Thioredoxin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Thioredoxin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB12_LEIBR

TriTrypDb:

LbrM.20.2510 , LBRM2903_200037100

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	127	131	PF00082	0.414
CLV_PCSK_SKI1_1	13	17	PF00082	0.494
CLV_PCSK_SKI1_1	174	178	PF00082	0.385
CLV_PCSK_SKI1_1	184	188	PF00082	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DOC_MAPK_gen_1	44	52	PF00069	0.390
DOC_MAPK_MEF2A_6	44	52	PF00069	0.412
DOC_MAPK_MEF2A_6	70	78	PF00069	0.459
DOC_USP7_MATH_1	59	63	PF00917	0.645
DOC_USP7_UBL2_3	97	101	PF12436	0.554
DOC_WW_Pin1_4	69	74	PF00397	0.657
LIG_14-3-3_CanoR_1	109	118	PF00244	0.489
LIG_14-3-3_CanoR_1	4	9	PF00244	0.537
LIG_BRCT_BRCA1_1	150	154	PF00533	0.387
LIG_eIF4E_1	148	154	PF01652	0.385
LIG_FHA_1	148	154	PF00498	0.346
LIG_FHA_1	166	172	PF00498	0.375
LIG_FHA_1	43	49	PF00498	0.419
LIG_FHA_1	85	91	PF00498	0.734
LIG_FHA_1	98	104	PF00498	0.606
LIG_FHA_2	21	27	PF00498	0.649
LIG_LIR_Gen_1	141	149	PF02991	0.379
LIG_LIR_Gen_1	5	15	PF02991	0.500
LIG_LIR_Nem_3	141	146	PF02991	0.332
LIG_LIR_Nem_3	5	11	PF02991	0.448
LIG_Pex14_2	11	15	PF04695	0.409
LIG_PTB_Apo_2	9	16	PF02174	0.332
LIG_REV1ctd_RIR_1	8	17	PF16727	0.452
LIG_SH2_CRK	143	147	PF00017	0.329
LIG_SH2_NCK_1	143	147	PF00017	0.429
LIG_SH2_NCK_1	25	29	PF00017	0.483
LIG_SH2_NCK_1	58	62	PF00017	0.630
LIG_SH2_SRC	25	28	PF00017	0.487
LIG_SH2_STAP1	6	10	PF00017	0.343
LIG_SH2_STAT5	6	9	PF00017	0.424
LIG_SH3_3	128	134	PF00018	0.419
LIG_SH3_4	97	104	PF00018	0.433
LIG_SUMO_SIM_par_1	48	54	PF11976	0.421
LIG_SUMO_SIM_par_1	71	77	PF11976	0.457
LIG_UBA3_1	14	19	PF00899	0.361
MOD_CK1_1	110	116	PF00069	0.488
MOD_CK1_1	172	178	PF00069	0.419
MOD_CK1_1	62	68	PF00069	0.654
MOD_CK1_1	72	78	PF00069	0.539
MOD_CK2_1	20	26	PF00069	0.494
MOD_CK2_1	62	68	PF00069	0.430
MOD_GlcNHglycan	53	56	PF01048	0.425
MOD_GlcNHglycan	61	64	PF01048	0.514
MOD_GlcNHglycan	65	68	PF01048	0.534
MOD_GlcNHglycan	80	83	PF01048	0.695
MOD_GSK3_1	107	114	PF00069	0.491
MOD_GSK3_1	144	151	PF00069	0.412
MOD_GSK3_1	165	172	PF00069	0.411
MOD_GSK3_1	59	66	PF00069	0.573
MOD_GSK3_1	68	75	PF00069	0.658
MOD_GSK3_1	78	85	PF00069	0.695
MOD_NEK2_1	107	112	PF00069	0.468
MOD_NEK2_1	15	20	PF00069	0.485
MOD_NEK2_1	2	7	PF00069	0.475
MOD_NEK2_1	78	83	PF00069	0.604
MOD_PK_1	169	175	PF00069	0.390
MOD_PKB_1	167	175	PF00069	0.391
MOD_Plk_1	169	175	PF00069	0.390
MOD_Plk_4	148	154	PF00069	0.332
MOD_Plk_4	172	178	PF00069	0.416
MOD_Plk_4	4	10	PF00069	0.539
MOD_ProDKin_1	69	75	PF00069	0.660
MOD_SUMO_rev_2	124	129	PF00179	0.464
TRG_ENDOCYTIC_2	143	146	PF00928	0.329
TRG_ENDOCYTIC_2	6	9	PF00928	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG2	Leptomonas seymouri	64%	96%
A0A0S4J1H8	Bodo saltans	39%	100%
A0A0S4J255	Bodo saltans	39%	98%
A0A1X0PAS6	Trypanosomatidae	54%	100%
A0A3Q8IHE2	Leishmania donovani	79%	100%
A0A3R7K5Q8	Trypanosoma rangeli	56%	100%
A4IA69	Leishmania infantum	79%	100%
C9ZM37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B582	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2Q1	Leishmania major	78%	100%