Putative selenocysteine-specific elongation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

selenocysteine-specific elongation factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HB07_LEIBR

TriTrypDb:

LbrM.20.2460 , LBRM2903_200036300

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB07

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	1
GO:0006414	translational elongation	5	1
GO:0006417	regulation of translation	6	1
GO:0006451	translational readthrough	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003676	nucleic acid binding	3	9
GO:0003746	translation elongation factor activity	4	9
GO:0008135	translation factor activity, RNA binding	3	9
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.596
CLV_C14_Caspase3-7	574	578	PF00656	0.511
CLV_NRD_NRD_1	157	159	PF00675	0.234
CLV_NRD_NRD_1	164	166	PF00675	0.234
CLV_NRD_NRD_1	263	265	PF00675	0.376
CLV_NRD_NRD_1	490	492	PF00675	0.495
CLV_NRD_NRD_1	629	631	PF00675	0.723
CLV_PCSK_KEX2_1	156	158	PF00082	0.219
CLV_PCSK_KEX2_1	164	166	PF00082	0.231
CLV_PCSK_KEX2_1	490	492	PF00082	0.495
CLV_PCSK_KEX2_1	541	543	PF00082	0.728
CLV_PCSK_KEX2_1	629	631	PF00082	0.744
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.219
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.483
CLV_PCSK_SKI1_1	148	152	PF00082	0.213
CLV_PCSK_SKI1_1	16	20	PF00082	0.301
CLV_PCSK_SKI1_1	210	214	PF00082	0.424
CLV_PCSK_SKI1_1	264	268	PF00082	0.330
CLV_PCSK_SKI1_1	299	303	PF00082	0.299
CLV_PCSK_SKI1_1	41	45	PF00082	0.207
CLV_PCSK_SKI1_1	425	429	PF00082	0.388
CLV_PCSK_SKI1_1	449	453	PF00082	0.333
CLV_PCSK_SKI1_1	606	610	PF00082	0.330
CLV_PCSK_SKI1_1	633	637	PF00082	0.578
CLV_PCSK_SKI1_1	655	659	PF00082	0.440
CLV_Separin_Metazoa	65	69	PF03568	0.349
DEG_COP1_1	253	260	PF00400	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.440
DEG_SPOP_SBC_1	619	623	PF00917	0.448
DOC_CKS1_1	521	526	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.307
DOC_MAPK_gen_1	164	174	PF00069	0.457
DOC_MAPK_gen_1	219	227	PF00069	0.246
DOC_MAPK_gen_1	264	271	PF00069	0.326
DOC_MAPK_gen_1	356	366	PF00069	0.467
DOC_MAPK_gen_1	496	504	PF00069	0.349
DOC_MAPK_gen_1	563	571	PF00069	0.414
DOC_MAPK_gen_1	601	609	PF00069	0.340
DOC_MAPK_gen_1	652	660	PF00069	0.368
DOC_MAPK_MEF2A_6	164	173	PF00069	0.408
DOC_MAPK_MEF2A_6	280	289	PF00069	0.215
DOC_MAPK_MEF2A_6	41	49	PF00069	0.410
DOC_MAPK_MEF2A_6	563	571	PF00069	0.334
DOC_MAPK_MEF2A_6	601	609	PF00069	0.340
DOC_MAPK_MEF2A_6	652	660	PF00069	0.456
DOC_MAPK_RevD_3	649	662	PF00069	0.449
DOC_PP1_RVXF_1	604	610	PF00149	0.329
DOC_PP2B_LxvP_1	409	412	PF13499	0.305
DOC_PP2B_LxvP_1	428	431	PF13499	0.337
DOC_PP4_FxxP_1	272	275	PF00568	0.369
DOC_PP4_FxxP_1	354	357	PF00568	0.301
DOC_PP4_FxxP_1	609	612	PF00568	0.360
DOC_PP4_FxxP_1	614	617	PF00568	0.393
DOC_PP4_FxxP_1	650	653	PF00568	0.513
DOC_USP7_MATH_1	305	309	PF00917	0.503
DOC_USP7_MATH_1	313	317	PF00917	0.384
DOC_USP7_MATH_1	536	540	PF00917	0.657
DOC_USP7_MATH_1	576	580	PF00917	0.564
DOC_USP7_MATH_1	583	587	PF00917	0.641
DOC_USP7_MATH_1	666	670	PF00917	0.459
DOC_WW_Pin1_4	141	146	PF00397	0.438
DOC_WW_Pin1_4	32	37	PF00397	0.407
DOC_WW_Pin1_4	461	466	PF00397	0.385
