Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB21_LEIBR

TriTrypDb:

LbrM.20.2600 , LBRM2903_200038000

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB21

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.588
CLV_C14_Caspase3-7	597	601	PF00656	0.751
CLV_C14_Caspase3-7	829	833	PF00656	0.567
CLV_C14_Caspase3-7	872	876	PF00656	0.551
CLV_NRD_NRD_1	193	195	PF00675	0.591
CLV_NRD_NRD_1	210	212	PF00675	0.537
CLV_NRD_NRD_1	256	258	PF00675	0.711
CLV_NRD_NRD_1	289	291	PF00675	0.620
CLV_NRD_NRD_1	400	402	PF00675	0.529
CLV_NRD_NRD_1	463	465	PF00675	0.529
CLV_NRD_NRD_1	466	468	PF00675	0.479
CLV_NRD_NRD_1	521	523	PF00675	0.529
CLV_NRD_NRD_1	581	583	PF00675	0.643
CLV_NRD_NRD_1	60	62	PF00675	0.845
CLV_NRD_NRD_1	827	829	PF00675	0.677
CLV_PCSK_FUR_1	254	258	PF00082	0.593
CLV_PCSK_FUR_1	287	291	PF00082	0.609
CLV_PCSK_FUR_1	464	468	PF00082	0.529
CLV_PCSK_FUR_1	825	829	PF00082	0.571
CLV_PCSK_KEX2_1	193	195	PF00082	0.591
CLV_PCSK_KEX2_1	210	212	PF00082	0.537
CLV_PCSK_KEX2_1	256	258	PF00082	0.711
CLV_PCSK_KEX2_1	289	291	PF00082	0.620
CLV_PCSK_KEX2_1	399	401	PF00082	0.529
CLV_PCSK_KEX2_1	463	465	PF00082	0.529
CLV_PCSK_KEX2_1	466	468	PF00082	0.479
CLV_PCSK_KEX2_1	581	583	PF00082	0.643
CLV_PCSK_KEX2_1	60	62	PF00082	0.845
CLV_PCSK_KEX2_1	827	829	PF00082	0.688
CLV_PCSK_KEX2_1	857	859	PF00082	0.599
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.594
CLV_PCSK_PC7_1	56	62	PF00082	0.580
CLV_PCSK_PC7_1	577	583	PF00082	0.619
CLV_PCSK_SKI1_1	352	356	PF00082	0.369
CLV_PCSK_SKI1_1	434	438	PF00082	0.529
DEG_APCC_DBOX_1	760	768	PF00400	0.569
DEG_Nend_UBRbox_3	1	3	PF02207	0.850
DEG_SCF_FBW7_1	672	678	PF00400	0.552
DOC_CKS1_1	672	677	PF01111	0.656
DOC_MAPK_DCC_7	857	867	PF00069	0.583
DOC_MAPK_gen_1	266	274	PF00069	0.569
DOC_MAPK_gen_1	287	294	PF00069	0.595
DOC_MAPK_JIP1_4	268	274	PF00069	0.565
DOC_MAPK_MEF2A_6	340	347	PF00069	0.614
DOC_MAPK_MEF2A_6	703	711	PF00069	0.573
DOC_MAPK_MEF2A_6	858	867	PF00069	0.584
DOC_PIKK_1	326	334	PF02985	0.661
DOC_PP1_RVXF_1	49	56	PF00149	0.583
DOC_PP1_RVXF_1	586	593	PF00149	0.653
DOC_PP2B_LxvP_1	272	275	PF13499	0.549
DOC_PP4_FxxP_1	81	84	PF00568	0.585
DOC_USP7_MATH_1	195	199	PF00917	0.574
DOC_USP7_MATH_1	415	419	PF00917	0.529
DOC_USP7_MATH_1	446	450	PF00917	0.261
DOC_USP7_MATH_1	675	679	PF00917	0.544
DOC_USP7_MATH_1	753	757	PF00917	0.783
DOC_USP7_MATH_1	763	767	PF00917	0.708
DOC_USP7_MATH_1	811	815	PF00917	0.641
DOC_USP7_MATH_1	818	822	PF00917	0.630
DOC_USP7_MATH_1	84	88	PF00917	0.668
DOC_USP7_UBL2_3	523	527	PF12436	0.529
DOC_WW_Pin1_4	113	118	PF00397	0.730
DOC_WW_Pin1_4	145	150	PF00397	0.742
DOC_WW_Pin1_4	179	184	PF00397	0.737
DOC_WW_Pin1_4	185	190	PF00397	0.789
DOC_WW_Pin1_4	204	209	PF00397	0.595
DOC_WW_Pin1_4	536	541	PF00397	0.553
