Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania braziliensis

UniProt:

A4HAZ9_LEIBR

TriTrypDb:

LbrM.20.2380 , LBRM2903_200035000

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HAZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.577
CLV_C14_Caspase3-7	579	583	PF00656	0.421
CLV_NRD_NRD_1	195	197	PF00675	0.339
CLV_NRD_NRD_1	20	22	PF00675	0.386
CLV_NRD_NRD_1	344	346	PF00675	0.598
CLV_NRD_NRD_1	458	460	PF00675	0.509
CLV_NRD_NRD_1	532	534	PF00675	0.608
CLV_PCSK_FUR_1	530	534	PF00082	0.495
CLV_PCSK_KEX2_1	195	197	PF00082	0.330
CLV_PCSK_KEX2_1	20	22	PF00082	0.386
CLV_PCSK_KEX2_1	344	346	PF00082	0.598
CLV_PCSK_KEX2_1	458	460	PF00082	0.509
CLV_PCSK_KEX2_1	532	534	PF00082	0.611
CLV_PCSK_SKI1_1	2	6	PF00082	0.391
CLV_PCSK_SKI1_1	253	257	PF00082	0.392
CLV_PCSK_SKI1_1	310	314	PF00082	0.540
CLV_PCSK_SKI1_1	344	348	PF00082	0.612
CLV_PCSK_SKI1_1	35	39	PF00082	0.431
CLV_PCSK_SKI1_1	543	547	PF00082	0.486
CLV_PCSK_SKI1_1	562	566	PF00082	0.458
CLV_PCSK_SKI1_1	73	77	PF00082	0.393
DEG_APCC_DBOX_1	343	351	PF00400	0.435
DEG_APCC_DBOX_1	480	488	PF00400	0.252
DEG_APCC_DBOX_1	561	569	PF00400	0.371
DEG_Nend_UBRbox_1	1	4	PF02207	0.594
DEG_SPOP_SBC_1	515	519	PF00917	0.229
DOC_CYCLIN_RxL_1	248	258	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.303
DOC_MAPK_DCC_7	378	386	PF00069	0.356
DOC_MAPK_gen_1	209	218	PF00069	0.548
DOC_MAPK_gen_1	425	435	PF00069	0.256
DOC_MAPK_gen_1	446	456	PF00069	0.307
DOC_MAPK_MEF2A_6	301	309	PF00069	0.382
DOC_MAPK_MEF2A_6	378	386	PF00069	0.306
DOC_MAPK_MEF2A_6	428	436	PF00069	0.341
DOC_PP1_RVXF_1	18	25	PF00149	0.578
DOC_PP4_FxxP_1	109	112	PF00568	0.652
DOC_PP4_FxxP_1	360	363	PF00568	0.262
DOC_USP7_MATH_1	585	589	PF00917	0.376
DOC_USP7_MATH_2	468	474	PF00917	0.265
DOC_WW_Pin1_4	108	113	PF00397	0.573
DOC_WW_Pin1_4	428	433	PF00397	0.289
DOC_WW_Pin1_4	61	66	PF00397	0.576
LIG_14-3-3_CanoR_1	266	270	PF00244	0.625
LIG_14-3-3_CanoR_1	31	38	PF00244	0.633
LIG_14-3-3_CanoR_1	310	315	PF00244	0.446
LIG_14-3-3_CanoR_1	389	395	PF00244	0.272
LIG_14-3-3_CanoR_1	43	50	PF00244	0.782
LIG_14-3-3_CanoR_1	532	539	PF00244	0.373
LIG_14-3-3_CanoR_1	7	13	PF00244	0.645
LIG_Actin_WH2_2	381	398	PF00022	0.357
LIG_BRCT_BRCA1_1	607	611	PF00533	0.279
LIG_CtBP_PxDLS_1	505	509	PF00389	0.280
LIG_deltaCOP1_diTrp_1	602	611	PF00928	0.320
LIG_eIF4E_1	539	545	PF01652	0.305
LIG_FHA_1	145	151	PF00498	0.564
LIG_FHA_1	17	23	PF00498	0.577
LIG_FHA_1	188	194	PF00498	0.525
LIG_FHA_1	304	310	PF00498	0.325
LIG_FHA_1	31	37	PF00498	0.576
LIG_FHA_1	311	317	PF00498	0.313
LIG_FHA_1	429	435	PF00498	0.291
