Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HAZ4_LEIBR

TriTrypDb:

LbrM.20.2330 , LBRM2903_200033900

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.593
CLV_C14_Caspase3-7	41	45	PF00656	0.433
CLV_MEL_PAP_1	77	83	PF00089	0.332
CLV_NRD_NRD_1	363	365	PF00675	0.454
CLV_NRD_NRD_1	451	453	PF00675	0.411
CLV_PCSK_FUR_1	370	374	PF00082	0.411
CLV_PCSK_KEX2_1	363	365	PF00082	0.454
CLV_PCSK_KEX2_1	372	374	PF00082	0.361
CLV_PCSK_KEX2_1	412	414	PF00082	0.474
CLV_PCSK_KEX2_1	451	453	PF00082	0.411
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.513
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.474
CLV_PCSK_SKI1_1	183	187	PF00082	0.364
CLV_PCSK_SKI1_1	213	217	PF00082	0.261
CLV_PCSK_SKI1_1	363	367	PF00082	0.513
CLV_PCSK_SKI1_1	451	455	PF00082	0.411
CLV_PCSK_SKI1_1	67	71	PF00082	0.470
DEG_APCC_KENBOX_2	274	278	PF00400	0.261
DEG_SCF_FBW7_1	384	389	PF00400	0.474
DOC_CKS1_1	623	628	PF01111	0.525
DOC_CYCLIN_RxL_1	180	189	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	18	21	PF00134	0.482
DOC_MAPK_gen_1	193	203	PF00069	0.400
DOC_MAPK_HePTP_8	130	145	PF00069	0.538
DOC_MAPK_HePTP_8	69	81	PF00069	0.474
DOC_MAPK_MEF2A_6	193	202	PF00069	0.397
DOC_MAPK_MEF2A_6	336	343	PF00069	0.497
DOC_MAPK_MEF2A_6	72	81	PF00069	0.478
DOC_PP1_RVXF_1	178	185	PF00149	0.493
DOC_PP2B_LxvP_1	18	21	PF13499	0.482
DOC_PP2B_LxvP_1	242	245	PF13499	0.261
DOC_PP4_FxxP_1	526	529	PF00568	0.441
DOC_USP7_MATH_1	21	25	PF00917	0.341
DOC_USP7_MATH_1	3	7	PF00917	0.468
DOC_USP7_MATH_1	301	305	PF00917	0.323
DOC_USP7_MATH_1	316	320	PF00917	0.343
DOC_USP7_MATH_1	327	331	PF00917	0.479
DOC_USP7_MATH_1	551	555	PF00917	0.564
DOC_USP7_UBL2_3	271	275	PF12436	0.261
DOC_WW_Pin1_4	110	115	PF00397	0.411
DOC_WW_Pin1_4	266	271	PF00397	0.411
DOC_WW_Pin1_4	356	361	PF00397	0.411
DOC_WW_Pin1_4	382	387	PF00397	0.478
DOC_WW_Pin1_4	394	399	PF00397	0.323
DOC_WW_Pin1_4	405	410	PF00397	0.411
DOC_WW_Pin1_4	484	489	PF00397	0.665
DOC_WW_Pin1_4	593	598	PF00397	0.558
DOC_WW_Pin1_4	622	627	PF00397	0.520
LIG_14-3-3_CanoR_1	246	252	PF00244	0.261
LIG_14-3-3_CanoR_1	28	37	PF00244	0.421
LIG_14-3-3_CanoR_1	363	371	PF00244	0.416
LIG_14-3-3_CanoR_1	80	88	PF00244	0.329
LIG_Actin_WH2_2	39	55	PF00022	0.511
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	170	174	PF00533	0.655
LIG_Clathr_ClatBox_1	467	471	PF01394	0.531
LIG_deltaCOP1_diTrp_1	326	335	PF00928	0.513
LIG_FHA_1	125	131	PF00498	0.582
LIG_FHA_1	160	166	PF00498	0.580
LIG_FHA_1	225	231	PF00498	0.357
LIG_FHA_1	295	301	PF00498	0.261
LIG_FHA_1	383	389	PF00498	0.524
LIG_FHA_1	413	419	PF00498	0.332
LIG_FHA_1	54	60	PF00498	0.359
LIG_FHA_2	248	254	PF00498	0.407
LIG_FHA_2	319	325	PF00498	0.488
LIG_FHA_2	364	370	PF00498	0.261
LIG_FHA_2	73	79	PF00498	0.382
