Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HAZ1_LEIBR

TriTrypDb:

LbrM.20.2300 , LBRM2903_200033700

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005737	cytoplasm	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAZ1

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	11
GO:0001510	RNA methylation	4	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0031167	rRNA methylation	5	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0036265	RNA (guanine-N7)-methylation	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0070475	rRNA base methylation	6	11
GO:0070476	rRNA (guanine-N7)-methylation	6	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008649	rRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016435	rRNA (guanine) methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140102	catalytic activity, acting on a rRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.728
CLV_C14_Caspase3-7	323	327	PF00656	0.725
CLV_C14_Caspase3-7	410	414	PF00656	0.527
CLV_NRD_NRD_1	22	24	PF00675	0.547
CLV_NRD_NRD_1	229	231	PF00675	0.419
CLV_NRD_NRD_1	243	245	PF00675	0.428
CLV_NRD_NRD_1	31	33	PF00675	0.510
CLV_NRD_NRD_1	353	355	PF00675	0.724
CLV_NRD_NRD_1	382	384	PF00675	0.285
CLV_NRD_NRD_1	405	407	PF00675	0.287
CLV_NRD_NRD_1	420	422	PF00675	0.306
CLV_PCSK_FUR_1	29	33	PF00082	0.336
CLV_PCSK_FUR_1	380	384	PF00082	0.368
CLV_PCSK_FUR_1	403	407	PF00082	0.339
CLV_PCSK_KEX2_1	22	24	PF00082	0.595
CLV_PCSK_KEX2_1	229	231	PF00082	0.415
CLV_PCSK_KEX2_1	243	245	PF00082	0.428
CLV_PCSK_KEX2_1	31	33	PF00082	0.545
CLV_PCSK_KEX2_1	355	357	PF00082	0.704
CLV_PCSK_KEX2_1	369	371	PF00082	0.234
CLV_PCSK_KEX2_1	382	384	PF00082	0.279
CLV_PCSK_KEX2_1	403	405	PF00082	0.282
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.704
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.234
CLV_PCSK_PC7_1	378	384	PF00082	0.325
CLV_PCSK_SKI1_1	244	248	PF00082	0.479
CLV_PCSK_SKI1_1	35	39	PF00082	0.404
CLV_PCSK_SKI1_1	387	391	PF00082	0.296
CLV_PCSK_SKI1_1	96	100	PF00082	0.439
DEG_Kelch_Keap1_1	327	332	PF01344	0.530
DOC_MAPK_gen_1	285	293	PF00069	0.403
DOC_MAPK_gen_1	29	39	PF00069	0.509
DOC_PP2B_LxvP_1	45	48	PF13499	0.492
DOC_PP4_FxxP_1	302	305	PF00568	0.506
DOC_USP7_MATH_1	175	179	PF00917	0.729
DOC_USP7_MATH_1	371	375	PF00917	0.547
LIG_14-3-3_CanoR_1	22	27	PF00244	0.460
LIG_14-3-3_CanoR_1	406	416	PF00244	0.562
LIG_Actin_WH2_2	227	245	PF00022	0.443
LIG_Actin_WH2_2	81	98	PF00022	0.526
LIG_EVH1_2	11	15	PF00568	0.542
LIG_FHA_1	130	136	PF00498	0.636
LIG_FHA_1	307	313	PF00498	0.614
LIG_FHA_2	408	414	PF00498	0.482
LIG_LIR_Gen_1	237	246	PF02991	0.433
LIG_LIR_Gen_1	392	402	PF02991	0.482
LIG_LIR_Nem_3	237	242	PF02991	0.399
LIG_LIR_Nem_3	392	398	PF02991	0.482
LIG_PCNA_PIPBox_1	228	237	PF02747	0.404
LIG_PCNA_yPIPBox_3	222	235	PF02747	0.427
LIG_SH2_CRK	239	243	PF00017	0.383
LIG_SH2_STAT5	24	27	PF00017	0.431
