EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4HB14_LEIBR

TriTrypDb:

LbrM.20.2530 , LBRM2903_200037300

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB14

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.328
CLV_NRD_NRD_1	103	105	PF00675	0.414
CLV_NRD_NRD_1	151	153	PF00675	0.566
CLV_NRD_NRD_1	237	239	PF00675	0.413
CLV_NRD_NRD_1	359	361	PF00675	0.608
CLV_NRD_NRD_1	57	59	PF00675	0.262
CLV_PCSK_KEX2_1	19	21	PF00082	0.419
CLV_PCSK_KEX2_1	57	59	PF00082	0.262
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.502
CLV_PCSK_SKI1_1	19	23	PF00082	0.413
CLV_PCSK_SKI1_1	239	243	PF00082	0.510
CLV_PCSK_SKI1_1	332	336	PF00082	0.427
CLV_PCSK_SKI1_1	370	374	PF00082	0.469
CLV_PCSK_SKI1_1	57	61	PF00082	0.390
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DOC_CYCLIN_RxL_1	16	26	PF00134	0.434
DOC_CYCLIN_RxL_1	262	270	PF00134	0.433
DOC_MAPK_gen_1	17	24	PF00069	0.431
DOC_PP1_RVXF_1	17	24	PF00149	0.443
DOC_PP2B_LxvP_1	296	299	PF13499	0.505
DOC_PP2B_LxvP_1	323	326	PF13499	0.459
DOC_USP7_MATH_1	179	183	PF00917	0.461
DOC_USP7_MATH_1	202	206	PF00917	0.525
DOC_USP7_MATH_1	263	267	PF00917	0.461
DOC_USP7_MATH_1	274	278	PF00917	0.533
DOC_USP7_MATH_1	299	303	PF00917	0.549
DOC_USP7_MATH_1	326	330	PF00917	0.428
DOC_WW_Pin1_4	23	28	PF00397	0.608
DOC_WW_Pin1_4	324	329	PF00397	0.491
DOC_WW_Pin1_4	363	368	PF00397	0.601
DOC_WW_Pin1_4	98	103	PF00397	0.389
LIG_Actin_WH2_2	88	106	PF00022	0.486
LIG_BRCT_BRCA1_1	340	344	PF00533	0.513
LIG_eIF4E_1	319	325	PF01652	0.490
LIG_FHA_1	16	22	PF00498	0.393
LIG_FHA_1	88	94	PF00498	0.382
LIG_FHA_2	145	151	PF00498	0.544
LIG_FHA_2	156	162	PF00498	0.556
LIG_FHA_2	307	313	PF00498	0.331
LIG_FHA_2	373	379	PF00498	0.487
LIG_FHA_2	75	81	PF00498	0.449
LIG_LIR_Apic_2	348	354	PF02991	0.515
LIG_LIR_Gen_1	157	165	PF02991	0.330
LIG_LIR_Gen_1	188	198	PF02991	0.417
LIG_LIR_Gen_1	406	413	PF02991	0.454
LIG_LIR_Gen_1	90	100	PF02991	0.470
LIG_LIR_Nem_3	157	162	PF02991	0.332
LIG_LIR_Nem_3	173	178	PF02991	0.367
LIG_LIR_Nem_3	188	194	PF02991	0.372
LIG_LIR_Nem_3	406	412	PF02991	0.476
LIG_LIR_Nem_3	90	95	PF02991	0.470
LIG_Pex14_1	340	344	PF04695	0.486
LIG_Pex14_2	155	159	PF04695	0.408
LIG_Pex14_2	373	377	PF04695	0.404
LIG_RPA_C_Fungi	233	245	PF08784	0.536
LIG_SH2_CRK	178	182	PF00017	0.375
LIG_SH2_CRK	351	355	PF00017	0.505
LIG_SH2_STAP1	320	324	PF00017	0.490
LIG_SH2_STAT3	396	399	PF00017	0.465
LIG_SH2_STAT5	297	300	PF00017	0.422
LIG_SH2_STAT5	396	399	PF00017	0.428
LIG_SH3_1	361	367	PF00018	0.337
LIG_SH3_3	295	301	PF00018	0.307
LIG_SH3_3	361	367	PF00018	0.337
