Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB25_LEIBR

TriTrypDb:

LbrM.20.2640 , LBRM2903_200038400

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HB25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB25

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	1
GO:0005215	transporter activity	1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	1
GO:0005347	ATP transmembrane transporter activity	5	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015216	purine nucleotide transmembrane transporter activity	5	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.583
CLV_NRD_NRD_1	254	256	PF00675	0.344
CLV_NRD_NRD_1	33	35	PF00675	0.371
CLV_NRD_NRD_1	49	51	PF00675	0.457
CLV_NRD_NRD_1	70	72	PF00675	0.420
CLV_PCSK_KEX2_1	33	35	PF00082	0.367
CLV_PCSK_KEX2_1	70	72	PF00082	0.464
CLV_PCSK_SKI1_1	137	141	PF00082	0.447
CLV_PCSK_SKI1_1	320	324	PF00082	0.468
CLV_PCSK_SKI1_1	51	55	PF00082	0.583
CLV_Separin_Metazoa	204	208	PF03568	0.308
DEG_APCC_DBOX_1	32	40	PF00400	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_CDC14_PxL_1	156	164	PF14671	0.435
DOC_CKS1_1	145	150	PF01111	0.478
DOC_PP4_FxxP_1	146	149	PF00568	0.346
DOC_USP7_MATH_1	119	123	PF00917	0.618
DOC_USP7_MATH_1	243	247	PF00917	0.330
DOC_USP7_MATH_1	95	99	PF00917	0.541
DOC_WW_Pin1_4	113	118	PF00397	0.592
DOC_WW_Pin1_4	144	149	PF00397	0.465
LIG_14-3-3_CanoR_1	34	40	PF00244	0.361
LIG_Actin_WH2_2	322	337	PF00022	0.270
LIG_deltaCOP1_diTrp_1	5	12	PF00928	0.423
LIG_FHA_1	186	192	PF00498	0.330
LIG_FHA_1	341	347	PF00498	0.330
LIG_FHA_1	88	94	PF00498	0.528
LIG_FHA_2	126	132	PF00498	0.509
LIG_FHA_2	79	85	PF00498	0.482
LIG_GBD_Chelix_1	28	36	PF00786	0.417
LIG_Integrin_isoDGR_2	300	302	PF01839	0.270
LIG_LIR_Apic_2	144	149	PF02991	0.327
LIG_LIR_Gen_1	147	156	PF02991	0.468
LIG_LIR_Gen_1	25	32	PF02991	0.349
LIG_LIR_Gen_1	343	350	PF02991	0.273
LIG_LIR_Nem_3	147	153	PF02991	0.489
LIG_LIR_Nem_3	217	222	PF02991	0.273
LIG_LIR_Nem_3	25	29	PF02991	0.312
LIG_LIR_Nem_3	323	329	PF02991	0.273
LIG_LIR_Nem_3	343	347	PF02991	0.148
LIG_LIR_Nem_3	5	11	PF02991	0.439
LIG_PCNA_yPIPBox_3	315	326	PF02747	0.330
LIG_Pex14_2	146	150	PF04695	0.345
LIG_Pex14_2	218	222	PF04695	0.330
LIG_Pex14_2	26	30	PF04695	0.353
LIG_SH2_NCK_1	240	244	PF00017	0.270
LIG_SH2_STAP1	40	44	PF00017	0.353
LIG_SH2_STAT3	250	253	PF00017	0.446
LIG_SH2_STAT5	333	336	PF00017	0.270
LIG_SH2_STAT5	35	38	PF00017	0.419
LIG_SH3_3	111	117	PF00018	0.547
LIG_SH3_3	280	286	PF00018	0.270
LIG_TRAF2_1	60	63	PF00917	0.357
