Tegument protein UL21

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAY8_LEIBR

TriTrypDb:

LbrM.20.2270 , LBRM2903_200033300

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.718
CLV_C14_Caspase3-7	231	235	PF00656	0.768
CLV_NRD_NRD_1	21	23	PF00675	0.737
CLV_NRD_NRD_1	211	213	PF00675	0.787
CLV_NRD_NRD_1	266	268	PF00675	0.600
CLV_NRD_NRD_1	356	358	PF00675	0.568
CLV_NRD_NRD_1	382	384	PF00675	0.513
CLV_NRD_NRD_1	96	98	PF00675	0.822
CLV_PCSK_KEX2_1	21	23	PF00082	0.737
CLV_PCSK_KEX2_1	211	213	PF00082	0.787
CLV_PCSK_KEX2_1	266	268	PF00082	0.508
CLV_PCSK_KEX2_1	356	358	PF00082	0.568
CLV_PCSK_KEX2_1	381	383	PF00082	0.590
CLV_PCSK_KEX2_1	95	97	PF00082	0.820
CLV_PCSK_PC7_1	92	98	PF00082	0.829
CLV_PCSK_SKI1_1	35	39	PF00082	0.597
CLV_Separin_Metazoa	246	250	PF03568	0.560
DEG_SCF_FBW7_1	174	181	PF00400	0.776
DEG_SPOP_SBC_1	87	91	PF00917	0.732
DOC_CKS1_1	175	180	PF01111	0.728
DOC_CKS1_1	63	68	PF01111	0.550
DOC_CYCLIN_RxL_1	356	366	PF00134	0.472
DOC_MAPK_gen_1	356	364	PF00069	0.533
DOC_MAPK_gen_1	46	54	PF00069	0.565
DOC_MAPK_gen_1	78	87	PF00069	0.792
DOC_PP1_RVXF_1	355	362	PF00149	0.540
DOC_PP1_SILK_1	387	392	PF00149	0.500
DOC_PP2B_LxvP_1	196	199	PF13499	0.752
DOC_SPAK_OSR1_1	314	318	PF12202	0.395
DOC_USP7_MATH_1	124	128	PF00917	0.630
DOC_USP7_MATH_1	178	182	PF00917	0.814
DOC_USP7_MATH_1	71	75	PF00917	0.816
DOC_USP7_MATH_1	86	90	PF00917	0.589
DOC_USP7_MATH_1	99	103	PF00917	0.607
DOC_WW_Pin1_4	174	179	PF00397	0.783
DOC_WW_Pin1_4	190	195	PF00397	0.735
DOC_WW_Pin1_4	62	67	PF00397	0.547
LIG_14-3-3_CanoR_1	128	134	PF00244	0.556
LIG_14-3-3_CanoR_1	187	192	PF00244	0.742
LIG_14-3-3_CanoR_1	249	259	PF00244	0.673
LIG_14-3-3_CanoR_1	33	38	PF00244	0.608
LIG_14-3-3_CanoR_1	351	359	PF00244	0.599
LIG_14-3-3_CanoR_1	381	386	PF00244	0.584
LIG_14-3-3_CanoR_1	415	423	PF00244	0.406
LIG_Actin_WH2_2	289	306	PF00022	0.587
LIG_BIR_II_1	1	5	PF00653	0.764
LIG_BIR_III_2	197	201	PF00653	0.801
LIG_CaM_NSCaTE_8	264	271	PF13499	0.348
LIG_FHA_1	223	229	PF00498	0.680
LIG_FHA_1	260	266	PF00498	0.568
LIG_FHA_1	397	403	PF00498	0.547
LIG_FHA_1	420	426	PF00498	0.400
LIG_FHA_1	77	83	PF00498	0.685
LIG_FHA_2	51	57	PF00498	0.545
LIG_FHA_2	78	84	PF00498	0.701
LIG_FHA_2	88	94	PF00498	0.702
