Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB05_LEIBR

TriTrypDb:

LbrM.20.2440 , LBRM2903_200036000

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB05

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.430
CLV_MEL_PAP_1	444	450	PF00089	0.225
CLV_NRD_NRD_1	13	15	PF00675	0.613
CLV_NRD_NRD_1	313	315	PF00675	0.581
CLV_NRD_NRD_1	457	459	PF00675	0.362
CLV_NRD_NRD_1	548	550	PF00675	0.297
CLV_NRD_NRD_1	582	584	PF00675	0.353
CLV_NRD_NRD_1	65	67	PF00675	0.631
CLV_PCSK_FUR_1	220	224	PF00082	0.562
CLV_PCSK_KEX2_1	121	123	PF00082	0.603
CLV_PCSK_KEX2_1	13	15	PF00082	0.528
CLV_PCSK_KEX2_1	171	173	PF00082	0.729
CLV_PCSK_KEX2_1	222	224	PF00082	0.751
CLV_PCSK_KEX2_1	312	314	PF00082	0.577
CLV_PCSK_KEX2_1	457	459	PF00082	0.355
CLV_PCSK_KEX2_1	471	473	PF00082	0.358
CLV_PCSK_KEX2_1	548	550	PF00082	0.297
CLV_PCSK_KEX2_1	582	584	PF00082	0.353
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.543
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.549
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.751
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.405
CLV_PCSK_PC7_1	167	173	PF00082	0.599
CLV_PCSK_PC7_1	308	314	PF00082	0.518
CLV_PCSK_SKI1_1	360	364	PF00082	0.398
CLV_PCSK_SKI1_1	461	465	PF00082	0.432
CLV_PCSK_SKI1_1	54	58	PF00082	0.548
CLV_PCSK_SKI1_1	576	580	PF00082	0.314
CLV_PCSK_SKI1_1	614	618	PF00082	0.665
CLV_Separin_Metazoa	249	253	PF03568	0.551
DEG_SPOP_SBC_1	116	120	PF00917	0.569
DEG_SPOP_SBC_1	240	244	PF00917	0.551
DOC_ANK_TNKS_1	176	183	PF00023	0.545
DOC_CKS1_1	342	347	PF01111	0.503
DOC_MAPK_gen_1	350	359	PF00069	0.484
DOC_MAPK_gen_1	471	478	PF00069	0.454
DOC_MAPK_gen_1	66	76	PF00069	0.437
DOC_PP1_RVXF_1	145	152	PF00149	0.628
DOC_PP1_RVXF_1	472	479	PF00149	0.398
DOC_PP2B_LxvP_1	224	227	PF13499	0.548
DOC_PP4_FxxP_1	627	630	PF00568	0.541
DOC_USP7_MATH_1	114	118	PF00917	0.643
DOC_USP7_MATH_1	129	133	PF00917	0.567
DOC_USP7_MATH_1	184	188	PF00917	0.708
DOC_USP7_MATH_1	190	194	PF00917	0.586
DOC_USP7_MATH_1	446	450	PF00917	0.432
DOC_USP7_UBL2_3	346	350	PF12436	0.506
DOC_USP7_UBL2_3	389	393	PF12436	0.483
DOC_USP7_UBL2_3	54	58	PF12436	0.549
DOC_WW_Pin1_4	222	227	PF00397	0.743
DOC_WW_Pin1_4	341	346	PF00397	0.501
DOC_WW_Pin1_4	614	619	PF00397	0.542
DOC_WW_Pin1_4	621	626	PF00397	0.575
DOC_WW_Pin1_4	84	89	PF00397	0.612
LIG_14-3-3_CanoR_1	111	117	PF00244	0.601
LIG_14-3-3_CanoR_1	124	129	PF00244	0.587
LIG_14-3-3_CanoR_1	134	138	PF00244	0.533
LIG_14-3-3_CanoR_1	252	261	PF00244	0.565
LIG_14-3-3_CanoR_1	323	333	PF00244	0.542
LIG_14-3-3_CanoR_1	425	430	PF00244	0.432
LIG_14-3-3_CanoR_1	447	451	PF00244	0.374
LIG_14-3-3_CanoR_1	457	461	PF00244	0.259
LIG_14-3-3_CanoR_1	582	586	PF00244	0.409
LIG_14-3-3_CanoR_1	595	601	PF00244	0.489
LIG_14-3-3_CanoR_1	612	621	PF00244	0.431
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BIR_III_2	628	632	PF00653	0.632