LIG_LIR_Apic_2	524	529	PF02991	0.439
LIG_LIR_Apic_2	563	568	PF02991	0.384
LIG_LIR_Gen_1	24	34	PF02991	0.517
LIG_LIR_Gen_1	256	266	PF02991	0.343
LIG_LIR_Gen_1	326	335	PF02991	0.404
LIG_LIR_Gen_1	84	93	PF02991	0.538
LIG_LIR_LC3C_4	519	523	PF02991	0.434
LIG_LIR_Nem_3	24	29	PF02991	0.528
LIG_LIR_Nem_3	256	261	PF02991	0.355
LIG_LIR_Nem_3	326	331	PF02991	0.448
LIG_LIR_Nem_3	333	338	PF02991	0.325
LIG_LIR_Nem_3	617	623	PF02991	0.755
LIG_LIR_Nem_3	84	90	PF02991	0.545
LIG_MYND_1	16	20	PF01753	0.496
LIG_PCNA_yPIPBox_3	412	423	PF02747	0.511
LIG_PCNA_yPIPBox_3	606	620	PF02747	0.668
LIG_PCNA_yPIPBox_3	98	111	PF02747	0.459
LIG_Pex14_2	331	335	PF04695	0.411
LIG_SH2_CRK	406	410	PF00017	0.474
LIG_SH2_CRK	565	569	PF00017	0.415
LIG_SH2_PTP2	258	261	PF00017	0.333
LIG_SH2_PTP2	26	29	PF00017	0.437
LIG_SH2_SRC	258	261	PF00017	0.421
LIG_SH2_SRC	38	41	PF00017	0.369
LIG_SH2_SRC	460	463	PF00017	0.418
LIG_SH2_STAT5	12	15	PF00017	0.454
LIG_SH2_STAT5	190	193	PF00017	0.411
LIG_SH2_STAT5	258	261	PF00017	0.421
LIG_SH2_STAT5	26	29	PF00017	0.447
LIG_SH2_STAT5	42	45	PF00017	0.547
LIG_SH2_STAT5	531	534	PF00017	0.463
LIG_SH2_STAT5	619	622	PF00017	0.648
LIG_SH2_STAT5	68	71	PF00017	0.319
LIG_SH3_1	111	117	PF00018	0.439
LIG_SH3_2	601	606	PF14604	0.810
LIG_SH3_3	111	117	PF00018	0.439
LIG_SH3_3	136	142	PF00018	0.655
LIG_SH3_3	459	465	PF00018	0.419
LIG_SH3_3	564	570	PF00018	0.417
LIG_SH3_3	598	604	PF00018	0.625
LIG_SH3_3	608	614	PF00018	0.701
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.357
LIG_SUMO_SIM_par_1	521	527	PF11976	0.439
LIG_SUMO_SIM_par_1	58	65	PF11976	0.313
LIG_TRAF2_2	126	131	PF00917	0.707
LIG_UBA3_1	203	208	PF00899	0.355
LIG_WW_2	567	570	PF00397	0.454
MOD_CDC14_SPxK_1	397	400	PF00782	0.513
MOD_CDK_SPK_2	266	271	PF00069	0.261
MOD_CDK_SPxK_1	394	400	PF00069	0.513
MOD_CDK_SPxK_1	593	599	PF00069	0.560
MOD_CDK_SPxxK_3	356	363	PF00069	0.513
MOD_CDK_SPxxK_3	405	412	PF00069	0.402
MOD_CDK_SPxxK_3	484	491	PF00069	0.562
MOD_CK1_1	103	109	PF00069	0.452
MOD_CK1_1	147	153	PF00069	0.787
MOD_CK1_1	154	160	PF00069	0.661
MOD_CK1_1	304	310	PF00069	0.509
MOD_CK1_1	311	317	PF00069	0.402
MOD_CK1_1	318	324	PF00069	0.286
MOD_CK1_1	330	336	PF00069	0.187
MOD_CK1_1	408	414	PF00069	0.443
MOD_CK1_1	425	431	PF00069	0.411
MOD_CK1_1	574	580	PF00069	0.744
MOD_CK1_1	581	587	PF00069	0.768
MOD_CK1_1	588	594	PF00069	0.822
MOD_CK1_1	622	628	PF00069	0.525
MOD_CK2_1	281	287	PF00069	0.261
MOD_CK2_1	309	315	PF00069	0.513
MOD_CK2_1	408	414	PF00069	0.450
MOD_CK2_1	425	431	PF00069	0.411
MOD_CK2_1	576	582	PF00069	0.638
MOD_GlcNHglycan	1	4	PF01048	0.719
MOD_GlcNHglycan	146	149	PF01048	0.572
MOD_GlcNHglycan	154	157	PF01048	0.563
MOD_GlcNHglycan	303	306	PF01048	0.424
MOD_GlcNHglycan	457	460	PF01048	0.354
MOD_GlcNHglycan	526	529	PF01048	0.394