LIG_HCF-1_HBM_1	376	379	PF13415	0.506
LIG_Integrin_isoDGR_2	5	7	PF01839	0.574
LIG_LIR_Apic_2	157	163	PF02991	0.605
LIG_LIR_Apic_2	65	71	PF02991	0.556
LIG_LIR_Gen_1	341	350	PF02991	0.320
LIG_LIR_Nem_3	341	347	PF02991	0.335
LIG_LIR_Nem_3	348	353	PF02991	0.290
LIG_LIR_Nem_3	57	63	PF02991	0.665
LIG_MYND_1	257	261	PF01753	0.589
LIG_Pex14_2	316	320	PF04695	0.452
LIG_Pex14_2	406	410	PF04695	0.435
LIG_REV1ctd_RIR_1	313	323	PF16727	0.471
LIG_SH2_CRK	160	164	PF00017	0.599
LIG_SH2_CRK	344	348	PF00017	0.355
LIG_SH2_CRK	350	354	PF00017	0.401
LIG_SH2_GRB2like	60	63	PF00017	0.542
LIG_SH2_STAP1	133	137	PF00017	0.781
LIG_SH2_STAT5	133	136	PF00017	0.686
LIG_SH2_STAT5	28	31	PF00017	0.572
LIG_SH2_STAT5	295	298	PF00017	0.475
LIG_SH2_STAT5	379	382	PF00017	0.526
LIG_SH2_STAT5	401	404	PF00017	0.524
LIG_SH2_STAT5	433	436	PF00017	0.530
LIG_SH2_STAT5	64	67	PF00017	0.707
LIG_SH3_1	276	282	PF00018	0.646
LIG_SH3_1	304	310	PF00018	0.410
LIG_SH3_3	188	194	PF00018	0.775
LIG_SH3_3	244	250	PF00018	0.613
LIG_SH3_3	276	282	PF00018	0.490
LIG_SH3_3	304	310	PF00018	0.410
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.556
LIG_TYR_ITIM	342	347	PF00017	0.351
LIG_WRC_WIRS_1	439	444	PF05994	0.429
LIG_WW_3	246	250	PF00397	0.560
MOD_CDK_SPK_2	62	67	PF00069	0.547
MOD_CK1_1	100	106	PF00069	0.841
MOD_CK1_1	126	132	PF00069	0.760
MOD_CK1_1	136	142	PF00069	0.647
MOD_CK1_1	181	187	PF00069	0.734
MOD_CK1_1	190	196	PF00069	0.661
MOD_CK1_1	283	289	PF00069	0.458
MOD_CK1_1	297	303	PF00069	0.530
MOD_CK1_1	414	420	PF00069	0.523
MOD_CK2_1	414	420	PF00069	0.523
MOD_CK2_1	77	83	PF00069	0.597
MOD_Cter_Amidation	209	212	PF01082	0.788
MOD_GlcNHglycan	102	105	PF01048	0.833
MOD_GlcNHglycan	113	116	PF01048	0.732
MOD_GlcNHglycan	128	131	PF01048	0.610
MOD_GlcNHglycan	143	146	PF01048	0.688
MOD_GlcNHglycan	156	159	PF01048	0.702
MOD_GlcNHglycan	160	163	PF01048	0.564
MOD_GlcNHglycan	23	27	PF01048	0.710
MOD_GlcNHglycan	252	255	PF01048	0.707
MOD_GlcNHglycan	297	300	PF01048	0.323
MOD_GlcNHglycan	329	332	PF01048	0.592
MOD_GlcNHglycan	372	375	PF01048	0.382
MOD_GlcNHglycan	394	397	PF01048	0.691
MOD_GlcNHglycan	71	74	PF01048	0.681
MOD_GSK3_1	107	114	PF00069	0.618
MOD_GSK3_1	122	129	PF00069	0.741
MOD_GSK3_1	131	138	PF00069	0.627