LIG_SUMO_SIM_anti_2	187	196	PF11976	0.392
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.475
LIG_SUMO_SIM_par_1	254	260	PF11976	0.496
LIG_TRAF2_1	170	173	PF00917	0.383
LIG_TRAF2_1	354	357	PF00917	0.442
LIG_TRAF2_1	66	69	PF00917	0.377
LIG_UBA3_1	75	84	PF00899	0.475
LIG_WRC_WIRS_1	33	38	PF05994	0.538
MOD_CDC14_SPxK_1	101	104	PF00782	0.481
MOD_CDK_SPxK_1	98	104	PF00069	0.383
MOD_CDK_SPxxK_3	363	370	PF00069	0.593
MOD_CDK_SPxxK_3	98	105	PF00069	0.425
MOD_CK1_1	157	163	PF00069	0.466
MOD_CK1_1	222	228	PF00069	0.603
MOD_CK2_1	144	150	PF00069	0.535
MOD_CK2_1	155	161	PF00069	0.484
MOD_CK2_1	167	173	PF00069	0.393
MOD_CK2_1	225	231	PF00069	0.544
MOD_CK2_1	299	305	PF00069	0.539
MOD_CK2_1	49	55	PF00069	0.396
MOD_CK2_1	63	69	PF00069	0.308
MOD_GlcNHglycan	169	172	PF01048	0.484
MOD_GlcNHglycan	242	245	PF01048	0.548
MOD_GlcNHglycan	259	262	PF01048	0.378
MOD_GlcNHglycan	27	30	PF01048	0.448
MOD_GlcNHglycan	328	331	PF01048	0.524
MOD_GlcNHglycan	399	402	PF01048	0.493
MOD_GlcNHglycan	51	54	PF01048	0.392
MOD_GSK3_1	11	18	PF00069	0.423
MOD_GSK3_1	202	209	PF00069	0.482
MOD_GSK3_1	240	247	PF00069	0.496
MOD_GSK3_1	263	270	PF00069	0.470
MOD_GSK3_1	32	39	PF00069	0.479
MOD_GSK3_1	83	90	PF00069	0.444
MOD_N-GLC_1	63	68	PF02516	0.437
MOD_N-GLC_1	98	103	PF02516	0.472
MOD_NEK2_1	11	16	PF00069	0.459
MOD_NEK2_1	155	160	PF00069	0.414
MOD_NEK2_1	208	213	PF00069	0.484
MOD_NEK2_1	267	272	PF00069	0.492
MOD_NEK2_1	36	41	PF00069	0.519
MOD_NEK2_1	46	51	PF00069	0.458
MOD_PIKK_1	46	52	PF00454	0.584
MOD_Plk_1	187	193	PF00069	0.393
MOD_Plk_1	225	231	PF00069	0.543
MOD_Plk_1	63	69	PF00069	0.421
MOD_Plk_2-3	120	126	PF00069	0.306
MOD_Plk_4	187	193	PF00069	0.391
MOD_Plk_4	244	250	PF00069	0.444
MOD_Plk_4	299	305	PF00069	0.505
MOD_ProDKin_1	23	29	PF00069	0.603
MOD_ProDKin_1	324	330	PF00069	0.490
MOD_ProDKin_1	363	369	PF00069	0.594
MOD_ProDKin_1	98	104	PF00069	0.383
MOD_SUMO_rev_2	160	170	PF00179	0.552
MOD_SUMO_rev_2	341	349	PF00179	0.424
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.403
TRG_ENDOCYTIC_2	178	181	PF00928	0.375
TRG_ENDOCYTIC_2	320	323	PF00928	0.372
TRG_ER_diArg_1	56	58	PF00400	0.262
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R2	Leptomonas seymouri	66%	100%
A0A0S4J207	Bodo saltans	33%	97%
A0A1X0PAP2	Trypanosomatidae	40%	100%
A0A3Q8IHP2	Leishmania donovani	84%	100%
A0A422N4H8	Trypanosoma rangeli	42%	100%
A4IA71	Leishmania infantum	84%	100%
C9ZM35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B584	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2P9	Leishmania major	83%	100%
V5B5A3	Trypanosoma cruzi	42%	100%