Signal recognition particle subunit SRP68

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAZ6_LEIBR

TriTrypDb:

LbrM.20.2350 , LBRM2903_200034100

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0048500	signal recognition particle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4HAZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006612	protein targeting to membrane	5	11
GO:0006613	cotranslational protein targeting to membrane	6	11
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051668	localization within membrane	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11
GO:0072657	protein localization to membrane	4	11
GO:0090150	establishment of protein localization to membrane	4	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005047	signal recognition particle binding	4	11
GO:0005048	signal sequence binding	4	11
GO:0005488	binding	1	11
GO:0008312	7S RNA binding	5	11
GO:0030942	endoplasmic reticulum signal peptide binding	5	11
GO:0033218	amide binding	2	11
GO:0042277	peptide binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.206
CLV_NRD_NRD_1	297	299	PF00675	0.231
CLV_NRD_NRD_1	342	344	PF00675	0.254
CLV_NRD_NRD_1	353	355	PF00675	0.183
CLV_NRD_NRD_1	377	379	PF00675	0.308
CLV_NRD_NRD_1	385	387	PF00675	0.270
CLV_NRD_NRD_1	96	98	PF00675	0.246
CLV_PCSK_KEX2_1	115	117	PF00082	0.204
CLV_PCSK_KEX2_1	297	299	PF00082	0.231
CLV_PCSK_KEX2_1	342	344	PF00082	0.254
CLV_PCSK_KEX2_1	353	355	PF00082	0.183
CLV_PCSK_KEX2_1	96	98	PF00082	0.200
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.218
CLV_PCSK_SKI1_1	119	123	PF00082	0.231
CLV_PCSK_SKI1_1	162	166	PF00082	0.244
CLV_PCSK_SKI1_1	258	262	PF00082	0.246
CLV_PCSK_SKI1_1	343	347	PF00082	0.213
CLV_PCSK_SKI1_1	35	39	PF00082	0.291
CLV_PCSK_SKI1_1	360	364	PF00082	0.241
CLV_PCSK_SKI1_1	468	472	PF00082	0.288
CLV_PCSK_SKI1_1	50	54	PF00082	0.167
CLV_PCSK_SKI1_1	543	547	PF00082	0.225
CLV_PCSK_SKI1_1	55	59	PF00082	0.126
CLV_Separin_Metazoa	401	405	PF03568	0.431
DOC_ANK_TNKS_1	313	320	PF00023	0.472
DOC_CKS1_1	221	226	PF01111	0.360
DOC_MAPK_MEF2A_6	66	73	PF00069	0.422
DOC_MAPK_NFAT4_5	66	74	PF00069	0.512
DOC_PP1_RVXF_1	117	124	PF00149	0.418
DOC_PP4_FxxP_1	221	224	PF00568	0.360
DOC_USP7_MATH_1	230	234	PF00917	0.377
DOC_USP7_MATH_1	337	341	PF00917	0.360
DOC_USP7_MATH_1	409	413	PF00917	0.501
DOC_USP7_MATH_1	506	510	PF00917	0.563
DOC_USP7_UBL2_3	115	119	PF12436	0.418
DOC_USP7_UBL2_3	122	126	PF12436	0.418
DOC_USP7_UBL2_3	51	55	PF12436	0.474
DOC_WW_Pin1_4	220	225	PF00397	0.431
DOC_WW_Pin1_4	395	400	PF00397	0.429
DOC_WW_Pin1_4	507	512	PF00397	0.525
DOC_WW_Pin1_4	55	60	PF00397	0.467
DOC_WW_Pin1_4	574	579	PF00397	0.594
