Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HB18_LEIBR

TriTrypDb:

LbrM.20.2570 , LBRM2903_200037700

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HB18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.502
CLV_C14_Caspase3-7	137	141	PF00656	0.493
CLV_MEL_PAP_1	28	34	PF00089	0.485
CLV_NRD_NRD_1	104	106	PF00675	0.647
CLV_NRD_NRD_1	111	113	PF00675	0.638
CLV_NRD_NRD_1	214	216	PF00675	0.560
CLV_NRD_NRD_1	253	255	PF00675	0.522
CLV_NRD_NRD_1	288	290	PF00675	0.443
CLV_NRD_NRD_1	30	32	PF00675	0.623
CLV_NRD_NRD_1	356	358	PF00675	0.469
CLV_NRD_NRD_1	410	412	PF00675	0.419
CLV_PCSK_FUR_1	109	113	PF00082	0.602
CLV_PCSK_KEX2_1	104	106	PF00082	0.633
CLV_PCSK_KEX2_1	111	113	PF00082	0.623
CLV_PCSK_KEX2_1	213	215	PF00082	0.567
CLV_PCSK_KEX2_1	253	255	PF00082	0.522
CLV_PCSK_KEX2_1	29	31	PF00082	0.627
CLV_PCSK_KEX2_1	356	358	PF00082	0.469
CLV_PCSK_KEX2_1	367	369	PF00082	0.338
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.320
CLV_PCSK_PC7_1	100	106	PF00082	0.458
CLV_PCSK_SKI1_1	367	371	PF00082	0.438
DEG_SPOP_SBC_1	147	151	PF00917	0.545
DOC_ANK_TNKS_1	30	37	PF00023	0.488
DOC_CKS1_1	270	275	PF01111	0.502
DOC_MAPK_gen_1	213	225	PF00069	0.499
DOC_MAPK_gen_1	232	241	PF00069	0.463
DOC_MAPK_gen_1	356	363	PF00069	0.437
DOC_MAPK_gen_1	367	375	PF00069	0.375
DOC_MAPK_HePTP_8	231	243	PF00069	0.462
DOC_MAPK_MEF2A_6	234	243	PF00069	0.474
DOC_MAPK_MEF2A_6	326	334	PF00069	0.460
DOC_MAPK_MEF2A_6	368	377	PF00069	0.341
DOC_MAPK_RevD_3	38	53	PF00069	0.479
DOC_PIKK_1	66	74	PF02985	0.591
DOC_USP7_MATH_1	123	127	PF00917	0.487
DOC_USP7_MATH_1	138	142	PF00917	0.540
DOC_USP7_MATH_1	147	151	PF00917	0.540
DOC_USP7_MATH_1	161	165	PF00917	0.618
DOC_USP7_MATH_1	167	171	PF00917	0.634
DOC_WW_Pin1_4	121	126	PF00397	0.610
DOC_WW_Pin1_4	254	259	PF00397	0.595
DOC_WW_Pin1_4	269	274	PF00397	0.599
DOC_WW_Pin1_4	381	386	PF00397	0.457
LIG_14-3-3_CanoR_1	13	20	PF00244	0.510
LIG_14-3-3_CanoR_1	162	166	PF00244	0.574
LIG_14-3-3_CanoR_1	169	177	PF00244	0.534
LIG_14-3-3_CanoR_1	234	241	PF00244	0.469
LIG_14-3-3_CanoR_1	289	295	PF00244	0.538
LIG_14-3-3_CanoR_1	29	39	PF00244	0.568
LIG_14-3-3_CanoR_1	368	375	PF00244	0.361
LIG_14-3-3_CanoR_1	393	398	PF00244	0.436
LIG_BRCT_BRCA1_1	330	334	PF00533	0.287
LIG_BRCT_BRCA1_2	330	336	PF00533	0.294
LIG_FHA_1	193	199	PF00498	0.625
LIG_FHA_1	368	374	PF00498	0.363
LIG_FHA_2	135	141	PF00498	0.577
LIG_FHA_2	169	175	PF00498	0.622
LIG_FHA_2	177	183	PF00498	0.629
LIG_FHA_2	62	68	PF00498	0.570
LIG_GBD_Chelix_1	98	106	PF00786	0.454
LIG_KLC1_Yacidic_2	67	72	PF13176	0.473
LIG_LIR_Gen_1	277	286	PF02991	0.538
LIG_LIR_Gen_1	8	16	PF02991	0.602
LIG_LIR_Nem_3	277	281	PF02991	0.550
LIG_LIR_Nem_3	8	12	PF02991	0.618
LIG_SH2_STAP1	296	300	PF00017	0.426
