Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania braziliensis

UniProt:

A4HAZ7_LEIBR

TriTrypDb:

LbrM.20.2360 , LBRM2903_200034400 , LBRM2903_200034500

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HAZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.337
CLV_NRD_NRD_1	273	275	PF00675	0.620
CLV_NRD_NRD_1	384	386	PF00675	0.527
CLV_NRD_NRD_1	426	428	PF00675	0.509
CLV_NRD_NRD_1	458	460	PF00675	0.666
CLV_PCSK_FUR_1	456	460	PF00082	0.543
CLV_PCSK_KEX2_1	126	128	PF00082	0.329
CLV_PCSK_KEX2_1	273	275	PF00082	0.620
CLV_PCSK_KEX2_1	384	386	PF00082	0.527
CLV_PCSK_KEX2_1	426	428	PF00082	0.509
CLV_PCSK_KEX2_1	458	460	PF00082	0.669
CLV_PCSK_SKI1_1	182	186	PF00082	0.396
CLV_PCSK_SKI1_1	239	243	PF00082	0.534
CLV_PCSK_SKI1_1	273	277	PF00082	0.631
CLV_PCSK_SKI1_1	4	8	PF00082	0.400
DEG_APCC_DBOX_1	145	153	PF00400	0.667
DEG_APCC_DBOX_1	272	280	PF00400	0.452
DEG_APCC_DBOX_1	406	414	PF00400	0.265
DOC_CYCLIN_RxL_1	177	187	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.309
DOC_MAPK_DCC_7	307	315	PF00069	0.365
DOC_MAPK_DCC_7	426	434	PF00069	0.307
DOC_MAPK_gen_1	140	149	PF00069	0.569
DOC_MAPK_gen_1	307	315	PF00069	0.356
DOC_MAPK_gen_1	351	361	PF00069	0.335
DOC_MAPK_gen_1	372	382	PF00069	0.306
DOC_MAPK_gen_1	426	434	PF00069	0.307
DOC_MAPK_HePTP_8	305	317	PF00069	0.244
DOC_MAPK_MEF2A_6	230	238	PF00069	0.403
DOC_MAPK_MEF2A_6	307	315	PF00069	0.317
DOC_MAPK_MEF2A_6	354	362	PF00069	0.361
DOC_PP4_FxxP_1	289	292	PF00568	0.267
DOC_PP4_FxxP_1	40	43	PF00568	0.665
DOC_USP7_MATH_1	65	69	PF00917	0.640
DOC_USP7_MATH_2	394	400	PF00917	0.290
DOC_WW_Pin1_4	354	359	PF00397	0.302
DOC_WW_Pin1_4	39	44	PF00397	0.586
LIG_14-3-3_CanoR_1	195	199	PF00244	0.620
LIG_14-3-3_CanoR_1	239	244	PF00244	0.461
LIG_Actin_WH2_2	310	327	PF00022	0.374
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_CtBP_PxDLS_1	431	435	PF00389	0.360
LIG_FHA_1	119	125	PF00498	0.544
LIG_FHA_1	240	246	PF00498	0.341
LIG_FHA_1	29	35	PF00498	0.510
LIG_FHA_1	355	361	PF00498	0.302
LIG_FHA_1	393	399	PF00498	0.428
LIG_FHA_1	76	82	PF00498	0.576
LIG_LIR_Apic_2	145	151	PF02991	0.464
LIG_LIR_Nem_3	111	115	PF02991	0.459
LIG_LIR_Nem_3	199	204	PF02991	0.460
LIG_LIR_Nem_3	78	82	PF02991	0.539
LIG_Pex14_2	216	220	PF04695	0.310
LIG_REV1ctd_RIR_1	4	13	PF16727	0.553
LIG_SH2_CRK	201	205	PF00017	0.287
LIG_SH2_CRK	79	83	PF00017	0.544
LIG_SH2_SRC	52	55	PF00017	0.483
LIG_SH2_STAP1	32	36	PF00017	0.530
LIG_SH2_STAT3	225	228	PF00017	0.374
LIG_SH2_STAT5	148	151	PF00017	0.600
LIG_SH2_STAT5	196	199	PF00017	0.510
LIG_SH2_STAT5	52	55	PF00017	0.565
LIG_SH3_3	281	287	PF00018	0.403
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.229
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.306
LIG_SUMO_SIM_anti_2	437	442	PF11976	0.498
LIG_SUMO_SIM_par_1	42	49	PF11976	0.578
LIG_SUMO_SIM_par_1	95	101	PF11976	0.583
LIG_SxIP_EBH_1	152	164	PF03271	0.456
LIG_TRAF2_1	128	131	PF00917	0.487
LIG_TRAF2_1	417	420	PF00917	0.293
LIG_TYR_ITSM	197	204	PF00017	0.375
MOD_CK1_1	399	405	PF00069	0.546
MOD_CK2_1	105	111	PF00069	0.555