LIG_BRCT_BRCA1_1	147	151	PF00533	0.478
LIG_BRCT_BRCA1_1	279	283	PF00533	0.712
LIG_FHA_1	139	145	PF00498	0.675
LIG_FHA_1	211	217	PF00498	0.568
LIG_FHA_1	242	248	PF00498	0.735
LIG_FHA_1	386	392	PF00498	0.394
LIG_FHA_1	397	403	PF00498	0.344
LIG_FHA_1	526	532	PF00498	0.221
LIG_FHA_1	575	581	PF00498	0.350
LIG_FHA_2	279	285	PF00498	0.721
LIG_FHA_2	364	370	PF00498	0.490
LIG_FHA_2	426	432	PF00498	0.374
LIG_Integrin_RGD_1	549	551	PF01839	0.225
LIG_LIR_Apic_2	624	630	PF02991	0.573
LIG_LIR_Gen_1	36	45	PF02991	0.598
LIG_LIR_Gen_1	398	408	PF02991	0.314
LIG_LIR_Gen_1	557	568	PF02991	0.397
LIG_LIR_Gen_1	584	592	PF02991	0.406
LIG_LIR_Nem_3	263	268	PF02991	0.677
LIG_LIR_Nem_3	36	41	PF02991	0.543
LIG_LIR_Nem_3	398	404	PF02991	0.314
LIG_LIR_Nem_3	427	432	PF02991	0.406
LIG_LIR_Nem_3	459	463	PF02991	0.380
LIG_LIR_Nem_3	557	563	PF02991	0.353
LIG_LIR_Nem_3	584	588	PF02991	0.399
LIG_LIR_Nem_3	603	609	PF02991	0.332
LIG_PTB_Apo_2	27	34	PF02174	0.353
LIG_PTB_Phospho_1	27	33	PF10480	0.351
LIG_SH2_CRK	460	464	PF00017	0.382
LIG_SH2_SRC	505	508	PF00017	0.337
LIG_SH2_STAT3	142	145	PF00017	0.522
LIG_SH2_STAT5	475	478	PF00017	0.357
LIG_SH2_STAT5	505	508	PF00017	0.406
LIG_SH3_3	202	208	PF00018	0.700
LIG_SH3_3	339	345	PF00018	0.567
LIG_SH3_3	416	422	PF00018	0.432
LIG_SH3_3	528	534	PF00018	0.406
LIG_Sin3_3	571	578	PF02671	0.225
LIG_SUMO_SIM_anti_2	543	548	PF11976	0.478
LIG_TRAF2_1	260	263	PF00917	0.690
LIG_TRAF2_1	292	295	PF00917	0.634
LIG_TRAF2_1	300	303	PF00917	0.578
LIG_TRAF2_1	59	62	PF00917	0.567
LIG_TRAF2_1	599	602	PF00917	0.566
LIG_UBA3_1	634	642	PF00899	0.469
LIG_WRC_WIRS_1	1	6	PF05994	0.617
MOD_CDK_SPK_2	341	346	PF00069	0.501
MOD_CK1_1	107	113	PF00069	0.681
MOD_CK1_1	115	121	PF00069	0.666
MOD_CK1_1	132	138	PF00069	0.598
MOD_CK1_1	200	206	PF00069	0.707
MOD_CK1_1	239	245	PF00069	0.679
MOD_CK1_1	277	283	PF00069	0.579
MOD_CK1_1	327	333	PF00069	0.472
MOD_CK1_1	581	587	PF00069	0.374
MOD_CK1_1	79	85	PF00069	0.533
MOD_CK2_1	117	123	PF00069	0.739
MOD_CK2_1	251	257	PF00069	0.714
MOD_CK2_1	278	284	PF00069	0.804
MOD_CK2_1	501	507	PF00069	0.430
MOD_CK2_1	596	602	PF00069	0.369
MOD_Cter_Amidation	169	172	PF01082	0.611
MOD_DYRK1A_RPxSP_1	614	618	PF00069	0.532
MOD_GlcNHglycan	104	107	PF01048	0.706
MOD_GlcNHglycan	131	134	PF01048	0.741
MOD_GlcNHglycan	184	187	PF01048	0.652
MOD_GlcNHglycan	188	191	PF01048	0.640
MOD_GlcNHglycan	197	200	PF01048	0.674
MOD_GlcNHglycan	276	279	PF01048	0.570
MOD_GlcNHglycan	537	540	PF01048	0.400
MOD_GlcNHglycan	614	617	PF01048	0.559
MOD_GlcNHglycan	94	97	PF01048	0.652
MOD_GSK3_1	112	119	PF00069	0.632
MOD_GSK3_1	129	136	PF00069	0.705
MOD_GSK3_1	151	158	PF00069	0.597
MOD_GSK3_1	171	178	PF00069	0.657
MOD_GSK3_1	180	187	PF00069	0.688
MOD_GSK3_1	210	217	PF00069	0.639
MOD_GSK3_1	236	243	PF00069	0.820
MOD_GSK3_1	251	258	PF00069	0.645
