Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB23_LEIBR

TriTrypDb:

LbrM.20.2620 , LBRM2903_200038200

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.532
CLV_C14_Caspase3-7	82	86	PF00656	0.616
CLV_NRD_NRD_1	108	110	PF00675	0.474
CLV_NRD_NRD_1	250	252	PF00675	0.562
CLV_NRD_NRD_1	362	364	PF00675	0.543
CLV_NRD_NRD_1	490	492	PF00675	0.379
CLV_NRD_NRD_1	534	536	PF00675	0.410
CLV_PCSK_KEX2_1	108	110	PF00082	0.470
CLV_PCSK_KEX2_1	252	254	PF00082	0.494
CLV_PCSK_KEX2_1	489	491	PF00082	0.395
CLV_PCSK_KEX2_1	534	536	PF00082	0.410
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.399
CLV_PCSK_SKI1_1	293	297	PF00082	0.444
CLV_PCSK_SKI1_1	326	330	PF00082	0.445
CLV_PCSK_SKI1_1	364	368	PF00082	0.385
DEG_SPOP_SBC_1	409	413	PF00917	0.544
DOC_ANK_TNKS_1	534	541	PF00023	0.416
DOC_CYCLIN_RxL_1	323	332	PF00134	0.338
DOC_CYCLIN_RxL_1	361	371	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	429	435	PF00134	0.479
DOC_MAPK_gen_1	156	166	PF00069	0.413
DOC_MAPK_gen_1	232	241	PF00069	0.534
DOC_MAPK_MEF2A_6	119	126	PF00069	0.468
DOC_MAPK_RevD_3	239	253	PF00069	0.550
DOC_MAPK_RevD_3	477	491	PF00069	0.306
DOC_MAPK_RevD_3	520	535	PF00069	0.409
DOC_PP2B_LxvP_1	207	210	PF13499	0.736
DOC_PP2B_LxvP_1	73	76	PF13499	0.488
DOC_PP4_FxxP_1	281	284	PF00568	0.436
DOC_PP4_FxxP_1	297	300	PF00568	0.430
DOC_PP4_FxxP_1	344	347	PF00568	0.325
DOC_USP7_MATH_1	214	218	PF00917	0.744
DOC_USP7_MATH_1	219	223	PF00917	0.720
DOC_USP7_MATH_1	306	310	PF00917	0.422
DOC_USP7_MATH_1	354	358	PF00917	0.382
DOC_USP7_MATH_1	391	395	PF00917	0.670
DOC_USP7_MATH_1	409	413	PF00917	0.498
DOC_USP7_MATH_1	7	11	PF00917	0.669
DOC_USP7_UBL2_3	11	15	PF12436	0.691
DOC_USP7_UBL2_3	224	228	PF12436	0.666
DOC_USP7_UBL2_3	232	236	PF12436	0.662
DOC_USP7_UBL2_3	5	9	PF12436	0.684
DOC_WW_Pin1_4	124	129	PF00397	0.579
DOC_WW_Pin1_4	239	244	PF00397	0.619
DOC_WW_Pin1_4	381	386	PF00397	0.505
DOC_WW_Pin1_4	498	503	PF00397	0.467
DOC_WW_Pin1_4	87	92	PF00397	0.449
LIG_14-3-3_CanoR_1	159	165	PF00244	0.483
LIG_14-3-3_CanoR_1	293	298	PF00244	0.429
LIG_14-3-3_CanoR_1	305	311	PF00244	0.420
LIG_14-3-3_CanoR_1	534	538	PF00244	0.407
LIG_APCC_ABBA_1	148	153	PF00400	0.539
LIG_BIR_III_4	58	62	PF00653	0.538
LIG_BRCT_BRCA1_1	89	93	PF00533	0.411
LIG_Clathr_ClatBox_1	92	96	PF01394	0.324
LIG_CSL_BTD_1	120	123	PF09270	0.454
LIG_FHA_1	161	167	PF00498	0.477
LIG_FHA_1	26	32	PF00498	0.572
LIG_FHA_1	369	375	PF00498	0.422
LIG_FHA_1	424	430	PF00498	0.465