DOC_WW_Pin1_4	626	631	PF00397	0.706
DOC_WW_Pin1_4	671	676	PF00397	0.660
DOC_WW_Pin1_4	739	744	PF00397	0.612
DOC_WW_Pin1_4	756	761	PF00397	0.722
DOC_WW_Pin1_4	772	777	PF00397	0.547
DOC_WW_Pin1_4	80	85	PF00397	0.585
DOC_WW_Pin1_4	892	897	PF00397	0.568
LIG_14-3-3_CanoR_1	196	201	PF00244	0.566
LIG_14-3-3_CanoR_1	399	407	PF00244	0.529
LIG_14-3-3_CanoR_1	486	491	PF00244	0.529
LIG_14-3-3_CanoR_1	703	711	PF00244	0.841
LIG_14-3-3_CanoR_1	761	771	PF00244	0.796
LIG_14-3-3_CanoR_1	85	90	PF00244	0.848
LIG_14-3-3_CanoR_1	870	878	PF00244	0.542
LIG_14-3-3_CanoR_1	92	96	PF00244	0.621
LIG_Actin_WH2_2	350	365	PF00022	0.529
LIG_BIR_III_2	627	631	PF00653	0.578
LIG_BIR_III_4	604	608	PF00653	0.765
LIG_BRCT_BRCA1_1	505	509	PF00533	0.529
LIG_BRCT_BRCA1_1	820	824	PF00533	0.579
LIG_deltaCOP1_diTrp_1	502	509	PF00928	0.529
LIG_FHA_1	163	169	PF00498	0.571
LIG_FHA_1	367	373	PF00498	0.298
LIG_FHA_1	404	410	PF00498	0.529
LIG_FHA_1	451	457	PF00498	0.454
LIG_FHA_1	514	520	PF00498	0.488
LIG_FHA_1	699	705	PF00498	0.730
LIG_FHA_1	740	746	PF00498	0.717
LIG_FHA_1	869	875	PF00498	0.805
LIG_FHA_2	305	311	PF00498	0.513
LIG_FHA_2	312	318	PF00498	0.577
LIG_FHA_2	839	845	PF00498	0.691
LIG_FHA_2	870	876	PF00498	0.563
LIG_LIR_Apic_2	78	84	PF02991	0.585
LIG_LIR_Gen_1	304	311	PF02991	0.614
LIG_LIR_Gen_1	484	491	PF02991	0.529
LIG_LIR_Gen_1	502	512	PF02991	0.241
LIG_LIR_Gen_1	565	576	PF02991	0.590
LIG_LIR_Nem_3	28	34	PF02991	0.506
LIG_LIR_Nem_3	304	309	PF02991	0.377
LIG_LIR_Nem_3	406	410	PF02991	0.529
LIG_LIR_Nem_3	484	490	PF02991	0.529
LIG_LIR_Nem_3	502	508	PF02991	0.241
LIG_LIR_Nem_3	518	524	PF02991	0.295
LIG_LIR_Nem_3	549	553	PF02991	0.583
LIG_LIR_Nem_3	565	571	PF02991	0.328
LIG_LIR_Nem_3	573	579	PF02991	0.457
LIG_LIR_Nem_3	773	777	PF02991	0.609
LIG_MLH1_MIPbox_1	820	824	PF16413	0.579
LIG_NRBOX	503	509	PF00104	0.529
LIG_Pex14_1	505	509	PF04695	0.529
LIG_Pex14_2	302	306	PF04695	0.614
LIG_REV1ctd_RIR_1	821	832	PF16727	0.574
LIG_RPA_C_Fungi	285	297	PF08784	0.377
LIG_SH2_CRK	177	181	PF00017	0.594
LIG_SH2_CRK	410	414	PF00017	0.529
LIG_SH2_CRK	487	491	PF00017	0.529
LIG_SH2_CRK	568	572	PF00017	0.583
LIG_SH2_NCK_1	177	181	PF00017	0.594
LIG_SH2_NCK_1	487	491	PF00017	0.529
LIG_SH2_STAP1	487	491	PF00017	0.529
LIG_SH2_STAP1	568	572	PF00017	0.583
LIG_SH2_STAP1	843	847	PF00017	0.565
LIG_SH2_STAT3	171	174	PF00017	0.585
LIG_SH2_STAT5	171	174	PF00017	0.585
LIG_SH2_STAT5	374	377	PF00017	0.445
LIG_SH2_STAT5	410	413	PF00017	0.529
LIG_SH2_STAT5	455	458	PF00017	0.420
LIG_SH3_1	177	183	PF00018	0.587
LIG_SH3_3	108	114	PF00018	0.778
LIG_SH3_3	177	183	PF00018	0.692
LIG_SH3_3	202	208	PF00018	0.592
LIG_SH3_3	615	621	PF00018	0.567
LIG_SH3_3	669	675	PF00018	0.754
LIG_SH3_3	757	763	PF00018	0.563
