Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania braziliensis

UniProt:

A4HB01_LEIBR

TriTrypDb:

LbrM.20.2400 , LBRM2903_200035000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HB01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.578
CLV_C14_Caspase3-7	543	547	PF00656	0.423
CLV_NRD_NRD_1	159	161	PF00675	0.336
CLV_NRD_NRD_1	308	310	PF00675	0.600
CLV_NRD_NRD_1	422	424	PF00675	0.511
CLV_NRD_NRD_1	496	498	PF00675	0.617
CLV_PCSK_FUR_1	494	498	PF00082	0.507
CLV_PCSK_KEX2_1	159	161	PF00082	0.327
CLV_PCSK_KEX2_1	308	310	PF00082	0.600
CLV_PCSK_KEX2_1	422	424	PF00082	0.511
CLV_PCSK_KEX2_1	496	498	PF00082	0.619
CLV_PCSK_SKI1_1	217	221	PF00082	0.393
CLV_PCSK_SKI1_1	274	278	PF00082	0.530
CLV_PCSK_SKI1_1	308	312	PF00082	0.615
CLV_PCSK_SKI1_1	37	41	PF00082	0.398
CLV_PCSK_SKI1_1	507	511	PF00082	0.486
CLV_PCSK_SKI1_1	526	530	PF00082	0.461
DEG_APCC_DBOX_1	307	315	PF00400	0.437
DEG_APCC_DBOX_1	444	452	PF00400	0.256
DEG_APCC_DBOX_1	525	533	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DEG_SPOP_SBC_1	479	483	PF00917	0.257
DOC_CYCLIN_RxL_1	212	222	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.304
DOC_MAPK_DCC_7	342	350	PF00069	0.355
DOC_MAPK_gen_1	173	182	PF00069	0.549
DOC_MAPK_gen_1	389	399	PF00069	0.257
DOC_MAPK_gen_1	410	420	PF00069	0.289
DOC_MAPK_MEF2A_6	265	273	PF00069	0.385
DOC_MAPK_MEF2A_6	342	350	PF00069	0.306
DOC_MAPK_MEF2A_6	392	400	PF00069	0.344
DOC_PP4_FxxP_1	324	327	PF00568	0.266
DOC_PP4_FxxP_1	73	76	PF00568	0.659
DOC_USP7_MATH_1	549	553	PF00917	0.380
DOC_USP7_MATH_2	432	438	PF00917	0.282
DOC_WW_Pin1_4	25	30	PF00397	0.578
DOC_WW_Pin1_4	392	397	PF00397	0.290
DOC_WW_Pin1_4	72	77	PF00397	0.580
LIG_14-3-3_CanoR_1	199	203	PF00244	0.502
LIG_14-3-3_CanoR_1	230	234	PF00244	0.622
LIG_14-3-3_CanoR_1	274	279	PF00244	0.444
LIG_14-3-3_CanoR_1	353	359	PF00244	0.269
LIG_14-3-3_CanoR_1	496	503	PF00244	0.380
LIG_14-3-3_CanoR_1	7	14	PF00244	0.784
LIG_Actin_WH2_2	345	362	PF00022	0.360
LIG_BRCT_BRCA1_1	571	575	PF00533	0.287
LIG_CtBP_PxDLS_1	469	473	PF00389	0.297
LIG_deltaCOP1_diTrp_1	566	575	PF00928	0.326
LIG_eIF4E_1	503	509	PF01652	0.309
LIG_FHA_1	109	115	PF00498	0.561
LIG_FHA_1	152	158	PF00498	0.515
LIG_FHA_1	275	281	PF00498	0.307
LIG_FHA_1	393	399	PF00498	0.293
LIG_FHA_1	551	557	PF00498	0.381
LIG_FHA_1	62	68	PF00498	0.499
LIG_FHA_1	9	15	PF00498	0.598
LIG_FHA_2	182	188	PF00498	0.599
LIG_LIR_Gen_1	473	479	PF02991	0.279
LIG_LIR_Nem_3	111	115	PF02991	0.525
LIG_LIR_Nem_3	144	148	PF02991	0.452
LIG_LIR_Nem_3	234	239	PF02991	0.455
LIG_LIR_Nem_3	473	478	PF02991	0.283
LIG_PDZ_Wminus1_1	582	584	PF00595	0.277
LIG_Pex14_2	251	255	PF04695	0.298
LIG_REV1ctd_RIR_1	37	46	PF16727	0.557
LIG_SH2_CRK	112	116	PF00017	0.521
LIG_SH2_CRK	236	240	PF00017	0.277
LIG_SH2_CRK	561	565	PF00017	0.382
LIG_SH2_GRB2like	503	506	PF00017	0.285
LIG_SH2_NCK_1	561	565	PF00017	0.377
LIG_SH2_SRC	561	564	PF00017	0.406
LIG_SH2_SRC	85	88	PF00017	0.477
LIG_SH2_STAP1	65	69	PF00017	0.512
LIG_SH2_STAT3	260	263	PF00017	0.363
LIG_SH2_STAT5	181	184	PF00017	0.549
LIG_SH2_STAT5	231	234	PF00017	0.529
LIG_SH2_STAT5	503	506	PF00017	0.359
LIG_SH2_STAT5	85	88	PF00017	0.548
LIG_SH3_3	316	322	PF00018	0.388
LIG_SUMO_SIM_anti_2	394	401	PF11976	0.294
LIG_SUMO_SIM_par_1	128	134	PF11976	0.574
LIG_SUMO_SIM_par_1	468	473	PF11976	0.287
LIG_SUMO_SIM_par_1	75	82	PF11976	0.537
LIG_TRAF2_1	161	164	PF00917	0.476
LIG_TRAF2_1	455	458	PF00917	0.288
LIG_TYR_ITIM	559	564	PF00017	0.354
LIG_TYR_ITSM	232	239	PF00017	0.523
MOD_CDK_SPxxK_3	25	32	PF00069	0.529
