Thioredoxin-like fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAZ2_LEIBR

TriTrypDb:

LbrM.20.2310 , LBRM2903_200033800

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.608
CLV_NRD_NRD_1	131	133	PF00675	0.415
CLV_NRD_NRD_1	275	277	PF00675	0.488
CLV_NRD_NRD_1	57	59	PF00675	0.484
CLV_PCSK_KEX2_1	131	133	PF00082	0.415
CLV_PCSK_KEX2_1	275	277	PF00082	0.484
CLV_PCSK_KEX2_1	57	59	PF00082	0.484
CLV_PCSK_PC7_1	271	277	PF00082	0.467
CLV_PCSK_SKI1_1	183	187	PF00082	0.427
CLV_PCSK_SKI1_1	222	226	PF00082	0.565
CLV_Separin_Metazoa	254	258	PF03568	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DOC_CYCLIN_RxL_1	177	190	PF00134	0.399
DOC_MAPK_MEF2A_6	57	66	PF00069	0.425
DOC_PP1_RVXF_1	130	137	PF00149	0.313
DOC_USP7_MATH_1	104	108	PF00917	0.728
DOC_USP7_MATH_1	210	214	PF00917	0.416
DOC_WW_Pin1_4	191	196	PF00397	0.385
LIG_Actin_WH2_2	194	209	PF00022	0.377
LIG_BRCT_BRCA1_1	195	199	PF00533	0.349
LIG_FHA_1	169	175	PF00498	0.356
LIG_FHA_1	20	26	PF00498	0.392
LIG_FHA_1	45	51	PF00498	0.387
LIG_FHA_2	145	151	PF00498	0.375
LIG_FHA_2	165	171	PF00498	0.322
LIG_FHA_2	70	76	PF00498	0.609
LIG_LIR_Gen_1	156	166	PF02991	0.449
LIG_LIR_Nem_3	156	162	PF02991	0.440
LIG_LYPXL_yS_3	61	64	PF13949	0.486
LIG_NRBOX	181	187	PF00104	0.387
LIG_PALB2_WD40_1	237	245	PF16756	0.458
LIG_Pex14_1	238	242	PF04695	0.462
LIG_SH2_CRK	159	163	PF00017	0.462
LIG_SH2_CRK	208	212	PF00017	0.352
LIG_SH2_NCK_1	208	212	PF00017	0.366
LIG_SH2_STAT5	200	203	PF00017	0.381
LIG_SH2_STAT5	208	211	PF00017	0.416
LIG_SH2_STAT5	92	95	PF00017	0.542
LIG_SH3_3	61	67	PF00018	0.513
LIG_TRAF2_1	167	170	PF00917	0.366
LIG_TRAF2_1	288	291	PF00917	0.514
LIG_TYR_ITIM	206	211	PF00017	0.324
LIG_TYR_ITIM	59	64	PF00017	0.471
MOD_CDK_SPxxK_3	191	198	PF00069	0.443
MOD_CK1_1	193	199	PF00069	0.493
MOD_CK2_1	164	170	PF00069	0.451
MOD_CK2_1	69	75	PF00069	0.769
MOD_CK2_1	8	14	PF00069	0.608
MOD_CMANNOS	238	241	PF00535	0.463
MOD_GlcNHglycan	212	215	PF01048	0.536
MOD_GlcNHglycan	233	236	PF01048	0.542
MOD_GSK3_1	164	171	PF00069	0.369
MOD_GSK3_1	206	213	PF00069	0.430
MOD_GSK3_1	4	11	PF00069	0.628
MOD_N-GLC_1	69	74	PF02516	0.544
MOD_N-GLC_2	40	42	PF02516	0.368
MOD_NEK2_1	206	211	PF00069	0.399
MOD_NEK2_1	231	236	PF00069	0.454
MOD_OFUCOSY	142	148	PF10250	0.372
MOD_PIKK_1	95	101	PF00454	0.685
MOD_PKA_2	124	130	PF00069	0.524
MOD_PKA_2	206	212	PF00069	0.415
MOD_Plk_1	144	150	PF00069	0.375
MOD_Plk_2-3	8	14	PF00069	0.608
MOD_Plk_2-3	85	91	PF00069	0.618
MOD_Plk_4	157	163	PF00069	0.548
MOD_ProDKin_1	191	197	PF00069	0.381
TRG_DiLeu_BaEn_2	183	189	PF01217	0.315
TRG_ENDOCYTIC_2	114	117	PF00928	0.441
TRG_ENDOCYTIC_2	159	162	PF00928	0.451
TRG_ENDOCYTIC_2	208	211	PF00928	0.416
TRG_ENDOCYTIC_2	61	64	PF00928	0.486
TRG_ER_diArg_1	56	58	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P606	Leptomonas seymouri	60%	100%
A0A3S7X837	Leishmania donovani	84%	100%
A4IA52	Leishmania infantum	84%	100%
E9B566	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2R9	Leishmania major	83%	100%