DOC_WW_Pin1_4	468	473	PF00397	0.449
DOC_WW_Pin1_4	520	525	PF00397	0.523
DOC_WW_Pin1_4	529	534	PF00397	0.506
LIG_14-3-3_CanoR_1	158	164	PF00244	0.361
LIG_14-3-3_CanoR_1	25	32	PF00244	0.405
LIG_14-3-3_CanoR_1	41	46	PF00244	0.408
LIG_14-3-3_CanoR_1	498	503	PF00244	0.384
LIG_14-3-3_CanoR_1	630	638	PF00244	0.785
LIG_Actin_WH2_2	119	137	PF00022	0.478
LIG_Actin_WH2_2	194	212	PF00022	0.463
LIG_AP2alpha_2	374	376	PF02296	0.268
LIG_APCC_ABBA_1	373	378	PF00400	0.266
LIG_APCC_ABBAyCdc20_2	554	560	PF00400	0.391
LIG_eIF4E_1	417	423	PF01652	0.281
LIG_FHA_1	168	174	PF00498	0.499
LIG_FHA_1	191	197	PF00498	0.535
LIG_FHA_1	239	245	PF00498	0.297
LIG_FHA_1	252	258	PF00498	0.320
LIG_FHA_1	261	267	PF00498	0.512
LIG_FHA_1	42	48	PF00498	0.407
LIG_FHA_1	469	475	PF00498	0.561
LIG_FHA_1	499	505	PF00498	0.328
LIG_FHA_1	514	520	PF00498	0.351
LIG_FHA_1	583	589	PF00498	0.580
LIG_FHA_1	600	606	PF00498	0.341
LIG_FHA_2	293	299	PF00498	0.501
LIG_FHA_2	378	384	PF00498	0.345
LIG_FHA_2	471	477	PF00498	0.688
LIG_FHA_2	521	527	PF00498	0.447
LIG_FHA_2	76	82	PF00498	0.407
LIG_LIR_Apic_2	611	617	PF02991	0.393
LIG_LIR_Gen_1	221	232	PF02991	0.228
LIG_LIR_Gen_1	416	426	PF02991	0.300
LIG_LIR_Gen_1	445	453	PF02991	0.461
LIG_LIR_Gen_1	556	565	PF02991	0.495
LIG_LIR_Nem_3	166	171	PF02991	0.400
LIG_LIR_Nem_3	221	227	PF02991	0.328
LIG_LIR_Nem_3	371	376	PF02991	0.432
LIG_LIR_Nem_3	414	420	PF02991	0.321
LIG_LIR_Nem_3	445	450	PF02991	0.483
LIG_LIR_Nem_3	556	561	PF02991	0.503
LIG_SH2_CRK	327	331	PF00017	0.476
LIG_SH2_CRK	418	422	PF00017	0.299
LIG_SH2_CRK	499	503	PF00017	0.533
LIG_SH2_STAP1	418	422	PF00017	0.299
LIG_SH2_STAT5	353	356	PF00017	0.321
LIG_SH3_3	252	258	PF00018	0.415
LIG_SH3_3	401	407	PF00018	0.463
LIG_SH3_3	567	573	PF00018	0.439
LIG_SH3_3	577	583	PF00018	0.615
LIG_SH3_3	77	83	PF00018	0.407
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.495
LIG_SUMO_SIM_par_1	100	107	PF11976	0.407
LIG_SUMO_SIM_par_1	169	175	PF11976	0.495
LIG_SUMO_SIM_par_1	253	259	PF11976	0.454
LIG_SUMO_SIM_par_1	419	424	PF11976	0.289
LIG_SUMO_SIM_par_1	516	523	PF11976	0.555
LIG_SUMO_SIM_par_1	566	572	PF11976	0.384
LIG_TYR_ITIM	325	330	PF00017	0.472
LIG_UBA3_1	656	662	PF00899	0.443
LIG_ULM_U2AF65_1	164	169	PF00076	0.501
MOD_CDK_SPxK_1	529	535	PF00069	0.477
MOD_CDK_SPxxK_3	141	148	PF00069	0.438
MOD_CK1_1	14	20	PF00069	0.407
MOD_CK1_1	304	310	PF00069	0.551
MOD_CK1_1	35	41	PF00069	0.400
MOD_CK1_1	392	398	PF00069	0.618
MOD_CK1_1	399	405	PF00069	0.548
MOD_CK1_1	461	467	PF00069	0.413
MOD_CK1_1	477	483	PF00069	0.638
MOD_CK1_1	520	526	PF00069	0.564
MOD_CK2_1	292	298	PF00069	0.494
MOD_CK2_1	377	383	PF00069	0.320
MOD_CK2_1	47	53	PF00069	0.501
MOD_CK2_1	666	672	PF00069	0.508
MOD_GlcNHglycan	13	16	PF01048	0.207
MOD_GlcNHglycan	280	283	PF01048	0.397
MOD_GlcNHglycan	303	306	PF01048	0.374
MOD_GlcNHglycan	307	310	PF01048	0.446
MOD_GlcNHglycan	366	369	PF01048	0.553
MOD_GlcNHglycan	401	404	PF01048	0.454
MOD_GlcNHglycan	49	52	PF01048	0.207
MOD_GlcNHglycan	529	532	PF01048	0.625
MOD_GlcNHglycan	538	541	PF01048	0.601
MOD_GlcNHglycan	633	636	PF01048	0.695
MOD_GlcNHglycan	637	641	PF01048	0.653
MOD_GlcNHglycan	645	648	PF01048	0.529
MOD_GlcNHglycan	668	671	PF01048	0.611
