Putative GPI transamidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase subunit 16, putative

Species:

Leishmania braziliensis

UniProt:

A4HAY9_LEIBR

TriTrypDb:

LbrM.20.2280 , LBRM2903_200033400

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HAY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.585
CLV_C14_Caspase3-7	547	551	PF00656	0.369
CLV_C14_Caspase3-7	634	638	PF00656	0.277
CLV_NRD_NRD_1	118	120	PF00675	0.565
CLV_NRD_NRD_1	42	44	PF00675	0.599
CLV_NRD_NRD_1	539	541	PF00675	0.561
CLV_NRD_NRD_1	621	623	PF00675	0.658
CLV_NRD_NRD_1	7	9	PF00675	0.715
CLV_NRD_NRD_1	718	720	PF00675	0.456
CLV_PCSK_KEX2_1	117	119	PF00082	0.563
CLV_PCSK_KEX2_1	42	44	PF00082	0.599
CLV_PCSK_KEX2_1	6	8	PF00082	0.708
CLV_PCSK_KEX2_1	621	623	PF00082	0.646
CLV_PCSK_KEX2_1	656	658	PF00082	0.759
CLV_PCSK_KEX2_1	718	720	PF00082	0.438
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.694
CLV_PCSK_SKI1_1	171	175	PF00082	0.655
CLV_PCSK_SKI1_1	286	290	PF00082	0.536
CLV_PCSK_SKI1_1	376	380	PF00082	0.643
CLV_PCSK_SKI1_1	478	482	PF00082	0.570
CLV_PCSK_SKI1_1	8	12	PF00082	0.527
DEG_APCC_DBOX_1	375	383	PF00400	0.315
DEG_APCC_DBOX_1	488	496	PF00400	0.337
DEG_APCC_DBOX_1	656	664	PF00400	0.411
DEG_APCC_DBOX_1	7	15	PF00400	0.396
DEG_SPOP_SBC_1	31	35	PF00917	0.362
DEG_SPOP_SBC_1	400	404	PF00917	0.417
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.467
DOC_MAPK_DCC_7	478	487	PF00069	0.398
DOC_MAPK_DCC_7	587	595	PF00069	0.453
DOC_MAPK_gen_1	223	232	PF00069	0.466
DOC_MAPK_gen_1	327	336	PF00069	0.267
DOC_MAPK_gen_1	358	366	PF00069	0.479
DOC_MAPK_gen_1	42	48	PF00069	0.341
DOC_MAPK_gen_1	554	564	PF00069	0.460
DOC_MAPK_gen_1	6	15	PF00069	0.400
DOC_MAPK_HePTP_8	3	15	PF00069	0.410
DOC_MAPK_MEF2A_6	286	294	PF00069	0.261
DOC_MAPK_MEF2A_6	358	366	PF00069	0.460
DOC_MAPK_MEF2A_6	426	435	PF00069	0.437
DOC_MAPK_MEF2A_6	587	596	PF00069	0.371
DOC_MAPK_MEF2A_6	6	15	PF00069	0.400
DOC_PP1_RVXF_1	121	127	PF00149	0.439
DOC_PP2B_LxvP_1	73	76	PF13499	0.355
DOC_PP4_FxxP_1	296	299	PF00568	0.426
DOC_PP4_FxxP_1	696	699	PF00568	0.227
DOC_USP7_MATH_1	222	226	PF00917	0.492
DOC_USP7_MATH_1	239	243	PF00917	0.420
DOC_USP7_MATH_1	288	292	PF00917	0.437
DOC_USP7_MATH_1	29	33	PF00917	0.461
DOC_USP7_MATH_1	378	382	PF00917	0.389
DOC_USP7_MATH_1	383	387	PF00917	0.424
DOC_USP7_MATH_1	399	403	PF00917	0.459
DOC_USP7_MATH_1	405	409	PF00917	0.534
DOC_USP7_MATH_1	599	603	PF00917	0.540
DOC_USP7_MATH_1	608	612	PF00917	0.524
DOC_WW_Pin1_4	210	215	PF00397	0.383