DOC_WW_Pin1_4	585	590	PF00397	0.655
LIG_14-3-3_CanoR_1	116	122	PF00244	0.411
LIG_14-3-3_CanoR_1	153	161	PF00244	0.449
LIG_14-3-3_CanoR_1	179	189	PF00244	0.489
LIG_14-3-3_CanoR_1	200	204	PF00244	0.512
LIG_14-3-3_CanoR_1	342	346	PF00244	0.450
LIG_14-3-3_CanoR_1	35	40	PF00244	0.446
LIG_14-3-3_CanoR_1	360	369	PF00244	0.369
LIG_14-3-3_CanoR_1	448	455	PF00244	0.428
LIG_14-3-3_CanoR_1	522	530	PF00244	0.383
LIG_Actin_WH2_2	326	344	PF00022	0.512
LIG_APCC_ABBA_1	71	76	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BRCT_BRCA1_1	351	355	PF00533	0.395
LIG_BRCT_BRCA1_1	372	376	PF00533	0.554
LIG_deltaCOP1_diTrp_1	445	453	PF00928	0.532
LIG_FHA_1	142	148	PF00498	0.453
LIG_FHA_1	247	253	PF00498	0.483
LIG_FHA_1	277	283	PF00498	0.554
LIG_FHA_1	31	37	PF00498	0.431
LIG_FHA_1	342	348	PF00498	0.521
LIG_FHA_1	512	518	PF00498	0.491
LIG_FHA_1	521	527	PF00498	0.454
LIG_FHA_2	550	556	PF00498	0.521
LIG_Integrin_RGD_1	97	99	PF01839	0.160
LIG_LIR_Gen_1	173	181	PF02991	0.504
LIG_LIR_Gen_1	184	194	PF02991	0.390
LIG_LIR_Gen_1	323	333	PF02991	0.516
LIG_LIR_Gen_1	4	11	PF02991	0.317
LIG_LIR_Gen_1	536	545	PF02991	0.363
LIG_LIR_Nem_3	173	178	PF02991	0.444
LIG_LIR_Nem_3	184	190	PF02991	0.445
LIG_LIR_Nem_3	23	28	PF02991	0.449
LIG_LIR_Nem_3	323	328	PF02991	0.516
LIG_LIR_Nem_3	4	8	PF02991	0.310
LIG_LIR_Nem_3	536	540	PF02991	0.363
LIG_LIR_Nem_3	551	556	PF02991	0.421
LIG_SH2_CRK	175	179	PF00017	0.515
LIG_SH2_CRK	325	329	PF00017	0.421
LIG_SH2_CRK	396	400	PF00017	0.401
LIG_SH2_CRK	537	541	PF00017	0.363
LIG_SH2_GRB2like	301	304	PF00017	0.512
LIG_SH2_STAP1	253	257	PF00017	0.472
LIG_SH2_STAP1	351	355	PF00017	0.403
LIG_SH2_STAT3	203	206	PF00017	0.512
LIG_SH2_STAT5	146	149	PF00017	0.474
LIG_SH2_STAT5	203	206	PF00017	0.435
LIG_SH2_STAT5	31	34	PF00017	0.443
LIG_SH2_STAT5	331	334	PF00017	0.385
LIG_SH2_STAT5	460	463	PF00017	0.568
LIG_SH2_STAT5	474	477	PF00017	0.382
LIG_SH2_STAT5	515	518	PF00017	0.431
LIG_SH3_3	528	534	PF00018	0.461
LIG_SH3_3	538	544	PF00018	0.382
LIG_SH3_3	551	557	PF00018	0.348
LIG_SH3_3	575	581	PF00018	0.510
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.431
LIG_SUMO_SIM_par_1	290	296	PF11976	0.431
LIG_TRAF2_1	182	185	PF00917	0.360
LIG_TYR_ITSM	321	328	PF00017	0.421
LIG_UBA3_1	7	12	PF00899	0.262
LIG_WW_1	534	537	PF00397	0.418
MOD_CDK_SPxxK_3	585	592	PF00069	0.467
MOD_CK1_1	238	244	PF00069	0.561
MOD_CK1_1	371	377	PF00069	0.464
MOD_CK2_1	179	185	PF00069	0.363
MOD_CK2_1	241	247	PF00069	0.376
MOD_CK2_1	318	324	PF00069	0.446
MOD_CK2_1	395	401	PF00069	0.433
MOD_CK2_1	409	415	PF00069	0.441
MOD_CK2_1	474	480	PF00069	0.528
MOD_GlcNHglycan	237	240	PF01048	0.346