LIG_SH3_3	784	790	PF00018	0.732
LIG_TRAF2_1	19	22	PF00917	0.529
LIG_TRAF2_1	314	317	PF00917	0.768
LIG_TRAF2_1	46	49	PF00917	0.579
LIG_TRAF2_1	667	670	PF00917	0.571
LIG_TYR_ITIM	574	579	PF00017	0.317
LIG_WW_3	473	477	PF00397	0.529
MOD_CAAXbox	904	907	PF01239	0.713
MOD_CDC14_SPxK_1	207	210	PF00782	0.585
MOD_CDK_SPK_2	756	761	PF00069	0.775
MOD_CDK_SPK_2	80	85	PF00069	0.585
MOD_CDK_SPK_2	892	897	PF00069	0.568
MOD_CDK_SPxK_1	204	210	PF00069	0.748
MOD_CDK_SPxK_1	892	898	PF00069	0.567
MOD_CDK_SPxxK_3	204	211	PF00069	0.591
MOD_CDK_SPxxK_3	739	746	PF00069	0.547
MOD_CDK_SPxxK_3	892	899	PF00069	0.563
MOD_CK1_1	145	151	PF00069	0.682
MOD_CK1_1	154	160	PF00069	0.786
MOD_CK1_1	16	22	PF00069	0.774
MOD_CK1_1	162	168	PF00069	0.682
MOD_CK1_1	262	268	PF00069	0.592
MOD_CK1_1	377	383	PF00069	0.369
MOD_CK1_1	418	424	PF00069	0.529
MOD_CK1_1	449	455	PF00069	0.261
MOD_CK1_1	489	495	PF00069	0.529
MOD_CK1_1	756	762	PF00069	0.547
MOD_CK1_1	814	820	PF00069	0.594
MOD_CK1_1	88	94	PF00069	0.823
MOD_CK1_1	892	898	PF00069	0.567
MOD_CK2_1	16	22	PF00069	0.774
MOD_CK2_1	298	304	PF00069	0.642
MOD_CK2_1	311	317	PF00069	0.526
MOD_CK2_1	43	49	PF00069	0.586
MOD_CK2_1	465	471	PF00069	0.529
MOD_CK2_1	72	78	PF00069	0.607
MOD_CK2_1	762	768	PF00069	0.840
MOD_CK2_1	772	778	PF00069	0.654
MOD_CK2_1	838	844	PF00069	0.695
MOD_CK2_1	897	903	PF00069	0.546
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.573
MOD_GlcNHglycan	153	156	PF01048	0.674
MOD_GlcNHglycan	161	164	PF01048	0.705
MOD_GlcNHglycan	198	201	PF01048	0.565
MOD_GlcNHglycan	260	264	PF01048	0.866
MOD_GlcNHglycan	376	379	PF01048	0.369
MOD_GlcNHglycan	38	41	PF01048	0.594
MOD_GlcNHglycan	600	603	PF01048	0.531
MOD_GlcNHglycan	645	648	PF01048	0.755
MOD_GlcNHglycan	677	680	PF01048	0.643
MOD_GlcNHglycan	698	701	PF01048	0.663
MOD_GlcNHglycan	711	714	PF01048	0.628
MOD_GlcNHglycan	807	811	PF01048	0.749
MOD_GlcNHglycan	813	816	PF01048	0.617
MOD_GSK3_1	102	109	PF00069	0.830
MOD_GSK3_1	12	19	PF00069	0.806
MOD_GSK3_1	154	161	PF00069	0.604
MOD_GSK3_1	298	305	PF00069	0.639
MOD_GSK3_1	317	324	PF00069	0.393
MOD_GSK3_1	36	43	PF00069	0.681
MOD_GSK3_1	399	406	PF00069	0.529
MOD_GSK3_1	436	443	PF00069	0.529
MOD_GSK3_1	445	452	PF00069	0.380
MOD_GSK3_1	482	489	PF00069	0.529
MOD_GSK3_1	594	601	PF00069	0.597
MOD_GSK3_1	671	678	PF00069	0.639
MOD_GSK3_1	698	705	PF00069	0.831
MOD_GSK3_1	723	730	PF00069	0.575
MOD_GSK3_1	80	87	PF00069	0.784
MOD_GSK3_1	814	821	PF00069	0.667
MOD_GSK3_1	857	864	PF00069	0.582
MOD_N-GLC_1	12	17	PF02516	0.722
MOD_N-GLC_1	151	156	PF02516	0.749
MOD_N-GLC_1	159	164	PF02516	0.609
MOD_N-GLC_1	169	174	PF02516	0.552
MOD_N-GLC_1	6	11	PF02516	0.824
MOD_NEK2_1	277	282	PF00069	0.703
MOD_NEK2_1	302	307	PF00069	0.612
MOD_NEK2_1	465	470	PF00069	0.529
