Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAY6_LEIBR

TriTrypDb:

LbrM.20.2250 , LBRM2903_200033100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.680
CLV_NRD_NRD_1	209	211	PF00675	0.570
CLV_NRD_NRD_1	459	461	PF00675	0.513
CLV_PCSK_KEX2_1	120	122	PF00082	0.609
CLV_PCSK_KEX2_1	199	201	PF00082	0.681
CLV_PCSK_KEX2_1	208	210	PF00082	0.576
CLV_PCSK_KEX2_1	315	317	PF00082	0.577
CLV_PCSK_KEX2_1	417	419	PF00082	0.536
CLV_PCSK_KEX2_1	459	461	PF00082	0.513
CLV_PCSK_KEX2_1	494	496	PF00082	0.544
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.467
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.606
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.487
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.535
CLV_PCSK_SKI1_1	225	229	PF00082	0.514
CLV_PCSK_SKI1_1	414	418	PF00082	0.584
CLV_PCSK_SKI1_1	430	434	PF00082	0.388
CLV_PCSK_SKI1_1	451	455	PF00082	0.504
DEG_APCC_DBOX_1	175	183	PF00400	0.605
DEG_APCC_DBOX_1	425	433	PF00400	0.482
DOC_CKS1_1	66	71	PF01111	0.558
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.500
DOC_PP2B_LxvP_1	147	150	PF13499	0.628
DOC_USP7_MATH_1	161	165	PF00917	0.656
DOC_USP7_MATH_1	438	442	PF00917	0.548
DOC_USP7_MATH_1	465	469	PF00917	0.678
DOC_USP7_MATH_1	61	65	PF00917	0.545
DOC_WW_Pin1_4	219	224	PF00397	0.707
DOC_WW_Pin1_4	376	381	PF00397	0.627
DOC_WW_Pin1_4	391	396	PF00397	0.633
DOC_WW_Pin1_4	401	406	PF00397	0.604
DOC_WW_Pin1_4	527	532	PF00397	0.525
DOC_WW_Pin1_4	539	544	PF00397	0.609
DOC_WW_Pin1_4	57	62	PF00397	0.659
DOC_WW_Pin1_4	65	70	PF00397	0.547
LIG_14-3-3_CanoR_1	104	114	PF00244	0.605
LIG_14-3-3_CanoR_1	225	232	PF00244	0.519
LIG_14-3-3_CanoR_1	399	408	PF00244	0.589
LIG_14-3-3_CanoR_1	451	461	PF00244	0.589
LIG_14-3-3_CanoR_1	462	469	PF00244	0.508
LIG_14-3-3_CanoR_1	545	553	PF00244	0.594
LIG_14-3-3_CanoR_1	62	66	PF00244	0.536
LIG_BIR_III_2	501	505	PF00653	0.556
LIG_FHA_1	108	114	PF00498	0.640
LIG_FHA_1	2	8	PF00498	0.515
LIG_FHA_1	271	277	PF00498	0.744
LIG_FHA_1	345	351	PF00498	0.525
LIG_FHA_1	464	470	PF00498	0.558
LIG_FHA_2	164	170	PF00498	0.637
LIG_FHA_2	18	24	PF00498	0.487
LIG_FHA_2	453	459	PF00498	0.659
LIG_Integrin_RGD_1	364	366	PF01839	0.543
LIG_LIR_Apic_2	63	69	PF02991	0.587
LIG_LIR_Gen_1	115	123	PF02991	0.474
LIG_LIR_Gen_1	285	294	PF02991	0.480
LIG_LIR_Gen_1	434	444	PF02991	0.560
LIG_LIR_Gen_1	515	522	PF02991	0.558
LIG_LIR_Gen_1	68	78	PF02991	0.537
LIG_LIR_Nem_3	115	119	PF02991	0.484
LIG_LIR_Nem_3	434	439	PF02991	0.545
LIG_LIR_Nem_3	506	511	PF02991	0.627
LIG_LIR_Nem_3	515	520	PF02991	0.552
LIG_LIR_Nem_3	68	74	PF02991	0.535
LIG_Pex14_1	283	287	PF04695	0.493
LIG_Pex14_1	290	294	PF04695	0.472
LIG_Pex14_2	242	246	PF04695	0.471
LIG_SH2_CRK	116	120	PF00017	0.624
LIG_SH2_CRK	294	298	PF00017	0.486
LIG_SH2_CRK	436	440	PF00017	0.556
LIG_SH2_CRK	508	512	PF00017	0.522
LIG_SH2_CRK	66	70	PF00017	0.625
LIG_SH2_STAP1	284	288	PF00017	0.525
LIG_SH2_STAP1	298	302	PF00017	0.497
LIG_SH2_STAT3	293	296	PF00017	0.484
LIG_SH2_STAT3	298	301	PF00017	0.497
LIG_SH3_2	392	397	PF14604	0.640
LIG_SH3_3	244	250	PF00018	0.522
LIG_SH3_3	389	395	PF00018	0.678
LIG_SH3_3	476	482	PF00018	0.668