DOC_WW_Pin1_4	218	223	PF00397	0.439
DOC_WW_Pin1_4	261	266	PF00397	0.506
DOC_WW_Pin1_4	384	389	PF00397	0.502
DOC_WW_Pin1_4	393	398	PF00397	0.574
DOC_WW_Pin1_4	403	408	PF00397	0.455
DOC_WW_Pin1_4	411	416	PF00397	0.400
DOC_WW_Pin1_4	522	527	PF00397	0.416
DOC_WW_Pin1_4	58	63	PF00397	0.489
LIG_14-3-3_CanoR_1	171	179	PF00244	0.410
LIG_14-3-3_CanoR_1	306	313	PF00244	0.473
LIG_14-3-3_CanoR_1	331	335	PF00244	0.401
LIG_14-3-3_CanoR_1	376	385	PF00244	0.295
LIG_14-3-3_CanoR_1	42	47	PF00244	0.388
LIG_14-3-3_CanoR_1	503	508	PF00244	0.258
LIG_14-3-3_CanoR_1	598	604	PF00244	0.450
LIG_14-3-3_CanoR_1	657	667	PF00244	0.482
LIG_14-3-3_CanoR_1	678	682	PF00244	0.493
LIG_14-3-3_CanoR_1	718	727	PF00244	0.723
LIG_AP_GAE_1	105	111	PF02883	0.460
LIG_APCC_ABBA_1	505	510	PF00400	0.256
LIG_BRCT_BRCA1_1	163	167	PF00533	0.493
LIG_BRCT_BRCA1_1	183	187	PF00533	0.194
LIG_BRCT_BRCA1_1	292	296	PF00533	0.281
LIG_Clathr_ClatBox_1	439	443	PF01394	0.489
LIG_deltaCOP1_diTrp_1	125	133	PF00928	0.362
LIG_EH1_1	492	500	PF00400	0.426
LIG_eIF4E_1	493	499	PF01652	0.448
LIG_FHA_1	151	157	PF00498	0.469
LIG_FHA_1	161	167	PF00498	0.311
LIG_FHA_1	17	23	PF00498	0.421
LIG_FHA_1	258	264	PF00498	0.418
LIG_FHA_1	321	327	PF00498	0.481
LIG_FHA_1	430	436	PF00498	0.341
LIG_FHA_1	477	483	PF00498	0.388
LIG_FHA_1	50	56	PF00498	0.410
LIG_FHA_1	500	506	PF00498	0.411
LIG_FHA_1	507	513	PF00498	0.400
LIG_FHA_1	735	741	PF00498	0.697
LIG_FHA_2	101	107	PF00498	0.401
LIG_FHA_2	81	87	PF00498	0.378
LIG_HCF-1_HBM_1	427	430	PF13415	0.455
LIG_LIR_Apic_2	136	140	PF02991	0.480
LIG_LIR_Apic_2	293	299	PF02991	0.293
LIG_LIR_Gen_1	164	174	PF02991	0.435
LIG_LIR_Gen_1	181	190	PF02991	0.437
LIG_LIR_Gen_1	249	258	PF02991	0.432
LIG_LIR_Gen_1	297	307	PF02991	0.272
LIG_LIR_Gen_1	427	438	PF02991	0.404
LIG_LIR_Gen_1	614	624	PF02991	0.478
LIG_LIR_Gen_1	641	651	PF02991	0.469
LIG_LIR_Nem_3	105	111	PF02991	0.391
LIG_LIR_Nem_3	164	170	PF02991	0.448
LIG_LIR_Nem_3	181	185	PF02991	0.339
LIG_LIR_Nem_3	244	250	PF02991	0.377
LIG_LIR_Nem_3	297	303	PF02991	0.332
LIG_LIR_Nem_3	427	433	PF02991	0.359
LIG_LIR_Nem_3	614	619	PF02991	0.391
LIG_LIR_Nem_3	641	646	PF02991	0.265
LIG_MLH1_MIPbox_1	292	296	PF16413	0.263
LIG_NRBOX	10	16	PF00104	0.484
LIG_NRBOX	515	521	PF00104	0.368
LIG_NRBOX	726	732	PF00104	0.686
LIG_Pex14_1	202	206	PF04695	0.356
LIG_Pex14_2	104	108	PF04695	0.459
LIG_Pex14_2	285	289	PF04695	0.363
LIG_Pex14_2	296	300	PF04695	0.301
LIG_Pex14_2	567	571	PF04695	0.314
LIG_SH2_CRK	182	186	PF00017	0.394
LIG_SH2_CRK	250	254	PF00017	0.407