MOD_GlcNHglycan	585	588	PF01048	0.719
MOD_GlcNHglycan	590	593	PF01048	0.717
MOD_GSK3_1	117	124	PF00069	0.728
MOD_GSK3_1	143	150	PF00069	0.780
MOD_GSK3_1	152	159	PF00069	0.671
MOD_GSK3_1	304	311	PF00069	0.380
MOD_GSK3_1	327	334	PF00069	0.386
MOD_GSK3_1	382	389	PF00069	0.411
MOD_GSK3_1	394	401	PF00069	0.411
MOD_GSK3_1	408	415	PF00069	0.440
MOD_GSK3_1	574	581	PF00069	0.619
MOD_GSK3_1	68	75	PF00069	0.581
MOD_N-GLC_1	309	314	PF02516	0.432
MOD_N-GLC_1	331	336	PF02516	0.411
MOD_N-GLC_1	588	593	PF02516	0.620
MOD_N-GLC_2	235	237	PF02516	0.261
MOD_N-GLC_2	530	532	PF02516	0.485
MOD_NEK2_1	100	105	PF00069	0.440
MOD_NEK2_1	109	114	PF00069	0.539
MOD_NEK2_1	143	148	PF00069	0.645
MOD_NEK2_1	151	156	PF00069	0.713
MOD_NEK2_1	158	163	PF00069	0.682
MOD_NEK2_1	295	300	PF00069	0.389
MOD_NEK2_1	331	336	PF00069	0.378
MOD_NEK2_1	351	356	PF00069	0.485
MOD_NEK2_1	380	385	PF00069	0.513
MOD_NEK2_1	388	393	PF00069	0.381
MOD_NEK2_1	453	458	PF00069	0.288
MOD_NEK2_1	521	526	PF00069	0.438
MOD_PIKK_1	121	127	PF00454	0.803
MOD_PIKK_1	295	301	PF00454	0.261
MOD_PIKK_1	363	369	PF00454	0.411
MOD_PIKK_1	460	466	PF00454	0.686
MOD_PIKK_1	494	500	PF00454	0.565
MOD_PIKK_1	571	577	PF00454	0.556
MOD_PKA_1	363	369	PF00069	0.454
MOD_PKA_1	372	378	PF00069	0.361
MOD_PKA_1	412	418	PF00069	0.261
MOD_PKA_2	363	369	PF00069	0.411
MOD_PKA_2	372	378	PF00069	0.411
MOD_PKA_2	412	418	PF00069	0.261
MOD_PKA_2	79	85	PF00069	0.343
MOD_Plk_1	331	337	PF00069	0.411
MOD_Plk_4	100	106	PF00069	0.443
MOD_Plk_4	261	267	PF00069	0.290
MOD_Plk_4	38	44	PF00069	0.523
MOD_Plk_4	521	527	PF00069	0.420
MOD_Plk_4	72	78	PF00069	0.351
MOD_ProDKin_1	110	116	PF00069	0.425
MOD_ProDKin_1	266	272	PF00069	0.411
MOD_ProDKin_1	356	362	PF00069	0.411
MOD_ProDKin_1	382	388	PF00069	0.478
MOD_ProDKin_1	394	400	PF00069	0.323
MOD_ProDKin_1	405	411	PF00069	0.411
MOD_ProDKin_1	484	490	PF00069	0.661
MOD_ProDKin_1	593	599	PF00069	0.560
MOD_ProDKin_1	622	628	PF00069	0.525
MOD_SUMO_for_1	207	210	PF00179	0.411
MOD_SUMO_for_1	371	374	PF00179	0.478
MOD_SUMO_rev_2	311	319	PF00179	0.339
MOD_SUMO_rev_2	61	69	PF00179	0.570
TRG_DiLeu_BaEn_1	199	204	PF01217	0.411
TRG_DiLeu_BaEn_2	82	88	PF01217	0.327
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.471
TRG_ENDOCYTIC_2	231	234	PF00928	0.513
TRG_ENDOCYTIC_2	258	261	PF00928	0.327
TRG_ENDOCYTIC_2	26	29	PF00928	0.447
TRG_ENDOCYTIC_2	531	534	PF00928	0.510
TRG_ER_diArg_1	362	364	PF00400	0.443
TRG_ER_diArg_1	451	453	PF00400	0.411
TRG_NES_CRM1_1	199	210	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E6	Leptomonas seymouri	53%	100%
A0A3S7X863	Leishmania donovani	72%	100%
A4IA54	Leishmania infantum	72%	100%
E9B568	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2R7	Leishmania major	71%	100%