MOD_CK1_1	10	16	PF00069	0.689
MOD_CK1_1	28	34	PF00069	0.495
MOD_CK1_1	437	443	PF00069	0.477
MOD_CK2_1	138	144	PF00069	0.628
MOD_CK2_1	452	458	PF00069	0.288
MOD_CK2_1	518	524	PF00069	0.282
MOD_GlcNHglycan	140	143	PF01048	0.438
MOD_GlcNHglycan	236	239	PF01048	0.287
MOD_GlcNHglycan	240	243	PF01048	0.280
MOD_GlcNHglycan	283	287	PF01048	0.685
MOD_GlcNHglycan	303	307	PF01048	0.627
MOD_GlcNHglycan	337	340	PF01048	0.580
MOD_GlcNHglycan	41	45	PF01048	0.409
MOD_GlcNHglycan	439	442	PF01048	0.612
MOD_GlcNHglycan	498	501	PF01048	0.509
MOD_GlcNHglycan	532	535	PF01048	0.532
MOD_GlcNHglycan	542	545	PF01048	0.568
MOD_GSK3_1	10	17	PF00069	0.665
MOD_GSK3_1	234	241	PF00069	0.447
MOD_GSK3_1	255	262	PF00069	0.413
MOD_GSK3_1	331	338	PF00069	0.362
MOD_GSK3_1	40	47	PF00069	0.660
MOD_N-GLC_1	108	113	PF02516	0.370
MOD_N-GLC_1	255	260	PF02516	0.496
MOD_NEK2_1	14	19	PF00069	0.682
MOD_NEK2_1	229	234	PF00069	0.637
MOD_NEK2_1	282	287	PF00069	0.461
MOD_NEK2_1	40	45	PF00069	0.564
MOD_NEK2_1	460	465	PF00069	0.351
MOD_NEK2_1	515	520	PF00069	0.359
MOD_NEK2_1	550	555	PF00069	0.271
MOD_NEK2_1	574	579	PF00069	0.301
MOD_PIKK_1	259	265	PF00454	0.345
MOD_PIKK_1	274	280	PF00454	0.295
MOD_PIKK_1	460	466	PF00454	0.373
MOD_PKA_1	496	502	PF00069	0.434
MOD_PKA_2	198	204	PF00069	0.507
MOD_PKA_2	229	235	PF00069	0.581
MOD_PKA_2	352	358	PF00069	0.338
MOD_PKA_2	496	502	PF00069	0.385
MOD_PKB_1	300	308	PF00069	0.289
MOD_PKB_1	401	409	PF00069	0.356
MOD_PKB_1	494	502	PF00069	0.284
MOD_Plk_1	255	261	PF00069	0.262
MOD_Plk_1	282	288	PF00069	0.404
MOD_Plk_1	302	308	PF00069	0.386
MOD_Plk_1	355	361	PF00069	0.411
MOD_Plk_4	198	204	PF00069	0.495
MOD_Plk_4	331	337	PF00069	0.304
MOD_ProDKin_1	25	31	PF00069	0.572
MOD_ProDKin_1	392	398	PF00069	0.286
MOD_ProDKin_1	72	78	PF00069	0.567
TRG_DiLeu_BaEn_1	394	399	PF01217	0.322
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.295
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.249
TRG_ENDOCYTIC_2	112	115	PF00928	0.596
TRG_ENDOCYTIC_2	145	148	PF00928	0.523
TRG_ENDOCYTIC_2	236	239	PF00928	0.298
TRG_ENDOCYTIC_2	412	415	PF00928	0.364
TRG_ENDOCYTIC_2	561	564	PF00928	0.385
TRG_ER_diArg_1	307	309	PF00400	0.407
TRG_ER_diArg_1	400	403	PF00400	0.351
TRG_ER_diArg_1	422	424	PF00400	0.295
TRG_ER_diArg_1	493	496	PF00400	0.466
TRG_NES_CRM1_1	357	372	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	43%	89%
A0A0N1PB02	Leptomonas seymouri	68%	89%
A0A0S4J6C6	Bodo saltans	44%	90%
A0A1X0P9A6	Trypanosomatidae	53%	86%
A0A3Q8IHH1	Leishmania donovani	41%	80%
A0A3R7K2Y9	Trypanosoma rangeli	52%	85%
A0A3S5H668	Leishmania donovani	47%	100%
A0A3S5H669	Leishmania donovani	46%	92%
A0A3S7X835	Leishmania donovani	70%	100%
A4H5C9	Leishmania braziliensis	48%	100%
A4H5D0	Leishmania braziliensis	47%	100%
A4HAZ7	Leishmania braziliensis	94%	100%
A4HAZ9	Leishmania braziliensis	99%	100%
A4HTM0	Leishmania infantum	47%	100%
A4HTM1	Leishmania infantum	46%	92%
A4IA57	Leishmania infantum	69%	100%
C6K3V8	Leptomonas seymouri	47%	96%
C6K3V9	Leptomonas seymouri	44%	89%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	87%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	93%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	92%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q1U8	Leishmania major	42%	100%
Q4Q2R4	Leishmania major	70%	100%
Q4Q310	Leishmania major	43%	100%
Q4Q312	Leishmania major	42%	100%
Q4Q340	Leishmania major	43%	100%
Q4Q342	Leishmania major	43%	100%
Q4QI90	Leishmania major	43%	100%
Q4QI91	Leishmania major	46%	99%