LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HB13_LEIBR
TriTrypDb:
LbrM.20.2520 , LBRM2903_200037200
Length:
294

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 150 152 PF00675 0.591
CLV_NRD_NRD_1 214 216 PF00675 0.521
CLV_NRD_NRD_1 288 290 PF00675 0.501
CLV_NRD_NRD_1 36 38 PF00675 0.526
CLV_NRD_NRD_1 51 53 PF00675 0.629
CLV_NRD_NRD_1 8 10 PF00675 0.721
CLV_PCSK_KEX2_1 120 122 PF00082 0.665
CLV_PCSK_KEX2_1 150 152 PF00082 0.644
CLV_PCSK_KEX2_1 35 37 PF00082 0.543
CLV_PCSK_KEX2_1 51 53 PF00082 0.643
CLV_PCSK_KEX2_1 8 10 PF00082 0.721
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.689
CLV_PCSK_PC1ET2_1 150 152 PF00082 0.662
CLV_PCSK_SKI1_1 191 195 PF00082 0.570
CLV_PCSK_SKI1_1 219 223 PF00082 0.440
CLV_PCSK_SKI1_1 261 265 PF00082 0.504
CLV_PCSK_SKI1_1 41 45 PF00082 0.658
DEG_APCC_KENBOX_2 221 225 PF00400 0.370
DOC_MAPK_RevD_3 23 36 PF00069 0.389
DOC_PP4_FxxP_1 65 68 PF00568 0.676
DOC_USP7_MATH_1 115 119 PF00917 0.642
DOC_USP7_MATH_1 12 16 PF00917 0.468
DOC_WW_Pin1_4 145 150 PF00397 0.642
DOC_WW_Pin1_4 200 205 PF00397 0.416
LIG_14-3-3_CanoR_1 114 124 PF00244 0.626
LIG_14-3-3_CanoR_1 280 286 PF00244 0.721
LIG_BIR_II_1 1 5 PF00653 0.636
LIG_BRCT_BRCA1_1 275 279 PF00533 0.586
LIG_BRCT_BRCA1_1 83 87 PF00533 0.556
LIG_CtBP_PxDLS_1 177 181 PF00389 0.478
LIG_eIF4E_1 124 130 PF01652 0.439
LIG_eIF4E_1 205 211 PF01652 0.388
LIG_FHA_1 192 198 PF00498 0.674
LIG_FHA_1 92 98 PF00498 0.606
LIG_FHA_2 56 62 PF00498 0.704
LIG_IBAR_NPY_1 273 275 PF08397 0.573
LIG_LIR_Apic_2 198 204 PF02991 0.547
LIG_LIR_Gen_1 203 211 PF02991 0.450
LIG_LIR_Gen_1 94 104 PF02991 0.650
LIG_LIR_Nem_3 20 26 PF02991 0.498
LIG_LIR_Nem_3 203 208 PF02991 0.501
LIG_LIR_Nem_3 74 80 PF02991 0.613
LIG_SH2_CRK 205 209 PF00017 0.556
LIG_SH2_CRK 275 279 PF00017 0.619
LIG_SH2_NCK_1 275 279 PF00017 0.619
LIG_SH2_PTP2 201 204 PF00017 0.551
LIG_SH2_STAP1 275 279 PF00017 0.586
LIG_SH2_STAT3 234 237 PF00017 0.649
LIG_SH2_STAT5 138 141 PF00017 0.469
LIG_SH2_STAT5 201 204 PF00017 0.573
LIG_SH3_1 21 27 PF00018 0.533
LIG_SH3_3 21 27 PF00018 0.573
LIG_SUMO_SIM_par_1 255 260 PF11976 0.591
LIG_TYR_ITSM 73 80 PF00017 0.682
MOD_CDC14_SPxK_1 148 151 PF00782 0.411
MOD_CDK_SPK_2 145 150 PF00069 0.405
MOD_CDK_SPxK_1 145 151 PF00069 0.406
MOD_CDK_SPxxK_3 145 152 PF00069 0.408
MOD_CDK_SPxxK_3 200 207 PF00069 0.412
MOD_CK1_1 281 287 PF00069 0.557
MOD_CK1_1 3 9 PF00069 0.505
MOD_CK2_1 178 184 PF00069 0.528
MOD_CK2_1 55 61 PF00069 0.702
MOD_Cter_Amidation 49 52 PF01082 0.699
MOD_GlcNHglycan 117 120 PF01048 0.617
MOD_GlcNHglycan 197 200 PF01048 0.689
MOD_GSK3_1 134 141 PF00069 0.634
MOD_GSK3_1 191 198 PF00069 0.685
MOD_GSK3_1 257 264 PF00069 0.401
MOD_GSK3_1 274 281 PF00069 0.584
MOD_GSK3_1 68 75 PF00069 0.464
MOD_GSK3_1 87 94 PF00069 0.557
MOD_N-GLC_1 189 194 PF02516 0.596
MOD_N-GLC_1 211 216 PF02516 0.552
MOD_N-GLC_1 223 228 PF02516 0.564
MOD_N-GLC_1 281 286 PF02516 0.476
MOD_NEK2_1 189 194 PF00069 0.605
MOD_NEK2_1 210 215 PF00069 0.550
MOD_NEK2_1 233 238 PF00069 0.531
MOD_NEK2_1 243 248 PF00069 0.445
MOD_NEK2_1 70 75 PF00069 0.677
MOD_NEK2_1 99 104 PF00069 0.665
MOD_NEK2_2 274 279 PF00069 0.590
MOD_PIKK_1 233 239 PF00454 0.602
MOD_PIKK_1 3 9 PF00454 0.486
MOD_PKA_1 120 126 PF00069 0.612
MOD_PKA_2 120 126 PF00069 0.643
MOD_PKA_2 195 201 PF00069 0.696
MOD_Plk_1 189 195 PF00069 0.672
MOD_Plk_1 261 267 PF00069 0.540
MOD_Plk_1 281 287 PF00069 0.479
MOD_Plk_4 134 140 PF00069 0.572
MOD_Plk_4 226 232 PF00069 0.650
MOD_Plk_4 274 280 PF00069 0.595
MOD_Plk_4 99 105 PF00069 0.656
MOD_ProDKin_1 145 151 PF00069 0.642
MOD_ProDKin_1 200 206 PF00069 0.413
TRG_DiLeu_BaEn_2 37 43 PF01217 0.673
TRG_ENDOCYTIC_2 205 208 PF00928 0.598
TRG_ENDOCYTIC_2 275 278 PF00928 0.613
TRG_ENDOCYTIC_2 77 80 PF00928 0.606
TRG_ER_diArg_1 151 154 PF00400 0.642
TRG_ER_diArg_1 34 37 PF00400 0.531
TRG_NLS_MonoCore_2 149 154 PF00514 0.431
TRG_NLS_MonoExtC_3 150 155 PF00514 0.490
TRG_NLS_MonoExtN_4 149 155 PF00514 0.551
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 219 223 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 41 46 PF00026 0.691

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAU8 Leptomonas seymouri 63% 100%
A0A1X0PA38 Trypanosomatidae 29% 100%
A0A3Q8ILA3 Leishmania donovani 73% 96%
A0A3R7KSA4 Trypanosoma rangeli 34% 100%
A4IA70 Leishmania infantum 73% 100%
C9ZM36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9B583 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4Q2Q0 Leishmania major 74% 100%
V5BV16 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS