Ubiquitin-related modifier 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin related modifier (urm1)-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB06_LEIBR

TriTrypDb:

LbrM.20.2450 , LBRM2903_200036200

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HB06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB06

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	12
GO:0002098	tRNA wobble uridine modification	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0032446	protein modification by small protein conjugation	6	12
GO:0032447	protein urmylation	7	12
GO:0034227	tRNA thio-modification	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0031386	protein tag	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.321
CLV_PCSK_KEX2_1	46	48	PF00082	0.321
CLV_PCSK_SKI1_1	6	10	PF00082	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DOC_MAPK_gen_1	51	58	PF00069	0.459
DOC_MAPK_gen_1	6	12	PF00069	0.415
DOC_MAPK_JIP1_4	66	72	PF00069	0.444
DOC_MAPK_MEF2A_6	51	58	PF00069	0.455
DOC_MAPK_MEF2A_6	66	73	PF00069	0.455
DOC_PP2B_PxIxI_1	66	72	PF00149	0.468
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.468
LIG_BIR_III_4	59	63	PF00653	0.504
LIG_FHA_2	25	31	PF00498	0.493
LIG_FHA_2	35	41	PF00498	0.403
LIG_LIR_Nem_3	79	84	PF02991	0.368
LIG_SH2_STAT5	49	52	PF00017	0.463
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.368
MOD_CK2_1	34	40	PF00069	0.368
MOD_GlcNHglycan	12	15	PF01048	0.306
MOD_N-GLC_2	74	76	PF02516	0.244
MOD_NEK2_1	96	101	PF00069	0.444
MOD_PK_1	22	28	PF00069	0.488
MOD_Plk_1	22	28	PF00069	0.515
MOD_Plk_2-3	24	30	PF00069	0.368
TRG_DiLeu_BaEn_4	23	29	PF01217	0.368
TRG_ER_diArg_1	45	47	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X8	Leptomonas seymouri	76%	100%
A0A0S4J1Y6	Bodo saltans	67%	100%
A0A1X0P9S0	Trypanosomatidae	58%	100%
A0A3Q8IIP5	Leishmania donovani	84%	100%
A0A3R7KKF6	Trypanosoma rangeli	56%	100%
A0MDQ1	Arabidopsis thaliana	44%	100%
A3GFM6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	40%	100%
A4IA62	Leishmania infantum	83%	100%
A5DTV4	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	100%
A6R989	Ajellomyces capsulatus (strain NAm1 / WU24)	37%	85%
A6S5X1	Botryotinia fuckeliana (strain B05.10)	37%	97%
A6ZVR0	Saccharomyces cerevisiae (strain YJM789)	35%	100%
A7ETU4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	37%	97%
A7TQ77	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	38%	100%
A8IC48	Chlamydomonas reinhardtii	48%	100%
A8P008	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	44%	83%
A9YUB5	Capra hircus	43%	100%
B0D4J6	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	43%	84%
B0W3S2	Culex quinquefasciatus	34%	94%
B2WIC3	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	43%	96%
B3LTL7	Saccharomyces cerevisiae (strain RM11-1a)	35%	100%
B3M611	Drosophila ananassae	41%	100%
B3NFA2	Drosophila erecta	43%	100%
B4GUT1	Drosophila persimilis	42%	100%
B4HVA2	Drosophila sechellia	41%	100%
B4J272	Drosophila grimshawi	41%	99%
B4KYT0	Drosophila mojavensis	43%	99%
B4LE67	Drosophila virilis	42%	100%
B4MLV0	Drosophila willistoni	40%	100%
B4PCA1	Drosophila yakuba	42%	100%
B4QKW3	Drosophila simulans	40%	100%
B5DQK2	Drosophila pseudoobscura pseudoobscura	42%	100%
B5FVI0	Yarrowia lipolytica (strain CLIB 122 / E 150)	34%	100%
B6SXH2	Zea mays	40%	100%
C9ZM44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B574	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P0CT26	Ustilago maydis (strain 521 / FGSC 9021)	47%	96%
P40554	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
Q0D6M1	Oryza sativa subsp. japonica	43%	100%
Q148F0	Bos taurus	43%	100%
Q16Y28	Aedes aegypti	37%	94%
Q1E493	Coccidioides immitis (strain RS)	41%	90%
Q1HQ10	Bombyx mori	38%	94%
Q2U9H6	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	41%	86%
Q4Q2R1	Leishmania major	84%	100%
Q54QN0	Dictyostelium discoideum	48%	100%
Q59WK2	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	100%
Q5ZJU4	Gallus gallus	43%	100%
Q6BVZ7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	100%
Q6CQU4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
Q6FWQ3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q75AD1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	100%
Q7GBC8	Oryza sativa subsp. indica	43%	100%
Q7KU86	Drosophila melanogaster	42%	100%
Q7Q6I6	Anopheles gambiae	35%	94%
Q9BTM9	Homo sapiens	42%	100%
Q9C245	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	94%
Q9D2P4	Mus musculus	41%	100%
Q9P3U9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
V5BV79	Trypanosoma cruzi	57%	100%