LIG_SH2_NCK_1	182	186	PF00017	0.413
LIG_SH2_NCK_1	532	536	PF00017	0.427
LIG_SH2_SRC	536	539	PF00017	0.463
LIG_SH2_STAP1	44	48	PF00017	0.354
LIG_SH2_STAP1	532	536	PF00017	0.427
LIG_SH2_STAT5	114	117	PF00017	0.432
LIG_SH2_STAT5	295	298	PF00017	0.443
LIG_SH2_STAT5	356	359	PF00017	0.392
LIG_SH2_STAT5	430	433	PF00017	0.376
LIG_SH3_3	17	23	PF00018	0.608
LIG_SH3_3	382	388	PF00018	0.489
LIG_SH3_3	586	592	PF00018	0.497
LIG_SH3_3	73	79	PF00018	0.467
LIG_SUMO_SIM_anti_2	515	523	PF11976	0.399
LIG_SUMO_SIM_par_1	438	443	PF11976	0.470
LIG_SUMO_SIM_par_1	502	510	PF11976	0.339
LIG_TRAF2_1	307	310	PF00917	0.466
LIG_TYR_ITIM	111	116	PF00017	0.547
LIG_UBA3_1	663	668	PF00899	0.470
LIG_WRC_WIRS_1	466	471	PF05994	0.361
MOD_CDK_SPK_2	218	223	PF00069	0.574
MOD_CDK_SPK_2	384	389	PF00069	0.526
MOD_CDK_SPxxK_3	403	410	PF00069	0.717
MOD_CK1_1	150	156	PF00069	0.571
MOD_CK1_1	183	189	PF00069	0.431
MOD_CK1_1	208	214	PF00069	0.474
MOD_CK1_1	216	222	PF00069	0.536
MOD_CK1_1	237	243	PF00069	0.667
MOD_CK1_1	32	38	PF00069	0.422
MOD_CK1_1	406	412	PF00069	0.640
MOD_CK1_1	506	512	PF00069	0.471
MOD_CK1_1	611	617	PF00069	0.680
MOD_CK1_1	638	644	PF00069	0.471
MOD_CK1_1	683	689	PF00069	0.674
MOD_CK2_1	100	106	PF00069	0.387
MOD_CK2_1	337	343	PF00069	0.590
MOD_CK2_1	384	390	PF00069	0.558
MOD_CK2_1	51	57	PF00069	0.582
MOD_CK2_1	80	86	PF00069	0.624
MOD_Cter_Amidation	654	657	PF01082	0.643
MOD_GlcNHglycan	125	129	PF01048	0.298
MOD_GlcNHglycan	149	152	PF01048	0.746
MOD_GlcNHglycan	163	166	PF01048	0.651
MOD_GlcNHglycan	239	242	PF01048	0.608
MOD_GlcNHglycan	271	274	PF01048	0.658
MOD_GlcNHglycan	296	299	PF01048	0.463
MOD_GlcNHglycan	403	406	PF01048	0.711
MOD_GlcNHglycan	445	448	PF01048	0.535
MOD_GlcNHglycan	462	465	PF01048	0.610
MOD_GlcNHglycan	546	549	PF01048	0.559
MOD_GlcNHglycan	573	576	PF01048	0.549
MOD_GlcNHglycan	627	630	PF01048	0.633
MOD_GlcNHglycan	660	663	PF01048	0.726
MOD_GlcNHglycan	682	685	PF01048	0.651
MOD_GSK3_1	150	157	PF00069	0.598
MOD_GSK3_1	205	212	PF00069	0.472
MOD_GSK3_1	213	220	PF00069	0.531
MOD_GSK3_1	233	240	PF00069	0.537
MOD_GSK3_1	257	264	PF00069	0.511
MOD_GSK3_1	27	34	PF00069	0.545
MOD_GSK3_1	290	297	PF00069	0.504
MOD_GSK3_1	301	308	PF00069	0.478
MOD_GSK3_1	374	381	PF00069	0.493
MOD_GSK3_1	399	406	PF00069	0.707
MOD_GSK3_1	465	472	PF00069	0.605
MOD_GSK3_1	499	506	PF00069	0.538
MOD_GSK3_1	676	683	PF00069	0.565
MOD_GSK3_1	714	721	PF00069	0.643
MOD_N-GLC_1	233	238	PF02516	0.576
MOD_N-GLC_1	314	319	PF02516	0.517