LIG_TYR_ITIM	230	235	PF00017	0.330
LIG_UBA3_1	179	187	PF00899	0.330
LIG_UBA3_1	248	256	PF00899	0.462
LIG_UBA3_1	309	315	PF00899	0.191
LIG_WRC_WIRS_1	110	115	PF05994	0.443
MOD_CK1_1	112	118	PF00069	0.541
MOD_CK1_1	144	150	PF00069	0.414
MOD_CK1_1	263	269	PF00069	0.424
MOD_CK1_1	324	330	PF00069	0.270
MOD_CK1_1	340	346	PF00069	0.270
MOD_CK1_1	78	84	PF00069	0.539
MOD_CK2_1	125	131	PF00069	0.515
MOD_CK2_1	255	261	PF00069	0.402
MOD_CK2_1	35	41	PF00069	0.364
MOD_CK2_1	78	84	PF00069	0.508
MOD_GlcNHglycan	103	106	PF01048	0.541
MOD_GlcNHglycan	241	244	PF01048	0.337
MOD_GlcNHglycan	265	268	PF01048	0.413
MOD_GlcNHglycan	306	309	PF01048	0.337
MOD_GlcNHglycan	326	329	PF01048	0.148
MOD_GlcNHglycan	339	342	PF01048	0.270
MOD_GlcNHglycan	62	67	PF01048	0.475
MOD_GSK3_1	109	116	PF00069	0.513
MOD_GSK3_1	239	246	PF00069	0.314
MOD_GSK3_1	275	282	PF00069	0.330
MOD_GSK3_1	289	296	PF00069	0.217
MOD_GSK3_1	320	327	PF00069	0.330
MOD_GSK3_1	62	69	PF00069	0.386
MOD_GSK3_1	83	90	PF00069	0.590
MOD_N-GLC_1	164	169	PF02516	0.330
MOD_NEK2_1	239	244	PF00069	0.330
MOD_NEK2_1	274	279	PF00069	0.270
MOD_NEK2_2	321	326	PF00069	0.270
MOD_NEK2_2	35	40	PF00069	0.347
MOD_PIKK_1	293	299	PF00454	0.270
MOD_PIKK_1	45	51	PF00454	0.292
MOD_PKA_1	255	261	PF00069	0.349
MOD_PKA_2	45	51	PF00069	0.324
MOD_PKB_1	291	299	PF00069	0.270
MOD_Plk_1	141	147	PF00069	0.395
MOD_Plk_1	164	170	PF00069	0.330
MOD_Plk_1	260	266	PF00069	0.394
MOD_Plk_4	109	115	PF00069	0.465
MOD_Plk_4	141	147	PF00069	0.389
MOD_Plk_4	243	249	PF00069	0.330
MOD_Plk_4	321	327	PF00069	0.270
MOD_Plk_4	340	346	PF00069	0.270
MOD_Plk_4	35	41	PF00069	0.359
MOD_Plk_4	75	81	PF00069	0.528
MOD_ProDKin_1	113	119	PF00069	0.592
MOD_ProDKin_1	144	150	PF00069	0.467
MOD_SUMO_for_1	60	63	PF00179	0.344
MOD_SUMO_rev_2	130	134	PF00179	0.337
TRG_ENDOCYTIC_2	219	222	PF00928	0.270
TRG_ENDOCYTIC_2	232	235	PF00928	0.270
TRG_ENDOCYTIC_2	306	309	PF00928	0.270
TRG_ER_diArg_1	290	293	PF00400	0.270
TRG_ER_diArg_1	32	34	PF00400	0.359
TRG_NLS_Bipartite_1	33	54	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG6	Leptomonas seymouri	69%	68%
A0A3Q8INL3	Leishmania donovani	80%	100%
A4IA82	Leishmania infantum	80%	100%
C9ZM27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	93%
E9B595	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
F4JU70	Arabidopsis thaliana	27%	100%
Q09461	Caenorhabditis elegans	23%	99%
Q4Q2N8	Leishmania major	78%	100%
Q6DG32	Danio rerio	26%	100%
Q86AV5	Dictyostelium discoideum	24%	100%
Q9SB52	Arabidopsis thaliana	25%	100%