MOD_GSK3_1	274	281	PF00069	0.617
MOD_GSK3_1	340	347	PF00069	0.467
MOD_GSK3_1	363	370	PF00069	0.478
MOD_GSK3_1	574	581	PF00069	0.314
MOD_GSK3_1	75	82	PF00069	0.653
MOD_LATS_1	610	616	PF00433	0.487
MOD_N-GLC_1	112	117	PF02516	0.713
MOD_N-GLC_1	240	245	PF02516	0.710
MOD_N-GLC_1	29	34	PF02516	0.377
MOD_N-GLC_1	396	401	PF02516	0.406
MOD_NEK2_1	104	109	PF00069	0.553
MOD_NEK2_1	112	117	PF00069	0.765
MOD_NEK2_1	229	234	PF00069	0.769
MOD_NEK2_1	362	367	PF00069	0.396
MOD_NEK2_1	462	467	PF00069	0.486
MOD_NEK2_1	478	483	PF00069	0.465
MOD_NEK2_1	634	639	PF00069	0.671
MOD_NEK2_1	76	81	PF00069	0.512
MOD_NEK2_2	133	138	PF00069	0.532
MOD_NEK2_2	261	266	PF00069	0.710
MOD_NEK2_2	396	401	PF00069	0.243
MOD_PIKK_1	284	290	PF00454	0.776
MOD_PIKK_1	344	350	PF00454	0.547
MOD_PK_1	155	161	PF00069	0.431
MOD_PK_1	171	177	PF00069	0.496
MOD_PK_1	374	380	PF00069	0.472
MOD_PKA_1	171	177	PF00069	0.625
MOD_PKA_1	312	318	PF00069	0.588
MOD_PKA_2	107	113	PF00069	0.618
MOD_PKA_2	133	139	PF00069	0.601
MOD_PKA_2	171	177	PF00069	0.682
MOD_PKA_2	210	216	PF00069	0.616
MOD_PKA_2	251	257	PF00069	0.608
MOD_PKA_2	312	318	PF00069	0.607
MOD_PKA_2	319	325	PF00069	0.540
MOD_PKA_2	424	430	PF00069	0.432
MOD_PKA_2	446	452	PF00069	0.374
MOD_PKA_2	456	462	PF00069	0.259
MOD_PKA_2	581	587	PF00069	0.406
MOD_PKB_1	122	130	PF00069	0.545
MOD_Plk_1	112	118	PF00069	0.538
MOD_Plk_1	155	161	PF00069	0.493
MOD_Plk_1	229	235	PF00069	0.795
MOD_Plk_1	29	35	PF00069	0.359
MOD_Plk_1	327	333	PF00069	0.568
MOD_Plk_1	396	402	PF00069	0.406
MOD_Plk_1	408	414	PF00069	0.406
MOD_Plk_1	501	507	PF00069	0.432
MOD_Plk_1	602	608	PF00069	0.474
MOD_Plk_2-3	257	263	PF00069	0.690
MOD_Plk_4	374	380	PF00069	0.418
MOD_Plk_4	396	402	PF00069	0.350
MOD_Plk_4	501	507	PF00069	0.432
MOD_Plk_4	634	640	PF00069	0.447
MOD_ProDKin_1	222	228	PF00069	0.743
MOD_ProDKin_1	341	347	PF00069	0.499
MOD_ProDKin_1	614	620	PF00069	0.546
MOD_ProDKin_1	621	627	PF00069	0.576
MOD_ProDKin_1	84	90	PF00069	0.613
MOD_SUMO_rev_2	46	56	PF00179	0.471
MOD_SUMO_rev_2	535	544	PF00179	0.432
TRG_AP2beta_CARGO_1	263	272	PF09066	0.735
TRG_DiLeu_BaEn_1	507	512	PF01217	0.285
TRG_DiLeu_LyEn_5	507	512	PF01217	0.225
TRG_ENDOCYTIC_2	38	41	PF00928	0.513
TRG_ENDOCYTIC_2	460	463	PF00928	0.399
TRG_ENDOCYTIC_2	475	478	PF00928	0.386
TRG_ENDOCYTIC_2	560	563	PF00928	0.397
TRG_ER_diArg_1	12	14	PF00400	0.504
TRG_ER_diArg_1	312	314	PF00400	0.552
TRG_ER_diArg_1	472	475	PF00400	0.395
TRG_ER_diArg_1	547	549	PF00400	0.285
TRG_NES_CRM1_1	371	383	PF08389	0.475
TRG_NLS_MonoExtN_4	64	70	PF00514	0.400
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	46%	93%
A0A1X0PA25	Trypanosomatidae	37%	100%
A0A3S7X836	Leishmania donovani	63%	100%
A4IA61	Leishmania infantum	63%	100%
E9B573	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q2R2	Leishmania major	64%	99%
V5DLV2	Trypanosoma cruzi	34%	100%