LIG_FHA_1	482	488	PF00498	0.503
LIG_FHA_1	565	571	PF00498	0.534
LIG_FHA_1	62	68	PF00498	0.527
LIG_FHA_1	92	98	PF00498	0.336
LIG_FHA_2	125	131	PF00498	0.502
LIG_FHA_2	317	323	PF00498	0.530
LIG_FHA_2	436	442	PF00498	0.317
LIG_IBAR_NPY_1	149	151	PF08397	0.521
LIG_IRF3_LxIS_1	327	332	PF10401	0.269
LIG_LIR_Apic_2	280	284	PF02991	0.497
LIG_LIR_Apic_2	296	300	PF02991	0.425
LIG_LIR_Apic_2	343	347	PF02991	0.323
LIG_LIR_Gen_1	37	45	PF02991	0.516
LIG_LIR_Gen_1	469	478	PF02991	0.321
LIG_LIR_Gen_1	513	522	PF02991	0.389
LIG_LIR_Gen_1	582	587	PF02991	0.494
LIG_LIR_Nem_3	120	124	PF02991	0.510
LIG_LIR_Nem_3	332	337	PF02991	0.450
LIG_LIR_Nem_3	35	39	PF02991	0.568
LIG_LIR_Nem_3	469	475	PF02991	0.319
LIG_LIR_Nem_3	513	517	PF02991	0.385
LIG_LIR_Nem_3	582	586	PF02991	0.492
LIG_PCNA_yPIPBox_3	108	122	PF02747	0.385
LIG_PCNA_yPIPBox_3	549	558	PF02747	0.265
LIG_Pex14_2	32	36	PF04695	0.569
LIG_PTB_Apo_2	309	316	PF02174	0.422
LIG_RPA_C_Fungi	445	457	PF08784	0.284
LIG_SH2_CRK	334	338	PF00017	0.422
LIG_SH2_CRK	353	357	PF00017	0.538
LIG_SH2_NCK_1	353	357	PF00017	0.402
LIG_SH2_NCK_1	39	43	PF00017	0.513
LIG_SH2_SRC	151	154	PF00017	0.517
LIG_SH2_SRC	537	540	PF00017	0.409
LIG_SH2_STAP1	151	155	PF00017	0.502
LIG_SH2_STAP1	483	487	PF00017	0.448
LIG_SH2_STAT3	260	263	PF00017	0.514
LIG_SH2_STAT5	160	163	PF00017	0.516
LIG_SH2_STAT5	277	280	PF00017	0.543
LIG_SH2_STAT5	334	337	PF00017	0.348
LIG_SH2_STAT5	478	481	PF00017	0.399
LIG_SH2_STAT5	483	486	PF00017	0.442
LIG_SH2_STAT5	537	540	PF00017	0.440
LIG_SH2_STAT5	561	564	PF00017	0.436
LIG_SH3_1	491	497	PF00018	0.520
LIG_SH3_2	194	199	PF14604	0.490
LIG_SH3_3	135	141	PF00018	0.686
LIG_SH3_3	188	194	PF00018	0.486
LIG_SH3_3	321	327	PF00018	0.383
LIG_SH3_3	491	497	PF00018	0.503
LIG_SH3_3	60	66	PF00018	0.495
LIG_SH3_4	224	231	PF00018	0.536
LIG_SUMO_SIM_anti_2	70	79	PF11976	0.509
LIG_SUMO_SIM_par_1	122	127	PF11976	0.483
LIG_SUMO_SIM_par_1	326	332	PF11976	0.427
LIG_SUMO_SIM_par_1	430	436	PF11976	0.339
LIG_SUMO_SIM_par_1	70	79	PF11976	0.525
LIG_SUMO_SIM_par_1	93	99	PF11976	0.434
LIG_TRAF2_1	142	145	PF00917	0.662
LIG_TRAF2_1	438	441	PF00917	0.314
LIG_WRC_WIRS_1	278	283	PF05994	0.497
MOD_CK1_1	10	16	PF00069	0.607
MOD_CK1_1	318	324	PF00069	0.450
MOD_CK1_1	384	390	PF00069	0.421
MOD_CK1_1	46	52	PF00069	0.431
MOD_CK2_1	10	16	PF00069	0.688
MOD_CK2_1	124	130	PF00069	0.707
MOD_CK2_1	41	47	PF00069	0.450
MOD_CK2_1	435	441	PF00069	0.318
MOD_CK2_1	533	539	PF00069	0.412