LIG_SH2_STAT5	290	293	PF00017	0.375
LIG_SH2_STAT5	416	419	PF00017	0.482
LIG_SH3_3	196	202	PF00018	0.414
LIG_SH3_3	251	257	PF00018	0.527
LIG_SH3_3	275	281	PF00018	0.416
LIG_SH3_3	300	306	PF00018	0.440
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.473
LIG_SUMO_SIM_par_1	63	69	PF11976	0.531
LIG_UBA3_1	44	49	PF00899	0.566
LIG_UBA3_1	94	99	PF00899	0.406
MOD_CK1_1	327	333	PF00069	0.741
MOD_CK1_1	414	420	PF00069	0.478
MOD_CK1_1	71	77	PF00069	0.407
MOD_CK2_1	252	258	PF00069	0.501
MOD_CK2_1	326	332	PF00069	0.644
MOD_GlcNHglycan	151	154	PF01048	0.734
MOD_GlcNHglycan	166	169	PF01048	0.818
MOD_GlcNHglycan	172	175	PF01048	0.809
MOD_GlcNHglycan	177	180	PF01048	0.752
MOD_GlcNHglycan	282	285	PF01048	0.485
MOD_GlcNHglycan	326	329	PF01048	0.662
MOD_GlcNHglycan	336	339	PF01048	0.760
MOD_GlcNHglycan	374	377	PF01048	0.311
MOD_GlcNHglycan	60	63	PF01048	0.510
MOD_GlcNHglycan	68	71	PF01048	0.449
MOD_GlcNHglycan	73	76	PF01048	0.351
MOD_GSK3_1	164	171	PF00069	0.782
MOD_GSK3_1	311	318	PF00069	0.752
MOD_GSK3_1	320	327	PF00069	0.753
MOD_GSK3_1	407	414	PF00069	0.482
MOD_N-GLC_1	16	21	PF02516	0.465
MOD_N-GLC_1	58	63	PF02516	0.601
MOD_NEK2_1	121	126	PF00069	0.681
MOD_NEK2_1	130	135	PF00069	0.674
MOD_NEK2_1	217	222	PF00069	0.501
MOD_NEK2_1	234	239	PF00069	0.295
MOD_NEK2_1	334	339	PF00069	0.497
MOD_NEK2_1	348	353	PF00069	0.469
MOD_PKA_1	22	28	PF00069	0.554
MOD_PKA_2	169	175	PF00069	0.552
MOD_PKA_2	22	28	PF00069	0.462
MOD_PKA_2	371	377	PF00069	0.554
MOD_PKB_1	370	378	PF00069	0.538
MOD_Plk_1	130	136	PF00069	0.705
MOD_Plk_1	35	41	PF00069	0.499
MOD_Plk_1	58	64	PF00069	0.561
MOD_Plk_2-3	311	317	PF00069	0.657
MOD_Plk_2-3	320	326	PF00069	0.689
MOD_Plk_4	234	240	PF00069	0.422
MOD_SUMO_for_1	398	401	PF00179	0.534
TRG_DiLeu_BaEn_1	258	263	PF01217	0.315
TRG_ENDOCYTIC_2	105	108	PF00928	0.655
TRG_ENDOCYTIC_2	239	242	PF00928	0.376
TRG_ENDOCYTIC_2	289	292	PF00928	0.387
TRG_ER_diArg_1	22	24	PF00400	0.584
TRG_ER_diArg_1	229	231	PF00400	0.412
TRG_ER_diArg_1	242	244	PF00400	0.406
TRG_ER_diArg_1	29	32	PF00400	0.477
TRG_ER_diArg_1	354	357	PF00400	0.682
TRG_ER_diArg_1	380	383	PF00400	0.510
TRG_ER_diArg_1	403	406	PF00400	0.534
TRG_ER_diArg_1	418	421	PF00400	0.412
TRG_NLS_Bipartite_1	354	373	PF00514	0.397
TRG_NLS_Bipartite_1	403	425	PF00514	0.496
TRG_NLS_MonoCore_2	420	425	PF00514	0.678
TRG_NLS_MonoExtC_3	353	358	PF00514	0.786
TRG_NLS_MonoExtN_4	354	359	PF00514	0.735
TRG_NLS_MonoExtN_4	419	425	PF00514	0.496
TRG_PTS1	422	425	PF00515	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC68	Leptomonas seymouri	71%	100%
A0A1X0P9R3	Trypanosomatidae	52%	100%
A0A3Q8IFP3	Leishmania donovani	80%	100%
A0A3R7KRG3	Trypanosoma rangeli	52%	100%
A4IA51	Leishmania infantum	80%	100%
C9ZM51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B565	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2S0	Leishmania major	83%	100%
V5B593	Trypanosoma cruzi	52%	100%