Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAZ3_LEIBR

TriTrypDb:

LbrM.20.2320 , LBRM2903_200033600

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.499
CLV_NRD_NRD_1	100	102	PF00675	0.608
CLV_NRD_NRD_1	58	60	PF00675	0.769
CLV_PCSK_KEX2_1	57	59	PF00082	0.855
CLV_PCSK_KEX2_1	69	71	PF00082	0.666
CLV_PCSK_KEX2_1	99	101	PF00082	0.568
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.655
CLV_PCSK_SKI1_1	259	263	PF00082	0.566
CLV_PCSK_SKI1_1	78	82	PF00082	0.564
CLV_Separin_Metazoa	137	141	PF03568	0.571
DEG_APCC_DBOX_1	57	65	PF00400	0.578
DEG_SCF_FBW7_1	64	71	PF00400	0.570
DEG_SCF_FBW7_2	261	266	PF00400	0.566
DOC_ANK_TNKS_1	100	107	PF00023	0.630
DOC_CKS1_1	65	70	PF01111	0.711
DOC_CYCLIN_RxL_1	74	85	PF00134	0.560
DOC_MAPK_gen_1	29	37	PF00069	0.520
DOC_MAPK_MEF2A_6	330	339	PF00069	0.616
DOC_PP2B_LxvP_1	136	139	PF13499	0.572
DOC_PP2B_LxvP_1	231	234	PF13499	0.616
DOC_USP7_MATH_1	120	124	PF00917	0.768
DOC_USP7_MATH_1	169	173	PF00917	0.587
DOC_USP7_MATH_1	257	261	PF00917	0.597
DOC_USP7_MATH_1	269	273	PF00917	0.576
DOC_WW_Pin1_4	141	146	PF00397	0.703
DOC_WW_Pin1_4	2	7	PF00397	0.549
DOC_WW_Pin1_4	259	264	PF00397	0.567
DOC_WW_Pin1_4	325	330	PF00397	0.613
DOC_WW_Pin1_4	64	69	PF00397	0.712
LIG_14-3-3_CanoR_1	109	114	PF00244	0.573
LIG_14-3-3_CanoR_1	140	145	PF00244	0.703
LIG_14-3-3_CanoR_1	296	301	PF00244	0.675
LIG_Actin_WH2_2	79	96	PF00022	0.560
LIG_BIR_III_2	247	251	PF00653	0.563
LIG_BRCT_BRCA1_1	215	219	PF00533	0.540
LIG_FHA_1	133	139	PF00498	0.713
LIG_FHA_1	147	153	PF00498	0.569
LIG_FHA_1	233	239	PF00498	0.645
LIG_FHA_1	256	262	PF00498	0.567
LIG_FHA_1	276	282	PF00498	0.530
LIG_FHA_1	288	294	PF00498	0.536
LIG_FHA_2	155	161	PF00498	0.708
LIG_FHA_2	86	92	PF00498	0.744
LIG_LIR_Gen_1	20	28	PF02991	0.504
LIG_LIR_Nem_3	20	25	PF02991	0.511
LIG_PDZ_Class_2	343	348	PF00595	0.553
LIG_SH2_STAT3	124	127	PF00017	0.557
LIG_SH2_STAT5	177	180	PF00017	0.679
LIG_SH3_1	59	65	PF00018	0.698
LIG_SH3_2	65	70	PF14604	0.656
LIG_SH3_2	7	12	PF14604	0.551
LIG_SH3_3	203	209	PF00018	0.540
LIG_SH3_3	4	10	PF00018	0.545
LIG_SH3_3	59	65	PF00018	0.777
LIG_SUMO_SIM_anti_2	157	165	PF11976	0.618
LIG_SUMO_SIM_par_1	131	137	PF11976	0.565
LIG_SUMO_SIM_par_1	228	236	PF11976	0.628
LIG_UBA3_1	318	324	PF00899	0.504
LIG_WW_3	9	13	PF00397	0.562
MOD_CDK_SPK_2	325	330	PF00069	0.607
MOD_CDK_SPK_2	64	69	PF00069	0.712
MOD_CDK_SPxK_1	64	70	PF00069	0.658
MOD_CK1_1	123	129	PF00069	0.561
MOD_CK1_1	213	219	PF00069	0.600
MOD_CK1_1	270	276	PF00069	0.576
MOD_CK1_1	292	298	PF00069	0.702
MOD_CK1_1	299	305	PF00069	0.627
MOD_CK1_1	84	90	PF00069	0.705
MOD_CK2_1	17	23	PF00069	0.530
MOD_CK2_1	269	275	PF00069	0.594
MOD_CK2_1	85	91	PF00069	0.733
MOD_DYRK1A_RPxSP_1	259	263	PF00069	0.566
MOD_GlcNHglycan	128	131	PF01048	0.644
MOD_GlcNHglycan	14	17	PF01048	0.606
MOD_GlcNHglycan	47	50	PF01048	0.718
MOD_GlcNHglycan	74	77	PF01048	0.634
MOD_GSK3_1	128	135	PF00069	0.620
MOD_GSK3_1	140	147	PF00069	0.601
MOD_GSK3_1	189	196	PF00069	0.670
MOD_GSK3_1	221	228	PF00069	0.537
MOD_GSK3_1	251	258	PF00069	0.628
MOD_GSK3_1	267	274	PF00069	0.537
MOD_GSK3_1	288	295	PF00069	0.705
MOD_GSK3_1	41	48	PF00069	0.581
MOD_GSK3_1	64	71	PF00069	0.641
MOD_GSK3_1	81	88	PF00069	0.673
MOD_N-GLC_1	45	50	PF02516	0.567
MOD_NEK2_1	317	322	PF00069	0.519
MOD_NEK2_1	82	87	PF00069	0.552
MOD_NEK2_2	176	181	PF00069	0.578
MOD_PIKK_1	123	129	PF00454	0.594
MOD_PK_1	109	115	PF00069	0.712
MOD_PK_1	267	273	PF00069	0.572
MOD_PKA_2	295	301	PF00069	0.677
MOD_Plk_1	210	216	PF00069	0.541
MOD_Plk_1	45	51	PF00069	0.568
MOD_Plk_2-3	275	281	PF00069	0.573
MOD_Plk_4	129	135	PF00069	0.562
MOD_ProDKin_1	141	147	PF00069	0.704
MOD_ProDKin_1	2	8	PF00069	0.549
MOD_ProDKin_1	259	265	PF00069	0.566
MOD_ProDKin_1	325	331	PF00069	0.612
MOD_ProDKin_1	64	70	PF00069	0.712
TRG_ENDOCYTIC_2	177	180	PF00928	0.622
TRG_ER_diArg_1	29	32	PF00400	0.496
TRG_ER_diArg_1	57	59	PF00400	0.795
TRG_ER_diArg_1	99	101	PF00400	0.568
TRG_NES_CRM1_1	183	194	PF08389	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7X2	Leishmania donovani	53%	100%
A4IA53	Leishmania infantum	53%	100%
E9B567	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4Q2R8	Leishmania major	51%	98%