MOD_CK2_1	414	420	PF00069	0.350
MOD_GlcNHglycan	107	110	PF01048	0.553
MOD_GlcNHglycan	201	204	PF01048	0.307
MOD_GlcNHglycan	205	208	PF01048	0.300
MOD_GlcNHglycan	248	252	PF01048	0.637
MOD_GlcNHglycan	268	272	PF01048	0.557
MOD_GlcNHglycan	302	305	PF01048	0.479
MOD_GlcNHglycan	401	404	PF01048	0.527
MOD_GlcNHglycan	8	12	PF01048	0.511
MOD_GSK3_1	199	206	PF00069	0.293
MOD_GSK3_1	220	227	PF00069	0.481
MOD_GSK3_1	296	303	PF00069	0.459
MOD_GSK3_1	392	399	PF00069	0.367
MOD_GSK3_1	430	437	PF00069	0.385
MOD_GSK3_1	7	14	PF00069	0.581
MOD_N-GLC_1	220	225	PF02516	0.352
MOD_N-GLC_1	75	80	PF02516	0.468
MOD_NEK2_1	194	199	PF00069	0.539
MOD_NEK2_1	234	239	PF00069	0.425
MOD_NEK2_1	247	252	PF00069	0.605
MOD_NEK2_1	422	427	PF00069	0.455
MOD_NEK2_1	7	12	PF00069	0.436
MOD_PIKK_1	224	230	PF00454	0.441
MOD_PIKK_1	239	245	PF00454	0.350
MOD_PKA_2	194	200	PF00069	0.453
MOD_PKA_2	317	323	PF00069	0.404
MOD_PKA_2	457	463	PF00069	0.582
MOD_PKB_1	265	273	PF00069	0.351
MOD_PKB_1	363	371	PF00069	0.445
MOD_Plk_1	220	226	PF00069	0.296
MOD_Plk_1	247	253	PF00069	0.511
MOD_Plk_1	267	273	PF00069	0.499
MOD_Plk_1	320	326	PF00069	0.524
MOD_Plk_4	296	302	PF00069	0.383
MOD_Plk_4	65	71	PF00069	0.432
MOD_ProDKin_1	354	360	PF00069	0.347
MOD_ProDKin_1	39	45	PF00069	0.454
TRG_DiLeu_BaEn_1	356	361	PF01217	0.396
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.361
TRG_ENDOCYTIC_2	112	115	PF00928	0.405
TRG_ENDOCYTIC_2	201	204	PF00928	0.311
TRG_ENDOCYTIC_2	374	377	PF00928	0.458
TRG_ENDOCYTIC_2	79	82	PF00928	0.503
TRG_ER_diArg_1	272	274	PF00400	0.529
TRG_ER_diArg_1	362	365	PF00400	0.540
TRG_ER_diArg_1	384	386	PF00400	0.364
TRG_ER_diArg_1	455	458	PF00400	0.639
TRG_ER_diArg_1	461	464	PF00400	0.680
TRG_NES_CRM1_1	322	334	PF08389	0.446
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	71%
A0A0N1PB02	Leptomonas seymouri	65%	71%
A0A0S4J6C6	Bodo saltans	41%	72%
A0A1X0P9A6	Trypanosomatidae	50%	68%
A0A3R7K2Y9	Trypanosoma rangeli	49%	68%
A0A3S5H668	Leishmania donovani	45%	92%
A0A3S5H669	Leishmania donovani	44%	73%
A0A3S7X835	Leishmania donovani	66%	83%
A4H5C9	Leishmania braziliensis	46%	100%
A4H5D0	Leishmania braziliensis	45%	100%
A4HAZ9	Leishmania braziliensis	93%	75%
A4HB01	Leishmania braziliensis	94%	80%
A4HTM0	Leishmania infantum	45%	92%
A4HTM1	Leishmania infantum	44%	73%
A4HTM2	Leishmania infantum	40%	100%
A4IA57	Leishmania infantum	66%	83%
C6K3V8	Leptomonas seymouri	44%	77%
C6K3V9	Leptomonas seymouri	41%	71%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	69%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	74%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	77%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	92%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	73%
E9AMF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	85%
Q4Q1U8	Leishmania major	41%	100%
Q4Q2R4	Leishmania major	66%	100%
Q4Q310	Leishmania major	41%	70%
Q4Q312	Leishmania major	40%	70%
Q4Q340	Leishmania major	41%	70%
Q4Q342	Leishmania major	41%	70%
Q4QI90	Leishmania major	42%	100%
Q4QI91	Leishmania major	45%	100%