PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

patatin-like phospholipase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB10_LEIBR

TriTrypDb:

LbrM.20.2490 , LBRM2903_200036800

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005811	lipid droplet	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HB10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB10

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0016042	lipid catabolic process	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019433	triglyceride catabolic process	7	1
GO:0042592	homeostatic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046461	neutral lipid catabolic process	5	1
GO:0046464	acylglycerol catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016787	hydrolase activity	2	13
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.441
CLV_NRD_NRD_1	429	431	PF00675	0.526
CLV_NRD_NRD_1	66	68	PF00675	0.397
CLV_PCSK_KEX2_1	66	68	PF00082	0.498
CLV_PCSK_KEX2_1	73	75	PF00082	0.486
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.491
CLV_PCSK_SKI1_1	146	150	PF00082	0.550
CLV_PCSK_SKI1_1	336	340	PF00082	0.366
CLV_PCSK_SKI1_1	364	368	PF00082	0.380
CLV_PCSK_SKI1_1	386	390	PF00082	0.377
DEG_SPOP_SBC_1	11	15	PF00917	0.557
DOC_CDC14_PxL_1	412	420	PF14671	0.719
DOC_MAPK_gen_1	383	393	PF00069	0.598
DOC_MAPK_HePTP_8	312	324	PF00069	0.271
DOC_MAPK_MEF2A_6	315	324	PF00069	0.375
DOC_PP1_RVXF_1	362	368	PF00149	0.610
DOC_PP1_RVXF_1	71	78	PF00149	0.280
DOC_PP2B_LxvP_1	247	250	PF13499	0.307
DOC_PP4_FxxP_1	313	316	PF00568	0.249
DOC_USP7_MATH_1	11	15	PF00917	0.536
DOC_USP7_MATH_1	150	154	PF00917	0.281
DOC_WW_Pin1_4	211	216	PF00397	0.294
DOC_WW_Pin1_4	402	407	PF00397	0.613
DOC_WW_Pin1_4	416	421	PF00397	0.701
LIG_14-3-3_CanoR_1	354	360	PF00244	0.606
LIG_14-3-3_CanoR_1	370	378	PF00244	0.587
LIG_14-3-3_CanoR_1	66	75	PF00244	0.289
LIG_Actin_WH2_2	122	139	PF00022	0.349
LIG_APCC_ABBA_1	320	325	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	112	116	PF00533	0.338
LIG_BRCT_BRCA1_1	381	385	PF00533	0.610
LIG_deltaCOP1_diTrp_1	31	42	PF00928	0.449
LIG_EH1_1	303	311	PF00400	0.434
LIG_FHA_1	220	226	PF00498	0.288
LIG_FHA_1	354	360	PF00498	0.664
LIG_FHA_2	397	403	PF00498	0.659
LIG_IRF3_LxIS_1	322	329	PF10401	0.472
LIG_LIR_Gen_1	113	124	PF02991	0.286
LIG_LIR_Gen_1	173	183	PF02991	0.299
LIG_LIR_Gen_1	252	263	PF02991	0.275
LIG_LIR_Gen_1	295	305	PF02991	0.410
LIG_LIR_Gen_1	92	103	PF02991	0.333
LIG_LIR_Nem_3	113	119	PF02991	0.297
LIG_LIR_Nem_3	171	175	PF02991	0.284
LIG_LIR_Nem_3	243	247	PF02991	0.352
LIG_LIR_Nem_3	252	258	PF02991	0.357
LIG_LIR_Nem_3	295	300	PF02991	0.425
LIG_LIR_Nem_3	303	308	PF02991	0.355
LIG_LIR_Nem_3	345	349	PF02991	0.605
LIG_LIR_Nem_3	382	388	PF02991	0.559
LIG_LIR_Nem_3	92	98	PF02991	0.317
LIG_MYND_1	416	420	PF01753	0.690
LIG_PCNA_yPIPBox_3	377	388	PF02747	0.660
LIG_Pex14_1	47	51	PF04695	0.271
LIG_Pex14_2	240	244	PF04695	0.317
LIG_Pex14_2	349	353	PF04695	0.557
LIG_Pex14_2	48	52	PF04695	0.335
LIG_SH2_CRK	175	179	PF00017	0.377
LIG_SH2_CRK	255	259	PF00017	0.379
LIG_SH2_CRK	95	99	PF00017	0.362
LIG_SH2_NCK_1	57	61	PF00017	0.377
LIG_SH2_PTP2	323	326	PF00017	0.369
LIG_SH2_SRC	297	300	PF00017	0.442
LIG_SH2_STAT5	124	127	PF00017	0.276
LIG_SH2_STAT5	229	232	PF00017	0.363
LIG_SH2_STAT5	269	272	PF00017	0.337
LIG_SH2_STAT5	297	300	PF00017	0.438
LIG_SH2_STAT5	323	326	PF00017	0.347
