Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HB20_LEIBR

TriTrypDb:

LbrM.20.2590 , LBRM2903_200037900

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB20

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.478
CLV_NRD_NRD_1	213	215	PF00675	0.586
CLV_NRD_NRD_1	244	246	PF00675	0.601
CLV_PCSK_FUR_1	210	214	PF00082	0.535
CLV_PCSK_KEX2_1	15	17	PF00082	0.496
CLV_PCSK_KEX2_1	212	214	PF00082	0.449
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.449
CLV_PCSK_SKI1_1	10	14	PF00082	0.488
CLV_PCSK_SKI1_1	121	125	PF00082	0.282
CLV_PCSK_SKI1_1	75	79	PF00082	0.566
DEG_APCC_KENBOX_2	147	151	PF00400	0.455
DOC_MAPK_gen_1	146	155	PF00069	0.442
DOC_MAPK_RevD_3	1	16	PF00069	0.607
DOC_PP4_FxxP_1	83	86	PF00568	0.490
DOC_USP7_MATH_1	162	166	PF00917	0.423
DOC_USP7_UBL2_3	46	50	PF12436	0.531
DOC_WW_Pin1_4	197	202	PF00397	0.390
LIG_14-3-3_CanoR_1	15	23	PF00244	0.537
LIG_14-3-3_CanoR_1	226	236	PF00244	0.558
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_EH_1	135	139	PF12763	0.498
LIG_FHA_1	115	121	PF00498	0.452
LIG_FHA_1	33	39	PF00498	0.456
LIG_FHA_2	4	10	PF00498	0.526
LIG_LIR_Apic_2	80	86	PF02991	0.488
LIG_LIR_Apic_2	88	93	PF02991	0.482
LIG_LIR_Gen_1	103	112	PF02991	0.443
LIG_LIR_Gen_1	55	65	PF02991	0.367
LIG_LIR_Nem_3	103	107	PF02991	0.443
LIG_LIR_Nem_3	191	195	PF02991	0.419
LIG_LIR_Nem_3	55	60	PF02991	0.376
LIG_LYPXL_yS_3	126	129	PF13949	0.496
LIG_PTB_Apo_2	17	24	PF02174	0.534
LIG_PTB_Phospho_1	17	23	PF10480	0.532
LIG_Rb_LxCxE_1	103	122	PF01857	0.477
LIG_SH2_CRK	23	27	PF00017	0.626
LIG_SH2_STAP1	192	196	PF00017	0.386
LIG_SH2_STAT5	104	107	PF00017	0.442
LIG_SH2_STAT5	195	198	PF00017	0.303
LIG_SH3_3	134	140	PF00018	0.442
LIG_SH3_3	200	206	PF00018	0.457
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.442
LIG_TYR_ITIM	102	107	PF00017	0.371
LIG_TYR_ITIM	124	129	PF00017	0.410
MOD_CK1_1	235	241	PF00069	0.490
MOD_CK1_1	32	38	PF00069	0.519
MOD_CK2_1	73	79	PF00069	0.632
MOD_GlcNHglycan	242	245	PF01048	0.626
MOD_GlcNHglycan	31	34	PF01048	0.440
MOD_GSK3_1	162	169	PF00069	0.279
MOD_GSK3_1	216	223	PF00069	0.480
MOD_GSK3_1	232	239	PF00069	0.603
MOD_N-GLC_2	150	152	PF02516	0.327
MOD_NEK2_1	131	136	PF00069	0.240
MOD_NEK2_1	166	171	PF00069	0.355
MOD_NEK2_1	236	241	PF00069	0.538
MOD_PIKK_1	216	222	PF00454	0.544
MOD_PKA_2	14	20	PF00069	0.641
MOD_PKA_2	225	231	PF00069	0.653
MOD_Plk_2-3	73	79	PF00069	0.539
MOD_Plk_4	166	172	PF00069	0.336
MOD_Plk_4	73	79	PF00069	0.539
MOD_ProDKin_1	197	203	PF00069	0.396
TRG_ENDOCYTIC_2	104	107	PF00928	0.279
TRG_ENDOCYTIC_2	126	129	PF00928	0.410
TRG_ENDOCYTIC_2	23	26	PF00928	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F3	Leptomonas seymouri	70%	100%
A0A1X0PB71	Trypanosomatidae	48%	100%
A0A3S7X866	Leishmania donovani	86%	100%
A0A422N4N2	Trypanosoma rangeli	50%	99%
A4IA77	Leishmania infantum	86%	100%
C9ZM32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B590	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2P3	Leishmania major	84%	100%
V5BQF3	Trypanosoma cruzi	51%	100%