MOD_GlcNHglycan	221	224	PF01048	0.650
MOD_GlcNHglycan	25	28	PF01048	0.528
MOD_GlcNHglycan	356	359	PF01048	0.413
MOD_GlcNHglycan	386	389	PF01048	0.589
MOD_GlcNHglycan	435	438	PF01048	0.531
MOD_GlcNHglycan	525	529	PF01048	0.311
MOD_GlcNHglycan	539	543	PF01048	0.482
MOD_GSK3_1	113	120	PF00069	0.611
MOD_GSK3_1	122	129	PF00069	0.712
MOD_GSK3_1	219	226	PF00069	0.712
MOD_GSK3_1	23	30	PF00069	0.438
MOD_GSK3_1	34	41	PF00069	0.640
MOD_GSK3_1	387	394	PF00069	0.513
MOD_GSK3_1	409	416	PF00069	0.557
MOD_GSK3_1	423	430	PF00069	0.390
MOD_GSK3_1	431	438	PF00069	0.314
MOD_GSK3_1	5	12	PF00069	0.689
MOD_GSK3_1	529	536	PF00069	0.541
MOD_GSK3_1	87	94	PF00069	0.605
MOD_N-GLC_1	413	418	PF02516	0.633
MOD_N-GLC_2	591	593	PF02516	0.494
MOD_NEK2_1	117	122	PF00069	0.488
MOD_NEK2_1	315	320	PF00069	0.521
MOD_NEK2_1	329	334	PF00069	0.401
MOD_NEK2_1	435	440	PF00069	0.313
MOD_NEK2_1	524	529	PF00069	0.435
MOD_NEK2_2	27	32	PF00069	0.611
MOD_NEK2_2	34	39	PF00069	0.570
MOD_NEK2_2	564	569	PF00069	0.435
MOD_NEK2_2	597	602	PF00069	0.537
MOD_PIKK_1	329	335	PF00454	0.364
MOD_PIKK_1	368	374	PF00454	0.455
MOD_PK_1	529	535	PF00069	0.391
MOD_PKA_1	227	233	PF00069	0.654
MOD_PKA_1	234	240	PF00069	0.643
MOD_PKA_1	5	11	PF00069	0.686
MOD_PKA_2	533	539	PF00069	0.349
MOD_Plk_1	144	150	PF00069	0.637
MOD_Plk_1	34	40	PF00069	0.545
MOD_Plk_1	46	52	PF00069	0.300
MOD_Plk_1	505	511	PF00069	0.427
MOD_Plk_1	564	570	PF00069	0.444
MOD_Plk_4	113	119	PF00069	0.495
MOD_Plk_4	27	33	PF00069	0.571
MOD_Plk_4	551	557	PF00069	0.338
MOD_ProDKin_1	124	130	PF00069	0.584
MOD_ProDKin_1	239	245	PF00069	0.613
MOD_ProDKin_1	381	387	PF00069	0.516
MOD_ProDKin_1	498	504	PF00069	0.462
MOD_ProDKin_1	87	93	PF00069	0.429
MOD_SUMO_rev_2	244	254	PF00179	0.497
TRG_DiLeu_BaEn_1	47	52	PF01217	0.338
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.481
TRG_ENDOCYTIC_2	334	337	PF00928	0.357
TRG_ENDOCYTIC_2	39	42	PF00928	0.514
TRG_ER_diArg_1	489	491	PF00400	0.395
TRG_ER_diArg_1	533	535	PF00400	0.409
TRG_ER_diArg_1	568	571	PF00400	0.424
TRG_NLS_MonoExtC_3	233	238	PF00514	0.668
TRG_NLS_MonoExtN_4	2	8	PF00514	0.679
TRG_NLS_MonoExtN_4	232	239	PF00514	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J9	Leptomonas seymouri	54%	100%
A0A3S5H7X4	Leishmania donovani	75%	100%
A4IA80	Leishmania infantum	75%	100%
C9ZM29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B593	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q2P0	Leishmania major	75%	100%