Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HB16_LEIBR

TriTrypDb:

LbrM.20.2550 , LBRM2903_200037500

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.509
CLV_NRD_NRD_1	163	165	PF00675	0.455
CLV_NRD_NRD_1	183	185	PF00675	0.280
CLV_PCSK_KEX2_1	165	167	PF00082	0.460
CLV_PCSK_KEX2_1	174	176	PF00082	0.369
CLV_PCSK_KEX2_1	188	190	PF00082	0.435
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.525
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.521
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.551
CLV_PCSK_PC7_1	184	190	PF00082	0.535
CLV_Separin_Metazoa	42	46	PF03568	0.339
DOC_MAPK_gen_1	153	162	PF00069	0.527
DOC_MAPK_gen_1	164	173	PF00069	0.518
DOC_MAPK_gen_1	174	180	PF00069	0.517
DOC_MAPK_MEF2A_6	164	173	PF00069	0.491
DOC_MAPK_NFAT4_5	166	174	PF00069	0.489
DOC_USP7_MATH_1	128	132	PF00917	0.465
DOC_USP7_MATH_1	50	54	PF00917	0.524
LIG_14-3-3_CanoR_1	122	128	PF00244	0.489
LIG_14-3-3_CanoR_1	26	35	PF00244	0.515
LIG_Actin_WH2_2	109	126	PF00022	0.341
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	61	65	PF00533	0.538
LIG_FAT_LD_1	78	86	PF03623	0.515
LIG_FHA_1	118	124	PF00498	0.480
LIG_Integrin_isoDGR_2	54	56	PF01839	0.483
LIG_LIR_Nem_3	140	144	PF02991	0.485
LIG_NRBOX	39	45	PF00104	0.325
LIG_NRBOX	77	83	PF00104	0.313
LIG_NRP_CendR_1	188	191	PF00754	0.536
LIG_RPA_C_Fungi	172	184	PF08784	0.319
LIG_SH2_STAT3	144	147	PF00017	0.487
LIG_SH2_STAT5	144	147	PF00017	0.487
LIG_SH2_STAT5	84	87	PF00017	0.409
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.618
LIG_SUMO_SIM_par_1	158	163	PF11976	0.523
MOD_CK1_1	131	137	PF00069	0.443
MOD_CK1_1	68	74	PF00069	0.509
MOD_GlcNHglycan	130	133	PF01048	0.430
MOD_GlcNHglycan	134	137	PF01048	0.396
MOD_GlcNHglycan	61	64	PF01048	0.737
MOD_GlcNHglycan	68	71	PF01048	0.640
MOD_GSK3_1	128	135	PF00069	0.418
MOD_GSK3_1	59	66	PF00069	0.685
MOD_N-GLC_2	148	150	PF02516	0.310
MOD_NEK2_1	123	128	PF00069	0.523
MOD_NEK2_1	65	70	PF00069	0.672
MOD_PKA_1	184	190	PF00069	0.414
MOD_PKA_2	27	33	PF00069	0.533
MOD_PKB_1	182	190	PF00069	0.334
MOD_Plk_2-3	6	12	PF00069	0.658
MOD_Plk_4	6	12	PF00069	0.658
MOD_SUMO_rev_2	131	141	PF00179	0.488
MOD_SUMO_rev_2	167	176	PF00179	0.421
TRG_DiLeu_BaEn_1	111	116	PF01217	0.351
TRG_DiLeu_BaEn_1	6	11	PF01217	0.620
TRG_ER_diArg_1	175	178	PF00400	0.475
TRG_NLS_Bipartite_1	164	178	PF00514	0.543
TRG_NLS_MonoExtC_3	173	179	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR9	Leptomonas seymouri	65%	100%
A0A3Q8IEJ0	Leishmania donovani	76%	100%
A0A3R7NC13	Trypanosoma rangeli	30%	100%
A4IA73	Leishmania infantum	75%	100%
C9ZM34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B586	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q2P7	Leishmania major	74%	95%
V5B5F2	Trypanosoma cruzi	32%	100%