Cilia- and flagella-associated protein 418

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinal Maintenance, putative

Species:

Leishmania braziliensis

UniProt:

A4HB22_LEIBR

TriTrypDb:

LbrM.20.2610 , LBRM2903_200038100

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0001917	photoreceptor inner segment	2	10
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HB22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.595
CLV_C14_Caspase3-7	2	6	PF00656	0.690
CLV_C14_Caspase3-7	94	98	PF00656	0.747
CLV_NRD_NRD_1	193	195	PF00675	0.308
CLV_NRD_NRD_1	31	33	PF00675	0.799
CLV_NRD_NRD_1	339	341	PF00675	0.586
CLV_NRD_NRD_1	45	47	PF00675	0.578
CLV_PCSK_KEX2_1	30	32	PF00082	0.802
CLV_PCSK_KEX2_1	339	341	PF00082	0.588
CLV_PCSK_SKI1_1	128	132	PF00082	0.689
CLV_PCSK_SKI1_1	195	199	PF00082	0.300
CLV_PCSK_SKI1_1	279	283	PF00082	0.361
CLV_PCSK_SKI1_1	301	305	PF00082	0.361
CLV_PCSK_SKI1_1	318	322	PF00082	0.581
DEG_APCC_DBOX_1	150	158	PF00400	0.673
DEG_SPOP_SBC_1	69	73	PF00917	0.631
DOC_MAPK_DCC_7	128	136	PF00069	0.736
DOC_MAPK_gen_1	15	24	PF00069	0.520
DOC_MAPK_gen_1	339	345	PF00069	0.578
DOC_MAPK_HePTP_8	225	237	PF00069	0.561
DOC_MAPK_MEF2A_6	228	237	PF00069	0.556
DOC_PP1_RVXF_1	126	133	PF00149	0.680
DOC_PP2B_LxvP_1	331	334	PF13499	0.719
DOC_PP2B_PxIxI_1	121	127	PF00149	0.541
DOC_PP4_FxxP_1	132	135	PF00568	0.686
DOC_USP7_MATH_1	135	139	PF00917	0.698
DOC_USP7_MATH_1	147	151	PF00917	0.560
DOC_USP7_MATH_1	184	188	PF00917	0.411
DOC_USP7_MATH_1	25	29	PF00917	0.708
DOC_USP7_MATH_1	275	279	PF00917	0.584
DOC_USP7_MATH_1	70	74	PF00917	0.687
DOC_WW_Pin1_4	264	269	PF00397	0.561
LIG_14-3-3_CanoR_1	123	127	PF00244	0.659
LIG_14-3-3_CanoR_1	262	271	PF00244	0.490
LIG_14-3-3_CanoR_1	283	287	PF00244	0.591
LIG_14-3-3_CanoR_1	310	317	PF00244	0.715
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BIR_III_4	95	99	PF00653	0.787
LIG_EVH1_1	331	335	PF00568	0.517
LIG_FHA_1	72	78	PF00498	0.628
LIG_FHA_2	103	109	PF00498	0.561
LIG_FHA_2	167	173	PF00498	0.462
LIG_LIR_Apic_2	66	70	PF02991	0.686
LIG_LIR_Gen_1	259	268	PF02991	0.522
LIG_LIR_Gen_1	296	305	PF02991	0.490
LIG_LIR_Nem_3	259	263	PF02991	0.522
LIG_LIR_Nem_3	296	300	PF02991	0.490
LIG_MYND_1	129	133	PF01753	0.639
LIG_Pex14_2	132	136	PF04695	0.684
LIG_SH2_CRK	232	236	PF00017	0.490
LIG_SH2_CRK	67	71	PF00017	0.687
LIG_SH2_NCK_1	146	150	PF00017	0.699
LIG_SH2_NCK_1	67	71	PF00017	0.531
LIG_SH2_SRC	67	70	PF00017	0.532
LIG_SH2_STAT3	291	294	PF00017	0.490
LIG_SH2_STAT5	153	156	PF00017	0.604
LIG_SH2_STAT5	250	253	PF00017	0.508
LIG_SH2_STAT5	291	294	PF00017	0.499
LIG_SH3_3	10	16	PF00018	0.477
LIG_SH3_3	123	129	PF00018	0.663
LIG_SH3_3	131	137	PF00018	0.614
LIG_SH3_3	329	335	PF00018	0.525
LIG_TRAF2_1	169	172	PF00917	0.472
LIG_UBA3_1	7	15	PF00899	0.580
MOD_CK1_1	142	148	PF00069	0.705
MOD_CK1_1	26	32	PF00069	0.715
MOD_CK1_1	296	302	PF00069	0.499
MOD_CK1_1	71	77	PF00069	0.687
MOD_CK2_1	166	172	PF00069	0.713
MOD_CK2_1	70	76	PF00069	0.721
MOD_GlcNHglycan	264	267	PF01048	0.391
MOD_GSK3_1	135	142	PF00069	0.673
MOD_GSK3_1	162	169	PF00069	0.688
MOD_GSK3_1	26	33	PF00069	0.708
MOD_GSK3_1	68	75	PF00069	0.644
MOD_N-GLC_1	91	96	PF02516	0.639
MOD_N-GLC_2	18	20	PF02516	0.662
MOD_N-GLC_2	207	209	PF02516	0.308
MOD_NEK2_1	249	254	PF00069	0.476
MOD_NEK2_1	282	287	PF00069	0.595
MOD_NEK2_1	79	84	PF00069	0.507
MOD_PKA_1	30	36	PF00069	0.793
MOD_PKA_2	122	128	PF00069	0.656
MOD_PKA_2	282	288	PF00069	0.591
MOD_PKA_2	30	36	PF00069	0.713
MOD_PKA_2	309	315	PF00069	0.701
MOD_PKA_2	82	88	PF00069	0.690
MOD_Plk_1	214	220	PF00069	0.597
MOD_Plk_1	312	318	PF00069	0.765
MOD_Plk_1	75	81	PF00069	0.651
MOD_Plk_2-3	166	172	PF00069	0.524
MOD_Plk_2-3	3	9	PF00069	0.698
MOD_Plk_2-3	36	42	PF00069	0.731
MOD_Plk_2-3	91	97	PF00069	0.629
MOD_Plk_4	293	299	PF00069	0.527
MOD_Plk_4	3	9	PF00069	0.698
MOD_ProDKin_1	264	270	PF00069	0.561
MOD_SUMO_for_1	16	19	PF00179	0.628
TRG_DiLeu_BaEn_1	3	8	PF01217	0.696
TRG_ENDOCYTIC_2	232	235	PF00928	0.490
TRG_ENDOCYTIC_2	250	253	PF00928	0.355
TRG_ER_diArg_1	30	32	PF00400	0.802
TRG_ER_diArg_1	339	341	PF00400	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P513	Leptomonas seymouri	53%	95%
A0A1X0P9U1	Trypanosomatidae	38%	100%
A0A3S7X892	Leishmania donovani	73%	100%
A0A422N4K3	Trypanosoma rangeli	39%	100%
A4IA79	Leishmania infantum	73%	100%
C9ZM30	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B592	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2P1	Leishmania major	71%	100%