LIG_SH2_STAT5	216	219	PF00017	0.496
LIG_SH2_STAT5	354	357	PF00017	0.484
LIG_SH2_STAT5	70	73	PF00017	0.581
LIG_SH3_3	172	178	PF00018	0.548
LIG_SH3_3	260	266	PF00018	0.614
LIG_SH3_3	35	41	PF00018	0.496
LIG_SUMO_SIM_par_1	359	364	PF11976	0.418
LIG_SUMO_SIM_par_1	44	51	PF11976	0.553
LIG_TRAF2_1	156	159	PF00917	0.562
LIG_TRAF2_1	170	173	PF00917	0.530
LIG_UBA3_1	284	290	PF00899	0.410
LIG_UBA3_1	360	367	PF00899	0.280
LIG_WW_2	38	41	PF00397	0.499
MOD_CDK_SPxxK_3	254	261	PF00069	0.560
MOD_CK1_1	143	149	PF00069	0.604
MOD_CK1_1	151	157	PF00069	0.687
MOD_CK1_1	176	182	PF00069	0.630
MOD_CK1_1	257	263	PF00069	0.623
MOD_CK1_1	277	283	PF00069	0.379
MOD_CK2_1	153	159	PF00069	0.563
MOD_CK2_1	167	173	PF00069	0.592
MOD_CK2_1	176	182	PF00069	0.676
MOD_CK2_1	337	343	PF00069	0.304
MOD_GlcNHglycan	134	137	PF01048	0.581
MOD_GlcNHglycan	14	17	PF01048	0.441
MOD_GlcNHglycan	243	246	PF01048	0.527
MOD_GlcNHglycan	249	252	PF01048	0.619
MOD_GlcNHglycan	32	35	PF01048	0.450
MOD_GlcNHglycan	362	366	PF01048	0.414
MOD_GSK3_1	123	130	PF00069	0.637
MOD_GSK3_1	134	141	PF00069	0.578
MOD_GSK3_1	143	150	PF00069	0.584
MOD_GSK3_1	173	180	PF00069	0.595
MOD_GSK3_1	221	228	PF00069	0.409
MOD_GSK3_1	239	246	PF00069	0.761
MOD_GSK3_1	265	272	PF00069	0.613
MOD_GSK3_1	72	79	PF00069	0.535
MOD_NEK2_1	12	17	PF00069	0.533
MOD_NEK2_1	243	248	PF00069	0.629
MOD_NEK2_1	334	339	PF00069	0.366
MOD_NEK2_1	361	366	PF00069	0.410
MOD_NEK2_1	380	385	PF00069	0.339
MOD_PIKK_1	233	239	PF00454	0.461
MOD_PKA_1	30	36	PF00069	0.488
MOD_PKA_1	367	373	PF00069	0.318
MOD_PKA_2	12	18	PF00069	0.551
MOD_PKA_2	161	167	PF00069	0.594
MOD_PKA_2	168	174	PF00069	0.591
MOD_PKA_2	233	239	PF00069	0.547
MOD_PKA_2	252	258	PF00069	0.518
MOD_PKA_2	30	36	PF00069	0.565
MOD_PKA_2	367	373	PF00069	0.318
MOD_PKA_2	392	398	PF00069	0.430
MOD_Plk_1	173	179	PF00069	0.584
MOD_Plk_1	7	13	PF00069	0.543
MOD_Plk_1	72	78	PF00069	0.692
MOD_Plk_2-3	168	174	PF00069	0.594
MOD_Plk_4	123	129	PF00069	0.560
MOD_Plk_4	265	271	PF00069	0.600
MOD_Plk_4	274	280	PF00069	0.522
MOD_Plk_4	41	47	PF00069	0.515
MOD_ProDKin_1	121	127	PF00069	0.612
MOD_ProDKin_1	254	260	PF00069	0.596
MOD_ProDKin_1	269	275	PF00069	0.595
MOD_ProDKin_1	381	387	PF00069	0.448
MOD_SUMO_rev_2	48	55	PF00179	0.474
TRG_DiLeu_BaEn_4	188	194	PF01217	0.623
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.393
TRG_ER_diArg_1	104	106	PF00400	0.552
TRG_ER_diArg_1	108	111	PF00400	0.581
TRG_ER_diArg_1	212	215	PF00400	0.567
TRG_ER_diArg_1	28	31	PF00400	0.570
TRG_ER_diArg_1	355	357	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH6	Leptomonas seymouri	42%	100%
A0A3Q8IIQ7	Leishmania donovani	68%	99%
A4IA75	Leishmania infantum	68%	99%
E9B588	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q2P5	Leishmania major	67%	100%