MOD_GlcNHglycan	270	273	PF01048	0.311
MOD_GlcNHglycan	449	452	PF01048	0.301
MOD_GlcNHglycan	558	561	PF01048	0.655
MOD_GSK3_1	337	344	PF00069	0.418
MOD_GSK3_1	358	365	PF00069	0.469
MOD_GSK3_1	368	375	PF00069	0.421
MOD_GSK3_1	443	450	PF00069	0.462
MOD_GSK3_1	507	514	PF00069	0.522
MOD_GSK3_1	581	588	PF00069	0.579
MOD_N-GLC_1	117	122	PF02516	0.231
MOD_N-GLC_1	60	65	PF02516	0.246
MOD_N-GLC_2	567	569	PF02516	0.468
MOD_NEK2_1	117	122	PF00069	0.431
MOD_NEK2_1	147	152	PF00069	0.472
MOD_NEK2_1	341	346	PF00069	0.418
MOD_NEK2_1	362	367	PF00069	0.474
MOD_NEK2_1	495	500	PF00069	0.471
MOD_NEK2_2	337	342	PF00069	0.512
MOD_NEK2_2	474	479	PF00069	0.382
MOD_PIKK_1	11	17	PF00454	0.414
MOD_PIKK_1	238	244	PF00454	0.512
MOD_PIKK_1	368	374	PF00454	0.360
MOD_PIKK_1	521	527	PF00454	0.546
MOD_PKA_1	92	98	PF00069	0.472
MOD_PKA_2	171	177	PF00069	0.461
MOD_PKA_2	199	205	PF00069	0.508
MOD_PKA_2	341	347	PF00069	0.487
MOD_PKA_2	447	453	PF00069	0.431
MOD_PKA_2	521	527	PF00069	0.383
MOD_PKA_2	581	587	PF00069	0.507
MOD_Plk_1	117	123	PF00069	0.431
MOD_Plk_1	141	147	PF00069	0.474
MOD_Plk_1	246	252	PF00069	0.360
MOD_Plk_1	358	364	PF00069	0.474
MOD_Plk_4	230	236	PF00069	0.404
MOD_Plk_4	511	517	PF00069	0.512
MOD_Plk_4	549	555	PF00069	0.528
MOD_ProDKin_1	220	226	PF00069	0.431
MOD_ProDKin_1	395	401	PF00069	0.429
MOD_ProDKin_1	507	513	PF00069	0.525
MOD_ProDKin_1	55	61	PF00069	0.467
MOD_ProDKin_1	574	580	PF00069	0.597
MOD_ProDKin_1	585	591	PF00069	0.649
MOD_SUMO_for_1	139	142	PF00179	0.453
MOD_SUMO_for_1	572	575	PF00179	0.728
MOD_SUMO_for_1	91	94	PF00179	0.506
MOD_SUMO_rev_2	157	167	PF00179	0.474
MOD_SUMO_rev_2	44	52	PF00179	0.477
TRG_ENDOCYTIC_2	175	178	PF00928	0.446
TRG_ENDOCYTIC_2	325	328	PF00928	0.427
TRG_ENDOCYTIC_2	331	334	PF00928	0.388
TRG_ENDOCYTIC_2	537	540	PF00928	0.363
TRG_ER_diArg_1	113	116	PF00400	0.418
TRG_ER_diArg_1	297	299	PF00400	0.438
TRG_ER_diArg_1	341	343	PF00400	0.456
TRG_ER_diArg_1	353	355	PF00400	0.379
TRG_NLS_Bipartite_1	96	118	PF00514	0.360
TRG_NLS_MonoExtN_4	377	382	PF00514	0.391
TRG_NLS_MonoExtN_4	589	596	PF00514	0.615
TRG_PTS2	1	43	PF00400	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH42	Leptomonas seymouri	68%	100%
A0A0S4J2Z5	Bodo saltans	45%	100%
A0A1X0PAR6	Trypanosomatidae	47%	100%
A0A3S7X839	Leishmania donovani	81%	100%
A4IA56	Leishmania infantum	81%	100%
C9ZM46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B570	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q00004	Canis lupus familiaris	24%	97%
Q4Q2R5	Leishmania major	81%	100%
Q8BMA6	Mus musculus	24%	96%
Q9UHB9	Homo sapiens	24%	96%
Q9VSS2	Drosophila melanogaster	24%	100%
V5BV06	Trypanosoma cruzi	48%	100%