MOD_NEK2_1	124	129	PF00069	0.334
MOD_NEK2_1	206	211	PF00069	0.450
MOD_NEK2_1	215	220	PF00069	0.537
MOD_NEK2_1	294	299	PF00069	0.327
MOD_NEK2_1	465	470	PF00069	0.631
MOD_NEK2_1	499	504	PF00069	0.527
MOD_NEK2_1	519	524	PF00069	0.416
MOD_NEK2_1	571	576	PF00069	0.495
MOD_NEK2_1	646	651	PF00069	0.530
MOD_NEK2_1	71	76	PF00069	0.514
MOD_NEK2_2	290	295	PF00069	0.314
MOD_NEK2_2	599	604	PF00069	0.464
MOD_PIKK_1	195	201	PF00454	0.512
MOD_PIKK_1	257	263	PF00454	0.524
MOD_PIKK_1	305	311	PF00454	0.507
MOD_PIKK_1	369	375	PF00454	0.534
MOD_PK_1	503	509	PF00069	0.306
MOD_PKA_1	42	48	PF00069	0.450
MOD_PKA_1	718	724	PF00069	0.671
MOD_PKA_2	222	228	PF00069	0.629
MOD_PKA_2	305	311	PF00069	0.438
MOD_PKA_2	330	336	PF00069	0.501
MOD_PKA_2	42	48	PF00069	0.480
MOD_PKA_2	488	494	PF00069	0.413
MOD_PKA_2	677	683	PF00069	0.488
MOD_PKA_2	714	720	PF00069	0.502
MOD_Plk_1	135	141	PF00069	0.553
MOD_Plk_1	27	33	PF00069	0.436
MOD_Plk_1	520	526	PF00069	0.541
MOD_Plk_1	69	75	PF00069	0.433
MOD_Plk_2-3	100	106	PF00069	0.387
MOD_Plk_4	290	296	PF00069	0.501
MOD_Plk_4	330	336	PF00069	0.518
MOD_Plk_4	42	48	PF00069	0.502
MOD_Plk_4	465	471	PF00069	0.536
MOD_Plk_4	488	494	PF00069	0.489
MOD_Plk_4	60	66	PF00069	0.276
MOD_Plk_4	638	644	PF00069	0.335
MOD_ProDKin_1	210	216	PF00069	0.483
MOD_ProDKin_1	218	224	PF00069	0.554
MOD_ProDKin_1	261	267	PF00069	0.647
MOD_ProDKin_1	384	390	PF00069	0.652
MOD_ProDKin_1	393	399	PF00069	0.747
MOD_ProDKin_1	403	409	PF00069	0.573
MOD_ProDKin_1	411	417	PF00069	0.491
MOD_ProDKin_1	522	528	PF00069	0.517
MOD_ProDKin_1	58	64	PF00069	0.613
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.641
TRG_ENDOCYTIC_2	113	116	PF00928	0.541
TRG_ENDOCYTIC_2	182	185	PF00928	0.496
TRG_ENDOCYTIC_2	250	253	PF00928	0.502
TRG_ENDOCYTIC_2	430	433	PF00928	0.403
TRG_ENDOCYTIC_2	44	47	PF00928	0.524
TRG_ER_diArg_1	116	119	PF00400	0.440
TRG_ER_diArg_1	140	143	PF00400	0.608
TRG_ER_diArg_1	42	44	PF00400	0.499
TRG_ER_diArg_1	6	8	PF00400	0.643
TRG_ER_diArg_1	718	720	PF00400	0.601
TRG_NES_CRM1_1	325	338	PF08389	0.443
TRG_NES_CRM1_1	496	510	PF08389	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I790	Leptomonas seymouri	58%	100%
A0A1X0P9R2	Trypanosomatidae	35%	100%
A0A3R7MUC6	Trypanosoma rangeli	34%	100%
A0A3S7X824	Leishmania donovani	78%	100%
A4IA49	Leishmania infantum	77%	100%
C9ZM54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B563	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q2S2	Leishmania major	78%	100%
V5BV01	Trypanosoma cruzi	34%	100%