Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HB24_LEIBR

TriTrypDb:

LbrM.20.2630 , LBRM2903_200038300

Length:

178

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0012505	endomembrane system	2	3
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HB24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	30	32	PF00082	0.408
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.372
DOC_MAPK_gen_1	6	14	PF00069	0.263
DOC_MAPK_gen_1	87	95	PF00069	0.596
DOC_MAPK_MEF2A_6	6	14	PF00069	0.271
DOC_MAPK_MEF2A_6	90	97	PF00069	0.507
DOC_PP4_FxxP_1	106	109	PF00568	0.556
DOC_USP7_MATH_1	13	17	PF00917	0.424
DOC_USP7_MATH_1	66	70	PF00917	0.687
DOC_USP7_UBL2_3	156	160	PF12436	0.607
LIG_14-3-3_CanoR_1	31	40	PF00244	0.628
LIG_14-3-3_CanoR_1	90	96	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_FHA_1	19	25	PF00498	0.405
LIG_FHA_1	32	38	PF00498	0.639
LIG_LIR_Gen_1	89	100	PF02991	0.551
LIG_LIR_Nem_3	159	164	PF02991	0.588
LIG_LIR_Nem_3	170	176	PF02991	0.627
LIG_LIR_Nem_3	81	86	PF02991	0.536
LIG_LIR_Nem_3	89	95	PF02991	0.567
LIG_LYPXL_yS_3	161	164	PF13949	0.613
LIG_SH2_CRK	83	87	PF00017	0.532
LIG_SH2_GRB2like	134	137	PF00017	0.494
LIG_SH2_NCK_1	100	104	PF00017	0.514
LIG_SH2_STAP1	33	37	PF00017	0.610
LIG_SH2_STAT3	134	137	PF00017	0.494
LIG_SH2_STAT5	134	137	PF00017	0.494
LIG_SH2_STAT5	153	156	PF00017	0.428
LIG_SH2_STAT5	167	170	PF00017	0.551
LIG_SH2_STAT5	26	29	PF00017	0.559
LIG_SH2_STAT5	33	36	PF00017	0.707
LIG_SH2_STAT5	75	78	PF00017	0.611
LIG_SUMO_SIM_anti_2	143	152	PF11976	0.556
LIG_SUMO_SIM_par_1	10	16	PF11976	0.293
LIG_TRAF2_1	143	146	PF00917	0.517
LIG_UBA3_1	24	30	PF00899	0.282
MOD_CK1_1	2	8	PF00069	0.397
MOD_CK2_1	140	146	PF00069	0.548
MOD_CK2_1	52	58	PF00069	0.767
MOD_GlcNHglycan	15	18	PF01048	0.400
MOD_GlcNHglycan	61	64	PF01048	0.517
MOD_N-GLC_1	140	145	PF02516	0.356
MOD_NEK2_1	25	30	PF00069	0.452
MOD_PIKK_1	78	84	PF00454	0.526
MOD_Plk_4	20	26	PF00069	0.450
MOD_Plk_4	66	72	PF00069	0.634
MOD_SUMO_for_1	86	89	PF00179	0.556
TRG_DiLeu_BaEn_4	145	151	PF01217	0.556
TRG_ENDOCYTIC_2	113	116	PF00928	0.581
TRG_ENDOCYTIC_2	161	164	PF00928	0.570
TRG_ENDOCYTIC_2	83	86	PF00928	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I427	Leptomonas seymouri	74%	95%
A0A0S4IWT4	Bodo saltans	36%	100%
A0A0S4KHZ8	Bodo saltans	40%	100%
A0A3Q8IGX1	Leishmania donovani	41%	100%
A0A3S7WTB2	Leishmania donovani	37%	100%
A0A3S7X865	Leishmania donovani	83%	100%
A4H7Y9	Leishmania braziliensis	40%	100%
A4HQJ0	Leishmania braziliensis	36%	100%
A4HWB7	Leishmania infantum	38%	100%
A4IA81	Leishmania infantum	83%	100%
E9AHZ9	Leishmania infantum	41%	100%
E9AQ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q088	Leishmania major	35%	100%
Q4Q2N9	Leishmania major	84%	100%
Q4QFG4	Leishmania major	39%	100%
V5DM24	Trypanosoma cruzi	54%	99%