MOD_NEK2_1	481	486	PF00069	0.265
MOD_NEK2_1	55	60	PF00069	0.583
MOD_NEK2_1	570	575	PF00069	0.579
MOD_NEK2_1	696	701	PF00069	0.579
MOD_NEK2_2	6	11	PF00069	0.701
MOD_NEK2_2	715	720	PF00069	0.719
MOD_PIKK_1	129	135	PF00454	0.583
MOD_PIKK_1	162	168	PF00454	0.568
MOD_PIKK_1	366	372	PF00454	0.261
MOD_PIKK_1	399	405	PF00454	0.529
MOD_PIKK_1	55	61	PF00454	0.810
MOD_PIKK_1	665	671	PF00454	0.574
MOD_PIKK_1	883	889	PF00454	0.587
MOD_PK_1	486	492	PF00069	0.529
MOD_PK_1	534	540	PF00069	0.628
MOD_PK_1	857	863	PF00069	0.582
MOD_PKA_1	399	405	PF00069	0.529
MOD_PKA_1	857	863	PF00069	0.589
MOD_PKA_1	897	903	PF00069	0.546
MOD_PKA_2	195	201	PF00069	0.569
MOD_PKA_2	399	405	PF00069	0.529
MOD_PKA_2	465	471	PF00069	0.529
MOD_PKA_2	481	487	PF00069	0.265
MOD_PKA_2	55	61	PF00069	0.583
MOD_PKA_2	702	708	PF00069	0.840
MOD_PKA_2	84	90	PF00069	0.855
MOD_PKA_2	857	863	PF00069	0.589
MOD_PKA_2	869	875	PF00069	0.500
MOD_PKA_2	91	97	PF00069	0.629
MOD_PKB_1	194	202	PF00069	0.575
MOD_Plk_1	159	165	PF00069	0.702
MOD_Plk_1	169	175	PF00069	0.569
MOD_Plk_1	317	323	PF00069	0.610
MOD_Plk_1	534	540	PF00069	0.628
MOD_Plk_1	6	12	PF00069	0.823
MOD_Plk_1	727	733	PF00069	0.843
MOD_Plk_4	13	19	PF00069	0.720
MOD_Plk_4	570	576	PF00069	0.585
MOD_Plk_4	857	863	PF00069	0.582
MOD_ProDKin_1	113	119	PF00069	0.730
MOD_ProDKin_1	145	151	PF00069	0.744
MOD_ProDKin_1	179	185	PF00069	0.738
MOD_ProDKin_1	204	210	PF00069	0.656
MOD_ProDKin_1	536	542	PF00069	0.546
MOD_ProDKin_1	626	632	PF00069	0.704
MOD_ProDKin_1	671	677	PF00069	0.656
MOD_ProDKin_1	739	745	PF00069	0.611
MOD_ProDKin_1	756	762	PF00069	0.721
MOD_ProDKin_1	772	778	PF00069	0.547
MOD_ProDKin_1	80	86	PF00069	0.582
MOD_ProDKin_1	892	898	PF00069	0.567
MOD_SUMO_for_1	345	348	PF00179	0.592
MOD_SUMO_rev_2	348	354	PF00179	0.529
TRG_DiLeu_BaEn_1	326	331	PF01217	0.660
TRG_DiLeu_BaEn_2	548	554	PF01217	0.590
TRG_DiLeu_BaEn_4	21	27	PF01217	0.512
TRG_DiLeu_BaEn_4	316	322	PF01217	0.730
TRG_ENDOCYTIC_2	410	413	PF00928	0.529
TRG_ENDOCYTIC_2	487	490	PF00928	0.529
TRG_ENDOCYTIC_2	568	571	PF00928	0.586
TRG_ENDOCYTIC_2	576	579	PF00928	0.464
TRG_ENDOCYTIC_2	774	777	PF00928	0.599
TRG_ER_diArg_1	192	194	PF00400	0.597
TRG_ER_diArg_1	254	257	PF00400	0.593
TRG_ER_diArg_1	286	289	PF00400	0.604
TRG_ER_diArg_1	398	401	PF00400	0.529
TRG_ER_diArg_1	463	465	PF00400	0.529
TRG_ER_diArg_1	824	827	PF00400	0.576
TRG_NES_CRM1_1	502	513	PF08389	0.529
TRG_NES_CRM1_1	744	758	PF08389	0.546
TRG_NLS_MonoExtC_3	896	901	PF00514	0.544
TRG_NLS_MonoExtN_4	896	902	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFR1	Leishmania donovani	62%	96%
A4IA78	Leishmania infantum	63%	96%
E9B591	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	97%
Q4Q2P2	Leishmania major	62%	100%