DM10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside diphosphate kinase 3

Species:

Leishmania braziliensis

UniProt:

A4HB17_LEIBR

TriTrypDb:

LbrM.20.2560 , LBRM2903_200037600

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HB17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB17

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0004550	nucleoside diphosphate kinase activity	5	9
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	9
GO:0019205	nucleobase-containing compound kinase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.459
CLV_C14_Caspase3-7	53	57	PF00656	0.259
CLV_PCSK_KEX2_1	51	53	PF00082	0.377
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.397
CLV_PCSK_PC7_1	47	53	PF00082	0.415
CLV_PCSK_SKI1_1	256	260	PF00082	0.212
CLV_PCSK_SKI1_1	338	342	PF00082	0.305
CLV_PCSK_SKI1_1	9	13	PF00082	0.327
DEG_APCC_DBOX_1	255	263	PF00400	0.507
DEG_SPOP_SBC_1	57	61	PF00917	0.266
DOC_MAPK_gen_1	191	200	PF00069	0.409
DOC_MAPK_RevD_3	38	52	PF00069	0.492
DOC_PP4_FxxP_1	139	142	PF00568	0.317
DOC_PP4_FxxP_1	201	204	PF00568	0.384
DOC_PP4_FxxP_1	251	254	PF00568	0.439
DOC_PP4_FxxP_1	71	74	PF00568	0.467
DOC_SPAK_OSR1_1	120	124	PF12202	0.359
DOC_USP7_MATH_1	104	108	PF00917	0.468
DOC_USP7_MATH_1	204	208	PF00917	0.317
DOC_USP7_MATH_1	254	258	PF00917	0.550
DOC_USP7_MATH_1	58	62	PF00917	0.408
DOC_USP7_MATH_1	90	94	PF00917	0.411
DOC_USP7_UBL2_3	305	309	PF12436	0.522
LIG_14-3-3_CanoR_1	63	69	PF00244	0.467
LIG_Actin_WH2_2	36	53	PF00022	0.431
LIG_APCC_ABBA_1	129	134	PF00400	0.358
LIG_APCC_ABBA_1	198	203	PF00400	0.287
LIG_BIR_II_1	1	5	PF00653	0.456
LIG_FHA_1	1	7	PF00498	0.617
LIG_FHA_1	146	152	PF00498	0.333
LIG_FHA_1	193	199	PF00498	0.460
LIG_FHA_1	35	41	PF00498	0.401
LIG_FHA_1	65	71	PF00498	0.385
LIG_FHA_1	83	89	PF00498	0.301
LIG_FHA_1	94	100	PF00498	0.327
LIG_FHA_2	122	128	PF00498	0.380
LIG_FHA_2	174	180	PF00498	0.452
LIG_FHA_2	281	287	PF00498	0.475
LIG_FHA_2	51	57	PF00498	0.336
LIG_LIR_Apic_2	137	142	PF02991	0.440
LIG_LIR_Apic_2	250	254	PF02991	0.442
LIG_LIR_Gen_1	102	113	PF02991	0.344
LIG_LIR_Gen_1	162	172	PF02991	0.444
LIG_LIR_Gen_1	236	246	PF02991	0.467
LIG_LIR_LC3C_4	148	152	PF02991	0.185
LIG_LIR_Nem_3	102	108	PF02991	0.392
LIG_LIR_Nem_3	162	168	PF02991	0.430
LIG_LIR_Nem_3	236	241	PF02991	0.467
LIG_LIR_Nem_3	253	258	PF02991	0.453
LIG_LIR_Nem_3	267	272	PF02991	0.470
LIG_MYND_3	259	263	PF01753	0.413
LIG_NRBOX	224	230	PF00104	0.402
LIG_REV1ctd_RIR_1	337	343	PF16727	0.363
LIG_SH2_CRK	255	259	PF00017	0.433
LIG_SH2_CRK	298	302	PF00017	0.522
LIG_SH2_GRB2like	33	36	PF00017	0.243
LIG_SH2_SRC	33	36	PF00017	0.289
LIG_SH2_STAP1	298	302	PF00017	0.522