MOD_GlcNHglycan	68	71	PF01048	0.207
MOD_GSK3_1	159	166	PF00069	0.403
MOD_GSK3_1	21	28	PF00069	0.438
MOD_GSK3_1	301	308	PF00069	0.468
MOD_GSK3_1	343	350	PF00069	0.357
MOD_GSK3_1	37	44	PF00069	0.407
MOD_GSK3_1	389	396	PF00069	0.429
MOD_GSK3_1	461	468	PF00069	0.439
MOD_GSK3_1	470	477	PF00069	0.585
MOD_GSK3_1	509	516	PF00069	0.242
MOD_GSK3_1	578	585	PF00069	0.606
MOD_GSK3_1	595	602	PF00069	0.492
MOD_GSK3_1	619	626	PF00069	0.574
MOD_GSK3_1	66	73	PF00069	0.470
MOD_GSK3_1	84	91	PF00069	0.386
MOD_N-GLC_1	313	318	PF02516	0.268
MOD_N-GLC_1	364	369	PF02516	0.629
MOD_N-GLC_1	393	398	PF02516	0.365
MOD_N-GLC_1	481	486	PF02516	0.678
MOD_N-GLC_1	619	624	PF02516	0.465
MOD_N-GLC_2	446	448	PF02516	0.368
MOD_NEK2_1	159	164	PF00069	0.408
MOD_NEK2_1	23	28	PF00069	0.420
MOD_NEK2_1	240	245	PF00069	0.300
MOD_NEK2_1	260	265	PF00069	0.214
MOD_NEK2_1	312	317	PF00069	0.396
MOD_NEK2_1	338	343	PF00069	0.340
MOD_NEK2_1	364	369	PF00069	0.426
MOD_NEK2_1	376	381	PF00069	0.261
MOD_NEK2_1	452	457	PF00069	0.387
MOD_NEK2_1	47	52	PF00069	0.407
MOD_NEK2_1	599	604	PF00069	0.376
MOD_NEK2_1	88	93	PF00069	0.424
MOD_NEK2_2	235	240	PF00069	0.307
MOD_PIKK_1	313	319	PF00454	0.453
MOD_PIKK_1	35	41	PF00454	0.420
MOD_PIKK_1	481	487	PF00454	0.403
MOD_PKA_1	631	637	PF00069	0.560
MOD_PKA_2	163	169	PF00069	0.501
MOD_PKB_1	165	173	PF00069	0.420
MOD_PKB_1	496	504	PF00069	0.352
MOD_Plk_1	313	319	PF00069	0.400
MOD_Plk_1	377	383	PF00069	0.376
MOD_Plk_1	481	487	PF00069	0.471
MOD_Plk_1	52	58	PF00069	0.461
MOD_Plk_1	576	582	PF00069	0.503
MOD_Plk_1	595	601	PF00069	0.487
MOD_Plk_4	167	173	PF00069	0.349
MOD_Plk_4	235	241	PF00069	0.304
MOD_Plk_4	251	257	PF00069	0.319
MOD_Plk_4	343	349	PF00069	0.308
MOD_Plk_4	377	383	PF00069	0.309
MOD_Plk_4	75	81	PF00069	0.407
MOD_Plk_4	84	90	PF00069	0.407
MOD_ProDKin_1	141	147	PF00069	0.438
MOD_ProDKin_1	32	38	PF00069	0.407
MOD_ProDKin_1	461	467	PF00069	0.392
MOD_ProDKin_1	468	474	PF00069	0.452
MOD_ProDKin_1	520	526	PF00069	0.530
MOD_ProDKin_1	529	535	PF00069	0.509
TRG_DiLeu_BaEn_2	559	565	PF01217	0.349
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.297
TRG_ENDOCYTIC_2	224	227	PF00928	0.367
TRG_ENDOCYTIC_2	327	330	PF00928	0.473
TRG_ENDOCYTIC_2	417	420	PF00928	0.281
TRG_ENDOCYTIC_2	499	502	PF00928	0.529
TRG_ER_diArg_1	157	159	PF00400	0.437
TRG_ER_diArg_1	163	165	PF00400	0.441
TRG_ER_diArg_1	324	327	PF00400	0.354
TRG_ER_diArg_1	489	491	PF00400	0.486
TRG_NLS_MonoCore_2	629	634	PF00514	0.760
TRG_NLS_MonoExtN_4	629	635	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH5	Leptomonas seymouri	67%	95%
A0A1X0PAN1	Trypanosomatidae	50%	100%
A0A3Q8IIB7	Leishmania donovani	81%	99%
A0A3S5IRQ8	Trypanosoma rangeli	50%	100%
A0A3S7WV40	Leishmania donovani	26%	100%
A4H9I5	Leishmania braziliensis	25%	100%
A4IA63	Leishmania infantum	81%	99%
C9ZM43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AGQ3	Leishmania infantum	26%	100%
E9ARL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B575	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
P57772	Homo sapiens	35%	100%
Q4Q2R0	Leishmania major	79%	100%
Q4QDW8	Leishmania major	25%	100%
Q9JHW4	Mus musculus	35%	100%
V5BQE1	Trypanosoma cruzi	49%	100%