MOD_GSK3_1	141	148	PF00069	0.712
MOD_GSK3_1	154	161	PF00069	0.753
MOD_GSK3_1	170	177	PF00069	0.732
MOD_GSK3_1	186	193	PF00069	0.590
MOD_GSK3_1	222	229	PF00069	0.821
MOD_GSK3_1	255	262	PF00069	0.587
MOD_GSK3_1	29	36	PF00069	0.678
MOD_GSK3_1	294	301	PF00069	0.488
MOD_GSK3_1	345	352	PF00069	0.526
MOD_GSK3_1	392	399	PF00069	0.565
MOD_GSK3_1	50	57	PF00069	0.738
MOD_N-GLC_2	448	450	PF02516	0.462
MOD_NEK2_1	186	191	PF00069	0.641
MOD_NEK2_1	228	233	PF00069	0.597
MOD_NEK2_1	29	34	PF00069	0.475
MOD_NEK2_1	327	332	PF00069	0.614
MOD_NEK2_1	9	14	PF00069	0.584
MOD_NEK2_2	178	183	PF00069	0.596
MOD_PIKK_1	181	187	PF00454	0.632
MOD_PIKK_1	213	219	PF00454	0.718
MOD_PIKK_1	414	420	PF00454	0.558
MOD_PIKK_1	441	447	PF00454	0.480
MOD_PK_1	187	193	PF00069	0.685
MOD_PKA_1	21	27	PF00069	0.773
MOD_PKA_1	211	217	PF00069	0.595
MOD_PKA_1	381	387	PF00069	0.591
MOD_PKA_2	100	106	PF00069	0.841
MOD_PKA_2	186	192	PF00069	0.607
MOD_PKA_2	21	27	PF00069	0.771
MOD_PKA_2	211	217	PF00069	0.595
MOD_PKA_2	250	256	PF00069	0.531
MOD_PKA_2	370	376	PF00069	0.550
MOD_PKA_2	381	387	PF00069	0.539
MOD_PKA_2	414	420	PF00069	0.523
MOD_PKA_2	50	56	PF00069	0.792
MOD_PKA_2	69	75	PF00069	0.500
MOD_PKA_2	77	83	PF00069	0.562
MOD_PKA_2	9	15	PF00069	0.673
MOD_PKB_1	109	117	PF00069	0.593
MOD_PKB_1	95	103	PF00069	0.830
MOD_Plk_1	419	425	PF00069	0.467
MOD_Plk_4	298	304	PF00069	0.603
MOD_Plk_4	338	344	PF00069	0.641
MOD_Plk_4	345	351	PF00069	0.437
MOD_Plk_4	438	444	PF00069	0.384
MOD_ProDKin_1	174	180	PF00069	0.783
MOD_ProDKin_1	190	196	PF00069	0.734
MOD_ProDKin_1	62	68	PF00069	0.549
TRG_DiLeu_BaEn_3	420	426	PF01217	0.318
TRG_ENDOCYTIC_2	344	347	PF00928	0.325
TRG_ENDOCYTIC_2	350	353	PF00928	0.369
TRG_ENDOCYTIC_2	60	63	PF00928	0.743
TRG_ER_diArg_1	108	111	PF00400	0.602
TRG_ER_diArg_1	20	22	PF00400	0.762
TRG_ER_diArg_1	248	251	PF00400	0.583
TRG_ER_diArg_1	265	267	PF00400	0.545
TRG_ER_diArg_1	356	358	PF00400	0.568
TRG_ER_diArg_1	380	383	PF00400	0.572
TRG_ER_diArg_1	45	48	PF00400	0.576
TRG_ER_diArg_1	95	97	PF00400	0.809

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ09	Leptomonas seymouri	49%	92%
A0A3Q8IIN3	Leishmania donovani	68%	100%
A4IA47	Leishmania infantum	68%	100%
E9B561	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%