LIG_SH2_STAT5	51	54	PF00017	0.362
LIG_SH3_3	189	195	PF00018	0.271
LIG_SH3_3	236	242	PF00018	0.397
LIG_SH3_3	384	390	PF00018	0.608
LIG_SH3_3	5	11	PF00018	0.382
LIG_SUMO_SIM_par_1	219	226	PF11976	0.316
LIG_SUMO_SIM_par_1	355	361	PF11976	0.607
LIG_TRAF2_1	373	376	PF00917	0.665
LIG_TYR_ITIM	55	60	PF00017	0.294
LIG_WRC_WIRS_1	169	174	PF05994	0.362
MOD_CDK_SPK_2	211	216	PF00069	0.320
MOD_CDK_SPK_2	416	421	PF00069	0.556
MOD_CK1_1	171	177	PF00069	0.362
MOD_CK1_1	211	217	PF00069	0.340
MOD_CK1_1	3	9	PF00069	0.555
MOD_CK1_1	358	364	PF00069	0.590
MOD_CK1_1	379	385	PF00069	0.627
MOD_CK2_1	197	203	PF00069	0.362
MOD_CK2_1	369	375	PF00069	0.684
MOD_CK2_1	396	402	PF00069	0.662
MOD_Cter_Amidation	71	74	PF01082	0.491
MOD_GlcNHglycan	150	153	PF01048	0.562
MOD_GlcNHglycan	225	228	PF01048	0.532
MOD_GlcNHglycan	271	274	PF01048	0.575
MOD_GlcNHglycan	406	409	PF01048	0.493
MOD_GlcNHglycan	61	64	PF01048	0.517
MOD_GlcNHglycan	80	83	PF01048	0.377
MOD_GlcNHglycan	91	94	PF01048	0.471
MOD_GSK3_1	178	185	PF00069	0.257
MOD_GSK3_1	219	226	PF00069	0.317
MOD_GSK3_1	289	296	PF00069	0.411
MOD_GSK3_1	36	43	PF00069	0.326
MOD_GSK3_1	85	92	PF00069	0.313
MOD_N-GLC_1	211	216	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.387
MOD_NEK2_1	132	137	PF00069	0.304
MOD_NEK2_1	168	173	PF00069	0.343
MOD_NEK2_1	182	187	PF00069	0.206
MOD_NEK2_1	326	331	PF00069	0.413
MOD_NEK2_1	353	358	PF00069	0.613
MOD_NEK2_1	59	64	PF00069	0.318
MOD_NEK2_1	85	90	PF00069	0.317
MOD_NEK2_2	111	116	PF00069	0.362
MOD_PKA_1	101	107	PF00069	0.197
MOD_PKA_2	111	117	PF00069	0.271
MOD_PKA_2	178	184	PF00069	0.373
MOD_PKA_2	353	359	PF00069	0.648
MOD_PKA_2	369	375	PF00069	0.581
MOD_PKA_2	376	382	PF00069	0.598
MOD_PKA_2	75	81	PF00069	0.348
MOD_Plk_1	219	225	PF00069	0.386
MOD_Plk_1	231	237	PF00069	0.378
MOD_Plk_1	289	295	PF00069	0.390
MOD_Plk_1	36	42	PF00069	0.298
MOD_Plk_4	111	117	PF00069	0.280
MOD_Plk_4	156	162	PF00069	0.362
MOD_Plk_4	178	184	PF00069	0.339
MOD_Plk_4	240	246	PF00069	0.328
MOD_Plk_4	293	299	PF00069	0.436
MOD_Plk_4	4	10	PF00069	0.384
MOD_ProDKin_1	211	217	PF00069	0.294
MOD_ProDKin_1	402	408	PF00069	0.613
MOD_ProDKin_1	416	422	PF00069	0.699
MOD_SUMO_for_1	196	199	PF00179	0.362
MOD_SUMO_for_1	285	288	PF00179	0.394
MOD_SUMO_rev_2	70	75	PF00179	0.228
TRG_DiLeu_BaEn_1	307	312	PF01217	0.362
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.579
TRG_ENDOCYTIC_2	175	178	PF00928	0.304
TRG_ENDOCYTIC_2	255	258	PF00928	0.319
TRG_ENDOCYTIC_2	263	266	PF00928	0.266
TRG_ENDOCYTIC_2	297	300	PF00928	0.463
TRG_ENDOCYTIC_2	323	326	PF00928	0.331
TRG_ENDOCYTIC_2	350	353	PF00928	0.571
TRG_ENDOCYTIC_2	57	60	PF00928	0.377
TRG_ENDOCYTIC_2	95	98	PF00928	0.359
TRG_ER_diArg_1	143	146	PF00400	0.352
TRG_ER_diArg_1	235	238	PF00400	0.402
TRG_ER_diArg_1	65	67	PF00400	0.302
TRG_ER_diArg_1	74	77	PF00400	0.285
TRG_NES_CRM1_1	96	109	PF08389	0.197

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P509	Leptomonas seymouri	74%	100%
A0A0S4IY58	Bodo saltans	37%	100%
A0A0S4J309	Bodo saltans	39%	91%
A0A1X0P9X6	Trypanosomatidae	45%	100%
A0A3S5H7X3	Leishmania donovani	81%	100%
A0A422N4J2	Trypanosoma rangeli	42%	100%
A4IA67	Leishmania infantum	81%	100%
C9ZM39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B580	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2Q3	Leishmania major	80%	100%
V5DLV7	Trypanosoma cruzi	42%	100%