nem_3	506	512	PF02991	0.503
LIG_LIR_Nem_3	539	544	PF02991	0.289
LIG_LIR_Nem_3	584	590	PF02991	0.367
LIG_LIR_Nem_3	617	623	PF02991	0.369
LIG_MLH1_MIPbox_1	145	149	PF16413	0.471
LIG_NRBOX	449	455	PF00104	0.406
LIG_PCNA_PIPBox_1	328	337	PF02747	0.461
LIG_PCNA_yPIPBox_3	358	366	PF02747	0.593
LIG_Pex14_2	323	327	PF04695	0.562
LIG_Pex14_2	615	619	PF04695	0.450
LIG_REV1ctd_RIR_1	146	155	PF16727	0.440
LIG_SH2_CRK	150	154	PF00017	0.539
LIG_SH2_CRK	416	420	PF00017	0.604
LIG_SH2_CRK	455	459	PF00017	0.245
LIG_SH2_CRK	476	480	PF00017	0.247
LIG_SH2_SRC	347	350	PF00017	0.568
LIG_SH2_SRC	623	626	PF00017	0.254
LIG_SH2_STAP1	476	480	PF00017	0.226
LIG_SH2_STAP1	538	542	PF00017	0.339
LIG_SH2_STAT5	170	173	PF00017	0.577
LIG_SH2_STAT5	302	305	PF00017	0.628
LIG_SH2_STAT5	347	350	PF00017	0.525
LIG_SH2_STAT5	471	474	PF00017	0.283
LIG_SH2_STAT5	478	481	PF00017	0.259
LIG_SH2_STAT5	509	512	PF00017	0.534
LIG_SH2_STAT5	599	602	PF00017	0.459
LIG_SH2_STAT5	623	626	PF00017	0.519
LIG_SH3_3	117	123	PF00018	0.581
LIG_SH3_3	52	58	PF00018	0.616
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.503
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.255
LIG_SUMO_SIM_par_1	184	190	PF11976	0.535
LIG_SUMO_SIM_par_1	379	384	PF11976	0.415
LIG_SUMO_SIM_par_1	456	462	PF11976	0.447
LIG_SUMO_SIM_par_1	481	486	PF11976	0.267
LIG_TRAF2_1	220	223	PF00917	0.682
LIG_TRAF2_1	384	387	PF00917	0.485
LIG_TRAF2_1	91	94	PF00917	0.658
LIG_TRAF2_1	99	102	PF00917	0.561
LIG_TYR_ITIM	453	458	PF00017	0.231
LIG_WRC_WIRS_1	302	307	PF05994	0.569
LIG_WRC_WIRS_1	615	620	PF05994	0.266
MOD_CK1_1	199	205	PF00069	0.698
MOD_CK1_1	216	222	PF00069	0.757
MOD_CK1_1	322	328	PF00069	0.520
MOD_CK1_1	42	48	PF00069	0.631
MOD_CK1_1	525	531	PF00069	0.253
MOD_CK1_1	61	67	PF00069	0.742
MOD_CK2_1	119	125	PF00069	0.558
MOD_CK2_1	192	198	PF00069	0.640
MOD_CK2_1	216	222	PF00069	0.708
MOD_CK2_1	258	264	PF00069	0.717
MOD_CK2_1	275	281	PF00069	0.677
MOD_CK2_1	381	387	PF00069	0.522
MOD_CK2_1	88	94	PF00069	0.681
MOD_Cter_Amidation	37	40	PF01082	0.393
MOD_GlcNHglycan	194	197	PF01048	0.562
MOD_GlcNHglycan	198	201	PF01048	0.578
MOD_GlcNHglycan	215	218	PF01048	0.524
MOD_GlcNHglycan	563	566	PF01048	0.488
MOD_GlcNHglycan	60	63	PF01048	0.522
MOD_GlcNHglycan	64	67	PF01048	0.519
MOD_GlcNHglycan	77	80	PF01048	0.577
MOD_GSK3_1	192	199	PF00069	0.686
MOD_GSK3_1	209	216	PF00069	0.778
MOD_GSK3_1	301	308	PF00069	0.562
MOD_GSK3_1	318	325	PF00069	0.563
MOD_GSK3_1	39	46	PF00069	0.670
MOD_GSK3_1	479	486	PF00069	0.365
MOD_GSK3_1	58	65	PF00069	0.658
MOD_GSK3_1	591	598	PF00069	0.279
MOD_N-GLC_1	26	31	PF02516	0.561
MOD_N-GLC_1	58	63	PF02516	0.469
MOD_NEK2_1	153	158	PF00069	0.537
MOD_NEK2_1	192	197	PF00069	0.751
MOD_NEK2_1	275	280	PF00069	0.584
MOD_NEK2_1	305	310	PF00069	0.562
MOD_NEK2_1	365	370	PF00069	0.574
