TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HB15_LEIBR

TriTrypDb:

LbrM.20.2540 , LBRM2903_200037400

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.491
CLV_PCSK_KEX2_1	70	72	PF00082	0.491
CLV_PCSK_SKI1_1	124	128	PF00082	0.500
DEG_APCC_DBOX_1	221	229	PF00400	0.628
DEG_Nend_Nbox_1	1	3	PF02207	0.779
DOC_MAPK_gen_1	219	228	PF00069	0.627
DOC_MAPK_HePTP_8	121	133	PF00069	0.557
DOC_MAPK_MEF2A_6	124	133	PF00069	0.652
DOC_PP4_FxxP_1	134	137	PF00568	0.572
DOC_SPAK_OSR1_1	102	106	PF12202	0.604
DOC_SPAK_OSR1_1	89	93	PF12202	0.748
DOC_USP7_MATH_1	194	198	PF00917	0.639
DOC_USP7_MATH_1	63	67	PF00917	0.757
LIG_14-3-3_CanoR_1	188	193	PF00244	0.745
LIG_Actin_RPEL_3	82	101	PF02755	0.720
LIG_Actin_WH2_2	105	122	PF00022	0.677
LIG_APCC_ABBA_1	131	136	PF00400	0.569
LIG_Clathr_ClatBox_1	100	104	PF01394	0.744
LIG_deltaCOP1_diTrp_1	79	84	PF00928	0.560
LIG_EH1_1	89	97	PF00400	0.749
LIG_eIF4E_1	128	134	PF01652	0.557
LIG_eIF4E_1	146	152	PF01652	0.740
LIG_eIF4E_1	45	51	PF01652	0.513
LIG_FHA_1	14	20	PF00498	0.507
LIG_FHA_2	142	148	PF00498	0.583
LIG_GBD_Chelix_1	42	50	PF00786	0.398
LIG_NRBOX	22	28	PF00104	0.513
LIG_SH2_NCK_1	146	150	PF00017	0.735
LIG_SH2_PTP2	128	131	PF00017	0.650
LIG_SH2_SRC	146	149	PF00017	0.552
LIG_SH2_STAT5	113	116	PF00017	0.686
LIG_SH2_STAT5	128	131	PF00017	0.650
LIG_SH2_STAT5	45	48	PF00017	0.411
LIG_SH3_3	119	125	PF00018	0.749
LIG_SUMO_SIM_par_1	25	30	PF11976	0.513
LIG_TRAF2_2	194	199	PF00917	0.638
LIG_UBA3_1	151	160	PF00899	0.598
MOD_CK1_1	141	147	PF00069	0.651
MOD_CK1_1	197	203	PF00069	0.627
MOD_CK1_1	66	72	PF00069	0.572
MOD_CK2_1	147	153	PF00069	0.630
MOD_CMANNOS	81	84	PF00535	0.359
MOD_GlcNHglycan	114	117	PF01048	0.400
MOD_GlcNHglycan	164	167	PF01048	0.508
MOD_GlcNHglycan	183	186	PF01048	0.379
MOD_GlcNHglycan	196	199	PF01048	0.543
MOD_GSK3_1	147	154	PF00069	0.635
MOD_GSK3_1	158	165	PF00069	0.764
MOD_GSK3_1	188	195	PF00069	0.744
MOD_N-GLC_1	203	208	PF02516	0.541
MOD_N-GLC_1	217	222	PF02516	0.497
MOD_N-GLC_1	57	62	PF02516	0.425
MOD_NEK2_1	112	117	PF00069	0.581
MOD_NEK2_1	151	156	PF00069	0.590
MOD_NEK2_1	187	192	PF00069	0.632
MOD_NEK2_1	217	222	PF00069	0.707
MOD_NEK2_1	27	32	PF00069	0.513
MOD_NEK2_2	57	62	PF00069	0.454
MOD_PIKK_1	138	144	PF00454	0.560
MOD_PIKK_1	192	198	PF00454	0.639
MOD_PIKK_1	63	69	PF00454	0.680
MOD_PIKK_1	7	13	PF00454	0.718
MOD_PKA_2	187	193	PF00069	0.740
MOD_Plk_1	57	63	PF00069	0.430
MOD_Plk_2-3	147	153	PF00069	0.568
MOD_Plk_4	147	153	PF00069	0.592
MOD_SUMO_rev_2	68	77	PF00179	0.574
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.579
TRG_ENDOCYTIC_2	128	131	PF00928	0.684
TRG_ENDOCYTIC_2	45	48	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS2	Leptomonas seymouri	56%	100%
A0A3Q8IUS4	Leishmania donovani	69%	100%
A4IA72	Leishmania infantum	69%	100%
E9B585	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q2P8	Leishmania major	69%	100%