LIG_FHA_1	45	51	PF00498	0.596
LIG_FHA_1	587	593	PF00498	0.376
LIG_FHA_1	98	104	PF00498	0.509
LIG_FHA_2	218	224	PF00498	0.598
LIG_LIR_Gen_1	509	515	PF02991	0.265
LIG_LIR_Nem_3	147	151	PF02991	0.527
LIG_LIR_Nem_3	180	184	PF02991	0.454
LIG_LIR_Nem_3	270	275	PF02991	0.453
LIG_LIR_Nem_3	509	514	PF02991	0.268
LIG_PCNA_yPIPBox_3	195	206	PF02747	0.504
LIG_PDZ_Wminus1_1	618	620	PF00595	0.276
LIG_Pex14_2	287	291	PF04695	0.296
LIG_REV1ctd_RIR_1	73	82	PF16727	0.555
LIG_SH2_CRK	148	152	PF00017	0.530
LIG_SH2_CRK	272	276	PF00017	0.275
LIG_SH2_CRK	597	601	PF00017	0.353
LIG_SH2_GRB2like	539	542	PF00017	0.281
LIG_SH2_NCK_1	597	601	PF00017	0.348
LIG_SH2_SRC	121	124	PF00017	0.477
LIG_SH2_SRC	597	600	PF00017	0.372
LIG_SH2_STAP1	101	105	PF00017	0.521
LIG_SH2_STAT3	296	299	PF00017	0.362
LIG_SH2_STAT5	121	124	PF00017	0.546
LIG_SH2_STAT5	217	220	PF00017	0.547
LIG_SH2_STAT5	267	270	PF00017	0.538
LIG_SH2_STAT5	539	542	PF00017	0.354
LIG_SH3_3	352	358	PF00018	0.388
LIG_SUMO_SIM_anti_2	430	437	PF11976	0.293
LIG_SUMO_SIM_par_1	111	118	PF11976	0.544
LIG_SUMO_SIM_par_1	164	170	PF11976	0.571
LIG_SUMO_SIM_par_1	305	311	PF11976	0.247
LIG_SUMO_SIM_par_1	504	509	PF11976	0.271
LIG_TRAF2_1	197	200	PF00917	0.479
LIG_TRAF2_1	491	494	PF00917	0.262
LIG_TYR_ITIM	595	600	PF00017	0.327
LIG_TYR_ITSM	268	275	PF00017	0.527
MOD_CDK_SPxxK_3	61	68	PF00069	0.531
MOD_CK1_1	30	36	PF00069	0.793
MOD_CK1_1	369	375	PF00069	0.286
MOD_CK1_1	46	52	PF00069	0.686
MOD_CK1_1	473	479	PF00069	0.420
MOD_CK1_1	64	70	PF00069	0.497
MOD_CK1_1	8	14	PF00069	0.569
MOD_CK2_1	174	180	PF00069	0.636
MOD_CK2_1	217	223	PF00069	0.588
MOD_CK2_1	488	494	PF00069	0.266
MOD_CK2_1	554	560	PF00069	0.278
MOD_GlcNHglycan	176	179	PF01048	0.440
MOD_GlcNHglycan	272	275	PF01048	0.290
MOD_GlcNHglycan	276	279	PF01048	0.283
MOD_GlcNHglycan	319	323	PF01048	0.688
MOD_GlcNHglycan	339	343	PF01048	0.625
MOD_GlcNHglycan	373	376	PF01048	0.583
MOD_GlcNHglycan	475	478	PF01048	0.599
MOD_GlcNHglycan	534	537	PF01048	0.503
MOD_GlcNHglycan	568	571	PF01048	0.527
MOD_GlcNHglycan	578	581	PF01048	0.566
MOD_GlcNHglycan	77	81	PF01048	0.416
MOD_GSK3_1	270	277	PF00069	0.449
MOD_GSK3_1	291	298	PF00069	0.413
MOD_GSK3_1	367	374	PF00069	0.364
MOD_GSK3_1	46	53	PF00069	0.663
MOD_GSK3_1	76	83	PF00069	0.660
MOD_GSK3_1	8	15	PF00069	0.568
MOD_N-GLC_1	144	149	PF02516	0.372
MOD_N-GLC_1	291	296	PF02516	0.496
MOD_N-GLC_1	8	13	PF02516	0.394
MOD_NEK2_1	12	17	PF00069	0.653
MOD_NEK2_1	265	270	PF00069	0.640
MOD_NEK2_1	318	323	PF00069	0.469
MOD_NEK2_1	496	501	PF00069	0.340
MOD_NEK2_1	5	10	PF00069	0.649