MOD_NEK2_1	379	384	PF00069	0.458
MOD_NEK2_1	423	428	PF00069	0.535
MOD_NEK2_1	429	434	PF00069	0.531
MOD_NEK2_1	446	451	PF00069	0.319
MOD_NEK2_1	456	461	PF00069	0.310
MOD_NEK2_1	498	503	PF00069	0.533
MOD_NEK2_1	595	600	PF00069	0.278
MOD_NEK2_1	614	619	PF00069	0.385
MOD_NEK2_2	319	324	PF00069	0.546
MOD_NEK2_2	4	9	PF00069	0.607
MOD_NEK2_2	491	496	PF00069	0.281
MOD_NEK2_2	569	574	PF00069	0.454
MOD_PIKK_1	349	355	PF00454	0.520
MOD_PIKK_1	82	88	PF00454	0.688
MOD_PKA_1	39	45	PF00069	0.671
MOD_PKA_2	168	174	PF00069	0.550
MOD_PKA_2	182	188	PF00069	0.605
MOD_PKA_2	23	29	PF00069	0.782
MOD_PKA_2	236	242	PF00069	0.686
MOD_PKA_2	39	45	PF00069	0.599
MOD_PKA_2	423	429	PF00069	0.507
MOD_PKA_2	498	504	PF00069	0.591
MOD_PKA_2	561	567	PF00069	0.351
MOD_Plk_1	137	143	PF00069	0.557
MOD_Plk_1	26	32	PF00069	0.773
MOD_Plk_2-3	258	264	PF00069	0.567
MOD_Plk_4	131	137	PF00069	0.516
MOD_Plk_4	144	150	PF00069	0.576
MOD_Plk_4	158	164	PF00069	0.516
MOD_Plk_4	319	325	PF00069	0.580
MOD_Plk_4	446	452	PF00069	0.354
MOD_Plk_4	474	480	PF00069	0.281
MOD_Plk_4	508	514	PF00069	0.555
MOD_Plk_4	525	531	PF00069	0.335
MOD_Plk_4	591	597	PF00069	0.348
MOD_Plk_4	614	620	PF00069	0.342
MOD_ProDKin_1	119	125	PF00069	0.587
MOD_ProDKin_1	88	94	PF00069	0.765
MOD_SUMO_rev_2	122	129	PF00179	0.596
MOD_SUMO_rev_2	314	322	PF00179	0.478
TRG_DiLeu_BaEn_1	160	165	PF01217	0.581
TRG_DiLeu_BaEn_1	267	272	PF01217	0.691
TRG_DiLeu_BaEn_1	387	392	PF01217	0.514
TRG_DiLeu_BaEn_4	172	178	PF01217	0.640
TRG_ENDOCYTIC_2	150	153	PF00928	0.526
TRG_ENDOCYTIC_2	302	305	PF00928	0.618
TRG_ENDOCYTIC_2	324	327	PF00928	0.557
TRG_ENDOCYTIC_2	455	458	PF00928	0.345
TRG_ENDOCYTIC_2	476	479	PF00928	0.296
TRG_ENDOCYTIC_2	509	512	PF00928	0.501
TRG_ENDOCYTIC_2	538	541	PF00928	0.338
TRG_ENDOCYTIC_2	623	626	PF00928	0.442
TRG_ER_diArg_1	286	289	PF00400	0.759
TRG_ER_diArg_1	344	346	PF00400	0.506
TRG_ER_diArg_1	39	41	PF00400	0.709
TRG_ER_diArg_1	398	400	PF00400	0.581
TRG_ER_diArg_1	408	410	PF00400	0.576
TRG_ER_diArg_1	637	639	PF00400	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	30%	100%
A0A0N1HRT9	Leptomonas seymouri	30%	100%
A0A0N1P9A0	Leptomonas seymouri	31%	100%
A0A0N1PBU6	Leptomonas seymouri	51%	100%
A0A1X0P9W4	Trypanosomatidae	38%	100%
A0A3Q8IFF3	Leishmania donovani	32%	99%
A0A3Q8ISH4	Leishmania donovani	34%	100%
A0A3R7KFP4	Trypanosoma rangeli	37%	100%
A0A3S7X483	Leishmania donovani	33%	98%
A0A3S7X888	Leishmania donovani	67%	100%
A4HJ59	Leishmania braziliensis	29%	98%
A4HJ60	Leishmania braziliensis	32%	100%
A4I6H4	Leishmania infantum	33%	98%
A4I6H5	Leishmania infantum	34%	100%
A4IA83	Leishmania infantum	67%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q6I2	Leishmania major	34%	100%
Q4Q6I3	Leishmania major	34%	100%
V5B5A9	Trypanosoma cruzi	35%	100%