LIG_SH3_3	49	55	PF00018	0.577
LIG_SH3_4	397	404	PF00018	0.530
LIG_TRAF2_1	139	142	PF00917	0.472
LIG_TYR_ITIM	292	297	PF00017	0.448
MOD_CDC14_SPxK_1	222	225	PF00782	0.502
MOD_CDC14_SPxK_1	394	397	PF00782	0.663
MOD_CDC14_SPxK_1	542	545	PF00782	0.544
MOD_CDK_SPK_2	401	406	PF00069	0.661
MOD_CDK_SPK_2	57	62	PF00069	0.553
MOD_CDK_SPxK_1	219	225	PF00069	0.513
MOD_CDK_SPxK_1	391	397	PF00069	0.663
MOD_CDK_SPxK_1	539	545	PF00069	0.550
MOD_CK1_1	103	109	PF00069	0.693
MOD_CK1_1	270	276	PF00069	0.658
MOD_CK2_1	109	115	PF00069	0.500
MOD_CK2_1	163	169	PF00069	0.619
MOD_CK2_1	331	337	PF00069	0.810
MOD_CK2_1	516	522	PF00069	0.476
MOD_Cter_Amidation	313	316	PF01082	0.594
MOD_Cter_Amidation	492	495	PF01082	0.626
MOD_GlcNHglycan	163	166	PF01048	0.673
MOD_GlcNHglycan	169	173	PF01048	0.613
MOD_GlcNHglycan	185	188	PF01048	0.633
MOD_GlcNHglycan	235	238	PF01048	0.662
MOD_GlcNHglycan	259	262	PF01048	0.626
MOD_GlcNHglycan	270	273	PF01048	0.520
MOD_GlcNHglycan	333	336	PF01048	0.688
MOD_GlcNHglycan	372	375	PF01048	0.590
MOD_GlcNHglycan	410	413	PF01048	0.559
MOD_GlcNHglycan	463	466	PF01048	0.740
MOD_GSK3_1	100	107	PF00069	0.635
MOD_GSK3_1	185	192	PF00069	0.662
MOD_GSK3_1	215	222	PF00069	0.618
MOD_GSK3_1	326	333	PF00069	0.629
MOD_GSK3_1	397	404	PF00069	0.565
MOD_GSK3_1	461	468	PF00069	0.553
MOD_GSK3_1	50	57	PF00069	0.613
MOD_GSK3_1	503	510	PF00069	0.672
MOD_GSK3_1	523	530	PF00069	0.462
MOD_GSK3_1	534	541	PF00069	0.792
MOD_GSK3_1	61	68	PF00069	0.741
MOD_LATS_1	313	319	PF00433	0.478
MOD_N-GLC_1	257	262	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	102	107	PF00069	0.594
MOD_NEK2_1	17	22	PF00069	0.630
MOD_NEK2_1	232	237	PF00069	0.634
MOD_NEK2_1	267	272	PF00069	0.529
MOD_NEK2_2	61	66	PF00069	0.537
MOD_PIKK_1	1	7	PF00454	0.506
MOD_PIKK_1	123	129	PF00454	0.543
MOD_PIKK_1	397	403	PF00454	0.595
MOD_PKA_1	315	321	PF00069	0.615
MOD_PKA_2	103	109	PF00069	0.530
MOD_PKA_2	161	167	PF00069	0.669
MOD_PKA_2	315	321	PF00069	0.615
MOD_PKA_2	353	359	PF00069	0.547
MOD_PKA_2	461	467	PF00069	0.629
MOD_PKA_2	538	544	PF00069	0.693
MOD_PKA_2	61	67	PF00069	0.531
MOD_Plk_1	79	85	PF00069	0.498
MOD_Plk_4	61	67	PF00069	0.526
MOD_ProDKin_1	219	225	PF00069	0.707
MOD_ProDKin_1	376	382	PF00069	0.626
MOD_ProDKin_1	391	397	PF00069	0.633
MOD_ProDKin_1	401	407	PF00069	0.603
MOD_ProDKin_1	527	533	PF00069	0.526
MOD_ProDKin_1	539	545	PF00069	0.609
MOD_ProDKin_1	57	63	PF00069	0.659
MOD_ProDKin_1	65	71	PF00069	0.544
MOD_SUMO_for_1	432	435	PF00179	0.401
TRG_DiLeu_BaEn_2	448	454	PF01217	0.488
TRG_DiLeu_BaEn_4	434	440	PF01217	0.531
TRG_ENDOCYTIC_2	116	119	PF00928	0.624
TRG_ENDOCYTIC_2	288	291	PF00928	0.476
TRG_ENDOCYTIC_2	294	297	PF00928	0.482
TRG_ENDOCYTIC_2	436	439	PF00928	0.555
TRG_ENDOCYTIC_2	508	511	PF00928	0.527
TRG_ER_diArg_1	199	202	PF00400	0.567
TRG_ER_diArg_1	208	210	PF00400	0.544
TRG_ER_diArg_1	459	462	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P607	Leptomonas seymouri	29%	97%
A0A3Q8IEH1	Leishmania donovani	57%	97%
A4IA45	Leishmania infantum	57%	97%
E9B559	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	97%
Q4Q2S6	Leishmania major	57%	99%