MOD_NEK2_1	50	55	PF00069	0.679
MOD_NEK2_1	551	556	PF00069	0.365
MOD_NEK2_1	586	591	PF00069	0.267
MOD_NEK2_1	610	615	PF00069	0.297
MOD_NEK2_1	76	81	PF00069	0.570
MOD_PIKK_1	295	301	PF00454	0.343
MOD_PIKK_1	310	316	PF00454	0.294
MOD_PIKK_1	496	502	PF00454	0.360
MOD_PKA_1	532	538	PF00069	0.425
MOD_PKA_2	12	18	PF00069	0.579
MOD_PKA_2	265	271	PF00069	0.582
MOD_PKA_2	30	36	PF00069	0.591
MOD_PKA_2	388	394	PF00069	0.336
MOD_PKA_2	532	538	PF00069	0.376
MOD_PKB_1	336	344	PF00069	0.288
MOD_PKB_1	437	445	PF00069	0.360
MOD_PKB_1	530	538	PF00069	0.274
MOD_Plk_1	291	297	PF00069	0.262
MOD_Plk_1	318	324	PF00069	0.402
MOD_Plk_1	338	344	PF00069	0.383
MOD_Plk_1	391	397	PF00069	0.408
MOD_Plk_1	8	14	PF00069	0.594
MOD_ProDKin_1	108	114	PF00069	0.561
MOD_ProDKin_1	428	434	PF00069	0.284
MOD_ProDKin_1	61	67	PF00069	0.571
TRG_DiLeu_BaEn_1	430	435	PF01217	0.316
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.294
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.246
TRG_ENDOCYTIC_2	148	151	PF00928	0.599
TRG_ENDOCYTIC_2	181	184	PF00928	0.523
TRG_ENDOCYTIC_2	272	275	PF00928	0.296
TRG_ENDOCYTIC_2	448	451	PF00928	0.362
TRG_ENDOCYTIC_2	597	600	PF00928	0.351
TRG_ER_diArg_1	20	22	PF00400	0.590
TRG_ER_diArg_1	343	345	PF00400	0.404
TRG_ER_diArg_1	436	439	PF00400	0.356
TRG_ER_diArg_1	458	460	PF00400	0.293
TRG_ER_diArg_1	529	532	PF00400	0.451
TRG_NES_CRM1_1	393	408	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	43%	94%
A0A0N1PB02	Leptomonas seymouri	68%	95%
A0A0S4J6C6	Bodo saltans	44%	96%
A0A1X0P9A6	Trypanosomatidae	52%	91%
A0A3Q8IHH1	Leishmania donovani	41%	85%
A0A3R7K2Y9	Trypanosoma rangeli	51%	90%
A0A3S5H668	Leishmania donovani	47%	100%
A0A3S5H669	Leishmania donovani	45%	98%
A0A3S7WQC8	Leishmania donovani	38%	100%
A0A3S7X835	Leishmania donovani	69%	100%
A4H5C9	Leishmania braziliensis	47%	100%
A4H5D0	Leishmania braziliensis	47%	100%
A4HAZ7	Leishmania braziliensis	93%	100%
A4HB01	Leishmania braziliensis	99%	100%
A4HTM0	Leishmania infantum	46%	100%
A4HTM1	Leishmania infantum	45%	98%
A4IA57	Leishmania infantum	69%	100%
C6K3V8	Leptomonas seymouri	47%	100%
C6K3V9	Leptomonas seymouri	43%	95%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	92%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	98%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q1U8	Leishmania major	42%	100%
Q4Q2R4	Leishmania major	70%	100%
Q4Q310	Leishmania major	42%	100%
Q4Q312	Leishmania major	42%	100%
Q4Q340	Leishmania major	43%	100%
Q4Q342	Leishmania major	43%	100%
Q4QI90	Leishmania major	43%	100%
Q4QI91	Leishmania major	46%	99%