LIG_SH2_STAP1	336	340	PF00017	0.433
LIG_SH2_STAT5	111	114	PF00017	0.342
LIG_SH2_STAT5	31	34	PF00017	0.382
LIG_SH2_STAT5	49	52	PF00017	0.332
LIG_SH3_3	16	22	PF00018	0.562
LIG_SH3_3	207	213	PF00018	0.427
LIG_SH3_3	291	297	PF00018	0.406
LIG_SH3_3	52	58	PF00018	0.360
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.445
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.435
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.426
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.467
LIG_SUMO_SIM_par_1	150	156	PF11976	0.447
LIG_SUMO_SIM_par_1	277	283	PF11976	0.432
LIG_SUMO_SIM_par_1	36	42	PF11976	0.450
LIG_SUMO_SIM_par_1	93	103	PF11976	0.411
LIG_WRC_WIRS_1	266	271	PF05994	0.381
MOD_CK1_1	280	286	PF00069	0.512
MOD_CK1_1	93	99	PF00069	0.363
MOD_CK2_1	121	127	PF00069	0.432
MOD_GlcNHglycan	136	139	PF01048	0.455
MOD_GlcNHglycan	216	219	PF01048	0.291
MOD_GlcNHglycan	222	225	PF01048	0.284
MOD_GlcNHglycan	244	247	PF01048	0.273
MOD_GlcNHglycan	44	47	PF01048	0.480
MOD_GSK3_1	233	240	PF00069	0.485
MOD_GSK3_1	90	97	PF00069	0.464
MOD_N-GLC_1	204	209	PF02516	0.293
MOD_N-GLC_1	34	39	PF02516	0.389
MOD_NEK2_1	1	6	PF00069	0.462
MOD_NEK2_1	121	126	PF00069	0.333
MOD_NEK2_1	145	150	PF00069	0.348
MOD_NEK2_1	262	267	PF00069	0.454
MOD_NEK2_1	50	55	PF00069	0.378
MOD_NEK2_2	58	63	PF00069	0.367
MOD_PKA_2	119	125	PF00069	0.357
MOD_Plk_1	204	210	PF00069	0.278
MOD_Plk_1	93	99	PF00069	0.366
MOD_Plk_2-3	34	40	PF00069	0.367
MOD_Plk_4	204	210	PF00069	0.278
MOD_Plk_4	265	271	PF00069	0.496
MOD_Plk_4	297	303	PF00069	0.506
MOD_Plk_4	64	70	PF00069	0.361
MOD_Plk_4	72	78	PF00069	0.336
MOD_Plk_4	94	100	PF00069	0.324
TRG_ENDOCYTIC_2	111	114	PF00928	0.354
TRG_ENDOCYTIC_2	255	258	PF00928	0.427
TRG_ENDOCYTIC_2	298	301	PF00928	0.522
TRG_ENDOCYTIC_2	336	339	PF00928	0.447
TRG_ER_diArg_1	311	314	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	71%	100%
A0A0N1PC23	Leptomonas seymouri	30%	100%
A0A0S4IXH2	Bodo saltans	30%	100%
A0A1X0P5C0	Trypanosomatidae	32%	100%
A0A1X0PAT4	Trypanosomatidae	45%	98%
A0A3Q8IJQ8	Leishmania donovani	29%	100%
A0A3R7M6K1	Trypanosoma rangeli	46%	99%
A0A3R7N390	Trypanosoma rangeli	31%	100%
A0A3S7X855	Leishmania donovani	84%	100%
A4HN58	Leishmania braziliensis	29%	100%
A4IA74	Leishmania infantum	84%	100%
A4IBS5	Leishmania infantum	29%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AFL1	Leishmania major	29%	100%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q2P6	Leishmania major	82%	100%
Q5E9Y9	Bos taurus	25%	91%
Q9QXL7	Rattus norvegicus	26%	87%
Q9QXL8	Mus musculus	25%	87%
Q9Y5B8	Homo sapiens	25%	91%
V5BXY9	Trypanosoma cruzi	30%	99%
V5DLW4	Trypanosoma cruzi	44%	98%